Lymphocytes hla antigens. Medical search. Frequent questions

In humans, MHC proteins are encoded by the Human Leukocyte Antigen (HLA), a group of more than 200 genes located closely together on the short arm of chromosome 6. (antibodies-online.com)
Although a limited number of immunodominant peptide epitopes are consistently observed in diseases such as HIV-1 infection, the relationship between immunodominance and antigen processing in humans is largely unknown. (jci.org)

Tedopi is composed of synthetic tumoral neo-epitopes (peptide fragments) that target five tumoral antigens, permitting the activation of tumor-specific T-lymphocytes for patients who are HLA-A2 positive. (medscape.com)
for example the MHC Class II antibody based on clone IVA12 recognizes the shared epitopes of human leucocyte antigen (HLA) class II molecules HLA-DP, HLA-DQ and HLA-DR heterodimeric cell surface glycoproteins comprised of an α (heavy) chain and a β (light) chain. (antibodies-online.com)
In this study, we comprehensively screened HLA-A2 restricted MAGE-A3 tumor epitopes and characterized the corresponding TCRs using in vitro artificial antigen presentation cells (APC) system, single-cell transcriptome and TCR V(D)J sequencing, and machine-learning. (thno.org)
We identified the HLA-A2 restricted T cell epitopes from MAGE-A3 that could effectively induce the activation and cytotoxicity of CD8+ T cells using artificial APC in vitro . (thno.org)
A cohort of HLA-A2+ NSCLC donors demonstrated that the number of epitope specific CD8+ T cells increased in NSCLC than healthy controls when measured with tetramer derived from the candidate MAGE-A3 epitopes, especially epitope Mp4 (MAGE-A3: 160-169, LVFGIELMEV). (thno.org)
We used a novel in vitro degradation assay involving cytosolic extracts as well as endogenous intracellular processing assays to examine 2 well-characterized HIV-1 Gag overlapping epitopes presented by the same HLA class I allele, one of which is consistently immunodominant and the other subdominant in infected persons. (jci.org)
A vaccination strategy designed to enhance the immunogenicity of self-antigens that are overexpressed in tumor cells is to identify and slightly modify immunodominant epitopes that elicit T-cell responses. (aacrjournals.org)
RESULTS: The meta-analysis focused on a subset of data describing epitopes from 8 prostate-specific (PS) antigens. (bvsalud.org)
however, we found a significant positive correlation between the number of references per specific PS antigen and the number of reported epitopes. (bvsalud.org)
Forty-four different class I and 27 class II restrictions were found, with the most epitopes described for HLA-A*02:01 and HLA-DRB1*01:01. (bvsalud.org)
CONCLUSION: CEDAR provides a comprehensive repository of epitopes related to prostate-specific antigens. (bvsalud.org)
In a small group of women exposed to both HIV-1 and HIV-2 in Gambia, studied over 4 years, we have repeatedly detected HLA-B35-restricted CTL which exhibit cross-reactivity between the HIV-1 and HIV-2 sequences of the CTL epitopes. (ox.ac.uk)

Class I HLAs present peptides from inside the cell whereas class II HLAs present antigens from outside of the cell to T-lymphocytes. (antibodies-online.com)
A recent study shows that individuals with the allele HLA-B*46:01 have the fewest predicted binding peptides for SARS-CoV-2, suggesting they may be particularly vulnerable to COVID-19, as they were previously shown to be for SARS. (antibodies-online.com)
A different allele, HLA-B*15:03, showed the greatest capacity to present highly conserved SARS-CoV-2 peptides that are shared among common human coronaviruses, suggesting it could enable cross-protective T-cell based immunity. (antibodies-online.com)
Autologous mature dendritic cells derived from peripheral blood monocytes were pulsed with the HLA-A2-binding MUC1 peptides (M1.1 and M1.2). (aacrjournals.org)
The saga of MHC-bound peptides: a renaissance for antigen presentation? (jci.org)
HLA-DR molecules were affinity purified and bound peptides acid eluted. (jci.org)
For the first time, to our knowledge, we have identified HLA-bound peptides presented in vivo during an inflammatory condition. (jci.org)
This approach can be extended to characterize HLA-bound peptides in various autoimmune settings. (jci.org)
peptides bound to HLA-DR17 from bronchoalveolar lavage cells of sarcoidosis patients were analyzed in order to identify target antigens of the autoimmune response (see the related article beginning on page 3576). (jci.org)
HLA-DR is a heterodimeric transmembrane protein composed of alpha and beta subunits and plays an important role in the presentation of peptides to CD4+ T lymphocytes. (thermofisher.com)
Several novel MHC class I epitope prediction tools additionally incorporate the abundance levels of the peptides' source antigens and have shown improved performance for predicting immunogenicity. (bvsalud.org)

Although not a disease in itself, BeS, the innate immune response to beryllium identified by an abnormal beryllium lymphocyte proliferation test result, is a population-based predictor of CBD. (cdc.gov)
2003. Identification of an abnormal beryllium lymphocyte proliferation test. (cdc.gov)

MHC II proteins are also important for positive and negative selection in the thymus because they present antigens to immature T-cells, allowing the T cells to differentiate into proper functioning CD4+ T-lymphocytes. (wikipedia.org)
Immature dendritic cells phagocytose apoptotic cells via alphavbeta5 and CD36, and cross-present antigens to cytotoxic T lymphocytes. (nwbio.com)
B cells may play both pathogenic and protective roles in T-cell mediated autoimmune diseases such as multiple sclerosis (MS). These functions relate to the ability of B cells to bind and present antigens. (regionh.dk)

However, the redistribution of HL-A antigens fails to provoke the redistribution of all detectable ß2-µ molecules. (silverchair.com)
These results suggest that HL-A antigens may be associated with ß2-µ at the cell surface, but that all ß2-µ molecules are not bound to HL-A antigens. (silverchair.com)
Substances that provoke an immune reaction are recognized by the presence of certain molecules, called antigens , on their surface. (britannica.com)
HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and 27 kDa beta chain (DRB). (thermofisher.com)
T1D susceptibility is restored to normally resistant NOD.β2m -/- mice transgenically expressing human disease-associated HLA-A ∗ 02:01 or HLA-B ∗ 39:06 class I molecules in place of their murine counterparts. (elsevierpure.com)
However, NOD.β2m -/- mice also lack nonclassical MHC I family members, including FcRn, required for antigen presentation, and maintenance of serum IgG and albumin, precluding therapies dependent on these molecules. (elsevierpure.com)
The transporter associated with antigen processing (TAP), which is composed of two subunits (TAP1 and TAP2) that have different biochemical and functional properties, plays a key role in peptide loading and the cell surface expression of HLA class I molecules. (lu.se)
The TAP1 defect leads to unstable HLA class I molecules and their retention in the endoplasmic reticulum. (lu.se)

Genetic susceptibility to CBD is associated with alleles of the major histocompatibility gene, human leukocyte antigen DP (HLA-DP) containing glutamic acid at the 69th position of the beta chain (HLA-DPbeta-E69). (cdc.gov)
The technology uses the human leukocyte antigen (HLA) system, one of the keys for presenting antigens to T-lymphocytes. (medscape.com)
The TU169 monoclonal antibody specifically binds to the human Major Histocompatibility Complex (MHC) Class II HLA-DQ1 and DQ2 antigens and weakly to HLA-DQ3. (bdbiosciences.com)
Lack of strong immune selection pressure by the immunodominant, HLA-A 0201-restricted cytotoxic T lymphocyte response in chronic human immunodeficiency virus-1 infection. (anaspec.com)
Volunteer donors having 100 per cent matching Human Lymphocyte Antigen (HLA) have been kept on standby for bone marrow transplant if their condition worsens," he said. (thehindu.com)
Classical class I and class II Human Leukocyte Antigen (HLA) are leading candidates for infectious disease susceptibility. (antibodies-online.com)
Human Leukocyte Antigen Susceptibility Map for Severe Acute Respiratory Syndrome Coronavirus 2. (antibodies-online.com)
A scanning electron micrograph of a human T lymphocyte (or T cell) from the immune system of a healthy person. (britannica.com)
Antibodies directed against white blood cell (WBC) human leukocyte antigen (HLA) in otherwise compatible donor blood are one possible cause. (merckmanuals.com)
HLA restriction of cell-mediated lysis of influenza virus-infected human cells. (ox.ac.uk)
Description: The LN3 mAb reacts with the human major histocompatibility complex (MHC) class II, HLA-DR. HLA-DR is expressed on the surface of human antigen presenting cells (APC) including B cells, monocytes, macrophages, DCs, and activated T cells. (thermofisher.com)
It has been suggested that cytokine acc leukoreduction prevents transmission of cyc cumulation in plasma of platelet concenc tomegalovirus and decreases alloimmunizac trates (PC) during storage may contribute tion to human leukocyte antigen (HLA), it to development of nonchaemolytic febrile does not prevent allergic reactions. (who.int)
As control we used a human leukocyte antigen DR (HLA DR) antibody with equal inhibitory capacities on cell proliferation. (biomedcentral.com)
DR4 is one among copious alleles of a gene called DRB1, which itself is one among many in a large complex of genes - called the human lymphocyte antigen complex, or HLA - that's crucial to rendering cells' inner contents visible to the immune system. (alzheimersweekly.com)
Single amino acid substitutions were introduced to the CAP1 peptide (YLSGANLNL), an immunogenic HLA-A2 + -binding peptide derived from human carcinoembryonic antigen (CEA). (aacrjournals.org)
The tissue typing system is the Human Lymphocyte Antigen (HLA) system. (matrixrepatterning.com)
Some human leukocyte antigen (HLA) class II genes are more frequent in patients with Kikuchi disease, suggesting a genetic predisposition to the proposed autoimmune response. (medscape.com)
Human leukocyte antigen (HLA) alleles have been linked to HIV disease progression and attributed to differences in cytotoxic T lymphocyte (CTL) epitope representation. (cdc.gov)

HLA-DQ is expressed primarily on B cells, monocytes, macrophages, dendritic cells and activated T lymphocytes. (bdbiosciences.com)
For the activation of CD4 + T-helper lymphocytes, dendritic cells were further incubated with the PAN-DR-binding peptide PADRE. (aacrjournals.org)
Vaccination with tumor lysate-pulsed dendritic cells elicits antigen-specific, cytotoxic T-cells in patients with malignant glioma. (nwbio.com)
Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. (nwbio.com)
Babatz J, Röllig C, Löbel B, Folprecht G, Haack M, Günther H, Köhne CH, Ehninger G, Schmitz M, Bornhäuser M. Induction of cellular immune responses against carcinoembryonic antigen in patients with metastatic tumors after vaccination with altered peptide ligand-loaded dendritic cells. (nwbio.com)

Within HIV-1 RT the peptide appears to be the dominant HLA A*0201-restricted epitope. (anaspec.com)
Peptide presentation is critical for immune recognition of pathogen-infected cells by CD8+ T lymphocytes. (jci.org)
Under serum-free conditions we observed that 3-4% of circulating B cells from healthy donors were capable of binding the MS-associated self-antigen myelin basic protein (MBP) and of presenting the immunodominant peptide MBP85-99, as determined by staining with the mAb MK16 recognising the peptide presented by HLA-DR15-positive cells. (regionh.dk)
Here, we analyzed V and CDR3 TCR regions of single circulating naive T cells specifically detected ex vivo and isolated with HLA-A2/melan-A peptide multimers. (elsevierpure.com)

Various methodologies have been utilized to analyze epitope-specific responses in the context of non-self-antigens, such as those associated with infectious diseases and allergies, and in the context of self-antigens, such as those associated with transplantation, autoimmunity, and cancer. (bvsalud.org)
B46 had no detectable effect on HIV-specific Tcell responses, but this allele is unusual in containing an HLA-C epitope that binds inhibitory receptors on natural killer (NK) cells. (cdc.gov)

Since many of these patients lack HLA-identical sibling donors and are older or have comorbidity, a fully ablative HSCT is not feasible and an alternative approach is required. (nih.gov)
Hence the outcome of reduced intensity HSCT with lymphodepleting antibodies in older patients with intermediate/high-risk hematological malignancies appears comparable to that obtained with fully ablative transplantation in younger patients, even when these older recipients lack HLA-identical sibling donors. (nih.gov)
Broadly cross-reactive HIV-specific cytotoxic T-lymphocytes in highly-exposed persistently seronegative donors. (ox.ac.uk)

The diagnosis for Bare lymphocyte syndrome type II can be done via genetic testing A blood test could indicate decreased CD4+ T-cells(T-helper lymphocyte), as well as serum immunoglobulin In terms of treatment for major histocompatibility complex class II deficiency(Bare lymphocyte syndrome type II), one finds that according to Matheux, et al. (wikipedia.org)

The mechanisms described here refute the general assumption that B-cell presentation of self-antigens requires uptake via specific B-cell receptors, and may be important for maintenance of tolerance as well as for driving T-cell responses in autoimmune diseases. (regionh.dk)

MHC II proteins present exogenous antigens that activate CD4+ T-lymphocytes, immune cells that are responsible for activating other immune cells like CD8+ T-lymphocytes and macrophages. (wikipedia.org)
HLA-DR is expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. (thermofisher.com)

The adaptive immune response, primarily comprised of T and B lymphocytes, has important implications in the fracture healing process as well [ 3 , 4 ]. (hindawi.com)

Adoptive cell therapy using engineered T-cell receptors (TCRs) targeting cancer-testis antigens, such as Melanoma-associated antigen 3 (MAGE-A3), is a potential approach for the treatment of NSCLC. (thno.org)
The efficacy of a therapeutic antibody depends on the Fab fragment and its binding activity to the target antigen, but also depends on the Fc fragment and its interaction with key Fc receptors.Therefore, candidates must be tested against a panel of receptors during antibody engineering. (acrobiosystems.com)

HLA-DQ antigens exits as heterodimers comprised of polymorphic transmembrane HLA-DQ alpha and beta glycoproteins. (bdbiosciences.com)

The antibody-induced redistribution of ß2-microglobulin (ß2-µ) and HL-A antigens on the surface of living lymphocytes was studied by immunofluorescence. (silverchair.com)
This antibody does not cross-react with HLA-DR2 and HLA-DR7. (bdbiosciences.com)
The following product was used in this experiment: HLA-DR Monoclonal Antibody (LN3), Super Bright™ 436, eBioscience™ from Thermo Fisher Scientific, catalog # 62-9956-42, RRID AB_2744822. (thermofisher.com)

Bare lymphocyte syndrome type II (BLS II) is a rare recessive genetic condition in which a group of genes called major histocompatibility complex class II (MHC class II) are not expressed. (wikipedia.org)
The increased intestinal permeability was accompanied by augmented expression of genes marking immune cell infiltration and encoding key proteins for immune cell adhesion, antigen presentation, and cytokine signaling in the orbital tissue. (frontiersin.org)
These specialized proteins are the products of the HLA genes. (alzheimersweekly.com)

Adoptive immunotherapy using tumor-associated antigen (TAA)-specific CD8 + cytotoxic T lymphocytes (CTLs) and/or CD4 + helper T (Th) cells can induce the regression of large established tumor in not only mouse models but also cancer patients [ 1 - 3 ]. (oncotarget.com)

The evaluated functional avidity of these TCRs positively correlated with cell proliferation, cytokine production, and WT1-specific cytotoxicity of the TCR-transduced CD8 + T cells in response to WT1 antigen. (oncotarget.com)

T lymphocytes are responsible for cell-mediated immunity , so named because the T cells themselves latch onto the antigens of the invader and then initiate reactions that lead to the destruction of the nonself matter. (britannica.com)

The focus of Dr. Berg's work is on the signaling proteins and pathways regulating T lymphocyte development, differentiation, activation, and migration, with a strong emphasis on T-cell receptor (TCR) signaling. (cuanschutz.edu)

We have previously shown that Scandinavian sarcoidosis patients expressing the HLA-DR allele DRB1*0301 are characterized by large accumulations in the lungs of CD4+ T cells expressing the TCR AV2S3 gene segment. (jci.org)

HLA-B∗46 associates with rapid HIV disease progression in Asian cohorts and prominent differences in NK cell phenotype. (cdc.gov)

Natural killer (NK) cells, with a predominant morphology of large granular lymphocytes, represent a lineage of lymphoid cells with constitutive ability to mediate cytotoxicity toward pathologic target cells and secrete cytokines. (mhmedical.com)

PubMed Scholia has a topic profile for Bare lymphocyte syndrome type II. (wikipedia.org)

AHTR usually results from recipient plasma antibodies to donor RBC antigens. (merckmanuals.com)
DI-fusion Intrathecal donor lymphocyte infusion for the treatment of. (ac.be)
Intrathecal donor lymphocyte infusion for the treatment of suspected refractory lymphomatous meningitis: a case report. (ac.be)

T-regulatory cells (Tregs) are a sub-population of lymphocytes that act to suppress aberrant immune responses. (nih.gov)
The discovery and characterization of new antigens implicated in the pathogenesis of T1D is a high priority as it can lead to new diagnostic tools and anticipate that studies proposed by Dr. Baker will provide critical information to target autoreactive T cells though antigen-specific therapies. (cuanschutz.edu)
The key cells of the immune system are the white blood cells known as lymphocytes. (britannica.com)
T lymphocytes ( T cells ) and B lymphocytes ( B cells ). (britannica.com)
This association afforded us a unique opportunity to identify a sarcoidosis-specific antigen recognized by AV2S3+ T cells. (jci.org)
To identify candidates for the postulated sarcoidosis-specific antigen, lung cells from 16 HLA-DRB1*0301pos patients were obtained by bronchoalveolar lavage. (jci.org)
Adoptive T-cell therapy with T cell receptor (TCR) -engineered T cells is an attractive strategy for cancer treatment and the success in this therapy is dependent on the functional avidity of the transduced TCRs against targeted tumor antigens. (oncotarget.com)
Four different TCRs of HLA-A * 24:02-restricted Wilms' tumor gene 1 (WT1)-specific CD8 + cytotoxic T lymphocytes (CTLs) were transduced into 2D3 cells and the functional avidities of these four TCRs were evaluated. (oncotarget.com)
In this mesenchymal subtype, a decreased number of CD8 + tumor-infiltrating lymphocytes (TILs) were detected, suggesting an association between EMT tumor cells and exclusion of these immune cells from the TME. (encyclopedia.pub)
This line was obtained from peripheral blood mononuclear cells from an HLA-A2 + individual vaccinated with a vaccinia-CEA recombinant. (aacrjournals.org)

Moreover, these anergic lymphocytes were extremely sensitive for protein kinase C-mediated apoptosis, indicating that immunosuppressive mechanisms are inter-related. (biomedcentral.com)

Many observations point to a major role for classical HLA loci in determining susceptibility to viral infections 1 . (antibodies-online.com)

Positive for HBs antigen or HBV-DNA observed in serum 5. (mycancergenome.org)

Impact of autograft-absolute lymphocyte count on survival in double/triple hit lymphomas post-autologous stem cell transplantation. (astct.org)

However, systematic analysis of T cell immune responses to MAGE-A3 antigen and corresponding antigen-specific TCR is still lacking. (thno.org)

Lymphadenitis results from apoptotic cell death induced by cytotoxic T lymphocytes. (medscape.com)

This work identified candidate TCRs potentially suitable for TCR-T design targeting HLA-A2 restricted MAGE-A3 tumor antigen. (thno.org)

The use of previously developed COS-1 cell lines secreting noninfectious recombinant viral antigen is limited due to diminished antigen secretion over time. (cdc.gov)

Analogues were tested for binding to HLA-A2 and for recognition by an established CTL line directed against CAP1. (aacrjournals.org)
This enhanced recognition was shown not to be due to better binding to HLA-A2. (aacrjournals.org)
The specificity of recognition of pMHC complexes by T lymphocytes is determined by the V regions of the TCR α- and β-chains. (elsevierpure.com)

Antigen secretion was stable for at least 10 cell passages, as measured by enzyme-linked immunosorbent assays and immunofluorescence assays. (cdc.gov)

2000. Detection of beryllium sensitivity using a flow cytometric lymphocyte proliferation test: the Immuno-Be-LPT. (cdc.gov)

However, terminally differentiated HLA-DR + Tregs are mobilized the following day, which could represent a compensatory attempt by the host to restore immune homeostasis and limit excessive cell damage. (nih.gov)
Introduction tions of T-cell derived IL-2R are increased in mixed lymphocyte cultures. (who.int)
Transgenic expression of HLA-A2 or-B39 restored pathogenic CD8 + T-cell development and T1D susceptibility to NOD-cMHCI -/- mice. (elsevierpure.com)
Thirty-five cell lines (90%) had stable antigen expression over 10 passages, with three of these cell lines (7%) increasing in antigen expression and one cell line (3%) decreasing in antigen expression. (cdc.gov)
Antigen secretion in the HEK-293 cell lines was higher than in previously developed COS-1 cell line counterparts. (cdc.gov)
Antigen production was more stable and statistically higher in these newly developed cell lines than in their COS-1 cell line counterparts. (cdc.gov)
The use of these cell lines for production of flaviviral antigens will expand serological diagnostic testing of flaviviruses worldwide. (cdc.gov)

In 95% of cases, tumors express at least one of these five antigens. (medscape.com)

HLA and infectious diseases. (antibodies-online.com)

Anatomy37

Organisms10

Diseases11

Chemicals and Drugs121

Analytical, Diagnostic and Therapeutic Techniques and Equipment32

Phenomena and Processes43

Disciplines and Occupations1

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Named Groups1

Health Care1

Humans2

Epitopes12

Peptides11

Abnormal beryllium lymphocyte proliferation test2

Present antigens3

Molecules8

Human18

Dendritic cells5

Peptide4

Epitope2

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20001

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