AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
LymphomaLymphoma, T-CellLeukemiaLymphoma, B-CellBurkitt LymphomaLeukemia, T-CellLeukemia, B-CellLymphoma, Non-HodgkinGenes, bcl-2Leukemia-Lymphoma, Adult T-CellLeukemia, Myeloid, AcuteLymphoma, Large B-Cell, DiffuseLymphoma, FollicularImmunophenotypingGenes, mycLeukemia, Lymphocytic, Chronic, B-CellTranslocation, GeneticLymphoma, B-Cell, Marginal ZoneKiller Cells, NaturalLeukemia, LymphoidLeukemia, ExperimentalLymphoma, Mantle-CellLeukemia, Myelogenous, Chronic, BCR-ABL PositiveLymphoma, T-Cell, CutaneousLeukemia Virus, MurineLymphoma, T-Cell, PeripheralLymphoma, AIDS-RelatedLymphoma, Large-Cell, AnaplasticPrecursor Cell Lymphoblastic Leukemia-LymphomaHodgkin DiseaseLeukemia, Monocytic, AcuteLeukemia, Hairy CellMoloney murine leukemia virusVincristineLeukemia L1210Leukemia Virus, FelineLeukemia Virus, BovineLymphoma, Large-Cell, ImmunoblasticGene Expression Regulation, LeukemicLeukemia, Radiation-InducedRemission InductionAntineoplastic Combined Chemotherapy ProtocolsAntineoplastic AgentsCytarabinePrednisoneAntibodies, Monoclonal, Murine-DerivedMyeloid-Lymphoid Leukemia ProteinB-LymphocytesCyclophosphamideBone MarrowPrognosisTumor Cells, CulturedAntigens, CD20Gene RearrangementLeukemia P388DoxorubicinLeukemia, Biphenotypic, AcuteTreatment OutcomeFriend murine leukemia virusChromosomes, Human, Pair 14HL-60 CellsAntibodies, MonoclonalAKR murine leukemia virusLymphoma, Extranodal NK-T-CellNeoplasm ProteinsKaryotypingCell Line, TumorDNA, NeoplasmBase SequenceApoptosisFlow CytometryCell LinePrecursor B-Cell Lymphoblastic Leukemia-LymphomaLeukemia, Megakaryoblastic, AcuteAcute DiseaseChromosome AberrationsFusion Proteins, bcr-ablMolecular Sequence DataRecurrenceHerpesvirus 4, HumanThymus NeoplasmsLeukemia, Myeloid, Chronic-PhaseSurvival AnalysisAntigens, CD30T-LymphocytesDisease-Free SurvivalSurvival RatePolymerase Chain ReactionChromosomes, Human, Pair 18Immunoglobulin Heavy ChainsCentral Nervous System NeoplasmsCombined Modality TherapyK562 CellsDaunorubicinIn Situ Hybridization, FluorescenceFatal OutcomeHuman T-lymphotropic virus 1Cell Transformation, NeoplasticChromosomes, Human, Pair 11Leukemia, Plasma Cell
AcuteMyelomaTumorHodgkinLymphoblasticDiffuseMalignant Lymphoma2023HematologyMyelodysplastic syndromesPathologyHodgkin'sTherapyCancerPediatric leukemiaTumorsTherapeuticsChemotherapyPrognosticHematopathologyInhibitorsChronicResearchBcl2AggressiveImmunohistochemistryFifteenBiologyTherapiesMolecularPatients with leukemia1994Immune systemAmericaRegistryTreatmentChildhoodOrganizationStem cellDiagnosticsCellCellsMice
Acute23
  • One of the more recent approvals for MM came July 2019, when Xpovio (Selinexor) was approved for relapsed or refractory multiple myeloma (R/R MM). This drug has received extensive support from LLS: over $4M in 9 grants for acute myeloid leukemia, chronic lymphocytic leukemia, diffuse large B-cell lymphoma and for multiple myeloma. (lls.org)
  • This therapy is approved for use in Acute Lymphoid Leukemia as well as certain non-Hodgkin's lymphomas. (lls.org)
  • Seattle Children's is now offering CAR T-cell therapy for eligible patients up to the age of 25 with B-cell acute lymphoblastic leukemia that has not responded to or has returned after initial treatment. (seattlechildrens.org)
  • I practice diagnostic lymph node pathology and have done experimental research in acute leukemia and more applied, correlative research in lymphomas for a long time. (oicr.on.ca)
  • Acute lymphoblastic leukemia (ALL). (cookchildrens.org)
  • Cook Children's is honored to be one of only five pediatric cancer treatment centers to participate in Total Therapy Study XVII , a clinical research trial for patients with acute lymphoblastic leukemia and lymphoblastic lymphoma. (cookchildrens.org)
  • 3) We are defining the properties of cancer stem cells that initiate and sustain the unique disease features of acute leukemias through the use of various adoptive animal models. (stanford.edu)
  • Acute leukemias induced by MLL chimeric oncoproteins are among the subset of cancers distinguished by a paradoxical dependence on GSK-3 kinase activity for sustained proliferation. (stanford.edu)
  • This mechanism also applies to hematopoietic cells transformed by other HOX genes, including CDX2, which is highly expressed in a majority of acute myeloid leukemias, thus providing a molecular approach based on GSK-3 inhibitory strategies to target HOX-associated transcription in a broad spectrum of leukemias. (stanford.edu)
  • I specialize in leukemia and lymphoma in children and adolescents, with a specific focus on acute lymphoblastic leukemia (ALL) and Hodgkin lymphoma. (roswellpark.org)
  • For fifteen years, I was the Columbia University Medical Center site principal investigator for the Dana Farber Cancer Institute Acute Lymphoblastic Leukemia Consortium, where I oversaw 9 trials for the management of ALL and its complications. (roswellpark.org)
  • We provide comprehensive care through collaboration with members of the Divisions of Surgery, Radiation Oncology, Pathology, and Radiology and includes multidisciplinary tumor board conferences and coordination of care through the Memorial Hermann Cancer Center for the treatment of Acute and Chronic Leukemias, Malignant Lymphomas, and Plasma Cell Disorders (Multiple Myeloma, MGUS and Amyloid-related Disorders). (uth.edu)
  • The program for the management and treatment of acute leukemia is unique at McGovern Medical School and the Memorial Hermann System. (uth.edu)
  • It provides easy access for patients with acute leukemia either by direct referral or hospital-to-hospital transference from other institutions. (uth.edu)
  • We are committed to be a resource to the patients with acute leukemia in the Memorial Hermann System and in the greater Houston area. (uth.edu)
  • Our comprehensive array of programs allows us to be of service to patients with acute leukemia with specific clinical situations such as those with acute leukemia during pregnancy as well as patients with complex cardiovascular conditions. (uth.edu)
  • In August of 2017, tisagenlecleucel (Kymriah) was approved for the treatment of children and adolescents with B-cell acute lymphoblastic leukemia (ALL) who have relapsed or not responded to chemotherapy. (childrensmercy.org)
  • Clinical Pharmacology of Tisagenlecleucel in B-Cell Acute Lymphoblastic Leukemia. (childrensmercy.org)
  • When there isn't a good enough treatment available, we work to find a better one: Our researchers received $2 million from the NIH for innovations in acute myelogenous leukemia. (childrensnational.org)
  • Barnette is interested in the study of acute childhood leukemia, clinical trials of leukemia, and research and therapeutic advances in childhood leukemia. (utah.edu)
  • In acute myeloid leukemia (AML), internal tandem duplications (ITDs) of FLT3 are frequent mutations associated with unfavorable prognosis. (oncotarget.com)
  • Success of conventional chemotherapeutic regiment is based on the principle that tumors with high growth fractions (such as acute myelogenous leukemia and the lymphomas, including Hodgkin's disease) are more sensitive to chemotherapy because a larger proportion of the targeted cells are undergoing cell division at any given time. (justia.com)
  • The first, green-lighted in August , helps kids and young adults battle an especially nasty form of leukemia called B-cell acute lymphoblastic leukemia. (singularityhub.com)
Myeloma2
  • The LLS mission is: Cure leukemia, lymphoma, Hodgkin's disease, and myeloma, and improve the quality of life of patients and their families. (wikipedia.org)
  • The goal of participating in a clinical trial is to receive the highest possible standard of treatment for myeloma, whether that is an existing standard or a new, experimental treatment. (mymyelomateam.com)
Tumor3
  • The state of the art in single cell tumor immunology will be discussed, including tissue collection, technical and biological quality controls, analysis of cell signaling (phospho-flow), computational analysis, and integration of different experimental and clinical data types 3 . (uib.no)
  • Expression of Sirt1 and FoxP3 in classical Hodgkin lymphoma and tumor infiltrating lymphocytes: Implications for immune dysregulation, prognosis and potential therapeutic targeting. (uth.edu)
  • Tumor necrosis factor alpha polymorphism associated with increased susceptibility to development of adult T-cell leukemia/lymphoma in human T-lymphotropic virus type 1 carriers. (cdc.gov)
Hodgkin7
  • DLBCL is a type of non-Hodgkin lymphoma, a cancer of the white blood cells, that tends to grow quickly. (hematology.org)
  • I have chaired the NCI-supported Children's Oncology Group (COG) Hodgkin lymphoma committee since 2011 and led two national clinical trials for high-risk Hodgkin lymphoma through the COG. (roswellpark.org)
  • According to a recent article in the Pharma Times, E02463 is a therapy for indolent or slow growing, not yet problematic non-Hodgkin B cell lymphoma (iNHL). (patientworthy.com)
  • According to a story from Buzzfeed News, actor and activist Jane Fonda, age 84, recently announced that she was diagnosed with a form of non-Hodgkin lymphoma. (patientworthy.com)
  • A clinical trial led by Kathryn A. Lurain, M.D., M.P.H. , Assistant Research Physician in the HIV and AIDS Malignancies Branch , is researching a combination drug therapy for HIV-associated B-cell non-Hodgkin lymphomas. (cancer.gov)
  • Two months later, a therapy for adults with non-Hodgkin lymphoma hit the scene . (singularityhub.com)
  • Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes. (who.int)
Lymphoblastic1
  • Histological classification showed high-grade lymphomas prevalence (86,7%), corresponding to morphological subtypes: centroblastic (5), immunoblastic (4), lymphoblastic (2) and anaplastic (2). (vin.com)
Diffuse3
  • One study reveals the benefits of reducing the number of cycles of chemotherapy for treating patients with diffuse large B-cell lymphoma. (hematology.org)
  • Rituximab-COP-revlimid treatment of high-grade diffuse large B-cell lymphoma (HG-DLBCL) of the elderly with lenalidomide, rituximab, cyclophosphamide, and prednisone (abstract). (uth.edu)
  • Currently, ZYNLONTA (loncastuximab tesirine-lpyl) is approved for the treatment of individuals with relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL) for which two prior therapies had not worked. (patientworthy.com)
Malignant Lymphoma2
  • Enterome presented its findings to the 17th International Conference on Malignant Lymphoma (ICML) in June of this year. (patientworthy.com)
  • Missense mutation with/without nonsense mutation of the p53 gene is associated with large cell morphology in human malignant lymphoma. (cdc.gov)
20231
Hematology2
  • Cook Children's Hematology and Oncology Center provides advanced clinical care to all patients, thanks to access to the most current national trials and evidence-based, supportive and experimental therapies. (cookchildrens.org)
  • Elaine S. Jaffe, M.D. , NIH Distinguished Investigator in the Laboratory of Pathology , received the Lifetime Achievement Award from the Federation of American Societies for Experimental Biology (FASEB) for her pioneering work in the fields of hematology and hematopathology. (cancer.gov)
Myelodysplastic syndromes1
  • This talk will survey the use of mass cytometry for systems level characterization of cells in healthy human tissues, including blood, bone marrow, and tonsillar tissue, as well as diseases including melanoma, glioblastoma, lymphoma, leukemia, bone marrow failure and myelodysplastic syndromes, and graft vs. host disease. (uib.no)
Pathology1
  • The experimental research is mainly held at CRC, the Wallenberg laboratory and in the Pathology building. (lu.se)
Hodgkin's2
Therapy12
  • Seattle Children's doctors and researchers are leading efforts to better treat leukemia and lymphoma in children and young adults by using CAR T-cell therapy, an experimental cancer treatment that stimulates the immune system to fight disease. (seattlechildrens.org)
  • These trials are known as Pediatric Leukemia Adoptive Therapy ( PLAT ). (seattlechildrens.org)
  • Trials have shown patients who have no other options are seeing tumours and leukemias disappear over weeks after receiving CAR-T cell therapy. (newsroom.co.nz)
  • This experimental therapy marks an entirely new way to treat cancer - if scientists can make it work, safely. (newsroom.co.nz)
  • This allows the seamless transfer of cases to the leukemia floor and prompt initiation of therapy. (uth.edu)
  • cyclin-dependent kinase inhibitors in experimental therapy of lymphomas. (cuni.cz)
  • It's normal to be anxious about your child receiving an experimental therapy. (childrensnational.org)
  • Lasker Clinical Research Scholar in the Pediatric Oncology Branch , is researching CAR T-cell therapy for leukemias and lymphomas. (cancer.gov)
  • A clinical trial led by Mark Roschewski, M.D. , Senior Clinician in the Lymphoid Malignancies Branch , is researching a therapy for B-cell lymphoma of the central nervous system. (cancer.gov)
  • At the turn of the century, the death of an 18-year- old patient with inherited liver disease after an experimental gene therapy treatment put the entire field into a deep freeze. (singularityhub.com)
  • Last year marked the birth of gene therapy 2.0, in which the experimental dream finally became a clinical reality. (singularityhub.com)
  • Its use is contraindicated in pregnant women and immunocompromised patients, including patients with a history of primary or acquired immunodeficient states, leukemia, lymphoma, AIDS, or other clinical manifestations of infection with human immunodeficiency viruses, and patients on immunosuppressive therapy, because of the risk for life-threatening disseminated herpetic infection. (medscape.com)
Cancer11
  • The Leukemia & Lymphoma Society (LLS), a 501(c)(3) charitable organization founded in 1949, is a voluntary health organization dedicated to fighting blood cancer world-wide. (wikipedia.org)
  • The name was changed to The Leukemia & Lymphoma Society (LLS) in 2000 to reflect the organization's focus on all types of blood cancer. (wikipedia.org)
  • In 2021, The Leukemia & Lymphoma Society Registry began collecting COVID-19 vaccine data from blood cancer patients. (wikipedia.org)
  • Since its founding, The Leukemia & Lymphoma Society has invested more than $1.2 billion (USD) in blood cancer research, funding nearly all of today's most promising treatments. (wikipedia.org)
  • A month later doctors at the Fred Hutchinson Cancer Research Center couldn't find any signs of lymphoma in the Vancouver, Washington, man's body. (newsroom.co.nz)
  • Cancer kills about 600,000 Americans a year, including nearly 45,000 from leukemia and lymphoma. (newsroom.co.nz)
  • Half of the participants in a study will receive the new, experimental treatment, while the other half will receive the standard treatment currently given for the type of cancer they have. (mymyelomateam.com)
  • We offer experimental therapeutics for many types of cancer. (childrensnational.org)
  • Phillip Barnette, MD, DVM, is an associate professor in the University of Utah School of Medicine and a member of the Experimental Therapeutics Program at Huntsman Cancer Institute. (utah.edu)
  • Animal models for human tumour mental animals is not easy to answer does induce adult T-cell leukaemia/ viruses that make use of animal virus- for these agents, because cancer bi- lymphoma (ATLL), albeit in monkeys es are scarce. (who.int)
  • genic models are inadequate for number of activated CD8-positive T LMP1 was strongly expressed in the understanding the cancer etiology in cells increased considerably in the lymphoma tissues but was hardly the context of natural viral infection. (who.int)
Pediatric leukemia2
  • Presented by the Lois and W. Paul Bowman, MD Leukemia Program Endowment, Cook Children's Medical Center is proud to present an inter-professional forum addressing the latest advances in pediatric leukemia treatment and research. (cookchildrens.org)
  • In addition to providing ongoing care to my pediatric leukemia and lymphoma patients, I am also available for second opinions. (roswellpark.org)
Tumors1
  • Seattle Children's offers investigational CAR T-cell clinical trials for more types of childhood cancers including leukemia, lymphoma, brain and spinal cord tumors, and solid tumors than anywhere else. (seattlechildrens.org)
Therapeutics1
  • With exclusive access to new treatments, the Experimental Therapeutics Program at Children's National offers renewed hope for a good outcome to all families. (childrensnational.org)
Chemotherapy1
  • A unique feature of this program is the designation of a permanent regular bed for the Leukemia Program in the chemotherapy unit. (uth.edu)
Prognostic2
  • Thus, the identification of biologically prognostic factors in lymphomas must be investigated (Korkolopoulou et al . (vin.com)
  • Prognostic relevance of integrated genetic profiling in adult T-cell leukemia/lymphoma. (cdc.gov)
Hematopathology1
  • Journal of clinical and experimental hematopathology : JCEH 2015 55 (3): 145-9. (cdc.gov)
Inhibitors1
  • Previously treated with any oral Janus Kinase inhibitor (JAKi) or other kinase inhibitors, experimental or approved. (who.int)
Chronic3
  • A second study compares several drug combinations for treating older patients with chronic lymphocytic leukemia. (hematology.org)
  • Tsimberidou AM, Medina J, Cortes J, Rios A, Glisson, B, Faderl S. Kantarjian H, Garcia-Manero G. Chronic myeloid leukemia in a patient with acquired immune deficiency syndrome complete cytogenetic response with imatinib mesylate: report of a case and review of the literature. (uth.edu)
  • METHODS: In the clinical single-center study, prevalence of chronic CMV infection was compared between patients with B-cell leukemia/lymphoma and the healthy controls. (bvsalud.org)
Research12
  • The organization sponsored annual international research competitions with monetary awards to conduct research for treating leukemia. (wikipedia.org)
  • In 1951 the organization launched a contest for the best research paper on leukemia treatment. (wikipedia.org)
  • In 1968, the Leukemia Society of America published Closing In, Research on Leukemia, a book summarizing its progress in fighting leukemia. (wikipedia.org)
  • Due to his contributions to leukemia research and the organization, the Leukemia Society of America created the Dameshek Award in 1969. (wikipedia.org)
  • In 1987 the Leukemia Society of America partnered with the Leukemia Research Fund (U.K.). It launched the peer-reviewed medical Journal, Leukemia. (wikipedia.org)
  • In 2004, LLS became affiliated with the Leukemia Research Fund of Canada, which became known as The Leukemia & Lymphoma Society of Canada. (wikipedia.org)
  • Our research focuses on developmental pathways that regulate hematopoietic cell growth and differentiation and are disrupted in the course of neoplastic transformation, particularly in leukemias and lymphomas. (stanford.edu)
  • I currently serve as a member of both the Scientific Advisory Board and the Adolescent and Young Adult Initiative Committee of the Lymphoma Research Foundation. (roswellpark.org)
  • Leukemia research 2017 Aug 61 18-24. (cdc.gov)
  • A clinical trial led by Christopher Kanakry, M.D. , Lasker Clinical Research Scholar in the Center for Immuno-Oncology , is researching blood stem cell transplants for blood cancers such as leukemias or lymphomas. (cancer.gov)
  • The area of research for our group is malignant lymphomas - all possible aspects, aiming for the improvement of the quality of life and survival of these patients. (lu.se)
  • The clinical research is held in direct contact with the experimental research, but also out in the clinics. (lu.se)
Bcl21
  • cell leukemia/lymphoma 2 (Bcl2), was increased in the RTA compared with the LTA (p=0.02). (cdc.gov)
Aggressive2
  • Human T-cell leukemia virus type I Tax genotype analysis in Okinawa, the southernmost and remotest islands of Japan: Different distributions compared with mainland Japan and the potential value for the prognosis of aggressive adult T-cell leukemia/lymphoma. (cdc.gov)
  • The findings suggest that immunotherapy can prevent the progression of low-grade disease to high-grade disease, which has a poorer prognosis and can quickly turn into an aggressive and fatal B-cell lymphoma. (cancer.gov)
Immunohistochemistry1
  • 2005). The aim of this study was to investigate the expression of VEGF in dogs with lymphoma by means of immunohistochemistry and its relationship to biological behavior of canine lymphomas. (vin.com)
Fifteen1
  • Fifteen dogs with lymphoma referred to Oncology Unit in the Veterinary Hospital of São Paulo State University (UNESP/Jaboticabal) were included in this study. (vin.com)
Biology1
  • We employ a variety of experimental systems for our studies ranging from molecular biology to transgenic and knockout mice. (stanford.edu)
Therapies1
  • The most exciting current experimental therapies and trials in MM focus on immunotherapies: novel monospecific antibodies (such as isatuximab), bispecific antibodies (BiTEs), drugs that are linked to antibodies (ADCs) and CAR-T! (lls.org)
Molecular2
  • In addition to these basic issues concerning leukemia pathogenesis, we are devising new diagnostic procedures for detecting and monitoring leukemia patients based on molecular genetic abnormalities in the malignant cells. (stanford.edu)
  • EXPERIMENTAL DESIGN/METHODS:A multiomic approach comprising CRISPR, gene mapping of CNA and SV, methylation, expression, and mutational analysis was used to document the extent of chr1 molecular variants and their impact on pathway utilisation. (nyu.edu)
Patients with leukemia2
  • Dr. Jensen and colleagues conduct clinical trials of experimental T-cell strategies they created for pediatric patients with leukemia and lymphoma. (fredhutch.org)
  • Toki H, Hersh EM, Gutterman J, Haynie P, Glenn H, White RA, Rios A. Organ distribution and clearance studies of technetium-labeled corynebacterium in patients with leukemia. (uth.edu)
19942
Immune system1
  • Kymriah is a novel cellular immunotherapy that reprograms a patient's own immune system to identify and kill leukemia cells. (childrensmercy.org)
America2
Registry1
  • 2. Clinical epidemiology - using data from the Swedish Lymphoma Registry to provide clinically useful real world data on treatment and prognosis, in many cases in collaboration with Nordic colleagues. (lu.se)
Treatment1
Childhood1
Organization1
Stem cell1
  • We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. (stanford.edu)
Diagnostics1
  • The award recognizes her influential work in lymphoma diagnostics, as well as her devotion to education and mentorship. (cancer.gov)
Cell6
  • A pair of separate studies suggest the experimental drug luspatercept can help improve red blood cell production, reducing the need for transfusions in patients with anemia arising from different causes. (hematology.org)
  • Expression of constitutively activated NF-kB/mTOR pathway and response to CHOP with bortezomib in a patient with angio-immunoblastic peripheral cell lymphoma. (uth.edu)
  • TET2 Mutation in Adult T-Cell Leukemia/Lymphoma. (cdc.gov)
  • Adult T cell leukemia aggressivenness correlates with loss of both 5-hydroxymethylcytosine and TET2 expression. (cdc.gov)
  • Absence of FLT3 mutations in Iranian adult T-cell leukemia/lymphoma patients. (cdc.gov)
  • Also, SIV is distinct from simian T-cell lymphotropic virus type I (STLY-I) which shares extensive genomic sequences with human T-lymphotropic virus type I and is associated with T-cell lymphomas in nonhuman primates (12). (cdc.gov)
Cells4
  • We benchmarked PG2 using synthetic data and genomic, transcriptomic, and proteomic analysis of human leukemia cells. (biorxiv.org)
  • Early-stage studies are stirring hope as one-time infusions of supercharged immune cells help a remarkable number of patients with intractable leukemia or lymphoma. (newsroom.co.nz)
  • When leukemia patient Claude Bannick entered a Hutch CAR-T study in 2014, nurses hooked him to a machine that filtered out his white blood cells, including the T cells. (newsroom.co.nz)
  • Kymriah is manufactured by harvesting the patient's own T-cells using leukapheresis and engineering these cells to attack a specific target on leukemia cells, CD19. (childrensmercy.org)
Mice3
  • An experimental lymphocytic leukemia of mice . (online-medical-dictionary.org)
  • For instance, mice are able to reconstitute most lymphomas in monkeys and humans woodchuck hepatitis virus induces major components of the human provides strong support for a direct hepatocellular carcinoma (HCC) haematolymphoid system including oncogenic role of EBV in vivo. (who.int)
  • The ic mice had developed lymphoma. (who.int)