• rheumatoid
  • In addition to its reactivity to gut-associated lymphoid tissues, Act-1 antibody also stains large numbers of lymphocytes in rheumatoid synovium, and has been shown by Dr. A. A. Ansari of Emory University to prevent or delay onset of AIDS in a monkey-model of Simian Immunodeficiency Virus-induced AIDS. (wikipedia.org)
  • antibody
  • In 1972, Neils K. Jerne stated in the First Annual Report of the Basel Institute for Immunology, "For bursa cells and B lymphocytes, it is relatively easy to demonstrate that receptors are antibody-like molecules which enable the cell to recognize antigens. (jimmunol.org)
  • Williams J., Deloria D., Hansen J.A., Dinarello C., Loertscher J., Shapiro H., Strom T., 1985, The events of primary T-cell activation can be staged by use of sepharose-bound anti-T3 (64.1) Monoclonal antibody and purified interleukin. (springer.com)
  • Dr. Lynn Baird's group showed the antibody reacted with a single protein band of 63Kd, and Dr. Atul Bhan's group showed that it stained tissue lymphocytes but did not react with non-lymphoid tissues. (wikipedia.org)
  • Belimumab (trade name Benlysta, previously known as LymphoStat-B) is a human monoclonal antibody that inhibits B-cell activating factor (BAFF), also known as B-lymphocyte stimulator (BLyS). (wikipedia.org)
  • cells
  • Together, these two observations yielded the conclusion that ligand binding per se was insufficient for activation, and that instead primary B cells display an affinity threshold below which activation does not occur. (jimmunol.org)
  • The relative levels of inhibitory PD-L1 and costimulatory B7-1/B7-2 signals on antigen-presenting cells may determine the extent of T cell activation and consequently the threshold between tolerance and autoimmunity. (rupress.org)
  • T-cells are one of the most critical constituents of the adaptive immune system due to their ability to continue developing after activation. (wikipedia.org)
  • CD48 is expressed on all peripheral blood lymphocytes (PBL) including T cells, B cells, Null cell and thymocytes. (wikipedia.org)
  • B lymphocytes (B cells) are one of the immune cells responsible for the damage in autoimmune disease. (wikipedia.org)
  • B-cell activating factor (BAFF), also called B-lymphocyte stimulator (BLyS), is required for the development and survival of B cells. (wikipedia.org)
  • Kv1.3-channels can be found in various cells, including T-lymphocytes and macrophages. (wikipedia.org)
  • Potassium channels are required for the activation of T-cells. (wikipedia.org)
  • markers
  • T lymphocyte activation markers, CD134 (OX 40), CD137 (4-1BB), CD278 (ICOS), and CD279 (PD-1) were measured before and after culture at weeks 0 (infusion1), 2 (infusion 2) and 4 (infusion 3) using multi-color flow cytometry. (aacrjournals.org)
  • To determine the effect of maximum whole-body immune ablation on two different markers that detect lymphocyte activation in CSF-oligoclonal IgG bands and levels of CSF-sCD27. (bmj.com)
  • The persistence of CSF lymphocyte activation markers sCD27 and intrathecal oligoclonal IgG bands after maximum immunoablative treatment indicates that complete eradication of activated lymphocytes from the CNS has not been established. (bmj.com)
  • complexes
  • The answer to this riddle emerged from the experiment summarized in Table VI, which showed that as little as a 2-fold molar excess of monovalent ligand could thwart primary B cell activation by multiply substituted hapten carrier complexes. (jimmunol.org)
  • viral
  • The pentameric structure of IgM antibodies makes them efficient at binding antigens with repetitive epitopes (e.g. bacterial capsule, viral capsid) and activation of complement cascade. (wikipedia.org)
  • thresholds
  • Furthermore, the manner through which activation thresholds might be established, as well as how this could accommodate affinity and kinetic differences between primary and secondary responses, was unexplored territory. (jimmunol.org)
  • Pathways
  • Signaling pathways are often inactivated by enzymes that reverse the activation state and/or induce the degradation of signaling components. (wikipedia.org)
  • kinase
  • Ste5 has been proposed to direct mating signaling through the Fus3 MAPK by catalytically unlocking this particular kinase for activation by its MAPKK Ste7. (wikipedia.org)
  • The Ste5 scaffold directs mating signaling by catalytically unlocking the Fus3 MAP kinase for activation. (wikipedia.org)