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  • results
  • With the combination of the results of lymphatic vessel density, the pooled hazard ratios and 95% confidence intervals were 2.02 (1.69-2.40) for disease-free survival and 2.88 (2.07-4.01) for overall survival, respectively. (biomedcentral.com)
  • growth
  • Thirty seven out of 65 patients (56.9%) had at least one involved nonsentinel LN. Size of the sentinel LN metastasis ( P = 0.001), lymphovascular invasion ( P = 0.02), extracapsular growth ( P = 0.02), and LECP% ( P = 0.01) were correlated with a positive nonsentinel LN status. (aacrjournals.org)
  • immunohistochemistry
  • We further addressed the biological function of VEGF-D for induction of lymphatic metastasis in a nude mouse xenograft model using two human ductal pancreatic cancer cell lines with overexpression of VEGF-D. Compared to normal human pancreas, pancreatic cancer tissue showed overexpression of VEGF-D and VEGFR-3 in conjunction with a high lymphatic vascularization as determined by immunohistochemistry and in situ hybridization. (ox.ac.uk)
  • cDNA
  • Based on cDNA microarray analysis together with in vivo experiments, 107 candidates of metastasis-related genes were extracted. (nii.ac.jp)
  • Mice
  • In 90% of nude mice, lymph node metastasis was established by alloic transplantation of LS174T and LS174T-NEO, which expressed high levels of CD44. (nii.ac.jp)
  • In vivo, reconstitution of HAPLN1 in aged mice increased the number of LN metastases, but reduced visceral metastases. (aacrjournals.org)
  • The closest structural and functional relative of VEGF-C is VEGF-D. However, at least in mice, VEGF-C is absolutely essential for the development of the lymphatic system, whereas VEGF-D appears to be not necessary at all. (wikipedia.org)
  • incidence
  • Cell lines were divided into three groups (high, middle and low) according to the incidence of lymph node metastasis. (nii.ac.jp)
  • The purpose of this study is to prospectively analyze the incidence of occult lateral neck metastasis (LNM) and to elucidate the factors that predict LNM in papillary thyroid carcinoma (PTC) with central neck metastasis (CNM) by performing prophylactic selective lateral neck dissection (SND). (clinicaltrials.gov)
  • occurs
  • Initial nodal metastasis in PTC usually occurs in the paratracheal and pretracheal nodes in level VI of the central compartment of the ipsilateral neck and spreads to the lateral cervical lymph nodes. (clinicaltrials.gov)
  • The risk of metastasis after plaque radiotherapy is the same as that of enucleation, suggesting that micrometastatic spread occurs prior to treatment of the primary tumor. (wikipedia.org)
  • immunohistochemical
  • Likewise several histological and cytological factors are associated with higher risk of metastasis including presence and extent of cells with epithelioid morphology, presence of looping extracellular matrix patterns, increased infiltration of immune cells, as well as staining with several immunohistochemical markers. (wikipedia.org)