• rheumatoid
  • In addition to its reactivity to gut-associated lymphoid tissues, Act-1 antibody also stains large numbers of lymphocytes in rheumatoid synovium, and has been shown by Dr. A. A. Ansari of Emory University to prevent or delay onset of AIDS in a monkey-model of Simian Immunodeficiency Virus-induced AIDS. (wikipedia.org)
  • antibody
  • Williams J., Deloria D., Hansen J.A., Dinarello C., Loertscher J., Shapiro H., Strom T., 1985, The events of primary T-cell activation can be staged by use of sepharose-bound anti-T3 (64.1) Monoclonal antibody and purified interleukin. (springer.com)
  • Belimumab (trade name Benlysta, previously known as LymphoStat-B) is a human monoclonal antibody that inhibits B-cell activating factor (BAFF), also known as B-lymphocyte stimulator (BLyS). (wikipedia.org)
  • macrophages
  • TLR4-mediated activation of mouse macrophages by Korean mistletoe lectin-C (KML-C)," Biochemical and Biophysical Research Communications , vol. 396, no. 3, pp. 721-725, 2010. (hindawi.com)
  • CD48 interaction with CD2 has been shown to promote lipid raft formation, T cell activation and the formation of caveolae for macrophages through cell signal transductionthe via GPI moieties. (wikipedia.org)
  • Kv1.3-channels are important for the activation of T-lymphocytes, and thus for the activation of macrophages. (wikipedia.org)
  • complexes
  • The answer to this riddle emerged from the experiment summarized in Table VI, which showed that as little as a 2-fold molar excess of monovalent ligand could thwart primary B cell activation by multiply substituted hapten carrier complexes. (jimmunol.org)
  • viral
  • The pentameric structure of IgM antibodies makes them efficient at binding antigens with repetitive epitopes (e.g. bacterial capsule, viral capsid) and activation of complement cascade. (wikipedia.org)
  • thresholds
  • Furthermore, the manner through which activation thresholds might be established, as well as how this could accommodate affinity and kinetic differences between primary and secondary responses, was unexplored territory. (jimmunol.org)
  • Pathways
  • Signaling pathways are often inactivated by enzymes that reverse the activation state and/or induce the degradation of signaling components. (wikipedia.org)
  • kinase
  • Ste5 has been proposed to direct mating signaling through the Fus3 MAPK by catalytically unlocking this particular kinase for activation by its MAPKK Ste7. (wikipedia.org)
  • The Ste5 scaffold directs mating signaling by catalytically unlocking the Fus3 MAP kinase for activation. (wikipedia.org)
  • treatment
  • The persistence of CSF lymphocyte activation markers sCD27 and intrathecal oligoclonal IgG bands after maximum immunoablative treatment indicates that complete eradication of activated lymphocytes from the CNS has not been established. (bmj.com)