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LymphocytesAntigensLymphocyte ActivationAntigens, BacterialAntigens, SurfaceAntigens, NeoplasmT-LymphocytesAntigens, ViralLymphocyte SubsetsB-LymphocytesAntigens, CDLymphocyte CountHLA AntigensAntigens, ProtozoanAntibodies, MonoclonalAntigens, Polyomavirus TransformingH-2 AntigensReceptors, Antigen, T-CellAntigens, FungalSpleenReceptors, Antigen, B-CellAntigens, CD3Antigens, HelminthCells, CulturedT-Lymphocytes, CytotoxicLymphocyte Culture Test, MixedHistocompatibility AntigensEpitopesHLA-DR AntigensMice, Inbred BALB CFlow CytometryCD4-Positive T-LymphocytesCytotoxicity, ImmunologicHistocompatibility Antigens Class IICarcinoembryonic AntigenLymphocytes, Tumor-InfiltratingAntigens, Viral, TumorImmunoglobulin GMolecular Sequence DataMice, Inbred C57BLPhytohemagglutininsCD8-Positive T-LymphocytesCell LineImmunity, CellularAntigens, CD45HLA-A2 AntigenConcanavalin AAntigens, CD4Antibody FormationProliferating Cell Nuclear AntigenLymphocyte TransfusionInterleukin-2Enzyme-Linked Immunosorbent AssayLeukocyte CountInterferon-gammaLymph NodesFluorescent Antibody TechniqueHistocompatibility Antigens Class IT-Lymphocyte SubsetsAmino Acid SequenceProstate-Specific AntigenO AntigensHLA-A AntigensCross ReactionsAntigens, CD15Antibody SpecificityAntigens, DifferentiationAntigen-Antibody ReactionsImmunoglobulin MThymus GlandImmunizationAntigens, Tumor-Associated, CarbohydrateImmune SeraLymphocyte CooperationCytotoxicity Tests, ImmunologicClone CellsMitogensReceptors, AntigenAntigens, CD8Lymphocyte DepletionHepatitis B Surface AntigensRosette FormationImmunophenotypingLymphocyte Function-Associated Antigen-1Killer Cells, NaturalBlood Group AntigensBase SequenceMice, Inbred StrainsHLA-D AntigensImmunoglobulinsAntigens, CD19LectinsDendritic CellsReceptors, Lymphocyte HomingReceptors, Antigen, T-Cell, alpha-betaCell DivisionImmune ToleranceKi-67 AntigenCell SeparationTime Factors
Monoclonal antibody Ki-67AntibodyCytoplasmic antigensCytotoxicTumorProliferationProteinNuclearLymphoidDonorsLymphomaCellsDetectionReactiveInfiltrationPopulationsCellAbsentExpressionIndexFeaturesSubsetsReceptorAntibodiesPeripheralHumansProliferativeNeutrophilsActivationAbnormalImmuneActivityMiceAnalysisMaleAreas
Monoclonal antibody Ki-673
  • Characterisation of normal peripheral blood cells in cycle identified by monoclonal antibody Ki-67. (bmj.com)
  • The manufacturing of a mouse monoclonal antibody, Ki-67, is described. (th2response.com)
  • The monoclonal antibody Ki-67 was used to determine the numbers of cycling cells in hair follicles both in alopecia areata and in normal scalp skin. (medicaljournals.se)
Antibody8
  • METHODS: Single and double immunoenzymatic staining procedures, immunoperoxidase, and immunoalkaline phosphatase were used with Ki-67, a monoclonal antibody that recognises a nuclear antigen present in proliferating cells, with markers expressed in B and T lymphocytes and monocytes. (bmj.com)
  • Monocytes detected by the anti-lysozyme antibody were consistently Ki-67 negative. (bmj.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Lymphocyte Function Associated Antigen 3 (LFA3) in serum, plasma, cell lysatesand other biological fluids. (envite.org)
  • Manufacturing of a mouse monoclonal antibody reactive with a human nuclear antigen associated to cell proliferation. (th2response.com)
  • The Ki-67 antibody acknowledged a nuclear antigen present in proliferating cells, nonetheless absent in resting cells. (th2response.com)
  • Fast isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interplay of antibody-antigen complexes with protein A. The Cowan I pressure of the bacterium Staphylococcus aureus has been used as an adsorbent for antibodies complexed with radiolabeled antigens from cell lysates. (th2response.com)
  • Antibody-secreting hybrid cells have been derived from a fusion between mouse myeloma cells and spleen cells from a mouse immunized with membrane from human tonsil lymphocyte preparations. (th2response.com)
  • The Langerhans' cells (LC) were identified with a monoclonal antibody to OKT6 antigen, by employing an immunofluorescence technique. (medicaljournals.se)
Cytoplasmic antigens1
  • CONCLUSIONS: The methodology described is useful for the simultaneous detection of nuclear and cytoplasmic antigens. (bmj.com)
Cytotoxic1
  • Ligation of MHC-I/peptide complexes presented by antigen-presenting cells (APCs), triggers the recruitment of lymphocyte-specific protein tyrosine kinase (Lck), which leads to lymphokine production, motility and cytotoxic T lymphocyte (CTL) activation. (thermofisher.com)
Tumor6
  • Characterized by cell-surface molecules including CD103, CD69, and CD49a, T RM -like tumor-infiltrating lymphocytes (TILs) can be found in a wide range of human cancers, where they portend improved prognosis. (frontiersin.org)
  • T RM responses against tumor/self-antigens can concurrently result in the development of pathogenic T RM responses to self, with a growing number of autoimmune diseases and inflammatory pathologies being attributed to T RM responses. (frontiersin.org)
  • While innate immune cells are important for early tumor immune surveillance, T cells are fundamentally recognized for their crucial role in the antigen-specific recognition and elimination of malignantly transformed cells ( 2 ). (frontiersin.org)
  • The cancer diagnostics market is on the verge of explosion, as the researchers approach major technological breakthroughs in tumor diagnosis and therapy, discover new specific antigens, and unlock the mystery of the genetic basis of the disease. (aarkstore.com)
  • Nottingham histologic grade, lymphovascular invasion (LVI), mitotic count, and tumor-infiltrating lymphocytes (TILs) were evaluated. (nih.gov)
  • Tumor size, lymph node status, Ki-67 score, metastasis, overall survival (OS), and disease-free survival (DFS) were retrieved from medical records. (nih.gov)
Proliferation14
  • In conclusion, miR-425 inhibits the proliferation of MEC-1 cells, potentially by inhibiting BTK/PLCγ2 signalling, and Ki-67 and PCNA expression levels. (fatcat.wiki)
  • Comparison of data obtained in meningeal and white matter infiltrates revealed higher expression of genes related to interferonγ production, B cell differentiation, cell proliferation, lipid antigen presentation, and T cell and myeloid cell recruitment, as well as more widespread EBV infection in the meningeal samples. (biomedcentral.com)
  • Moreover, PMCs were able to stimulate CD4 + T-cell proliferation and Th22-cell differentiation by presenting tuberculosis-specific antigen. (atsjournals.org)
  • In particular, PMCs were able to function as antigen-presenting cells to stimulate CD4 + T-cell proliferation and Th22-cell differentiation. (atsjournals.org)
  • Pleural mesothelial cells stimulate CD4 + T-cell proliferation and Th22 cell differentiation in response to tuberculosis antigen. (atsjournals.org)
  • Most, if not all, cortical thymocytes did express the proliferation-associated nuclear antigen Ki-67. (unipg.it)
  • Nuclear Antigen Related to cell proliferation. (th2response.com)
  • J) Annexin V and (K) Ki-67 staining of CD33+ myeloid cells show apoptosis and proliferation, respectively. (eprf.ca)
  • Ki-67 Proliferation index. (scirp.org)
  • MCL can be both indolent or aggressive, in either case it responds poorly to chemotherapy and consequently the aggressive form has a dismal prognosis assessed by incorporating Ki-67 proliferation index and Mantle Cell International Prognostic Index scores. (bmj.com)
  • 2003. Clinical application of beryllium lymphocyte proliferation testing. (cdc.gov)
  • Variability, predictive value, and uses of the beryllium blood lymphocyte proliferation test (BLPT): preliminary analysis of the ongoing workforce survey. (cdc.gov)
  • 2000. Detection of beryllium sensitivity using a flow cytometric lymphocyte proliferation test: the Immuno-Be-LPT. (cdc.gov)
  • 2003. Identification of an abnormal beryllium lymphocyte proliferation test. (cdc.gov)
Protein1
  • Finally, BTK, PLCγ2, Ki-67 and PCNA expression was significantly inhibited at the mRNA and protein level in cells where miR-425 was upregulated. (fatcat.wiki)
Nuclear4
  • About 50% of the proliferating epithelial cells showed positive nuclear labeling for estrogen and progesterone receptors, and approximately one-third were positive for Ki-67. (scielo.br)
  • Aproximadamente 50% das células epiteliais proliferadas mostraram marcação nuclear positiva para receptores de estrógeno e progesterona e cerca de um terço dessas células era positivo para Ki-67. (scielo.br)
  • Furthermore, the expression levels of BTK, phospholipase Cγ2 (PLCγ2), Ki-67 and proliferating cell nuclear antigen (PCNA) were determined by RT-qPCR and western blotting. (fatcat.wiki)
  • In alopecia areata there is reduced nuclear Ki-67 binding in the bulb of anagen hair follicles. (medicaljournals.se)
Lymphoid2
  • Differentiating between low-grade lymphoma and reactive lymphocytes is often difficult by morphology alone as reactive lymphoid cells may acquire activation morphology from being exposed to different cytokines within the body fluid. (cytojournal.com)
  • Chimeric antigen receptor-modified T (CAR T) cells exhibit very effective function in elimination of relapsed/refractory B-cell lymphoid malignancies, we investigated their use in a patient with relapsed MCL. (bmj.com)
Donors1
  • RESULTS: In the five healthy donors 2.1% (range 1.6-3.7%) cells of the blood mononuclear fraction and 2.7% (range 2.3-3.9%) lymphocytes were Ki-67 positive. (bmj.com)
Lymphoma1
  • Biopsy showed complete effacement of the lymph node by a neoplastic population morphologically consistent with lymphoma/leukemia of precursor T-lymphocytes (so-called T-cell lymphoblastic lymphoma/leukemia). (unipg.it)
Cells14
  • Those nevus cells lack gp100 expression (with HMB-45) and show very low Ki67 expression (features characteristic of benign melanocytes). (medscape.com)
  • AIMS: To investigate the numbers, morphology, and lineage assignment of Ki-67 positive cells in peripheral blood from normal subjects. (bmj.com)
  • Forty one per cent of the Ki-67 positive cells were CD3 positive by double immunoenzymatic staining and corresponded to T lymphocytes, and 11.4% were mature B cells expressing kappa or lambda light chains. (bmj.com)
  • Half of the Ki-67 positive lymphocytes could not be accounted for by B or T cells with the markers used. (bmj.com)
  • The demonstration that a proportion of normal blood lymphocytes are in cell cycle raises the issue of whether immunophenotypic analysis of Ki-67 positive cells in haemopoietic malignancies with peripheral blood disease should be carried out to define more precisely the proportion of normal and neoplastic cells in cycle. (bmj.com)
  • Immunohistochemical examination demonstrated that these accumulated lymphocytes mainly comprised small- to medium-sized T cells expressing CD3, CD4, CD5, CD7, and CD103, but lacking CD8, CD56, and Epstein-Barr virus-encoded small RNAs. (springeropen.com)
  • Besides CD19 + CD138 − B cells, plasmablasts, and plasma cells were enriched in the tongue of mice colonized with C. albicans suggesting a potential role of B lymphocytes during oral fungal colonization. (frontiersin.org)
  • Cells in the lymphocyte gate were used for analysis. (thermofisher.com)
  • In the early 2000's, large and persistent populations of antigen (Ag)-specific CD8 T cells in peripheral tissues were initially classified as T EM cells in recirculation from the blood ( 8 , 11 ). (frontiersin.org)
  • γδ T cells, specifically the Vγ9Vδ2 subset, which is the dominate subset among γδ T cells in human peripheral blood, recognize target cells in a human leukocyte antigen (HLA)-independent manner. (nature.com)
  • The impacts of proinflammatory cytokines and antigen presentation by pleural mesothelial cells (PMCs) on Th22-cell differentiation were explored. (atsjournals.org)
  • Naive CD4 + T cells can develop into various helper T (Th) subsets with different cytokine profiles and play a discriminative role in translating antigen-specific immune responses into tissue functions or immunopathology. (atsjournals.org)
  • An accumulation of lymphocytes, especially CD4 + T cells, in TPE has been well documented ( 2 ). (atsjournals.org)
  • This review will which many cells play a role, in particular mast cells, eosino- phils, and T lymphocytes. (cdc.gov)
Detection1
  • Description: A sandwich ELISA kit for detection of Lymphocyte Function Associated Antigen 3 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (envite.org)
Reactive1
  • However, in most cases there are specific features that may aid in differentiating small reactive from non-reactive lymphocytes including the round shape of the nucleus, the absence of visible nucleoli and the presence of fine clumped chromatin. (cytojournal.com)
Infiltration1
  • In general, two distinct forms are recognized-an epitheliotropic form (in which there is infiltration by malignant lymphocytes into the epidermis and adnexa) and a nodular, nonepitheliotropic form. (merckvetmanual.com)
Populations1
  • Despite cell losses during the acute phase, upregulation of Ki-67 correlated with recovery of cell populations over time. (cdc.gov)
Cell3
  • T cell memory is antigen-specific, and can provide durable host-wide protection. (frontiersin.org)
  • Manufacturing of monoclonal antibodies to group A erythrocytes, HLA and different human cell floor antigens-new instruments for genetic evaluation. (th2response.com)
  • Neither the B-lymphocyte antigen CD19 nor the T-cell surface glycoprotein CD3 gamma chain (hybridization with a dual probe showed an absence of the fusion (Physique S3A). (eprf.ca)
Absent1
  • [ 4 . 5 ] Adding to the challenge, classic lymphoglandular bodies, representing remnants of lymphocyte cytoplasm, are typically inconspicuous or absent in effusion fluids, in contrast to FNA material from solid specimens. (cytojournal.com)
Expression2
Index1
Features1
  • the B lymphocytes in cycle showed abundant cytoplasm and features suggestive of lymphoplasmacytic differentiation. (bmj.com)
Subsets1
Receptor3
  • Here, to comprehensively map cell lineages, we use single-cell RNA sequencing and antigen receptor analysis of almost half a million cells from up to 5 anatomical regions in the developing and up to 11 distinct anatomical regions in the healthy paediatric and adult human gut. (nature.com)
  • The inability to predict the foreign antigens that an organism will encounter in its lifetime creates a need for the immune system to generate and maintain a diverse T cell receptor repertoire ( 1 - 3 ). (frontiersin.org)
  • [ 2 ] Options for second-line therapy in patients with relapsed/refractory disease include chemotherapy-free regimens with biologic targeted agents such as covalent Bruton tyrosine kinase (BTK) inhibitors, lenalidomide,venetoclax, and chimeric antigen receptor (CAR) T-cell therapy. (medscape.com)
Antibodies1
Peripheral3
  • 7. Low-dose interleukin-2 administered pre-operatively to patients with gastric cancer activates peripheral and peritumoral lymphocytes but does not affect prognosis . (nih.gov)
  • IL-7 assists in the development of lymphocytes and regulates peripheral T-cell populations [ 2 ]. (jcancer.org)
  • It reacts with medullary thymocytes, with mantle zone lymphocytes in follicles of lymph nodes and spleen, with lymphocytes of the paracortex, with peripheral blood B cells, with T suppressor/cytotoxic cells and NK cells. (biogenex.com)
Humans1
  • Varicella zoster-specific CD4+Foxp3+ T cells accumulate after cutaneous antigen challenge in humans. (ox.ac.uk)
Proliferative2
  • This modest proliferative activity (less than 25% Ki-67 expression) contrasts with Burkitt's-like lymphomas of the B-cell type which usually show greater than 80% Ki-67 expression. (arizona.edu)
  • proteins loss was within 50% of individuals with familial melanomas [10] SP600125 and was connected with high proliferative activity (as measured by Ki-67 staining) [11]. (himafund.org)
Neutrophils1
Activation1
Abnormal1
  • Traditional models of AD focused on genetic alterations, resulting in abnormal immune responses to typically harmless antigens. (biomedcentral.com)
Immune1
  • The phenotype of the Fli-1 transgenic mice included autoantibody production, renal deposition of immune complexes, glomerulonephritis, hypergammaglobulinaemia, an increased number of autoreactive T and B lymphocytes, and increased mortality [7]. (mirnasynthesis.com)
Activity1
  • Among different methods showing mitotic activity, Ki67% (highest) was the most statistically significant LI in differentiating grade I and grade II tumors. (iranpath.org)
Mice1
Analysis2
  • 14. Immunological and molecular analysis of B lymphocytes in low-grade MALT lymphoma of the stomach. (nih.gov)
  • The intention of this examine was to judge the effectivity of prostate-specific antigen (PSA) density (PSAD) calculated by way of prostate quantity (PV) obtained by way of transrectal ultrasound (TRUS) and magnetic resonance imaging (MRI) and precise prostate weight (PW) strategies obtained by way of pathological analysis on the prediction of biochemical recurrence (BCR) within the follow-ups of sufferers who had undergone radical prostatectomy (RP). (milansystem.org)
Male1
  • The male-to-female ratio in MCL is 3:1, and the age range at presentation is 35-85 years, with a median of 67 years. (medscape.com)
Areas1
  • and Ki areas making them one of the most potent and selective blockers of meprin β reported to the night out. (globaltechbiz.com)