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LymphocytesInterferonsInterferon Type ILymphocyte ActivationInterferon InducersT-LymphocytesReceptors, InterferonInterferon-alphaInterferon-gammaLymphocyte SubsetsLymphocyte CountB-LymphocytesInterferon-betaInterferon Regulatory Factor-3Interferon Regulatory Factor-1Interferon Regulatory FactorsCells, CulturedReceptor, Interferon alpha-betaSpleenLymphocyte Culture Test, MixedCell LineCD4-Positive T-LymphocytesRecombinant ProteinsInterferon Regulatory Factor-7Mice, Inbred C57BLPhytohemagglutininsAntiviral AgentsCytotoxicity, ImmunologicLymphocytes, Tumor-InfiltratingT-Lymphocytes, CytotoxicFlow CytometryMice, Inbred BALB CInterleukin-2CytokinesPoly I-CConcanavalin ACD8-Positive T-LymphocytesLeukocyte CountLymphocyte TransfusionKiller Cells, NaturalImmunity, CellularInterferon Regulatory Factor-2Newcastle disease virusT-Lymphocyte SubsetsRibavirinAntibodies, MonoclonalMacrophagesAntigens, CDMolecular Sequence DataAntigens, CD3Lymph NodesRNA, MessengerMitogensLymphocyte DepletionL Cells (Cell Line)Vesicular stomatitis Indiana virusVirus ReplicationSTAT1 Transcription FactorLeukocytes, MononuclearLymphocyte CooperationSignal Transduction2',5'-Oligoadenylate SynthetaseTime FactorsLeukocytesGene Expression RegulationMonocytesAntigens, Differentiation, T-LymphocyteRosette FormationCell DivisionAntigens, SurfaceReceptors, Lymphocyte HomingMice, KnockoutHepatitis C, ChronicLymphocyte Function-Associated Antigen-1Interleukin-4Thymus GlandImmunophenotypingBase SequenceImmunity, InnateCytotoxicity Tests, ImmunologicLectinsDendritic CellsClone CellsCell SeparationCD4 Lymphocyte CountMice, Inbred StrainsPolyethylene GlycolsTumor Necrosis Factor-alphaReceptors, Antigen, B-CellImmunoglobulinsMembrane GlycoproteinsLeukemia, LymphoidReceptors, Antigen, T-CellAmino Acid SequenceEncephalomyocarditis virusMice, Inbred C3HAntigensImmunoglobulin GAntibody FormationEpitopes
CytokinesActivated a type I interferon responseInterleukinInterleukinsLamina propria lymphocytesConsists of two subunitsPeripheralSubsetsMacrophageTumorLeukocyte interferonProliferationRelease assaysGeneStimulationInducersGenesInnateReceptorImmunityCytokinePatientsInducesDendritic cellsProteinMiceAntibodiesSubtypesAntigensCytotoxicMonocytesHumansMitogenCellsActivationTypeSpontaneousThymusParacrineHumanEtiologyBiologyResponse
Cytokines8
Activated a type I interferon response1
Interleukin1
  • Interferon γ (IFN-γ) and interleukin (IL)-4 RNA expression was examined in T lamina propria lymphocytes by quantitative reverse transcription-polymerase chain reaction. (bmj.com)
Interleukins2
Lamina propria lymphocytes1
  • Spontaneous release of interferon gamma by intestinal lamina propria lymphocytes in Crohn's disease. (google.it)
Consists of two subunits1
  • The type I IFNs bind to the interferon alpha receptor (IFNAR), which consists of two subunits, IFNAR1 (α-subunit) and IFNAR2 (β-subunit). (wikipedia.org)
Peripheral4
  • To elucidate peripheral immunologic alterations in PD, we characterized extended peripheral T-lymphocyte populations in 33 patients with PD and 34 normal subjects. (nih.gov)
  • Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes. (nih.gov)
  • Production of interferons and change of the lymphocyte subpopulation phenotype in peripheral blood at cervical papillomavirus infection. (wikigenes.org)
  • These cells inhibited T cell proliferation in a standard in vitro mixed lymphocyte assay and, moreover, attenuated the development of vasculopathy mediated by autologous peripheral blood mononuclear cells in a functionally relevant humanized mouse transplant model. (lu.se)
Subsets3
  • CD4+ T-cells and other lymphocyte subsets in persons infected with human immunodeficiency virus (HIV). (cdc.gov)
  • The guidelines describe single-platform technology (SPT), a process in which absolute counts of lymphocyte subsets are measured from a single tube by a single instrument. (cdc.gov)
  • With CD45 gating, the relative numbers of beads and lymphocyte subsets are enumerated, and their absolute numbers and percentage values are calculated. (cdc.gov)
Macrophage5
  • Interferon-gamma inhibits macrophage apolipoprotein E production by posttranslational mechanisms. (jci.org)
  • Macrophage-derived apolipoprotein (apo) E and multimers of a synthetic apo E-peptide display monokine-like functions by inhibiting mitogen- or antigen-driven lymphocyte proliferation. (jci.org)
  • This study demonstrated how the target lymphocyte itself can modulate macrophage apo E production. (jci.org)
  • These data illustrated that whereas CD47/SIRPα inhibition could potentiate tumor cell phagocytosis, CD40-mediated activation of a type I interferon response provided a bridge between macrophage- and T-cell-mediated immunity that significantly enhanced durable tumor control and rejection. (aacrjournals.org)
  • As observed in other systemic mycoses, the most relevant response against PCM is cellular immunity mediated by interferon- (IFN-) γ during macrophage activation [ 8 - 10 ]. (hindawi.com)
Tumor2
  • Adoptive cell therapy using tumor-infiltrating lymphocytes (TILs) has shown activity in melanoma, but has not been previously evaluated in metastatic non-small cell lung cancer. (nature.com)
  • Non-CPR patients showed an upregulation of proliferation, tumor marker, interferon signaling, housekeeping and tumor antigen pathways. (eurekalert.org)
Leukocyte interferon5
  • Leukocyte interferon is produced predominantly by B lymphocytes. (wikipedia.org)
  • Nucleotide sequence of a portion of human chromosome 9 containing a leukocyte interferon gene cluster. (nih.gov)
  • Bash JA, Woody JN, Neefe JR (1982) Phase I trial of immunomodulatory activities of human leukocyte interferon in advanced cancer patients. (springer.com)
  • V. Enhancement of spontaneous cytotoxicity in patients receiving human leukocyte interferon. (springer.com)
  • Karinieni AL, Timonen T, Kousa M (1980) Effect of leukocyte interferon on natural killer cells in healthy volunteers. (springer.com)
Proliferation2
  • Mercury at 1.5 ppm increased the PHA and LPS stimulation indices for T and B lymphocytes, respectively reflecting the observed decrease in basal splenocyte proliferation in mercury -treated mice. (cdc.gov)
  • Without further manipulation or selection, the resultant population delayed skin allograft rejection mediated by polyclonal CD4(+) effectors or donor-reactive CD8(+) T cell receptor transgenic T cells and inhibited both effector cell proliferation and T cell priming for interferon-γ production. (lu.se)
Release assays1
  • National screening guidelines have been revised but cost-effectiveness analyses are hampered by the lack of data on the comparative performance of tuberculin skin tests (TSTs) and interferon γ release assays (IGRAs) in immigrants. (bmj.com)
Gene8
  • Interferon alpha-1 is a protein that in humans is encoded by the IFNA1 gene. (wikipedia.org)
  • The virus-induced expression of IFNA/IFNB genes is primarily controlled at the gene transcription level, by the interferon regulatory factors (IRFs) and IFN-stimulated genes. (wikipedia.org)
  • Gene-environment interactions, sunlight and vitamin D, and T lymphocytes as autoimmune disease initiators and vitamin D targets are discussed to explain the rationale for reviewing vitamin D mechanisms in T cells. (frontiersin.org)
  • Oral exposure to inorganic mercury alters T-lymphocyte phenotypes and cytokine gene expression in BALB/C Mice. (cdc.gov)
  • The aims of this study were to investigate the effect of mercury on immune parameters, such as hematology, lymphocyte phenotypes and cytokine gene expression. (cdc.gov)
  • Transcriptional repressor that binds specifically to the PRDI element in the promoter of the beta-interferon gene (PubMed:1851123). (abcam.com)
  • Interferon gamma receptor 1 ( IFNGR1 ) also known as CD119 ( C luster of D ifferentiation 119 ), is a protein that in humans is encoded by the IFNGR1 gene . (wikidoc.org)
  • The gene IFNGR1 encodes IFN-γR1, which is the ligand-binding chain (alpha) of the heterodimeric gamma interferon receptor, which is found on macrophages . (wikidoc.org)
Stimulation5
  • However, stimulation of cells in these experiments was performed on crude T lymphocytes, allowing indirect regulation between different lymphocyte subtypes to take place. (lu.se)
  • Lamina propria T lymphocytes (T-LPL) isolated from the intestine of patients with active CD released interferon (IFN)-γ in response to gluten stimulation, and neutralisation of endogenous IFN-γ prevented the gliadin mediated morphological changes in an ex vivo organ culture of treated CD biopsies. (bmj.com)
  • Even if performance specifications of QFT are of great interest (specificity of 99% and sensitivity of 84%) [ 3 ], some patients remain with an "indeterminate result" because of failed positive control corresponding to the incapacity of lymphocytes to secrete interferon (IFN)-γ after 24 h of stimulation by phytohemagglutinin A (PHA). (ersjournals.com)
  • 1994). The nature of lymphocyte stimulation will determine which class of immunoglobulin will be produced (Waller & Renwick, 1994). (referat.ru)
  • Here, decreasing stimulation via the B-cell receptor by aging T-lymphocytes makes a difference. (medscape.com)
Inducers3
Genes4
  • In addition, canonical type I IFN signalling may activate STAT1 homodimers that bind to interferon-gamma-activating factor (GAF), which also translocates to the nucleus and activates transcription of IFN-stimulated genes. (wikipedia.org)
  • The group of FM patients showed increased expression of twenty-five interferon-regulated genes, such as S100A8 and S100A9, VCAM, CD163, SERPINA1, ANXA1, and an increased interferon score. (figshare.com)
  • We found that inhalation of GMA-SS welding fume was associated with activation of complement (C2, C3, C1QA-C, C4B), type 1 interferon pathways and increased expression of monocyte and lymphocyte chemotactic genes such as CCL2, CCL7 and CCL8. (cdc.gov)
  • In addition, genes encoding the expression of molecules involved in T lymphocyte and natural killer cell regulation were increased (CD86 and CD69). (cdc.gov)
Innate1
  • The pathways that lead to the development of tissue-resident lymphocytes, including liver type 1 innate lymphoid cells (ILC1s), remain unclear. (nih.gov)
Receptor3
Immunity2
  • HUMORAL IMMUNITYHumoral or antibody-mediated immunity is associated with B-lymphocyte cells. (referat.ru)
  • Our adaptive immunity, also called acquired immunity, is composed of lymphocyte cells that are triggered when a specific pathogen enters the body. (squareonepublishers.com)
Cytokine2
Patients8
  • Lymphocytes expressing interferon-γ (IFN-γ) on their surface were evaluated in 61 patients, all IV drug abusers, infected with human immunodeficiency virus type 1 (HIV-1), and in 85 healthy subjects (61 of whom were blood donors and 24 HIV-1 seronegative IV drug abusers). (unibs.it)
  • Data obtained demonstrated that IFN-γ-expressing T lymphocytes, mostly CD8+ cells, were present in HIV-1-infected patients, and that their percentage, always higher in HIV-1-infected patients than in healthy subjects (p ≤ 0.001), increased with progressive stages of HIV-1 infection. (unibs.it)
  • Cases of pulmonary arterial hypertension (PAH) have been reported in patients treated with interferon beta products, including BETASERON. (nih.gov)
  • For example, patients with chronic inflammatory conditions (high neutrophil to lymphocyte ratio) have been described as more likely to have indeterminate QFT than healthy subjects [ 6 ]. (ersjournals.com)
  • Further GSEA analysis showed an upregulation of pathways related to antigen processing, TCR coexpression and lymphocyte infiltrate in CPR patients. (eurekalert.org)
  • Maluish AE, Ortaldo JR, Herberman RB (1982) Modulation of NK activity by recombinant leucocyte interferon in advanced cancer patients. (springer.com)
  • Integrative analyses of a large-cohort COVID-19 dataset and our datasets revealed that NK2.1 cells from elderly COVID-19 patients are enriched for type I interferon signalling, which is positively correlated with disease severity in COVID-19. (cdc.gov)
  • et 20 témoins en bonne santé ne présentant pas d'infection par le virus de l'hépatite C. Une réduction importante de la fréquence des cellules tueuses naturelles totales dans le groupe des patients porteurs d'une infection chronique a été observée par rapport au groupe des témoins ( P = 0,001) ou au groupe des patients dont l'infection a connu une résolution spontanée ( P = 0,01). (who.int)
Induces1
Dendritic cells3
  • In addition, diabetic mice presented a reduced influx of TCD4+ cells, TCD8+ cells, B lymphocytes, NK cells, and dendritic cells compared to control infected groups. (hindawi.com)
  • Insulin treatment restored the leukocyte number in PeLF and restored the presence of B lymphocytes, dendritic cells, and NK cells in lungs of diabetic animals. (hindawi.com)
  • The data suggest that diabetic mice present impaired immunological response to Pb18 infection and insulin modulates inflammation by reducing IL-6 levels in lung and CINC-1 levels in spleen and liver homogenates, restoring leukocyte concentrations in PeLF and also restoring populations of dendritic cells and B lymphocytes in lungs of diabetic mice, permitting the host to better control the infection. (hindawi.com)
Protein1
  • TRIM22 (Staf50) is an interferon (IFN)-inducible protein with unknown function. (lu.se)
Mice2
  • A single injection of αβ-interferon (αβ-IFN) (30 000 units/mouse), a major biological modifier of natural killer (NK) cytolytic activity, strongly stimulated NK activity in normal mice, as expected, while the same treatment did not statistically alter the NK response in cyclophosphamide (CY)-suppressed animals. (springer.com)
  • Effect of Graves' disease intrathyroidal lymphocytes (ITL) on xenotransplants of human thyroid tissue in athymic nude mice. (wikigenes.org)
Antibodies1
  • Most often, these conditions occur when special white blood cells called T or B lymphocytes (or both) do not function normally or your body does not produce enough antibodies. (medlineplus.gov)
Subtypes1
  • Therefore, to prevent interaction between different lymphocyte subtypes, expression of TRIM22 was examined during activation of sorted T lymphocyte subpopulations. (lu.se)
Antigens1
Cytotoxic1
  • Herberman RB, Ortaldo JR, Mantovani A, Hobbs DS, Kung HF, Pestka S (1982) Effect of human recobinant interferon on cytotoxic activity of natural killer (NK) cells and monocytes. (springer.com)
Monocytes3
Humans1
  • Huddlestone JF, Marigan TC, Oldstone MB (1979) Induction and kinetics of natural killer cells in humans following interferon therapy. (springer.com)
Mitogen2
  • MIM 147570) is produced by mitogen- or antigen-stimulated T lymphocytes. (wikipedia.org)
  • Single-cell splenocyte cultures were used to determine the effects of mercury treatment on mitogen-induced lymphocyte blastogenesis. (cdc.gov)
Cells12
  • Interferon-γ (IFN-γ) production by the liver ILC1s themselves promotes the development of these cells in situ, through effects on their IFN-γR + liver progenitors. (nih.gov)
  • Together, the results shows that FM is associated with an interferon signature in B-cells and increased levels of a set of inflammatory serum proteins. (figshare.com)
  • Cloning, expression and biological activity of a new variant of human interferon alpha identified in virus induced lymphoblastoid cells. (nih.gov)
  • Interferon-1β (IFN-1β) is a molecule secreted by immune system cells, mainly fibroblasts. (revespcardiol.org)
  • The lymphokine interferon-gamma (IFN) dramatically inhibited the accumulation of apo E in the supernatant of human monocytic THP-1 cells when present during phorbol myristate acetate-induced differentiation. (jci.org)
  • Drives the maturation of B-lymphocytes into Ig secreting cells (PubMed:12626569). (abcam.com)
  • It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (joplink.net)
  • Controversy and debate surround the role of the non-classic human lymphocyte antigen (HLA) class I molecule HLA-G. 1, 2 Initially, the expression of HLA-G was reported to occur only in a limited subset of trophoblast cells at the fetal-maternal interface. (bmj.com)
  • The cells associated with this system, T Lymphocytes (T-cells), begin as the same stem cells as B-Lymphocytes (B-cells). (kemin.com)
  • Lymphocytes are divided into T-cells and B-cells. (loinc.org)
  • The development of skin sensitization is associated with, and requires, the activation and clonal expansion of allergen responsive T lymphocytes and it is these cells that orchestrate the cutaneous allergic reaction. (cdc.gov)
  • These memory-like NK2.1 cells accumulated with age, exhibited proinflammatory characteristics, and displayed a type I interferon response state. (cdc.gov)
Activation5
  • Moreover, expression of TRIM22 is high in lymphoid tissue, and levels decrease during T lymphocyte activation with CD3/CD2/CD28, suggesting that TRIM22 could exert antiproliferative effects. (lu.se)
  • In contrast to the marked changes of TRIM22 during activation of crude T lymphocytes, in isolated subpopulations, TRIM22 expression was not significantly affected in spite of IL-2-induced or CD3/CD2/CD28-induced activation. (lu.se)
  • Our data suggest a more complex role for TRIM22 during T lymphocyte activation than merely as an antiproliferative factor. (lu.se)
  • TRIM22 probably has an activation stage-specific role connected to the paracrine crosstalk during T lymphocyte activation. (lu.se)
  • BLyS expression is directly linked to interferon (IFN) pathway activation. (biomedcentral.com)
Type2
  • BST2, ISG15 and IFI27 involved in type I interferon signaling as well as, CD8B, SDHA, HMBS and OAS1. (eurekalert.org)
  • Possible cross-talk occurs between eosinophils and Th2-type lymphocytes in CSS via the secretion of IL-25, a potent Th2-response enhancer, by the eosinophils themselves. (medscape.com)
Spontaneous1
  • Einhorn S, Blomgren H, Strander H (1980) Interferon and spontaneous cytotoxicity in man. (springer.com)
Thymus1
  • Exposure to 7.5 and 37.5 ppm of mercury decreased the CD8+ T lymphocyte population in thymus, whereas double positive CD4+/CD8+ and CD4+ thymocytes were not altered. (cdc.gov)
Paracrine1
  • Evidence for CD4 + T-cell involvement in autoimmune disease pathogenesis and for paracrine calcitriol signaling to CD4 + T lymphocytes is summarized to support the thesis that calcitriol is sunlight's main protective signal transducer in autoimmune disease risk. (frontiersin.org)
Human2
  • Identification of interferon-alpha 7, -alpha 14, and -alpha 21 variants in the genome of a large human population. (nih.gov)
  • Single-platform technology (SPT) is designed to enable de- system and managing the health care of persons infected with terminations of both absolute and percentage lymphocyte sub- human immunodeficiency virus (HIV) ( 1-4 ). (cdc.gov)
Etiology1
  • This review summarizes and integrates research on vitamin D and CD4 + T-lymphocyte biology to develop new mechanistic insights into the molecular etiology of autoimmune disease. (frontiersin.org)
Biology1
  • This review highlights recent advances in vitamin D and T-lymphocyte biology in an effort to harness vitamin D's potential to reduce the impact of autoimmune diseases. (frontiersin.org)
Response1
  • In strict respect of pre-analytical procedures, the response to PHA relies on the functional integrity of lymphocytes, which can be altered in various clinical contexts. (ersjournals.com)