• Tumors
  • However, increasing evidence that CD4 + T-helper (Th) cells play a significant role in the regulation and maintenance of the CTL response to tumors ( 8 - 10 ) means it is important to identify CD4 + Th cell peptide-binding epitope(s) within the ALK protein to maximize the efficacy of future ALK-based immunotherapeutic strategies. (aacrjournals.org)
  • This phase I trial is studying the best dose of 3-AP and the side effects of giving 3-AP together with gemcitabine in treating patients with advanced solid tumors or lymphoma. (clinicaltrials.gov)
  • I. To determine the maximal tolerable dose (MTD) of 3-AP administered as a 24 hour infusion in combination with and fixed-dose gemcitabine hydrochloride (GEM) in patients with advanced solid tumors or lymphomas. (clinicaltrials.gov)
  • I. Determine the dose-limiting toxicity and maximum tolerated dose of 17-N-allylamino-17-demethoxygeldanamycin (17-AAG) (tanespimycin) and bortezomib in patients with advanced solid tumors or lymphomas (Accrual for Lymphoma Patients Closed as of 11/27/09). (clinicaltrials.gov)
  • HSP70, client proteins, and ubiquitination of proteins) in peripheral blood mononuclear cells and tumor specimens from patients with advanced solid tumors or lymphomas (Accrual for Lymphoma Patients Closed as of 11/27/09) treated with this regimen. (clinicaltrials.gov)
  • It is a potent antimitotic drug derived from peptides occurring in marine shell-less mollusc Dolabella auricularia called dolastatins which show potent activity in preclinical studies, both in vitro and in vivo, against a range of lymphomas, leukemia and solid tumors. (wikipedia.org)
  • tumor
  • There is complete consensus on the B-cell derivation of the tumor in most cases, and on the relevance of Epstein-Barr virus infection and defective cytokinesis in at least a proportion of patients. (hindawi.com)
  • 3-AP may also stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. (clinicaltrials.gov)
  • However, some body parts contain multiple types of tissue, so for greater precision, cancers are additionally classified by the type of cell that the tumor cells originated from. (wikipedia.org)
  • Germ cell tumor: Cancers derived from pluripotent cells, most often presenting in the testicle or the ovary (seminoma and dysgerminoma, respectively). (wikipedia.org)
  • For example, a benign tumor of smooth muscle cells is called a leiomyoma (the common name of this frequently occurring benign tumor in the uterus is fibroid). (wikipedia.org)
  • However, the usual treatment for each of these is chemotherapy, often in combination with an antibody targeted at the tumor cells. (wikipedia.org)
  • The World Health Organization (WHO) classification system defines more than a dozen subtypes, each of which can be differentiated based on the location of the tumor, the presence of other cells within the tumor (such as T cells), and whether the patient has certain other illnesses related to DLBCL. (wikipedia.org)
  • In some cases, a tumor may share many features with both DLBCL and Burkitt's lymphoma. (wikipedia.org)
  • A tumor can be classified as immunoblastic if greater than 90% of its cells are immunoblasts.This distinction can be problematic, however, because hematopathologists reviewing the microscope slides may often disagree on whether a collection of cells is best characterized as centroblasts or immunoblasts. (wikipedia.org)
  • The third morphologic variant, anaplastic, consists of tumor cells which appear very differently from their normal B cell counterparts. (wikipedia.org)
  • M8083/3 Basaloid squamous cell carcinoma M8084/3 Squamous cell carcinoma, clear cell type M8090/1 Basal cell tumor (C44. (wikipedia.org)
  • Fibroepithelioma of Pinkus type Fibroepithelial basal cell carcinoma, Pinkus type Pinkus tumor Fibroepithelioma, NOS M8094/3 Basosquamous carcinoma (C44. (wikipedia.org)
  • Cytotoxic (Killer) CD8 +ve Cytotoxic T cells (TC cells, CTLs, T-killer cells, killer T cells) destroy virus-infected cells and tumor cells, and are also implicated in transplant rejection. (wikipedia.org)
  • malignancies
  • A study of Escalating Doses of AGS67E Given as Monotherapy in Subjects With Refractory or Relapsed Lymphoid Malignancies Indusatumab vedotin (MLN-0264) Clinical Trials. (wikipedia.org)
  • aberrant
  • Finally, the degree of MUC1 glycosylation in lymphomas is relatively high, compared with the aberrant hypoglycosylation found in adenocarcinomas. (bmj.com)
  • Lymphocyte-variant hypereosinophila, also termed lymphocyte variant eosinophilia, is a rare disorder in which eosinophilia or hypereosinophilia (i.e. a large or extremely large increase in the number of eosinophils in the blood circulation) is caused by aberrant population of lymphocytes. (wikipedia.org)
  • These aberrant lymphocytes function abnormally by stimulating the proliferation and maturation of bone marrow eosinophil-precursor cells termed colony forming unit-Eosinophils or CFU-Eos. (wikipedia.org)
  • lymph
  • Morphologically, there are large immunoblast-like cells with large central nucleoli, often cellular clusters, with a predilection for the lymph node sinuses in a cohesive pattern that can suggest carcinoma cells. (wikipedia.org)
  • Lymphadenopathy or swelling of lymph nodes, is the primary presentation in lymphoma. (wikipedia.org)
  • They consist of: Fever Night sweats Weight loss Other symptoms: Loss of appetite or anorexia Fatigue Respiratory distress or dyspnea Itching Lymphoma is definitively diagnosed by a lymph node biopsy, meaning a partial or total excision of a lymph node examined under the microscope. (wikipedia.org)
  • T-zone lymphoma is so named for its involvement in a specific area of the lymph node that consists of a dense accumulation of T-cells. (wikipedia.org)
  • One of these well-defined groupings of particular note is "primary mediastinal (thymic) large B cell lymphoma", which arises within the thymus or mediastinal lymph nodes. (wikipedia.org)
  • tissue
  • The main cellular component of this tissue is the adipocyte, or fat cell. (wikipedia.org)
  • Sarcoma: Cancers arising from connective tissue (i.e. bone, cartilage, fat, nerve), each of which develop from cells originating in mesenchymal cells outside the bone marrow. (wikipedia.org)
  • Blastoma: Cancers derived from immature "precursor" cells or embryonic tissue. (wikipedia.org)
  • Subsequently, numerous new populations of memory T cells were discovered including tissue-resident memory T (Trm) cells, stem memory TSCM cells, and virtual memory T cells. (wikipedia.org)
  • autoimmune diseases
  • Risk factors for common types of non-Hodgkin lymphomas include autoimmune diseases, HIV/AIDS, infection with human T-lymphotropic virus, immunosuppressant medications, and some pesticides. (wikipedia.org)
  • Through IL-10, adenosine, and other molecules secreted by regulatory T cells, the CD8+ cells can be inactivated to an anergic state, which prevents autoimmune diseases. (wikipedia.org)
  • carcinoma
  • This lymphoma is often mistaken for metastatic carcinoma and malignant histiocytosis. (icd10data.com)
  • These types include: Carcinoma: Cancers derived from epithelial cells. (wikipedia.org)
  • Some types of cancer are named for the size and shape of the cells under a microscope, such as giant cell carcinoma, spindle cell carcinoma, and small-cell carcinoma. (wikipedia.org)
  • M8043/3 Small cell carcinoma, fusiform cell M8044/3 Small cell carcinoma, intermediate cell M8045/3 Combined small cell carcinoma Mixed small cell carcinoma Combined small cell-large cell carcinoma Combined small cell-adenocarcinoma Combined small cell-squamous cell carcinoma M8046/3 Non-small cell carcinoma (C34. (wikipedia.org)
  • Anal intraepithelial neoplasia, grade III (C21.1) AIN III (C21.1) M8078/3 Squamous cell carcinoma with horn formation M8080/2 Queyrat erythroplasia (C60. (wikipedia.org)
  • Intraepidermal squamous cell carcinoma, Bowen type (C44. (wikipedia.org)
  • M8090/3) Basal cell carcinoma, NOS (C44. (wikipedia.org)
  • Basal cell epithelioma Rodent ulcer Pigmented basal cell carcinoma M8091/3 Multifocal superficial basal cell carcinoma (C44. (wikipedia.org)
  • Multicentric basal cell carcinoma M8092/3 Infriltrating basal cell carcinoma, NOS (C44. (wikipedia.org)
  • Infiltrating basal cell carcinoma, non-sclerosing Infiltrating basal cell carcinoma, sclerosing Basal cell carcinoma, morpheic Basal cell carcinoma, desmoplastic type M8093/3 Basal cell carcinoma, fibroepithelial (C44. (wikipedia.org)
  • Mixed basal-squamous cell carcinoma M8095/3 Metatypical carcinoma M8096/0 Intraepidermal epithelioma of Jadassohn (C44. (wikipedia.org)
  • M8097/3 Basal cell carcinoma, nodular (C44. (wikipedia.org)
  • Basal cell carcinoma, micronodular M8098/3 Adenoid basal carcinoma (C53. (wikipedia.org)
  • Pilomatrixoma, malignant Pilomatricoma, malignant Matrical carcinoma M8120/0 Transitional cell papilloma, benign Transitional papilloma M8120/1 Urothelial papilloma, NOS Papilloma of baldder (C67. (wikipedia.org)
  • Transitional cell papilloma, NOS M8120/2 Transitional cell carcinoma in situ Urothelial carcinoma in situ M8120/3 Transitional cell carcinoma, NOS Urothelial carcinoma, NOS Transitional carcinoma M8121/0 Schneiderian papilloma, NOS (C30.0, C31. (wikipedia.org)
  • Cylindrical cell carcinoma M8122/3 Transitional cell carcinoma, spindle cell Transitional cell carcinoma, sarcomatoid M8123/3 Basaloid carcinoma M8124/3 Cloacogenic carcinoma (C21.2) M8130/1 Papillary transitional cell neoplasm of low malignant potential (C67. (wikipedia.org)
  • Papillary urothelial neoplasm of low malignant potential M8130/2 Papillary transitional cell carcinoma, non-invasive (C67. (wikipedia.org)
  • Papillary urothelial carcinoma, non-invasive M8130/3 Papillary transitional cell carcinoma (C67. (wikipedia.org)
  • Papillary urothelial carcinoma M8131/3 Transitional cell carcinoma, micropapillary ( C67. (wikipedia.org)
  • antibody
  • The linker to the monoclonal antibody is stable in extracellular fluid, but is cleaved by cathepsin once the conjugate has entered a tumour cell, thus activating the antimitotic mechanism. (wikipedia.org)
  • numerous tyrosine kinase cell signaling proteins are responsible for the growth and proliferation of eosinophils {see clonal eosinophilia}), methotrexate and Hydroxycarbamide (both are chemotherapy and immunosuppressant drugs), and Alemtuzumab (a antibody that binds to the CD52 antigen on mature lymphocytes thereby marking them for destruction by the body). (wikipedia.org)
  • The lack of B-lymphocytes in the testis is significant, since these are the antibody-producing cells of the immune system. (wikipedia.org)
  • proteins
  • Abgent has over fifteen years of experience producing recombinant proteins in E. coli and mammalian cells (CHO and HEK293, etc), and we have added a powerful yeast expression platform to our menu of services. (abgent.com)
  • cytoplasm
  • Most cases of DLBCL are centroblastic, having the appearance of medium-to-large-sized lymphocytes with scanty cytoplasm. (wikipedia.org)
  • marker
  • Intriguingly, the B cells within the HL cell lines expressed immunoglobulin light chain, the memory B-cell antigen CD27, and the stem cell marker aldehyde dehydrogenase (ALDH) [ 13 ]. (hindawi.com)
  • However, as with other T-cell lymphomas, they are usually negative for the pan T-cell marker CD3. (wikipedia.org)
  • TEMRA stands for terminally differentiated effector memory cells re-expressing CD45RA, which is a marker usually found on naive T cells. (wikipedia.org)
  • One cell surface marker that has been associated with TRM is the integrin αeβ7. (wikipedia.org)
  • relatively
  • Thus, although this population as a whole is abundant within the peripheral circulation, individual virtual memory T cell clones reside at relatively low frequencies. (wikipedia.org)
  • The majority of experiments have studied the rat testis due to its convenience: it is of relatively large size and is easily extracted from experimental animals. (wikipedia.org)
  • clinical
  • In many clinical settings, however, studies on the T cell receptor and IL-5 are not available and therefore not routine parts of the diagnostic work-up or criteria for the disease. (wikipedia.org)
  • differentiate
  • Antigen-naïve T cells expand and differentiate into memory and effector T cells after they encounter their cognate antigen within the context of an MHC molecule on the surface of a professional antigen presenting cell (e.g. a dendritic cell). (wikipedia.org)