• Patients
  • This study will evaluate HIV-negative patients with unusually low levels of CD4+ T lymphocytes (a type of white blood cell) to learn more about the clinical symptoms, cause, immunology, and biology of this problem. (clinicaltrials.gov)
  • Patients 8 years of age and older with CD4+ T cell counts below 300 cells/mm3 who test negative for HIV infection by standard blood tests may be eligible for this study. (clinicaltrials.gov)
  • Researchers discover that lymphocyte count indicates prognosis of patients with renal cell. (bio-medicine.org)
  • Now, researchers at Fox Chase Cancer Center have discovered that the lymphocyte countwhich is routinely measured in laboratory testsis a simple and effective prognostic indicator in patients with renal cell carcinoma (RCC). (bio-medicine.org)
  • RCC patients generally have a worse prognosis if they have a suppressed immune system, which is indicated by low lymphocyte levels. (bio-medicine.org)
  • By evaluating data from more than 500 patients with the most common form of RCCcalled clear cell RCCwho had their kidneys surgically removed at Fox Chase between 1994 and 2009, Al-Saleem and his colleagues found a clear relationship between low lymphocyte counts within three months prior to surgery and a poor prognosis. (bio-medicine.org)
  • For example, about half of RCC patients are over 60 years old, and if one of these patients has other health problems and a normal lymphocyte count, a doctor may decide to monitor the patient rather than perform surgery. (bio-medicine.org)
  • Results More than half (54.9%, 485/883) of all HIV positive patients presented with CD4 count of less than 250 cells/mm3. (bmj.com)
  • Less than a quarter (18.8%, 116/883) of patients came with CD4 count of 500 cells/mm3 or more. (bmj.com)
  • Routine cryptococcal antigen screening for HIV-infected patients with low CD4+ T-lymphocyte counts: time to implement in South Africa? (scielo.org.za)
  • 7 However, despite recent progress in expanding access to ART in South Africa, 8 the median CD4+ T-cell count of patients initiating ART remains low, and a high risk of new AIDS events and mortality persists during the first months of ART. (scielo.org.za)
  • To date, preventive strategies have consisted of routine fluconazole primary prophylaxis for all patients with low CD4+ T-cell counts. (scielo.org.za)
  • This study was undertaken to determine the prevalence of cryptosporidiosis in relation to CD4+ T- lymphocyte counts of people living with HIV/AIDS (PLWHA) in Jos, Plateau State, Nigeria using formol ether concentration and saturated sodium chloride floatation techniques, modified Ziehl-Neelsen staining method, history as well as clinical records of patients. (alliedacademies.org)
  • Based on CD4+ count, the highest prevalence of 54.8% (23/42) was observed among patients with CD4+ count of ≤100. (alliedacademies.org)
  • The study, however, did find an increased number of patients with higher intraepithelial lymphocytes (IELs, a type of white bloodcell) in the oat-eating cohort. (wikipedia.org)
  • tumor
  • They also found that low counts were associated with a lower overall survival rate, even when they accounted for patient age, tumor stage and metastasis. (bio-medicine.org)
  • cells
  • Lymphocytes are white blood cells that play an important role in the immune system. (reference.com)
  • Lymphocytes are made up of NK cells (natural killer cells), T cells and B cells. (reference.com)
  • Low CD4+ T-cells in the absence of known etiology has been called idiopathic CD4+ T lymphocytopenia, and a case definition was established by the CDC as a CD4 count less than 300 cells/mL on 2 consecutive samples in a patient uninfected by HIV and with no other disease or treatment that might provide a reasonable alternative explanation for CD4 lymphocytopenia. (clinicaltrials.gov)
  • 20.7% (183/883) reported with CD4 count less than 50 cell/mm3, 9.5% (84/883) with CD4 count of less than 100 cells/mm3, 24.7% (218/883) with CD4 count of less than 250 cells/mm3, 16.0% (141/883) with CD4 count of less than 350 cells/mm3, 10.3% (91/883) with CD4 count of less than 500. (bmj.com)
  • 70.9% came with CD4 count of less than 350 cells/mm3. (bmj.com)
  • White blood cells or lymphocytes are present in the body as an important component of blood cells. (charlies-magazines.com)
  • When the amount of white blood cells fell short of this normal range the condition is known as low lymphocyte count or lymphocytopenia. (charlies-magazines.com)
  • One of the main causes of low count of white blood cells or lymphocytopenia is AIDS. (charlies-magazines.com)
  • In this case, treatment includes the combination of antiviral drugs to increase the count of T cells in the body to prolong the time of survival of a person. (charlies-magazines.com)
  • T-PLL has the immunophenotype of a mature (post-thymic) T-lymphocyte, and the neoplastic cells are typically positive for pan-T antigens CD2, CD3, and CD7 and negative for TdT and CD1a. (wikipedia.org)
  • In a study on the effect of meditation on immune cells, Erik Solberg found that long term practice of meditation may influence absolute lymphocyte counts at rest. (wikipedia.org)
  • Lymphocytes include natural killer cells (Phagocytes) (which function in cell-mediated, cytotoxic innate immunity), T cells (for cell-mediated, cytotoxic adaptive immunity), and B cells (for humoral, antibody-driven adaptive immunity). (wikipedia.org)
  • The three major types of lymphocyte are T cells, B cells and natural killer (NK) cells. (wikipedia.org)
  • B cells mature into B lymphocytes in the bursa equivalent, which in humans is the GALT, which is thought to be located in the Peyer's patches of the intestine, while T cells migrate to and mature in a distinct organ, called the thymus. (wikipedia.org)
  • Effector lymphocytes function to eliminate the antigen, either by releasing antibodies (in the case of B cells), cytotoxic granules (cytotoxic T cells) or by signaling to other cells of the immune system (helper T cells). (wikipedia.org)
  • Leukocytosis is white cells (the leukocyte count) above the normal range in the blood. (wikipedia.org)
  • Lymphocytes can be further classified as T cells, B cells, and natural killer cells. (wikipedia.org)
  • Diseases
  • Some people who have inherited genetic diseases are more prone to get lymphocytopenia, which is the name for the condition of having a low lymphocyte count. (reference.com)
  • Low lymphocyte count hence makes the body weak in terms of resistance against infectious diseases. (charlies-magazines.com)
  • For lung diseases such as pneumonia and tuberculosis, WBC count is very important for the diagnosis of the disease, as leukocytosis is usually present. (wikipedia.org)
  • Levels
  • The study determined the CD4 lymphocytes count levels of HIV positive patient at first presentation at STI/HIV Clinic at Suntreso Government Hospital in Kumasi, Ghana. (bmj.com)
  • disease
  • A low hemoglobin count, also known as anemia, is caused by pregnancy, a menstrual period, a diet low in iron, blood loss, or a disease that causes the body. (reference.com)
  • Generally when a person gets blood test for other disease, the state of absolute lymphocyte count low is noticed. (charlies-magazines.com)
  • The number of leukocytes in the blood is often an indicator of disease, and thus the WBC count is an important subset of the complete blood count. (wikipedia.org)
  • medication
  • The purpose of this study is to test the safety of an investigational medication, TXA127, and its ability to increase T-lymphocyte counts, specifically CD4+ T-lymphocytes, in persons infected with human immunodeficiency virus who are taking highly active anti-retroviral therapy. (clinicaltrials.gov)
  • Healthy
  • For example, if a young RCC patient has a low lymphocyte count but is otherwise healthy, a doctor may decide to pursue more aggressive therapies, such as surgery and chemotherapy. (bio-medicine.org)
  • Both doses of ozanimod reached anticipated range of 60-70% decreased lymphocyte count, and were well tolerated, with a safety profile consistent with a previous phase 1 study in healthy volunteers. (wikipedia.org)
  • treatment
  • Although these findings should be explored further in prospective research studies, the researchers suggest that the lymphocyte count could factor into doctors' treatment decisions. (bio-medicine.org)
  • Therapy
  • This is a Phase I, single institution, open-label, within-dosing-cohort-schedule randomized, dose escalation study of TXA127 in HIV-infected subjects with CD4+ T-lymphocyte counts less than 250 per mm3 who have responded to highly active retroviral therapy (HAART). (clinicaltrials.gov)
  • CD4+ T lymphocyte (CD4) cell count testing is the standard method for determining eligibility for antiretroviral therapy (ART), but is not widely available in sub-Saharan Africa. (cdc.gov)
  • common
  • Fatigue is a common symptom associated with having a low red blood cell count, according to the Aplastic Anemia and MDS International Foundation (AAMDS), b. (reference.com)
  • type
  • The level of lymphocytes a type of white blood cell was one possible. (bio-medicine.org)
  • The level of lymphocytes, a type of white blood cell, was one possible prognostic indicator considered by Saroha, Tahseen Al-Saleem, MD, a cancer pathologist at Fox Chase, and their colleagues. (bio-medicine.org)