Mrna bzip proteins. Medical search. Frequent questions

Nuclear factor erythroid-2-related factor 2 (NRF2) is the most studied member of the Cap 'n' collar basic leucine zipper (CNC-bZIP) family of transcription factors. (hindawi.com)
Nrf2 is a master eukaryotic redox-active factor and belongs to Cap 'n' Collar (Cnc)-bZIP (basic leucine zipper) family of transcription factors. (springer.com)
AP-1 is composed of either homo or hetero dimers of basic leucine zipper (bZIP) family members [ 11 ]. (biomedcentral.com)
The basic leucine zipper ( bZIP ) family, a supergene family encoding transcription factors (TFs), is evolutionarily conserved and widely distributed across eukaryotic organisms [ 1 ]. (biomedcentral.com)
bZIP TFs contain a bZIP domain, generally composed of 60-80 amino acids, with two functionally distinct parts, a highly conserved basic region and a variable leucine-zipper region (explaining the name bZIP) [ 2 , 3 ]. (biomedcentral.com)
Spliced X-box binding protein-1 (XBP1s) is a protein that belongs to the cAMP-response element-binding (CREB)/activating transcription factor (ATF) b-ZIP family with a basic-region leucine zipper (bZIP). (mdpi.com)
Thyrotroph embryonic factor isoform 1, also known as TEF, is a 303 amino acid nuclear transcription factor that belongs to the bZIP (basic region/leucine zipper) family and PAR (proline and acidic amino acid-rich) subfamily. (creativebiomart.net)
It is thought to regulate dimerization, DNA binding, and transcriptional activity of basic region-leucine zipper (bZIP) proteins. (gzsys.org.cn)
Neural retina-specific leucine zipper protein is a protein that in humans is encoded by the NRL gene . (en-academic.com)

Extensive evidence has revealed that the core clock machinery involves "clock genes" and "clock proteins" functioning as molecular cogs. (bioone.org)
It is a main inductor of genes of antioxidant proteins and phase II detoxifying enzymes [ 1 ]. (hindawi.com)
Furthermore, mRNA accumulation studies revealed that the expression of these novel bZIP genes and CIP is not altered by exposure to light. (embl-heidelberg.de)
The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
The major characteristics of Nrf2 are to some extent mimicked by Nrf2-dependent genes and their proteins including heme oxygenase-1 (HO-1), which besides removing toxic heme, produces biliverdin, iron ions and carbon monoxide. (springer.com)
The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. (cancerindex.org)
In addition, steady-state mRNA levels of nine stress-responsive genes coding for either functional or regulatory proteins were induced to higher levels in the transgenic lines with or without drought stress. (biomedcentral.com)
Products of the former group function directly in protecting cells against damage derived from stresses and sustaining cell viability, and the latter is composed of regulatory proteins, such as transcription factors (TFs), protein kinases and protein phosphatases, that are responsible for transducing stress signaling and regulating expression of stress-responsive genes [ 5 ]. (biomedcentral.com)
Thus, stress response studies during these growth stages reveal novel differentially regulated genes or proteins with important functions in plant stress adaptation. (intechopen.com)
In this study, we identified 58 bZIP genes in the C. paliurus genome and analyzed phylogenetic relationships, chromosomal locations, gene structure, collinearity, and gene expression profiles. (biomedcentral.com)
The 58 bZIP genes could be divided into 11 groups and were unevenly distributed among 16 C. paliurus chromosomes. (biomedcentral.com)
The expression patterns of bZIP genes in leaves differed among developmental stages. (biomedcentral.com)
Our results provide insights into the evolutionary history of the bZIP gene family in C. paliurus and the function of these genes during leaf development and in the response to drought stress. (biomedcentral.com)
In addition to the essential regulatory functions in plant growth and development, bZIP genes participate in the response to abiotic stress. (biomedcentral.com)
We have learned that genes in mammalian cells are transcribed into messenger RNAs (mRNAs), which are to be translated into polypeptides (proteins). (intechopen.com)
An alternative mechanism of IRE1α action involves the splicing of XBP1 mRNA to yield an active transcription factors XBP1s which regulates the expression of genes functioning in protein folding. (cd-biosciences.com)
The transcription of XBP1-dependent genes improves the protein-folding capacity of ER and thus relieves ER stress. (cd-biosciences.com)
ATF6f is a bZIP transcription factors which migrates to the nucleus and regulates the expression of genes involved in ER homeostasis. (cd-biosciences.com)
Analyzing the cellular phenotypes regulated by genes/proteins of interest. (cd-biosciences.com)

The RPL24B protein of the large ribosomal subunit, which is encoded by SHORT VALVE1 , likewise fosters translation of uORF-containing mRNAs, for example mRNAs for auxin response transcription factors (ARFs). (biomedcentral.com)

It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). (cancerindex.org)
In this study, we showed that disruption of ORF57 in a KSHV genome led to increased accumulation of ORF50 and K8 pre-mRNAs and reduced expression of ORF50 and K-bZIP proteins but had no effect on latency-associated nuclear antigen (LANA). (pasteur.fr)
Accumulation of unfolded proteins in the ER lumen triggers the dissociation of GRP78 from its quiescent UPR mediators. (molvis.org)
Perturbation of ER homeostasis through the accumulation of unfolded or misfolded proteins results in a stress condition, i.e . (cd-biosciences.com)
Similar to ER UPR, the mitochondrial unfolded protein response (mito UPR or UPR mt ) is a stress response triggered by the accumulation of deleterious mitochondrial genomes, unfolded or misfolded proteins or damages from reactive oxygen species (ROS). (cd-biosciences.com)
Ageing leads to a gradual dysfunction of the proteostasis network and thus to proteome instability due to accumulation of damaged and/or misfolded proteins [ 2 ]. (hindawi.com)

Within the scanning model of translation initiation, reinitiation is a non-canonical mechanism that operates on mRNAs harboring upstream open reading frames. (biomedcentral.com)
In Arabidopsis, about 30% of full-length mRNAs harbor one or more upstream open reading frames (uORFs) in their 5' leader sequence [ 8 ]. (biomedcentral.com)
Paradoxically, eIF2α phosphorylation also results in the increased translation of select mRNA bearing upstream open reading frames that favor 5' cap-independent translation [ 3 ]. (biomedcentral.com)

Effect of ATF4 overexpression on mRNA levels in differentiated C2C12 myotubes. (omicsdi.org)
ATF4 is a bZIP transcription factor that that promotes skeletal muscle atrophy. (omicsdi.org)
The goal of these studies was to determine the effects of ATF4 overexpression on mRNA levels in differentiated C2C12 myotubes. (omicsdi.org)
Effect of ATF4 gene knockout on skeletal muscle mRNA levels in fasted mice. (omicsdi.org)
The goal of these studies was to determine how of loss of ATF4 affects skeletal muscle mRNA expression. (omicsdi.org)
mRNA levels in ATF4 mKO muscles were normalized to levels in littermate control muscles. (omicsdi.org)
Control myotubes were infected with adenovirus co-expressing eGFP and a transcriptionally inactive ATF4 construct (ATF4∆bZIP). (omicsdi.org)
The eIF2α kinases phosphorylate Ser51 of eIF2α which leads to suppression of global protein synthesis but selective enhancement of translation of some mRNAs, such as that encoding ATF4. (biomedcentral.com)
A subset of mRNAs, such as ATF4 and ATF5 escape the mechanism of translational inhibition to support cellular anti-oxidative response, facilitate autophagy, promote the transcription of ER chaperones , and drive apoptosis if necessary. (cd-biosciences.com)

AF310222.1 Arabidopsis thaliana bZIP protein BZO2H1 mRNA, complete cds, alternatively spliced. (gao-lab.org)
BT025558.1 Arabidopsis thaliana At4g02640 mRNA, complete cds. (gao-lab.org)
The h subunit of eukaryotic initiation factor 3 (eIF3) boosts translation reinitiation on the uORF-containing mRNA coding for the Arabidopsis bZip transcription factor, AtbZip11, among others. (biomedcentral.com)
Through de novo transcriptome assembly with the RNA-seq reads from whole organ samples of C. virgata at the germination stage (2 days after germination, DAG), early young development stage (8 DAG), young development stage (17 DAG), and adult development stage (28 DAG), we identified 21,589 unified transcripts (contigs) and found that 19,346 and 18,156 protein-coding transcripts were homologous to those in rice and Arabidopsis , respectively. (frontiersin.org)
The clock-regulated RNA-binding protein AtGRP7 (Arabidopsis thaliana glycine-rich RNA-binding protein) influences circadian oscillations of its transcript by negative feedback at the post-transcriptional level. (uni-bielefeld.de)

Isolation and characterization of four novel parsley proteins that interact with the transcriptional regulators CPRF1 and CPRF2. (embl-heidelberg.de)

The bZIP intron saccharomycetales is an unconventional bZIP intron located in the HAC1 mRNA in most budding yeast belonging to Saccharomycetales order. (wikipedia.org)
In some species this poorly conserved region can pair with the 5' UTR of the HAC1 mRNA forming a pseudoknot, which stalls the translation. (wikipedia.org)
Inhibition of hac1 mRNA splicing, which is mediated by IRE1, was then validated for the most active compound, namely, Î³-mangostin 3. (bvsalud.org)

Cotransfection of ORF57 and K8beta cDNA, which retains a suboptimal intron of K8 pre-mRNA due to alternative splicing, promoted RNA splicing of K8beta and production of K8alpha (K-bZIP). (pasteur.fr)

According to the canonical model of eukaryotic translation, the ribosome dissociates from the mRNA for good as soon as it has terminated translation at a stop codon. (biomedcentral.com)

Mutations that abrogated the hbz mRNA or disrupted a stem-loop in hbz mRNA, or mutations that eliminated or truncated the HBZ protein were introduced in a functional molecular clone of HTLV-1. (wustl.edu)
Scope includes mutations and abnormal protein expression. (cancerindex.org)

We found that this effect of hbz was indirect, as hbz represses another accessory gene, p30II, which is known to sequester tax mRNA in the nucleus. (wustl.edu)

Analysis from the Gene Expression Omnibus datasets supported the mRNA findings. (hindawi.com)
Furthermore, the miRNAs correlated negatively with the immunohistochemical expression of NRF1 and NRF2 but positively with their respective mRNA. (hindawi.com)
MicroRNAs (miRNAs) are small noncoding RNAs that posttranscriptionally regulate gene expression by imperfect matching of mRNA [ 6 ]. (hindawi.com)
We discuss the possible roles of the newly identified proteins in CPRF1- and CPRF2-dependent target gene expression. (embl-heidelberg.de)
The protein and stem-loop mutants had no effect on viral gene expression. (wustl.edu)
However, the mutant that disrupted hbz mRNA expressed lower levels of tax mRNA, suggesting that hbz promotes tax expression. (wustl.edu)
It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. (cancerindex.org)
These conditions include but are not limited to artery or vein occlusion in diabetic retinopathy, hypoxic retina in retinopathy of prematurity, aging in age-related macular degeneration, expression of mutant proteins in inherited retinal degeneration, traumatic injury leading to retinal detachment, and light sensitivity in the case of light-induced retinal degeneration. (molvis.org)
The expression of Lcn2 is induced during 3T3-L1 adipogenesis in a CCAAT/enhancer-binding protein-dependent manner. (diabetesjournals.org)
Moreover, C. albicans Hom6p affects expression of the cell wall protein Xog1p which is a major exoglucanase and is found to be involved in cell adhesion. (ncl.edu.tw)
We speculated that the defect of protein synthesis attenuated expression of other exoglucanases or glucan synthesis-related proteins, and then induced release of Xog1p to the cell wall. (ncl.edu.tw)
The results showed that mRNA expression of Akt/PI3K/mTOR was down-regulated in carrier, HAM/TSP, and ATLL patients, as well as MT-2, and Inf-3T3 cells, compared to the healthy individuals and untreated MT-2 and Inf-3T3 as controls. (htlv.net)
Treating the cells with rapamycin, wortmannin, and rigosertib decreased the phosphorylated forms of Akt and mTOR and restored their mRNA expression levels. (htlv.net)
the filamentous fungus aspergillus oryzae is a well-known expression host used to express homologous and heterologous proteins in a number of industrial applications. (liverpool.ac.uk)

Plus3 domains occur in the Saccharomyces cerevisiae Rtf1p protein, which interacts with Spt6p, and in parsley CIP, which interacts with the bZIP protein CPRF1. (embl-heidelberg.de)

Binds to the 5'-ACGT-3' motif of seed storage protein (SSP) encoding gene promoters (e.g. (gao-lab.org)
An analysis of cis-regulatory elements indicated that bZIP promoters were associated with phytohormones and stress responses. (biomedcentral.com)

HTLV-2 Encoded Antisense Protein APH-2 Suppresses HIV-1 Replication Abstract Antisense protein of Human T-cell. (htlv.net)

Effect of Gadd45a overexpression on mouse skeletal muscle mRNA levels. (omicsdi.org)
The goal of these studies was to determine the effects of Gadd45a overexpression on mRNA levels in mouse skeletal muscle. (omicsdi.org)

In animals, the ER UPR signaling pathway is initiated by three membrane-associated stress sensor proteins: inositol requiring enzyme 1α/β (IRE1), PKR-like ER kinase (PERK), and activating transcription factor 6α/β (ATF6). (cd-biosciences.com)

Phosphorylation of eIF2α on Ser51 inhibits 5' cap-dependent mRNA translation, resulting in the global suppression of protein synthesis to facilitate adaptation to a variety of stresses linked to protein synthesis, including proteotoxic stress, viral replication, heme depletion and amino acid withdrawal [ 2 ]. (biomedcentral.com)
It is an important site for the synthesis, folding, modification, and transport of proteins. (cd-biosciences.com)
C. albicans Hom6p thus had an effect on cell survival and cell adhesion by maintaining protein synthesis and cell wall function. (ncl.edu.tw)
The proteostasis network (PN) is an assembly of distinct dynamic molecular pathways that control the functionality of the proteome (proteome homeodynamics) during protein synthesis, folding, trafficking, and degradation. (hindawi.com)

In addition, NRF1 and NRF2 mRNA and miR-23B, miR-93, miR-144, miR-212, miR-340, miR-383, and miR-510 levels were analysed with real-time qPCR from 54 paraffin-embedded naevi and melanoma samples. (hindawi.com)
Nrf2 consists of six functional Neh domains (Neh1-Neh6), from which, the amino-terminal Neh2 domain controls binding Keap1-the inhibitor protein Kelch-like ECH-associated protein 1, that is responsible for the cytosolic sequestration of Nrf2 under physiological conditions (Fig. 2 a). (springer.com)

This enhancement of RNA splicing by ORF57 correlates with the intact N-terminal nuclear localization signal motifs of ORF57 and takes place in the absence of other viral proteins. (pasteur.fr)

The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. (cancerindex.org)
Here, we demonstrate that the endoplasmic reticulum stress sensor inositol-requiring enzyme 1 (IRE1α) and its substrate transcription factor X-box-binding protein 1 (XBP1) drive NK cell responses against viral infection and tumors in vivo. (cancerindex.org)

Recently published literature has provided evidence that the unfolded protein response (UPR) is involved in the development of retinal degeneration. (molvis.org)

Proteostasis is the dynamic regulation of protein homeostasis, where all the cellular pathways govern the production, folding, trafficking and degradation of proteins. (cd-biosciences.com)

In addition, several bZIP members were differentially expressed under drought stress. (biomedcentral.com)

The protein encoded by this gene is a heat stable, nuclear protein and functions as a molecular chaperone. (gzsys.org.cn)

In this study, we evaluated natural products targeting fungal IRE1 protein (UPR effector) and consequently increasing fungal susceptibility to plant defenses. (bvsalud.org)
This dissociation from PERK, ATF6, and IRE1 satisfies the demand for appropriate protein folding. (molvis.org)
Through its endoribonuclease domain, activated IRE1α has the propensity to cleave and degrade selected mRNAs and microRNAs in a process termed regulated IRE1-dependent decay (RIDD), and consequently reduce protein translation. (cd-biosciences.com)

Previous work on fungal mutants deficient in the unfolded protein response (UPR) supported that targeting this pathway is a promising plant disease control strategy. (bvsalud.org)
ER stress, and activates unfolded protein response (UPR). (cd-biosciences.com)

These strategies involve rearrangements at the molecular level starting from transcription, regulation of mRNA processing, translation, and protein modification or its turnover. (intechopen.com)
The molecular chaperone glucose-regulated protein 78 ( GRP78 ) or binding immunoglobulin protein (BiP), in addition to Ca 2+ binding and protein processing functions, possesses one more key role: master initiator of early UPR signaling. (molvis.org)

First, like eif3h mutants, rpl24b mutants under-translate the AtbZip11 mRNA, and the detailed spectrum of translational defects in rpl24b is remarkably similar to that of eif3h . (biomedcentral.com)

Snf1-RELATED KINASE1-Controlled C/S1-bZIP Signaling Activates Alternative Mitochondrial Metabolic Pathways to Ensure Plant Survival in Extended Darkness. (gao-lab.org)
One important heat shock protein is discussed further in the blog entry HSP70 to the rescue The relatively recent blog entries Mitohormesis and Radiation hormesis define hormesis in more detail and discuss it as it relates to mitochondrial oxidative stress and stress induced by radiation. (anti-agingfirewalls.com)

Oxidative stress generated during such stressful conditions may damage DNA and proteins, and as a consequence the cellular processes are disturbed. (springer.com)
This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. (cancerindex.org)
Cells express a pool of thousands of different proteins that need to be tightly controlled for proper cellular structure, organization, and function. (hindawi.com)

Like AtbZip11, the uORF-containing ARF mRNAs are indeed undertranslated in eif3h mutant seedlings. (biomedcentral.com)

Here we show that site-specific mutation of one conserved arginine to glutamine within the RNA recognition motif impairs binding of recombinant AtGRP7 to its pre-mRNA in vitro. (uni-bielefeld.de)
Recombinant human TEF protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. (creativebiomart.net)

Pathways to ensure proteostasis in different subcellular compartments are defined as unfolded protein responses (UPRs), which have evolved in the cytosol as cytosolic heat shock response (HSR), endoplasmic reticulum as UPR ER and mitochondria as UPR mt . (cd-biosciences.com)
The mitochondria have their own chaperones and proteolytic enzymes that remove damaged or unfolded proteins [ 18 - 20 ]. (hindawi.com)

against damage and regeneration failing after PH+I/R. which, once triggered, induces the unconventional splicing from the mRNA encoding X-box-binding proteins 1 (XBP-1). (cancerhugs.com)

PERK is activated after dissociation of ER chaperone BiP (GRP-78), which leads to the phosphorylation of eIF2α and attenuates global protein translation. (cd-biosciences.com)
These findings demonstrate that HTLV-1 downregulation of the mRNA level may occur as a negative feedback response to increased PI3K-Akt-mTOR phosphorylation by HTLV-1. (htlv.net)

functional characterization of nat/ncs2 proteins of aspergillus brasiliensis reveals a genuine xanthine-uric acid transporter and an intrinsically misfolded polypeptide. (liverpool.ac.uk)

A newly identified viral gene, HTLV-1 bZIP factor or hbz, has been shown to have pleiotropic effects as it functions differently in its protein and mRNA forms. (wustl.edu)

Most of the important insights regarding the specific function of AP-1 proteins have been established through the use of mice with either loss- or gain-of-function manipulations of various members of the bZIP protein family [ 13 ]. (biomedcentral.com)
The bZIP gene family has important roles in various biological processes, including development and stress responses. (biomedcentral.com)
The bZIP gene family has been studied extensively in plants. (biomedcentral.com)
The analysis of transcriptome data of the leaves in C. paliurus revealed the bZIP gene family was one of the most abundant TFs in this organism that regulate leaf development [ 26 ]. (biomedcentral.com)

That entry was the first to discuss the roles of heat shock and chaperone proteins in hormesis. (anti-agingfirewalls.com)

Keap1 is a cysteine-rich protein, known to be anchored to actin cytoskeleton [ 5 ], serving as an adaptor protein for the Cul3-dependent E3 ubiquitin ligase complex. (springer.com)

The discovery of leptin more than a decade ago established a paradigm in which secreted proteins from adipocytes coordinate energy balance and glucose homeostasis ( 2 , 3 ). (diabetesjournals.org)

PtrABF is a bZIP transcription factor and functions in positive modulation of drought stress tolerance. (biomedcentral.com)

mRNA levels in Gadd45a-transfected muscles were normalized to levels in control transfected muscles. (omicsdi.org)
mRNA levels in denervated muscles were normalized to levels in contralateral innervated muscles. (omicsdi.org)

Gadd45a is a stress-induced protein that causes skeletal muscle atrophy. (omicsdi.org)

Results DIM, but not I3C, increased adipocyte differentiation through upregulation of peroxisome proliferator‐activated receptor γ and CCAAT/enhancer‐binding protein α. (researchgate.net)

Synthetic lethal interactions suggest a role for the Saccharomyces cerevisiae Rtf1 protein in transcription elongation. (embl-heidelberg.de)
Here we present genetic results that indicate a role for the Saccharomyces cerevisiae Rtf1 protein in transcription elongation. (embl-heidelberg.de)

Anatomy7

Organisms4

Chemicals and Drugs42

Analytical, Diagnostic and Therapeutic Techniques and Equipment14

Phenomena and Processes39

Disciplines and Occupations1

Information Science3

Leucine zipper9

Genes19

Transcription factors1

Accumulation6

Upstream open readin3

ATF49

Arabidopsis5

Transcriptional1

HAC13

Intron1

Eukaryotic1

Mutations2

Nucleus1

Expression14

Interacts1

Promoters2

Abstract1

Overexpression2

Kinase1

Synthesis4

NRF22

Viral proteins1

XBP12

Retinal1

Degradation1

Differentially1

Nuclear1

IRE13

Unfolded protein2

Molecular2

Mutants1

Mitochondrial2

Cellular3

Mutant1

Recombinant2

Mitochondria2

Unconventional1

Phosphorylation2

Reveals1

Newly identified1

Family4

Roles1

Ubiquitin ligase1

Homeostasis1

Drought stress1

Levels2

Stress1

CCAAT1

Saccharomyces2