• metastatic
  • In this study, we compared differentially expressed genes in cell lines of high (468LN) vs. low (468GFP) lymphatic metastatic ability, and related these to clinical literature on genes associated with lymphatic metastatic ability and prognosis, to identify genes of potential clinical relevance. (spandidos-publications.com)
  • The lymphatic drainage pattern of the thyroid is uniform and consistent, and therefore, metastatic patterns are relatively predictable. (clinicaltrials.gov)
  • In one case study, a patient with advanced metastatic vulvar epithelioid sarcoma showed a partial resolution of both lung and pleural metastases when pazopanib was administered, whereas all other therapies had failed MET (mesenchymal to epithelial transition) is another biological pathway that is likely involved in the development and progression of epithelioid sarcoma. (wikipedia.org)
  • drainage
  • citation needed] Cancer with various primary sites (breast, melanoma, colorectal, etc.) often metastasize early to the first drainage lymphatic basin. (wikipedia.org)
  • colorectal
  • The lymphatic patterns of CRLM were determined using a well established murine model.CRLM were induced using a well established murine intrasplenic colorectal cancer model. (austin.org.au)
  • angiogenesis
  • Also indirectly VEGF-C can be responsible for hereditary lymphedema: The rare Hennekam syndrome can result from the inability of the mutated CCBE1 to assist the ADAMTS3 protease in activating VEGF-C. While a lack of VEGF-C results in lymphedema, too much VEGF-C is implicated in tumor angiogenesis and metastasis. (wikipedia.org)
  • It has been found that angiogenesis inhibitors would therefore prevent the growth of metastases. (wikipedia.org)
  • system
  • The closest structural and functional relative of VEGF-C is VEGF-D. However, at least in mice, VEGF-C is absolutely essential for the development of the lymphatic system, whereas VEGF-D appears to be not necessary at all. (wikipedia.org)
  • Lymph is the fluid that circulates throughout the lymphatic system. (wikipedia.org)
  • Metastasis is a key element in cancer staging systems such as the TNM staging system, where it represents the "M". In overall stage grouping, metastasis places a cancer in Stage IV. (wikipedia.org)
  • Metastasis involves a complex series of steps in which cancer cells leave the original tumor site and migrate to other parts of the body via the bloodstream, via the lymphatic system, or by direct extension. (wikipedia.org)
  • tissues
  • The location of the metastases is not always random, with different types of cancer tending to spread to particular organs and tissues at a rate that is higher than expected by statistical chance alone. (wikipedia.org)
  • Dissection
  • The purpose of this study is to prospectively analyze the incidence of occult lateral neck metastasis (LNM) and to elucidate the factors that predict LNM in papillary thyroid carcinoma (PTC) with central neck metastasis (CNM) by performing prophylactic selective lateral neck dissection (SND). (clinicaltrials.gov)
  • occurs
  • The risk of metastasis after plaque radiotherapy is the same as that of enucleation, suggesting that micrometastatic spread occurs prior to treatment of the primary tumor. (wikipedia.org)
  • bone
  • Melanoma can give bone metastases, but we are not aware of reports of this tumour metastatising to the carpal bones. (biomedsearch.com)
  • Hand metastases in a patient who is suffered melanoma should be ruled out if a lytic aggressive lesion appears on x-ray film or positive technetium bone scan is demonstrated. (biomedsearch.com)
  • patterns
  • Likewise several histological and cytological factors are associated with higher risk of metastasis including presence and extent of cells with epithelioid morphology, presence of looping extracellular matrix patterns, increased infiltration of immune cells, as well as staining with several immunohistochemical markers. (wikipedia.org)
  • cell
  • In our knowledge, we have only found a report of metastases in the capitate, a clear-cell sarcoma of the right foot, a tumour close to melanoma with some cytogenetic differences. (biomedsearch.com)