• cytokines
  • There is a dichotomous effect of MSCs/ACs on lymphocytes proliferating in response to the homeostatic IL 2, IL 7 and IL 15 cytokines likely to be encountered in both homeostatic and autoimmune inflammatory conditions. (bmj.com)
  • Multicentric Castleman disease (MCD) involves hyperactivation of the immune system, excessive release of proinflammatory chemicals (cytokines), proliferation of immune cells (B cells and T cells), and multiple organ system dysfunction. (wikipedia.org)
  • Two cytokines that down modulate FLT3 activity (& block FLT3-induced hematopoietic activity) are: TNF-Alpha (Tumor necrosis factor-alpha) TGF-Beta (Transforming growth factor-beta) TGF-Beta especially, decreases FLT3 protein levels and reverses the FLT3L-induced decrease in the time that hematopoietic progenitors spend in the G1-phase of the cell cycle. (wikipedia.org)
  • Cytokines are cell signaling molecules that can enhance the immune response. (wikipedia.org)
  • clonal
  • We diagnosed a new case of a clonal T-LGL proliferation in a 6-year-old girl presenting with severe neutropenia and pure red blood cell aplasia (PRCA). (kuleuven.be)
  • BACKGROUND Clonal T cell receptor (TCR) gene rearrangements and loss of T cell antigens such as CD8 and TCR-β in intraepithelial lymphocytes (IELs) may indicate the development of an enteropathy-type intestinal T cell lymphoma (EITCL) in patients with refractory sprue. (bmj.com)
  • CONCLUSIONS Clonal proliferations of phenotypically abnormal IELs in refractory sprue represent an early manifestation of EITCL, for which the term "sprue-like intestinal T cell lymphoma" is proposed. (bmj.com)
  • antigens
  • A vaccine had been shown to stimulate antibody- and cell-mediated immune responses against tumor-associated antigens. (jaoa.org)
  • 8 , 9 The idea that vaccines could be given to stimulate antibody- and cell-mediated immune responses against tumor-associated antigens made so much sense at the cellular level, and results of phase I and II clinical trials were so promising! (jaoa.org)
  • Antigen presentation occurs when degradation products of protein antigens become attached to molecules encoded by a group of genes called the Major Histocompatibility Complex (MHC) and displayed on cell surfaces. (encyclopedia.com)
  • Patients with CEDS have hypogammaglobulinemia, make poor antibody responses to pneumococcal polysaccharide antigens, and their B cells, T cells, and NK cells do not activate well to stimuli. (wikipedia.org)
  • spleen
  • This opsonization enhances the clearance of red blood cell by phagocytes in the liver, spleen, and lungs, a process termed extravascular hemolysis. (wikipedia.org)
  • autoimmune
  • This should be taken into account when planning cellular therapy for autoimmune disease (AD) using stromal derived cells such as MSCs. (bmj.com)
  • Cold agglutinin disease is an autoimmune disease characterized by the presence of high concentrations of circulating antibodies, usually IgM, directed against red blood cells. (wikipedia.org)
  • It is a form of autoimmune hemolytic anemia, specifically one in which antibodies only bind red blood cells at low body temperatures, typically 28-31 °C. Cold agglutinin disease was first described in 1957. (wikipedia.org)
  • Multicentric Castleman disease (MCD) involves "Castleman-like" lymph node changes at multiple sites and patients often demonstrate intense episodes of systemic inflammatory symptoms, polyclonal/reactive lymphocyte and plasma cell proliferation, autoimmune manifestations, and multiple organ system impairment. (wikipedia.org)
  • House, Douglas W., (1 April 2016) European Ad Comm backs Glaxo's stem cell therapy Strimvelis for rare autoimmune disorder, Seeking Alpha, Retrieved 13 April 2016 "Summary of opinion1 (initial authorisation) Strimvelis" (PDF). (wikipedia.org)
  • subsets
  • PBMCs, total-T cells and T cell subsets (CD4+ and CD8+) were stimulated with IL 2, IL 7 or IL 15 and exposed to cultured BM-MSCs and ACs at varying cell:cell ratio either in contact or in transwell conditions. (bmj.com)
  • lymphoid
  • If there are lymphoid aggregates OR greater than 10% of the tumor has moderate infiltrate of lymphocytes - such tumors are best classified as type AB thymomas. (humpath.com)
  • patients
  • Published in the journal Cancer Cell, the findings show that IL-15 is also overexpressed in patients with LGL leukemia and that it causes similar cellular changes, suggesting that the treatment should also benefit people with the malignancy. (redorbit.com)
  • The investigators conducted the research using cells isolated from patients with LGL leukemia and a mouse model of the disease. (redorbit.com)
  • Dendritic cell (DC) vaccination strategies have been shown to induce antitumor immune responses in human patients undergoing clinical trials for glioblastoma multiforme (GBM). (aacrjournals.org)
  • citation needed] In some patients, the malignant cell clone can become the dominant proliferating cell type, leading to frank lymphoma, a group of B cell lymphomas occurring in immunosuppressed patients following organ transplant. (wikipedia.org)
  • However, in immunosuppressed transplant patients, the lack of T-cell immunosurveillance can lead to the proliferation of these EBV-infected of B-lymphocytes. (wikipedia.org)
  • High levels of wild-type FLT3 have been reported for blast cells of some AML patients without FLT3 mutations. (wikipedia.org)
  • for refractory AML - particularly in patients who went on to have a stem cell transplant. (wikipedia.org)
  • receptors
  • This malignant transformation begins when IL-15 attaches to receptors on the surface of normal LGLs, an event that boosts levels of a cancer-causing protein called Myc (pronounced "mick") inside the cells. (redorbit.com)
  • Simply put, while billions of different antigen receptors can be made (in terms of antigen-binding specificity), each lymphocyte makes only one kind. (encyclopedia.com)
  • The functional role of the low pH sensitivity of the proton-sensing G protein-coupled receptors is being studied in several tissues where cells respond to conditions of low pH including bone and inflamed tissues. (wikipedia.org)
  • undergo
  • Some of these B-cells may undergo mutations which will render them malignant, giving rise to a lymphoma. (wikipedia.org)
  • immunoglobulin
  • Clinical features suggesting CEDS should be investigated by immunologic studies assessing serum immunoglobulin levels, antibody function, and lymphocyte activation. (wikipedia.org)
  • genes
  • This study had systematically identified the global genes and pathways by RNA sequencing in chicken lymphocytes after REV infection. (frontiersin.org)
  • Georg F. Weber has defined the genetic basis of metastasis formation as aberrant expression or splicing of a unique set of developmentally non-essential genes (stress response genes) that physiologically mediate the homing of immune system cells. (wikipedia.org)
  • doses
  • When doses of pig or human RBCs equivalent to those present in WBCs were added immediately after PLC stimulation, the cell-cycle kinetics were similar to those of WBCs. (scielo.br)
  • instability
  • In the formation of the membrane attack complex, several complement proteins are inserted into the red blood cell membrane, forming pores that lead to membrane instability and intravascular hemolysis (destruction of the red blood cell within the blood vessels). (wikipedia.org)
  • Frequency
  • The incorporation of either human or pig red blood cells (RBCs) in human PLCs and MLCs produced a RBC dose-dependent decrease in the frequency of SCEs (Larramendy and Reigosa, 1986). (scielo.br)
  • Isolated SK4-KO β-cells stimulated with 15 mmol/l glucose had an increased Ca 2+ action potential frequency, and single-action potentials were broadened. (diabetesjournals.org)
  • hematopoietic
  • They are primarily expressed in cells of the hematopoietic system, where they represent the Gardos channel ( 1 ). (diabetesjournals.org)
  • CD135 is an important cell surface marker used to identify certain types of hematopoietic (blood) progenitors in the bone marrow. (wikipedia.org)
  • This marker is therefore used to differentiate hematopoietic stem cells (HSC), which are CD135 negative, from MPPs, which are CD135 positive. (wikipedia.org)
  • epithelial
  • Type A thymoma (also known as Spindle Cell Thymoma) is composed of bland spindle or oval epithelial cells admixed with few or no lymphocytes . (humpath.com)
  • Kv1.2 channel regulates neurotransmitter release associated with heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, immunological response and cell volume. (wikipedia.org)
  • vascular
  • Cell behavior in vascular remodeling. (biokemi.org)
  • Castleman disease is diagnosed when a lymph node biopsy reveals regression of germinal centers, abnormal vascularity, and a range of hyaline vascular changes and/or polytypic plasma cell proliferation. (wikipedia.org)
  • generate
  • Reports suggest that the immunogenicity of DC vaccination strategies depends on the methodologies used to generate tumor cell lysates and condition DCs. (aacrjournals.org)
  • glycoprotein
  • 2 Vaccine activity was also associated with expression of CD69+ lymphocytes and CA27.29 (MUC-1), a high-molecular-weight glycoprotein rich in serine and threonine residues. (jaoa.org)
  • CD226 is a ~65 kDa glycoprotein expressed on the surface of natural killer cells, platelets, monocytes and a subset of T cells. (wikipedia.org)
  • reduction
  • In addition, the reduction of lymphocytes also might be responsible for the lower levels of IL8 and IL18, and the rescue of lymphocytes would been activated still through FOXO and p53 pathways. (frontiersin.org)
  • Shorter co-incubation periods or a reduction in the dose of RBCs made cell-cycle progression intermediate between PLC and WBC values. (scielo.br)
  • lysis
  • If the complement response is insufficient to form membrane attack complexes, then extravascular lysis will be favored over intravascular red blood cell lysis. (wikipedia.org)
  • physiological role
  • In this study, we investigated whether the Ca 2+ -activated K + channel of intermediate conductance SK4 (KCa3.1, IK1) plays a physiological role in pancreatic β-cell function. (diabetesjournals.org)
  • An important physiological role of the IK channel is to help maintain large electrical gradients for the sustained transport of ions such as Ca2+ that controls T lymphocyte (T cell) proliferation. (wikipedia.org)
  • membrane
  • If the complement response is sufficient, red blood cells are damaged by the membrane attack complex, an effector of the complement cascade. (wikipedia.org)
  • In lieu of the membrane attack complex, complement proteins (particularly C3b and C4b) are deposited on red blood cells. (wikipedia.org)
  • An increase in K + currents and concomitant membrane hyperpolarization could be evoked in WT β-cells by the SK4 channel opener DCEBIO (100 μmol/l). (diabetesjournals.org)
  • indicate
  • 4 The epitheliotropism and immunophenotypic properties-for example, expression of CD103-of EITCL indicate a derivation from intraepithelial T lymphocytes (IELs). (bmj.com)
  • entity
  • Several synonymous terms have been done for this entity: adenomatoid proliferation of alveolar epithelium, papillary alveolar hamartoma, multifocal alveolar hyperplasia, multinodular pneumocyte hyperplasia. (wikipedia.org)
  • protein
  • This complex remains in the cell until it is bound by another protein called Latent TGF-β-Binding Protein (LTBP), forming a larger complex called Large Latent Complex (LLC). (wikipedia.org)