• cancer
  • Drugs used in chemotherapy, such as 3-AP and gemcitabine (GEM), work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. (clinicaltrials.gov)
  • 3-AP may help gemcitabine kill more cancer cells by making the cells more sensitive to the drug. (clinicaltrials.gov)
  • Biological therapies, such as lenalidomide, may stimulate the immune system in different ways and stop cancer cells from growing. (clinicaltrials.gov)
  • Some block the ability of cancer cells to grow and spread. (clinicaltrials.gov)
  • Others find cancer cells and help kill them or carry cancer-killing substances to them. (clinicaltrials.gov)
  • Accrual for lymphoma patients closed as of 11/27/09) Drugs used in chemotherapy, such as tanespimycin, work in different ways to stop cancer cells from dividing so they stop growing or die. (clinicaltrials.gov)
  • Bortezomib may stop the growth of cancer cells by blocking the enzymes necessary for their growth. (clinicaltrials.gov)
  • It may also increase the effectiveness of tanespimycin by making cancer cells more sensitive to the drug. (clinicaltrials.gov)
  • Combining tanespimycin with bortezomib may kill more cancer cells. (clinicaltrials.gov)
  • Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. (clinicaltrials.gov)
  • I. Determine the dose-limiting toxicity and maximum tolerated dose of 17-N-allylamino-17-demethoxygeldanamycin (17-AAG) in patients with advanced epithelial cancer, malignant lymphoma, or sarcoma. (clinicaltrials.gov)
  • instead, it is linked to a monoclonal antibody (MAB) which directs it to the cancer cells. (wikipedia.org)
  • Cancer is a group of diseases that involve abnormal increases in the number of cells, with the potential to invade or spread to other parts of the body. (wikipedia.org)
  • For example, cancers of the liver parenchyma arising from malignant epithelial cells is called hepatocarcinoma, while a malignancy arising from primitive liver precursor cells is called a hepatoblastoma, and a cancer arising from fat cells is called a liposarcoma. (wikipedia.org)
  • Some types of cancer are named for the size and shape of the cells under a microscope, such as giant cell carcinoma, spindle cell carcinoma, and small-cell carcinoma. (wikipedia.org)
  • Diffuse large B-cell lymphoma (DLBCL or DLBL) is a cancer of B cells, a type of white blood cell responsible for producing antibodies. (wikipedia.org)
  • vedotin
  • A study of Escalating Doses of AGS67E Given as Monotherapy in Subjects With Refractory or Relapsed Lymphoid Malignancies Indusatumab vedotin (MLN-0264) Clinical Trials. (wikipedia.org)
  • aberrant
  • Lymphocyte-variant hypereosinophila, also termed lymphocyte variant eosinophilia, is a rare disorder in which eosinophilia or hypereosinophilia (i.e. a large or extremely large increase in the number of eosinophils in the blood circulation) is caused by aberrant population of lymphocytes. (wikipedia.org)
  • These aberrant lymphocytes function abnormally by stimulating the proliferation and maturation of bone marrow eosinophil-precursor cells termed colony forming unit-Eosinophils or CFU-Eos. (wikipedia.org)
  • nuclei
  • These so-called "hallmark" cells have lobulated and indented nuclei. (icd10data.com)
  • All morphological variants are characterized by a variable proportion of large hallmark cells with eccentric horse-shoe or kidney-shaped nuclei, often with eosinophilic region near the nucleus (Figure 1 ). (hindawi.com)
  • The classification acknowledges the recognition of large cells with pleomorphic nuclei and abundant cytoplasm. (wikipedia.org)
  • The hallmark cells are of medium size and feature abundant cytoplasm (which may be clear, amphophilic or eosinophilic), kidney shaped nuclei, and a paranuclear eosinophilic region. (wikipedia.org)
  • The cells are generally very large with a round, oval, or polygonal shape and pleomorphic nuclei, and may resemble Reed-Sternberg cells. (wikipedia.org)
  • bone marrow
  • Sarcoma: Cancers arising from connective tissue (i.e. bone, cartilage, fat, nerve), each of which develop from cells originating in mesenchymal cells outside the bone marrow. (wikipedia.org)
  • proteins
  • numerous tyrosine kinase cell signaling proteins are responsible for the growth and proliferation of eosinophils {see clonal eosinophilia}), methotrexate and Hydroxycarbamide (both are chemotherapy and immunosuppressant drugs), and Alemtuzumab (a antibody that binds to the CD52 antigen on mature lymphocytes thereby marking them for destruction by the body). (wikipedia.org)
  • clinically
  • Diffuse large B-cell lymphoma encompasses a biologically and clinically diverse set of diseases, many of which cannot be separated from one another by well-defined and widely accepted criteria. (wikipedia.org)
  • tissue
  • The main cellular component of this tissue is the adipocyte, or fat cell. (wikipedia.org)
  • Blastoma: Cancers derived from immature "precursor" cells or embryonic tissue. (wikipedia.org)
  • Subsequently, numerous new populations of memory T cells were discovered including tissue-resident memory T (Trm) cells, stem memory TSCM cells, and virtual memory T cells. (wikipedia.org)
  • variants
  • The small and lympho-histiocytic variants display a marked variability of the neoplastic cell size that ranges from small to large. (hindawi.com)
  • citation needed] Within cellular morphology, three variants are most commonly seen: centroblastic, immunoblastic, and anaplastic. (wikipedia.org)
  • lymphocytes
  • Lymphoma is a group of blood cancers that develop from lymphocytes (a type of white blood cell). (wikipedia.org)
  • Most cases of DLBCL are centroblastic, having the appearance of medium-to-large-sized lymphocytes with scanty cytoplasm. (wikipedia.org)
  • T cells can be distinguished from other lymphocytes, such as B cells and natural killer cells, by the presence of a T-cell receptor on the cell surface. (wikipedia.org)
  • Macrophages are directly involved in the fight against invading micro-organisms as well as being antigen-presenting cells which activate lymphocytes. (wikipedia.org)
  • The lack of B-lymphocytes in the testis is significant, since these are the antibody-producing cells of the immune system. (wikipedia.org)
  • T-lymphocytes (T-cells) are white blood cells which take part in cell-mediated immunity. (wikipedia.org)
  • antigen-prese
  • Helper T cells become activated when they are presented with peptide antigens by MHC class II molecules, which are expressed on the surface of antigen-presenting cells (APCs). (wikipedia.org)
  • diagnosis
  • The finding of T cells bearing abnormal immunophenotype cluster of differentiation markers is critical to making the diagnosis. (wikipedia.org)
  • thymus
  • They are called T cells because they mature in the thymus from thymocytes (although some also mature in the tonsils). (wikipedia.org)