• Dendritic cells (DCs) are antigen presenting cells for the induction of antigen specific T cell response. (wikipedia.org)
  • Plasmacytoid dendritic cells (pDCs) differentiate from lymphoid progenitor cells in the lymphoid tissues. (wikipedia.org)
  • It is an active cellular immunotherapy, which involves obtaining antigen-presenting autologous dendritic cells from the patient following a leukapheresis procedure. (wikipedia.org)
  • Despite lower co-stimulatory molecule expression, ProGP-4-generated Class II+/CD11c+ cells stimulated proliferation of allogeneic T cells and an antigen-specific T cell hybridoma as efficiently as bone marrow derived dendritic cells from untreated mice. (medscimonit.com)
  • Intraepithelial FMDV-negative, MHCII/CD11c-double-positive dendritic cells were present in close proximity to FMDV-positive cells, the researchers said. (thebeefsite.com)
  • CD11c is expressed by dendritic cells, a subset of Intestinal Intraepithelial Lymphocytes (IEL) and some activated T cells. (thermofisher.com)
  • N418 binds to CD11c on splenic dendritic cells in the T-dependent areas of mouse spleen and precipitates a 150, 90 kDa heterodimer. (thermofisher.com)
  • It is a single-chain membrane glycoprotein of approximately 200 kd that has 4 allotypic forms on myeloid cells (eg, erythrocytes, granulocytes, monocytes), lymphoid cells (mostly B cells), follicular dendritic cells, and glomerular podocytes. (medscape.com)
  • Dendritic cells (DCs) are specialized antigen presenting cells that instruct T cell responses through sensing environmental and inflammatory danger signals. (frontiersin.org)
  • Dendritic cells (DCs) comprise heterogeneous subsets of professional antigen-presenting cells, linking innate and adaptive immunity. (biomedcentral.com)
  • volume = {37}, number = {0046-8177 (Print)}, pages = {68--77}, abstract = {The mononuclear phagocyte system of human lymphoid tissue comprises macrophages and dendritic cells (DCs). (cnrs.fr)
  • In this study, the finding that a significant proportion of all dendritic cells (DCs) resident in vivo in the human postnatal thymus displayed a myeloid-related phenotype prompted us to re-examine the developmental origin of thymic DCs, a cell type hitherto considered to represent a homogeneous lymphoid-derived population. (ashpublications.org)
  • Dendritic cells (DCs) are hematopoietic-derived highly specialized antigen-presenting cells (APCs) that display potent ability to induce both specific immune responses and deletion of potentially autoreactive T cells. (ashpublications.org)
  • Dendritic cells (DCs) are bone-marrow-derived immune cells found in blood, lymphoid organs, and various tissue of the body. (origene.com)
  • Conventional dendritic cells (cDCs), also known as myeloid dendritic cells or classical dendritic cells, are a type of antigen-presenting cell (APC), cDCs originate from hematopoietic stem cells, specifically from the common myeloid progenitor in the bone marrow. (origene.com)
  • CD11c is a prefered marker for dendritic cells. (studybuff.com)
  • Cluster of differentiation 14 (CD14) was described as monocyte/ macrophage differentiation antigen on the surface of myeloid lineage, such as monocytes, macrophages and dendritic cells (DCs). (studybuff.com)
  • CD11c is a type I transmembrane protein that is expressed on monocytes, granulocytes, a subset of B cells, dendritic cells, and macrophages and may be demonstrated on B-cell chronic lymphocytic leukemia, marginal zone lymphomas, and hairy cell leukemia. (studybuff.com)
  • CONCLUSIONS: The data presented in this report highlight the ability of E. coli derived ProGP-4 to expand large numbers of functional DC in the peripheral blood and lymphoid organs in vivo using a rodent model of hematopoiesis. (medscimonit.com)
  • Class-switched Ig (swIg) storage B cells are produced in germinal centers (GCs), specific anatomic buildings in supplementary lymphoid organs where T cell-dependent affinity maturation and course switch recombination from the BCR takes place. (liveconscience.com)
  • CXCL13, also known as BCA-1 and Angie, is a small chemokine strongly expressed in the secondary lymphoid organs. (thermofisher.com)
  • 6 , 7 Murine DCs with the reciprocal CD8α + CD11b − phenotype, although present at various levels in all lymphoid organs, represent the prototype of the DC population resident in the postnatal thymus. (ashpublications.org)
  • CD11c-cre mediated Flip deficiency resulted in consistent reduction of the CD11c + CD8α + subset of DCs in central and peripheral lymphoid organs before or after the onset of arthritis. (acrabstracts.org)
  • Mature DCs express high levels of MHC and costimulatory molecules which enable them to activate naive T cells in T cell areas of secondary lymphoid organs [12]. (ufe-eg.org)
  • Myeloid or conventional DCs (cDCs) are derived from myeloid progenitor cells in the bone marrow and are characterized by expression of CD11c. (wikipedia.org)
  • In mice, cDCs (CD11c + MHCII + ) are sub-divided into functionally distinct phenotypes defined as cDC1 (CD8 + IRF8 + XCR1 + Clec9a + CD24 + ) and cDC2 (IRF4 + CD11b + SIRPα + ) whilst in humans the equivalent DC subsets are defined by expression of CD8 + IRF8 + XCR1 + Clec9a + CD141 + (cDC1) and IRF4 + CD1c + (cDC2) ( 1 - 4 ). (frontiersin.org)
  • Myeloid DCs (mDCs) correspond to mouse cDCs and express myeloid antigens such as CD11c, CD13, CD33, and CD11b. (ufe-eg.org)
  • pDCs express lower levels of CD11c than cDCs, and cDCs downregulate CD11c upon migration or activation. (studybuff.com)
  • Non-activated (immature) DCs are usually located in the peripheral non-lymphoid tissues and they can present self-antigens to T cells, that leads to immune tolerance either through T cell deletion or through the differentiation of regulatory T cells. (wikipedia.org)
  • Mature DCs have ability to present antigens in the lymphoid tissues, and to prime, activate, and expand immune effector cells with unique functions and cytokine profiles. (wikipedia.org)
  • By analysing iNKT cells from lymphoid tissues of mice and humans we demonstrate that their T cell receptor (TCR) repertoire is highly diverse and is distinct for cells from various tissues resulting in differential lipid-antigen recognition. (elifesciences.org)
  • This suggests that unique tissue-specific factors (including local lipid antigens, cytokines and/or hormones) may shape the population of iNKT cells resident in those tissues, ultimately regulating local immune responses. (elifesciences.org)
  • 2. NK-DC Interaction The bidirectional crosstalk between DCs and NK cells can occur in the periphery or in secondary lymphoid tissues where they interact with each other through cellCcell contact and soluble factors. (ufe-eg.org)
  • HCL is a well-defined entity in the 2017 revision of the World Health Organization (WHO) classification of the tumours of haematopoietic and lymphoid tissues. (fortuneonline.org)
  • Most DCs in tissues and blood are present in an immature state, but upon antigen acquisition and activation they mature. (jscimedcentral.com)
  • They should prime naïve T cell, and induce transition from chronically activated non-protective CD8+ T cells to healthy CD8+ T cells that can produce cytotoxic T lymphocytes (CTLs), which recognize and eliminate cancer cells by recognizing specific antigens. (wikipedia.org)
  • The most critical step in vaccination is the effective presentation of cancer antigens to T cells, and because of DCs are the most efficient antigen presenting cells, they are the promising option for improvement of therapeutic vaccines. (wikipedia.org)
  • The cells are incubated ex vivo in the presence of a recombinant fusion protein PA2024 containing a prostate antigen, prostate acid phosphatase and GM-CSF, an immune-cell activator. (wikipedia.org)
  • At early time points after aerosol inoculation, viral antigens were found together with cytokeratin-positive pharyngeal epithelial cells. (thebeefsite.com)
  • Humoral storage resides partly in antigen-specific storage B cells, that are thought as class-switched classically, somatically-mutated, long-lived cells that are extremely responsive to particular antigen problem (2C7). (liveconscience.com)
  • Following contact with cognate antigen, storage B cells proliferate and differentiate into antibody secreting cells (ACSs). (liveconscience.com)
  • utilized a stylish model for the impartial labeling of antigen-experienced/storage B Rabbit Polyclonal to USP32 cells, wherein activation-induced cytidine deaminase (Help)-expressing cells had been permanently marked pursuing Cre recombinase legislation of the reporter gene (16). (liveconscience.com)
  • In that scholarly study, mice immunized using a particulate antigen, SRBCs, generated both IgM and IgG memory B cells. (liveconscience.com)
  • Following supplementary encounter with antigen, the IgM storage B cells initiated a GC response, and produced swIg cells, aswell as extra IgM storage B cells. (liveconscience.com)
  • 18) used an antigen-based strategy to purify uncommon antigen-specific storage B cells within a style of PE immunization, and demonstrated that PTZ-343 both IgM and IgG PTZ-343 storage B cells were generated following immunization. (liveconscience.com)
  • As opposed to swIg storage B cells, IgM storage B cells had been unresponsive to antigen problem in immune system hosts. (liveconscience.com)
  • Nevertheless, upon transfer into na?ve hosts, the IgM memory B cells initiated GC formation, and underwent class-switch recombination when challenged with particular antigen (18). (liveconscience.com)
  • Yet, if and how the tissue environment shapes the antigen specificity of iNKT cells remains unknown. (elifesciences.org)
  • iNKT cells have been traditionally defined by the expression of an invariant TCR α-chain (Vα14-Jα18 in mice or Vα24-Jα18 in humans) and their capacity to recognise the glycolipid antigen α-galactosylceramide (αGalCer) presented on CD1d. (elifesciences.org)
  • Functionally, cDC1 cross-present exogenous antigens to activate CD8 + T cells and can promote IL-12 dependent Th1 responses ( 1 , 5 - 7 ). (frontiersin.org)
  • ATMs comprised CD11c + CD206 + cells in "crown" aggregates and solitary CD11c − CD206 + cells at adipocyte junctions. (diabetesjournals.org)
  • Tissue culture medium conditioned by CD11c + ATMs, but not CD11c − ATMs or other stromovascular cells, impaired insulin-stimulated glucose uptake by human adipocytes. (diabetesjournals.org)
  • While langerin+ cells are observed in comparable numbers and with comparable phenotypes in the epidermis, two distinct DC subsets bear langerin in peripheral, skin-draining lymph nodes of BALB/c mice (CD11c(high) CD8alpha(high) and CD11c(low) CD8alpha(low)), whereas only the latter subset is present in C57BL/6 mice. (cnrs.fr)
  • CD11c(low) langerin+ cells represent skin-derived Langerhans cells, as demonstrated by their high expression of DEC-205/CD205, maturation markers, and recruitment to skin-draining lymph nodes upon imiquimod-induced inflammation. (cnrs.fr)
  • 8 As these latter DCs derive from an intrathymic lymphoid-restricted progenitor able to generate also T, B, and NK cells, but not myeloid cells, upon transfer in vivo, 5 , 9 , 10 they have hitherto been considered of lymphoid origin. (ashpublications.org)
  • First discovered by Ralph Steinman and Zanvil A. Cohn in the 1970s, named for their tree-like branches or "dendrites", these cells patrol our bodies, ingest pathogens, process them, and present fragments (antigens) to T-cells, thus initiating a targeted immune response [2]. (origene.com)
  • cDC1: These cells are very effective at presenting antigens to CD8+ T cells, a type of cytotoxic T cell that can kill infected or cancerous cells. (origene.com)
  • cDC2: These cells are specialized in presenting antigens to CD4+ T cells, a type of helper T cell that helps coordinate the immune response. (origene.com)
  • Differentiating between low-grade lymphoma and reactive lymphocytes is often difficult by morphology alone as reactive lymphoid cells may acquire activation morphology from being exposed to different cytokines within the body fluid. (cytojournal.com)
  • IL-2 is a potent lymphoid cell growth factor which exerts its biological activity primarily on T cells, promoting proliferation and maturation. (biolegend.com)
  • Do B cells express CD11c? (studybuff.com)
  • Overall, CD11c was expressed in all B cell subpopulations, suggesting a role in all B-cell development steps, with an increased frequency in antigen-driven B cells, which accumulate with age of HD, independently of gender. (studybuff.com)
  • Invariant natural killer T (iNKT) cells are CD1d-restricted T cells, which respond rapidly to antigen recognition and promote development of anti-tumor immunity in many tumor models. (biomedcentral.com)
  • 0.05), suggesting the selective elimination of DCs cross-presenting tumor-associated antigens by iNKT cells. (biomedcentral.com)
  • Isolated B cells also imparted T cells with the CpG-associated phenotype and improved tumor immunity without the aid of additional antigen-presenting cells or other immune cells in the culture. (bmj.com)
  • Splenic marginal zone lymphoma with circulating villous lymphoid cells (SMZL) is a distinct and very different pathological entity since the WHO 2008 classification: it is characterized by an expansion of the splenic white pulp with the infiltration of the red pulp. (fortuneonline.org)
  • Hairy cells are small to medium-sized lymphoid cells with an oval or indented nucleus with homogeneous and spongy chromatin. (fortuneonline.org)
  • While CD4 T cells are by far the most abundant HIV-infected cell, DCs express a variety of HIV co-receptors and lectin receptors that modulate HIV uptake, antigen processing, and trans-infection to T cells, thus contributing to a wide variety of immunological outcomes. (jscimedcentral.com)
  • In addition, the ability of HIV to exploit DC surface receptors or intracellular routing mechanisms to avoid antigen-processing machinery also contributes to viral persistence and promotes trans or cis-infection of CD4 T cells. (jscimedcentral.com)
  • Activated B cells can present antigen to T cells, and such presentation is likely to be signal in electric cabletaining T cell escape to towardsward ongoing B cell responses, and in outsettaining an effective T H 2 response. (upb.ro)
  • Pre-requisite of tumor response to ICBs is the co-expression by cancer cells of immunogenic tumor antigens and targetable immune checkpoint molecules. (biomedcentral.com)
  • Additionally, IFNγ induces the production of cytokines, Fc receptor, and adhesion molecules and up-regulates MHC class I and II antigen expression by antigen presenting cells during an immune response. (bioxcell.com)
  • Natural killer (NK) cells are innate lymphoid cells, and their presence within human tumors correlates with better prognosis. (bioxcell.com)
  • They play an essential role in the induction of adaptive immune response against infectious agents and in generating tolerance against self-antigens [3]. (origene.com)
  • VAT CD206+CD11c− ATMs were increased in diabetic participants, were scavenger receptor-rich with low intracellular lipids, secreted proinflammatory cytokines, and diverged significantly from 2 CD11c+ ATM subtypes, which were lipid-laden, were lipid antigen presenting, and overlapped with monocyte signatures. (jci.org)
  • In addition, the machinery of CD11c + ATMs indicates they metabolize lipid and may initiate adaptive immune responses. (diabetesjournals.org)
  • In obese women, CD11c + ATM density was greater in subcutaneous than omental adipose tissue and correlated with markers of insulin resistance. (diabetesjournals.org)
  • Human plasmacytoid DCs lack myeloid antigens and express CD123, CD303, and CD304 [11]. (ufe-eg.org)
  • Furthermore, diabetic VAT was enriched for CD206+CD11c− ATM and inflammatory signatures, scavenger receptors, and MHC II antigen presentation genes. (jci.org)
  • Immature DCs possess a wide variety of receptors, such as Fc receptors, lectins, and langerin, which allow them to efficiently bind and internalize antigen. (jscimedcentral.com)
  • The solution showing clinical responses was pre-treatment with single-dose cyclophosphamide as well as vaccination with tumor associated antigens (TAAs) and granulocyte macrophage colony stimulating factor (GM-CSF). (wikipedia.org)
  • The initial studies showed that patients developed immune responses as measured by Interferon-gamma expression in the peripheral blood, systemic cytokine responses, or CD8+ antigen specific T cell expansion. (wikipedia.org)
  • CpG-2722 induced antigen-dependent T helper (Th)1 and Th17 responses, while 2'3'-c-di-AM(PS)2 induced a Th2 response. (ijbs.com)
  • The combination of CpG-2722 and 2'3'-c-di-AM(PS)2 generated a distinct antigen-dependent Th response profile characterized by higher Th1 and Th17, but lower Th2 responses. (ijbs.com)
  • Thus, the antigen-dependent Th responses observed in the animals immunized with different vaccines were shaped by the antigen-independent cytokine-inducing profiles of their adjuvant. (ijbs.com)
  • A failure of DCs to mature, as witnessed during HIV uptake, however, leads to attenuation of antigen-specific immune responses and may significantly contribute to induction of T cell regulatory responses. (jscimedcentral.com)
  • The failure of DCs to properly process and present HIV antigens and stimulate specific adaptive responses can prevent viral clearance and aid in establishment of viral reservoirs, two of the main obstacles to a therapeutic cure. (jscimedcentral.com)
  • Taken together, these data challenge the current view that the thymus is colonized by a lymphoid-restricted progenitor and provide evidence that a more immature precursor population with lymphoid and myelomonocytic potential is actually seeding the human postnatal thymus. (ashpublications.org)
  • Critically, in both diseases, upstream immunological processes have been poorly characterised ex vivo , particularly with respect to the site and nature of antigen presentation. (biomedcentral.com)
  • Flip plays a key role in the survival of the CD8α + CD11c + DC subset in vivo . (acrabstracts.org)
  • At the Leishmania inoculation site, various phagocytes have the potential to phagocytize and transport live amastigotes or killed parasites, which may also act as antigens, to the draining lymph node. (biomedcentral.com)
  • The CD11c(high) subset is detected in mesenteric lymph nodes and spleen of BALB/c mice, but is virtually absent from C57BL/6 mice. (cnrs.fr)
  • 1-3 These nonoverlapping functions have been proposed to result from the actions of 2 major DC populations which have been characterized as myeloid and lymphoid DCs, respectively, on the basis of their anatomical localization and cell-surface phenotypes and, ultimately, of their distinct developmental origin. (ashpublications.org)
  • Immature DCs in SF may contribute to the perpetuation of inflammation via sampling of the inflamed synovial environment, and in situ presentation of arthritogenic antigen. (biomedcentral.com)
  • Spleens from ProGP treated mice were evaluated by immunocytochemistry and enriched CD11c+ populations were functionally assessed in a mixed lymphocyte assay and in an antigen dependent CTL assay. (medscimonit.com)
  • Here, we studied the expression of 2 monocyte-derived markers, CD14 and CD169 (sialoadhesin), in reactive human lymphoid tissue as well as in a series of 51 B-cell lymphomas by immunohistochemistry on paraffin-embedded tissue. (cnrs.fr)
  • Description: The N418 monoclonal antibody reacts with mouse CD11c, the integrin alpha X. CD11c non-covalently associates with beta 2 integrin to form the CD11c/CD18 heterodimer. (thermofisher.com)
  • In addition, CD11c + ATMs were enriched for mitochondria and for RNA transcripts encoding mitochondrial, proteasomal, and lysosomal proteins, fatty acid metabolism enzymes, and T-cell chemoattractants, whereas CD11c − ATMs were enriched for transcripts involved in tissue maintenance and repair. (diabetesjournals.org)
  • VAT immunostaining found CD206+CD11c- ATMs concentrated in vascularized lymphoid clusters adjacent to CD206-CD11c+ ATMs, while CD206+CD11c+ were distributed between adipocytes. (jci.org)
  • These findings identify proinflammatory CD11c + ATMs as markers of insulin resistance in human obesity. (diabetesjournals.org)
  • The most well-known source of antigens used for vaccines in Glioblastoma (Aggressive type of brain tumor) investigations were whole tumor lysate, CMV antigen RNA and tumor associated peptides for instance EGFRvIII. (wikipedia.org)
  • Despite this prototypical TCR repertoire gene usage, in recent years it has become apparent that there are variations within the iNKT cell repertoire that ultimately impact the antigen recognition capacity and consequently the functional outcomes during an immune response. (elifesciences.org)
  • Figure 8 Open in a disjoined window A model explaining the contrasting effects of wild-type and eeat one's heart outated CD48 on T cell antigen recognition. (upb.ro)
  • The combination of Programmed Cell Death 1 (PD-1) and Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) blockade has dramatically improved the overall survival rate for malignant melanoma. (biomedcentral.com)
  • The gut needs to produce a strong protective immune response to resist the invasion of pathogenic antigens, while similar reactions to harmless antigens such as dietary proteins or symbiotic microorganisms, may lead to chronic inflammatory diseases. (frontiersin.org)
  • However, langerin is also detected among lymphoid tissue DC. (cnrs.fr)
  • DC function was examined by antigen presentation and T regulatory cell (Treg) induction. (acrabstracts.org)
  • The causing upsurge in antigen-specific serum Ig supports the clearance of pathogens in the web host (1, 8). (liveconscience.com)
  • EVs were isolated from the serum of acute myeloid leukemia (AML), acute lymphoid leukemia (ALL), chronic lymphoid leukemia (CLL) patients, and healthy volunteers. (nature.com)
  • DCs isolated from the DC-Flip-KO mice effectively presented antigen but were deficient in promoting the induction of Tregs. (acrabstracts.org)