• The Epstein-Barr virus, which infects >90% of the world population, is also a common cause of these disorders, being responsible for a wide range of non-malignant, pre-malignant, and malignant Epstein-Barr virus-associated lymphoproliferative diseases. (wikipedia.org)
  • A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. (ucdenver.edu)
  • Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. (sdsu.edu)
  • Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation. (sdsu.edu)
  • A malignant disease of the T-LYMPHOCYTES in the bone marrow, thymus, and/or blood. (nih.gov)
  • 20] It is found on cold agglutinin-producing malignant lymphoid cells in the bone marrow in persons with lymphoproliferative disorders, on a small proportion of normal lymphoid cells, and in the spleen of a 15-week-old fetus. (medscape.com)
  • Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)
  • The two major types of lymphocytes are B cells and T cells, which are derived from pluripotent hematopoietic stem cells in the bone marrow. (wikipedia.org)
  • Chronic lymphocytic leukemia ( CLL ) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell ). (wikipedia.org)
  • [4] [9] CLL results in the buildup of B cell lymphocytes in the bone marrow, lymph nodes, and blood . (wikipedia.org)
  • In CLL, the bone marrow makes abnormal lymphocytes (a type of white blood cell). (icdlist.com)
  • Boys with X-linked immunodeficiency syndrome are at a higher risk of mortality associated with Epstein-Barr virus infections, and are predisposed to develop a lymphoproliferative disorder or lymphoma. (wikipedia.org)
  • HHV-4, also known as Epstein-Barr virus (EBV), causes the primary infection infectious mononucleosis , and it is implicated in various diseases, such as African Burkitt lymphoma , other immunoproliferative disorders, and nasopharyngeal carcinoma. (medscape.com)
  • in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen. (ucdenver.edu)
  • The I/i antigen analogues are present on human lymphocytes, neutrophils, and monocytes and in human saliva, milk, and amniotic fluid. (medscape.com)
  • Lymphoproliferative disorders (LPDs) refer to a specific class of diagnoses, comprising a group of several conditions, in which lymphocytes are produced in excessive quantities. (wikipedia.org)
  • although, in terms of nomenclature, lymphoproliferative disorders are a subclass of immunoproliferative disorders-along with hypergammaglobulinemia and paraproteinemias. (wikipedia.org)
  • Individuals who have some sort of dysfunction with their immune system are susceptible to develop a lymphoproliferative disorder because when any of the numerous control points of the immune system become dysfunctional, immunodeficiency or deregulation of lymphocytes is more likely to occur. (wikipedia.org)
  • A mutation on the X chromosome is associated with a T cell and natural killer cell lymphoproliferative disorder. (wikipedia.org)
  • citation needed] Some children with autoimmune lymphoproliferative disorders are heterozygous for a mutation in the gene that codes for the Fas receptor, which is located on the long arm of chromosome 10 at position 24.1, denoted 10q24.1. (wikipedia.org)
  • citation needed] Children with common variable immunodeficiency (CVID) are also at a higher risk of developing a lymphoproliferative disorder. (wikipedia.org)
  • citation needed] Some disorders that predispose a person to lymphoproliferative disorders are severe combined immunodeficiency (SCID), Chédiak-Higashi syndrome, Wiskott-Aldrich syndrome (an X-linked recessive disorder), and ataxia-telangiectasia. (wikipedia.org)
  • citation needed] Even though ataxia telangiectasia is an autosomal recessive disorder, people who are heterozygotes for this still have an increased risk of developing a lymphoproliferative disorder. (wikipedia.org)
  • Viral infection is a very common cause of lymphoproliferative disorders. (wikipedia.org)
  • In children, the most common is believed to be congenital HIV infection because it is highly associated with acquired immunodeficiency, which often leads to lymphoproliferative disorders. (wikipedia.org)
  • There are many lymphoproliferative disorders that are associated with organ transplantation and immunosuppressant therapies. (wikipedia.org)
  • Winter, S.S. Lymphoproliferative disorders. (wikipedia.org)
  • It predominantly is caused by infection and lymphoproliferative disorders. (medscape.com)
  • Autoimmune and lymphoproliferative disorders can also be associated with the production of cold agglutinins. (medscape.com)
  • which may facilitate the development of various lymphoproliferative disorders. (lookformedical.com)
  • Diagnosis is typically based on blood tests finding high numbers of mature lymphocytes and smudge cells. (wikipedia.org)
  • Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS. (lookformedical.com)
  • HHV-6, which can produce acute infection in CD4 + T lymphocytes, causes roseola infantum , a febrile illness that affects young children. (medscape.com)
  • These disorders primarily present in patients who have a compromised immune system. (wikipedia.org)
  • Most people are diagnosed as having CLL based on the result of a routine blood test that shows a high white blood cell count, specifically a large increase in the number of circulating lymphocytes . (wikipedia.org)
  • 15. Monoclonal immunoglobulins and B cell lymphoproliferative disorders. (nih.gov)
  • Individuals who have some sort of dysfunction with their immune system are susceptible to develop a lymphoproliferative disorder because when any of the numerous control points of the immune system become dysfunctional, immunodeficiency or deregulation of lymphocytes is more likely to occur. (wikipedia.org)
  • A mutation on the X chromosome is associated with a T cell and natural killer cell lymphoproliferative disorder. (wikipedia.org)
  • citation needed] Children with common variable immunodeficiency (CVID) are also at a higher risk of developing a lymphoproliferative disorder. (wikipedia.org)
  • citation needed] Even though ataxia telangiectasia is an autosomal recessive disorder, people who are heterozygotes for this still have an increased risk of developing a lymphoproliferative disorder. (wikipedia.org)
  • Primary cold agglutinin disease is characterized by a clonal lymphoproliferative disorder. (medscape.com)
  • A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. (nih.gov)
  • Lymph (clear fluid) and lymphocytes travel through the lymph vessels and into the lymph nodes where the lymphocytes destroy harmful substances. (cancer.gov)
  • lymphomatoid granulomatosis (LYG)/angiocentric immunoproliferative lesions (AIL) consist of angiocentric and angiodestructive lymphoreticular proliferation predominantly involving the lungs and other extranodal sites, such as the central nervous system (CNS). (lookfordiagnosis.com)
  • The nodules resemble to some extent the GERMINAL CENTER of lymph node follicles and most likely represent neoplastic proliferation of lymph node-derived follicular center B-LYMPHOCYTES. (harvard.edu)
  • The I/i antigen analogs are present on human lymphocytes, neutrophils, and monocytes and in human saliva, milk, and amniotic fluid. (medscape.com)
  • Furthermore, on histopathology, epitheliotropic behavior of small lymphocytes of the intestinal mucosa was observed significantly more frequently in dogs with clonal rearrangement of antigen receptor genes (P=0.027). (nih.gov)
  • 1. Immunoperoxidase staining of surface and intracellular immunoglobulin in human neoplastic lymphoid cells. (nih.gov)
  • Immunohistological examination of the tumor showed that infiltrating lymphocytes consistent with AIL. (lookfordiagnosis.com)
  • In specific embodiments, the disclosure concerns adoptive cell therapy cancer treatment in which tumor-1 infiltrating lymphocytes and/or engineered T cells are modified to increase their efficacy as a cancer treatment. (justia.com)
  • In particular embodiments, the present disclosure involves the knockout (or knockdown, in certain cases) of genes in particular lymphoid cells, such as tumor-infiltrating lymphocytes (TILs) or engineered T cells, for example, to improve the function of the cells within the tumor microenvironment. (justia.com)
  • The Epstein-Barr virus, which infects >90% of the world population, is also a common cause of these disorders, being responsible for a wide range of non-malignant, pre-malignant, and malignant Epstein-Barr virus-associated lymphoproliferative diseases. (wikipedia.org)
  • 3. The ultrastructural localization of immunoglobulins in human b cells of immunoproliferative diseases. (nih.gov)
  • 17. The immunological profile of B-cell disorders and proposal of a scoring system for the diagnosis of CLL. (nih.gov)
  • although, in terms of nomenclature, lymphoproliferative disorders are a subclass of immunoproliferative disorders-along with hypergammaglobulinemia and paraproteinemias. (wikipedia.org)
  • It predominantly is caused by infection and lymphoproliferative disorders. (medscape.com)
  • Capsule?CAPD: Continuous ambulatory peritoneal dialysis?Caps: Capsules?CAPS: Cryopyrin-Associated Periodic Syndromes disorders?CAPTIA Syph G: ?CAPTIA Syph M: ?CAST: Cardiac arrhythmia suppression trials?CAT: Computerized axial tomography?Cataplasm. (kuwaitpharmacy.com)
  • These disorders primarily present in patients who have a compromised immune system. (wikipedia.org)
  • Particular embodiments of the disclosure concern modulation of particular immune cell surface proteins to enhance adoptive cell therapy, and in specific cases the immune cells are lymphoid cells, including at least T cells, tumor infiltrating lymphocytes, or B cells, for example. (justia.com)
  • There are many lymphoproliferative disorders that are associated with organ transplantation and immunosuppressant therapies. (wikipedia.org)
  • An organ in which T lymphocytes mature and multiply. (cancer.gov)
  • We recommend the imaging of kidneys for diagnosis and following renal biopsy to evaluate the renal involvement of angiocentric immunoproliferative lesions. (lookfordiagnosis.com)
  • Haematology is the study of blood, the blood forming organs and their disorders. (edu.ng)
  • Enfermedad maligna caracterizada por agrandamiento progresivo de los ganglios linfáticos, bazo y tejido linfático en general. (bvsalud.org)
  • Lymphoproliferative disorders (LPDs) refer to a specific class of diagnoses, comprising a group of several conditions, in which lymphocytes are produced in excessive quantities. (wikipedia.org)
  • A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes. (ucdenver.edu)
  • Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation. (rush.edu)
  • 2. Detection of T and B cell populations in some lymphoproliferative disorders. (nih.gov)
  • 5. Membrane phenotypic studies in B cell lymphoproliferative disorders. (nih.gov)
  • 19. Mouse red-cell rosettes in B-lymphoproliferative disorders. (nih.gov)