• reside
  • There was just one problem: Reflecting Ebola's ingenuity, both targets reside only in lysosomes deep within cells-making them invisible to the immune system and shielded from attack by conventional antibodies. (yu.edu)
  • uptake
  • Only the prototype FV (PFV) glycoprotein has also significant fusion activity at neutral pH, suggesting that its uptake mechanism may deviate from other FVs. (biomedcentral.com)
  • Interestingly, virions harboring fusion-defective glycoproteins still promoted virus attachment and uptake, but failed to show syncytia formation and perinuclear capsid accumulation. (biomedcentral.com)
  • receptor
  • Once the enzyme has dissociated from the mannose 6-phosphate receptor, it is translocated from the endosome to the lysosome where the phosphate tag is removed from the enzyme. (wikipedia.org)
  • viruses
  • Once safely inside the lysosomes, the viruses transform and expose key portions of their exterior that the research team successfully targeted using monoclonal antibodies. (yu.edu)
  • organelles
  • The various membranes that enclose the other subcellular organelles must therefore be constructed by transfer of lipids from these sites of synthesis. (wikipedia.org)
  • form
  • The system is defined more accurately as the set of membranes that form a single functional and developmental unit, either being connected directly, or exchanging material through vesicle transport. (wikipedia.org)
  • include
  • Importantly, the endomembrane system does not include the membranes of chloroplasts or mitochondria, but might have evolved from the latter (see below: Evolution). (wikipedia.org)
  • means
  • NPC1, which normally helps transport cholesterol within the cell, offers Ebola virus its only means of escaping the lysosome and multiplying. (yu.edu)
  • study
  • So the best therapy would be a monoclonal antibody that is active against the glycoproteins of all five ebolaviruses-and until our study, no such antibody had demonstrated the ability to do that. (yu.edu)