LysosomesEndosomesEndocytosisAutophagyProteolysisUbiquitinationEndosomal Sorting Complexes Required for TransportUbiquitinProteasome Endopeptidase ComplexProtein TransportLysosomal-Associated Membrane Protein 2ChloroquineLysosome-Associated Membrane GlycoproteinsPhagosomesProto-Oncogene Proteins c-cblCell LineUbiquitin-Protein LigasesSphingolipid Activator ProteinsSaposinsFetuinsLeupeptinsMultivesicular BodiesHEK293 CellsAsialoglycoproteinsCells, CulturedCathepsin DCysteine EndopeptidasesG(M2) Activator ProteinCathepsinsHeLa CellsCell MembraneProtein BindingDown-RegulationMolecular Sequence DataProtein Processing, Post-TranslationalUbiquitin ThiolesteraseVacuolesSignal TransductionVesicular Transport Proteinsrab GTP-Binding ProteinsAmino Acid SequenceMembrane ProteinsUbiquitinsMutationFibroblastsClathrinAmmonium ChlorideCysteine Proteinase InhibitorsProtein Structure, TertiaryModels, BiologicalKineticsGolgi ApparatusBiological TransportHSC70 Heat-Shock ProteinsRNA, Small InterferingRecombinant Fusion ProteinsMicroscopy, ConfocalSubcellular FractionsMicroscopy, ElectronCell Line, TumorMacrolidesHydrogen-Ion ConcentrationTransport VesiclesLiverEndoplasmic Reticulumrab5 GTP-Binding ProteinsCarrier ProteinsMicroscopy, FluorescenceMultienzyme ComplexesRNA InterferenceProteinsBiodegradation, EnvironmentalProteasome InhibitorsGreen Fluorescent ProteinsAcid PhosphataseMicrotubule-Associated ProteinsGangliosidosesEndopeptidasesDynaminsCell CompartmentationTransfectionCricetinaePhosphorylationMacrophagesCytoplasmCOS CellsBlotting, WesternGene Knockdown TechniquesMicroscopy, ImmunoelectronTime FactorsAcetylcysteineAmino Acid MotifsAdaptor Proteins, Signal TransducingCHO CellsImmunoblottingAdaptor Proteins, Vesicular TransportImmunoprecipitationGlycoproteinsReceptors, Cell SurfaceMembrane Glycoproteins