• cytokines
  • There is a dichotomous effect of MSCs/ACs on lymphocytes proliferating in response to the homeostatic IL 2, IL 7 and IL 15 cytokines likely to be encountered in both homeostatic and autoimmune inflammatory conditions. (bmj.com)
  • Multicentric Castleman disease (MCD) involves hyperactivation of the immune system, excessive release of proinflammatory chemicals (cytokines), proliferation of immune cells (B cells and T cells), and multiple organ system dysfunction. (wikipedia.org)
  • Cytokines are cell signaling molecules that can enhance the immune response. (wikipedia.org)
  • Two cytokines that down modulate FLT3 activity (& block FLT3-induced hematopoietic activity) are: TNF-Alpha (Tumor necrosis factor-alpha) TGF-Beta (Transforming growth factor-beta) TGF-Beta especially, decreases FLT3 protein levels and reverses the FLT3L-induced decrease in the time that hematopoietic progenitors spend in the G1-phase of the cell cycle. (wikipedia.org)
  • spleen
  • This opsonization enhances the clearance of red blood cell by phagocytes in the liver, spleen, and lungs, a process termed extravascular hemolysis. (wikipedia.org)
  • autoimmune
  • This should be taken into account when planning cellular therapy for autoimmune disease (AD) using stromal derived cells such as MSCs. (bmj.com)
  • Cold agglutinin disease is an autoimmune disease characterized by the presence of high concentrations of circulating antibodies, usually IgM, directed against red blood cells. (wikipedia.org)
  • It is a form of autoimmune hemolytic anemia, specifically one in which antibodies only bind red blood cells at low body temperatures, typically 28-31 °C. Cold agglutinin disease was first described in 1957. (wikipedia.org)
  • Multicentric Castleman disease (MCD) involves "Castleman-like" lymph node changes at multiple sites and patients often demonstrate intense episodes of systemic inflammatory symptoms, polyclonal/reactive lymphocyte and plasma cell proliferation, autoimmune manifestations, and multiple organ system impairment. (wikipedia.org)
  • House, Douglas W., (1 April 2016) European Ad Comm backs Glaxo's stem cell therapy Strimvelis for rare autoimmune disorder, Seeking Alpha, Retrieved 13 April 2016 "Summary of opinion1 (initial authorisation) Strimvelis" (PDF). (wikipedia.org)
  • clonal
  • We diagnosed a new case of a clonal T-LGL proliferation in a 6-year-old girl presenting with severe neutropenia and pure red blood cell aplasia (PRCA). (kuleuven.be)
  • BACKGROUND Clonal T cell receptor (TCR) gene rearrangements and loss of T cell antigens such as CD8 and TCR-β in intraepithelial lymphocytes (IELs) may indicate the development of an enteropathy-type intestinal T cell lymphoma (EITCL) in patients with refractory sprue. (bmj.com)
  • CONCLUSIONS Clonal proliferations of phenotypically abnormal IELs in refractory sprue represent an early manifestation of EITCL, for which the term "sprue-like intestinal T cell lymphoma" is proposed. (bmj.com)
  • antigen
  • Further work revealed that caspase-8 was essential for the induction of the transcription factor "nuclear factor κB" (NF-κB) after stimulation through antigen receptors, Fc receptors, or Toll-like receptor 4 in T, B, and natural killer cells. (wikipedia.org)
  • genes
  • BTB and CNC homology 2 (Bach2) is a transcriptional repressor that is required for the formation of the germinal center (GC) and reactions, including class switch recombination and somatic hypermutation of Ig genes in B cells, within the GC. (jimmunol.org)
  • Transcriptome analysis of BCR-engaged B cells from Bach2 −/− mice revealed reduced expression of the antiapoptotic gene Bcl2l1 encoding Bcl-x L and elevated expression of cyclin-dependent kinase inhibitor (CKI) family genes, including Cdkn1a , Cdkn2a , and Cdkn2b . (jimmunol.org)
  • This study had systematically identified the global genes and pathways by RNA sequencing in chicken lymphocytes after REV infection. (frontiersin.org)
  • Georg F. Weber has defined the genetic basis of metastasis formation as aberrant expression or splicing of a unique set of developmentally non-essential genes (stress response genes) that physiologically mediate the homing of immune system cells. (wikipedia.org)
  • subsets
  • PBMCs, total-T cells and T cell subsets (CD4+ and CD8+) were stimulated with IL 2, IL 7 or IL 15 and exposed to cultured BM-MSCs and ACs at varying cell:cell ratio either in contact or in transwell conditions. (bmj.com)
  • Chapter 8 Double staining of intracellular cytokine proteins and T-lymphocyte subsets. (uva.nl)
  • patients
  • Published in the journal Cancer Cell, the findings show that IL-15 is also overexpressed in patients with LGL leukemia and that it causes similar cellular changes, suggesting that the treatment should also benefit people with the malignancy. (redorbit.com)
  • The investigators conducted the research using cells isolated from patients with LGL leukemia and a mouse model of the disease. (redorbit.com)
  • These patients may develop infectious mononucleosis-like lesions or polyclonal polymorphic B-cell hyperplasia. (wikipedia.org)
  • citation needed] In some patients, the malignant cell clone can become the dominant proliferating cell type, leading to frank lymphoma, a group of B cell lymphomas occurring in immunosuppressed patients following organ transplant. (wikipedia.org)
  • However, in immunosuppressed transplant patients, the lack of T-cell immunosurveillance can lead to the proliferation of these EBV-infected of B-lymphocytes. (wikipedia.org)
  • High levels of wild-type FLT3 have been reported for blast cells of some AML patients without FLT3 mutations. (wikipedia.org)
  • for refractory AML - particularly in patients who went on to have a stem cell transplant. (wikipedia.org)
  • human
  • The addition of pig or human RBCs to PLCs accelerated the cell-cycle progression of pig lymphocytes. (scielo.br)
  • When doses of pig or human RBCs equivalent to those present in WBCs were added immediately after PLC stimulation, the cell-cycle kinetics were similar to those of WBCs. (scielo.br)
  • The incorporation of either human or pig red blood cells (RBCs) in human PLCs and MLCs produced a RBC dose-dependent decrease in the frequency of SCEs (Larramendy and Reigosa, 1986). (scielo.br)
  • Additionally, in both human and pig RBC-free cultures (PLCs and MLCs) the proliferation of lymphocytes is slower than in WBC. (scielo.br)
  • A549 (ATCC ® CCL-185™) are human lung non-small adenocarcinoma cell line, was proceeded in accordance with the ATCC protocol. (omicsonline.org)
  • 2. Multiple osteopontin splice variants are present in malignant, but not in benign human breast tumor cells. (wikipedia.org)
  • receptor
  • Similarly, REV infection would destroy the immune defense of lymphocytes through MAPK-AP1 via Toll-like receptor-, NOD-like receptor-, and salmonella infection pathways to reduce the secretion of IL8 and IL18. (frontiersin.org)
  • Moreover, the immune response for REV in lymphocytes would activate by up-regulating the expression of NOD1, MYD88 , and AP1 through Toll-like receptor-/NOD-like receptor/salmonella-MAPK-AP1 pathways. (frontiersin.org)
  • antibodies
  • Binding of antibodies to red blood cells activates the classical pathway of the complement system. (wikipedia.org)
  • Depletion of T cells by use of anti-T cell antibodies in the prevention or treatment of transplant rejection further increases the risk of developing post-transplant lymphoproliferative disorder. (wikipedia.org)
  • CD226 mediates cellular adhesion to other cells bearing its ligands, CD112 and CD155, and cross-linking CD226 with antibodies causes cellular activation. (wikipedia.org)
  • proteins
  • In the formation of the membrane attack complex, several complement proteins are inserted into the red blood cell membrane, forming pores that lead to membrane instability and intravascular hemolysis (destruction of the red blood cell within the blood vessels). (wikipedia.org)
  • In lieu of the membrane attack complex, complement proteins (particularly C3b and C4b) are deposited on red blood cells. (wikipedia.org)
  • Transforming growth factor beta (TGF-β) is a multifunctional cytokine belonging to the transforming growth factor superfamily that includes four different isoforms (TGF-β 1 to 4, HGNC symbols TGFB1, TGFB2, TGFB3, TGFB4) and many other signaling proteins produced by all white blood cell lineages. (wikipedia.org)
  • undergo
  • Some of these B-cells may undergo mutations which will render them malignant, giving rise to a lymphoma. (wikipedia.org)
  • cycle progression
  • Shorter co-incubation periods or a reduction in the dose of RBCs made cell-cycle progression intermediate between PLC and WBC values. (scielo.br)
  • assay
  • These compounds caused a dose dependent reduction in the viability of L-929 tumour cells in 72 h culture (IC 50 value of 2.7 μ g/mL and 3.3 μ g/mL) by the cell viability assay. (hindawi.com)
  • antibody
  • However, β-endorphin has been shown to decrease antibody production as measured by the plaque-forming cell response (5,9). (springer.com)
  • malignant
  • This malignant transformation begins when IL-15 attaches to receptors on the surface of normal LGLs, an event that boosts levels of a cancer-causing protein called Myc (pronounced "mick") inside the cells. (redorbit.com)
  • indicate
  • 4 The epitheliotropism and immunophenotypic properties-for example, expression of CD103-of EITCL indicate a derivation from intraepithelial T lymphocytes (IELs). (bmj.com)
  • concentration
  • In this study inhibition of TL proliferation in MLR was evaluated in cultures with MSCs-TL contact and in cultures without MSCs-TL contact (transwell), at different concentration of MSCs (ratio MSCs/TL: 0.3, 0.1, 0.03, 0.01). (irsn.fr)
  • MSCs
  • 3. Results of mRNA RT-PCR in MSCs showed an overexpression of IDO, HLA-G and LIF in cultures with cell contact and without cell contact. (irsn.fr)
  • genetic
  • The transformation of A-549 lung cancer cells was proved by morphological and genetic changes (AltAnalyze Platform) in dynamics. (omicsonline.org)
  • expression
  • 2 Vaccine activity was also associated with expression of CD69+ lymphocytes and CA27.29 (MUC-1), a high-molecular-weight glycoprotein rich in serine and threonine residues. (jaoa.org)
  • lysis
  • If the complement response is insufficient to form membrane attack complexes, then extravascular lysis will be favored over intravascular red blood cell lysis. (wikipedia.org)