• derivatives
  • CCP, added by 2010 Regulations) 1-(3-Chlorophenyl)piperazine (i.e. mCPP, added by 2010 Regulations) Chlorphentermine Diethylpropion Ethchlorvnol (presumably Ethchlorvynol) Ethinamate Flunitrazepam (moved up from Schedule 4 by 1993 Regulations) 4-Hydroxybutanoic acid (added by 1993 Regulations) Ketamine (added by 2010 Regulations) Mazindol Mephentermine Meprobamate Methyprylone Pemoline Pentazocine Phentermine Pipradrol Temazepam (moved up from Schedule 4 by 1993 Regulations) Controlled medicinal products (and certain derivatives thereof). (wikipedia.org)
  • Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol. (wikipedia.org)
  • A range of other piperazine derivatives have also been sold as ingredients in party pills, and many of these branded "proprietary blends" have subsequently been sold in countries around the world. (wikipedia.org)
  • agonists
  • Effect of a long-term low tryptophan diet on the prolactin responses to the 5-HT1A and 5-HT2C agonists, 8-OH-DPAT and mCPP in the male rat. (ox.ac.uk)
  • receptors
  • This is associated with an enhanced PRL response to mCPP probably resulting from a functional up-regulation of post-synaptic 5-HT2C receptors. (ox.ac.uk)
  • mCPP patients experience multiple side effects due to non-selectivity over 5-HT2A and 5-HT2B receptors. (wikipedia.org)
  • Zealand
  • A ban was intended to come into effect in New Zealand on December 18, 2007, but the law change did not go through until the following year, and the sale of BZP and the other listed piperazines became illegal in New Zealand as of 1 April 2008. (wikipedia.org)
  • In countries such as New Zealand where BZP and related piperazines have been made illegal, there is now increasing commercial interest in piperazine-free "party pills" which are purported to produce similar effects with ingredients that will circumvent the ban. (wikipedia.org)
  • analogue
  • It is unclear whether 2,3-DCPP is pharmacologically active similar to its close analogue 3-chlorophenylpiperazine (mCPP). (wikipedia.org)
  • party-pill
  • In 2007 piperazine based party-pill formulations started to become widely available nationwide which has caused concern with local authorities such as Health Canada and subsequently BZP has gained much media attention in 2008. (wikipedia.org)
  • humans
  • mCPP is known to induce headaches in humans and has been used for testing potential antimigraine medications. (wikipedia.org)
  • Repeated administration of mCPP to humans might result in decreased food intake and weight loss. (wikipedia.org)
  • amphetamine
  • 5 the European Early Warning System (EWS), such as substituted piperazines, N-methylated cathinones and halogenated amphetamine derivates among other chemical classes. (docplayer.net)
  • chemicals
  • The piperazine is separated from the product stream, which contains ethylenediamine, diethylenetriamine, and other related linear and cyclic chemicals of this type. (wikipedia.org)
  • Unlike
  • The thermal degradation rates for methyl diethanolamine (MDEA) and piperazine (PZ) are negligible, and PZ, unlike other metals, protect MDEA from oxidative degradation. (wikipedia.org)
  • pills
  • These piperazines are usually mixed with other ingredients such as caffeine, 5-HTP, Oxedrine (which has close effects to ephedrine), Camelia sinensis and a range of vitamins, minerals, amino acids and binders to make party pills. (wikipedia.org)
  • effects
  • Other effects of mCPP include nausea, hypoactivity, and penile erection, the latter two the result of increased 5-HT2C activity and the former likely via 5-HT3 stimulation. (wikipedia.org)
  • mCPP may be responsible for some of their side effects. (wikipedia.org)
  • Specifically, the effects of unilateral lesions of nigrostriatal DA neurons on oral dyskinesia and Fos protein expression induced by the non-selective 5-HT(2C) agonist 1-(m-chlorophenyl)piperazine (m-CPP) were examined. (mendeley.com)
  • chemical
  • Piperazines were originally named because of their chemical similarity with piperidine, part of the structure of piperine in the black pepper plant (Piper nigrum). (wikipedia.org)
  • nitrogen
  • 3C-PEP is related to meta-cholorophenylpiperazine (mCPP) and phenethylamine that can be thought of as mCPP having a phenylethyl group attached to the nitrogen atom at its 4-position. (wikipedia.org)
  • significant
  • The low TRP diet caused significant reductions in both plasma total TRP and brain cortical 5-HT content together with a significant increase in the PRL responses to mCPP. (ox.ac.uk)
  • Amine blends that are activated by concentrated piperazine are used extensively in commercial CO2 removal for carbon capture and storage (CCS) because piperazine advantageously allows for protection from significant thermal and oxidative degradation at typical coal flue gas conditions. (wikipedia.org)
  • Usually
  • 6H2O, which melts at 44 °C and boils at 125-130 °C. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid). (wikipedia.org)
  • federal
  • mCPP is not scheduled at the federal level in the United States, but it is possible that it could be considered a controlled substance analog of BZP, in which case purchase, sale, or possession could be prosecuted under the Federal Analog Act. (wikipedia.org)