• Peyer's
  • Fluorescently labeled T lymphocytes collected from rat intestinal lymph were injected into the jugular vein, and the kinetics of appearance of the infused lymphocytes were monitored in ileal Peyer's patches, spleen, and liver. (physiology.org)
  • ConA stimulation significantly increased the rolling velocity of T lymphocytes in postcapillary venules of Peyer's patches, and ConA-stimulated lymphocytes exhibited a loss of the selective adherence properties in Peyer's patches that is normally observed with naive T cells. (physiology.org)
  • In conclusion, activation of gut-derived T lymphocytes with ConA significantly alters their migration path, with a diminished localization to Peyer's patches and spleen and a preferential accumulation in hepatic sinusoids. (physiology.org)
  • vitro
  • By varying the molarity and form of the haptenic determinants used for stimulation in vitro, and then comparing these with the affinities of the elicited Abs, the studies highlighted here provided the first definitive demonstration of an affinity threshold for lymphocyte activation. (jimmunol.org)
  • Protein
  • In this report, the Global Lymphocyte Activation Gene 3 Protein Market is valued at USD XX million in 2016 and is expected to reach USD XX million by the end of 2022, growing at a CAGR of XX% between 2016 and 2022. (medgadget.com)
  • antibody
  • Williams J., Deloria D., Hansen J.A., Dinarello C., Loertscher J., Shapiro H., Strom T., 1985, The events of primary T-cell activation can be staged by use of sepharose-bound anti-T3 (64.1) Monoclonal antibody and purified interleukin. (springer.com)
  • Belimumab (trade name Benlysta, previously known as LymphoStat-B) is a human monoclonal antibody that inhibits B-cell activating factor (BAFF), also known as B-lymphocyte stimulator (BLyS). (wikipedia.org)
  • cells
  • Together, these two observations yielded the conclusion that ligand binding per se was insufficient for activation, and that instead primary B cells display an affinity threshold below which activation does not occur. (jimmunol.org)
  • The activation leads to the production of lymphoblasts which divide and form a population of effector cells. (oup.com)
  • The relative levels of inhibitory PD-L1 and costimulatory B7-1/B7-2 signals on antigen-presenting cells may determine the extent of T cell activation and consequently the threshold between tolerance and autoimmunity. (rupress.org)
  • an enzyme expressed in T lymphocytes of the immune system, is important for the activation and survival of these cells and their ability to mount many beneficial as well as pathological immune responses, e.g., protection against certain infections, and autoimmune and allergic diseases. (grantome.com)
  • Several systems have facilitated the study of gene activation in eukaryotic cells. (springer.com)
  • 3) How can these be used to understand gene activation in eukaryotic cells? (springer.com)
  • Naive CD4 T cells exhibited stronger activation, as measured by attachment and secretion of IL-2, with increasing substrate elastic modulus over the range of 10-200 kPa. (ox.ac.uk)
  • ConA activation also suppressed the accumulation of T cells in the spleen. (physiology.org)
  • T-cells are one of the most critical constituents of the adaptive immune system due to their ability to continue developing after activation. (wikipedia.org)
  • B lymphocytes (B cells) are one of the immune cells responsible for the damage in autoimmune disease. (wikipedia.org)
  • B-cell activating factor (BAFF), also called B-lymphocyte stimulator (BLyS), is required for the development and survival of B cells. (wikipedia.org)
  • Kv1.3-channels can be found in various cells, including T-lymphocytes and macrophages. (wikipedia.org)
  • Potassium channels are required for the activation of T-cells. (wikipedia.org)
  • transmembrane
  • Prominent in the early activation-related phenomena (minutes to a few hours after the activation signal) are the elevation of cytoplasmic calcium and changes in transmembrane electrical potential (TMP) (2-4). (springer.com)
  • complexes
  • The answer to this riddle emerged from the experiment summarized in Table VI, which showed that as little as a 2-fold molar excess of monovalent ligand could thwart primary B cell activation by multiply substituted hapten carrier complexes. (jimmunol.org)
  • mechanisms
  • represents a unique paradigm with respect to the mechanisms that regulate these events and, ultimately, lead to the activation of critical transcription factors, which determine T cell fate. (grantome.com)
  • affinity
  • Furthermore, the manner through which activation thresholds might be established, as well as how this could accommodate affinity and kinetic differences between primary and secondary responses, was unexplored territory. (jimmunol.org)
  • Activation leads to clonal expansion and affinity maturation. (wikipedia.org)
  • markers
  • T lymphocyte activation markers, CD134 (OX 40), CD137 (4-1BB), CD278 (ICOS), and CD279 (PD-1) were measured before and after culture at weeks 0 (infusion1), 2 (infusion 2) and 4 (infusion 3) using multi-color flow cytometry. (aacrjournals.org)
  • To determine the effect of maximum whole-body immune ablation on two different markers that detect lymphocyte activation in CSF-oligoclonal IgG bands and levels of CSF-sCD27. (bmj.com)
  • The persistence of CSF lymphocyte activation markers sCD27 and intrathecal oligoclonal IgG bands after maximum immunoablative treatment indicates that complete eradication of activated lymphocytes from the CNS has not been established. (bmj.com)
  • role
  • Given the presumed key role for autoreactive lymphocytes in multiple sclerosis (MS), treatment strategies have been developed to ablate lymphocyte activity. (bmj.com)
  • Based on our recent findings, and given the important role of Ca2+ signaling in determining the balance between productive T cell activation and anergy/apoptosis, we will characterize this pathway. (grantome.com)
  • The levels of surface expression of IgD isotype has been associated with differences in B cell activation status but their role in serum is poorly understood. (wikipedia.org)
  • Pathways
  • Signaling pathways are often inactivated by enzymes that reverse the activation state and/or induce the degradation of signaling components. (wikipedia.org)