AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesHealth Care
Lupus NephritisNephritisLupus Erythematosus, SystemicGlomerulonephritisAntibodies, AntinuclearKidney GlomerulusMice, Inbred MRL lprMice, Inbred NZBProteinuriaKidneyAutoantibodiesHeymann Nephritis Antigenic ComplexGlomerulonephritis, MembranoproliferativeImmunosuppressive AgentsGlomerulonephritis, MembranousAntigen-Antibody ComplexMycophenolic AcidBiopsyComplement C1qImmunoglobulin GAzathioprinePurpura, Schoenlein-HenochImmune Complex DiseasesBasement MembraneNephritis, HereditaryPrednisoloneComplement C3CyclophosphamideKidney TubulesGlomerular Basement MembraneGlomerulonephritis, IGAAutoantigensAutoimmune DiseasesCreatinineMethylprednisoloneBiological MarkersDisease Models, AnimalMice, CongenicComplement C4Severity of Illness IndexGlomerular MesangiumDNAKidney DiseasesLupus Erythematosus, DiscoidPulse Therapy, DrugHematuriaFluorescent Antibody TechniqueAnti-Glomerular Basement Membrane DiseaseDrug Therapy, CombinationComplement System ProteinsNephrotic SyndromeDisease ProgressionPlasmapheresisAntibodies, AntiphospholipidAutoimmunityTripterygiumKidney Failure, ChronicCryoglobulinsMesangial CellsVasculitisThrombotic MicroangiopathiesSerum SicknessMice, Inbred StrainsB-LymphocytesRetrospective StudiesAntibodiesAntibodies, AnticardiolipinEnzyme-Linked Immunosorbent AssayLupus VulgarisNephrosis, LipoidHypoalbuminemiaTreatment OutcomePrednisoneFluorescent Antibody Technique, DirectGlomerulosclerosis, Focal SegmentalHydroxychloroquineNephritis, InterstitialLipocalinsBlood Urea NitrogenChemokine CCL2Diagnostic Techniques, Urological
Active lupusProliferativeKidneysSystemic lupusMycophenolateBiopsyAmerican College of RSevereSymptoms of lupusAutoimmune diseasesCyclophosphamideImuran for lupus nephritisTreat lupus nephritisDevelop lupus nephritisChronicRheumatologyTherapeuticImmune system2020PathophysiologyProteinuriaTreatmentForm of lupus nephritisTherapy for lupus nephritisPeople with lupus nephritisUrinePerson with lupus nephritisMembranous lupus nephritisFoundation of AmericaDifferent types of lupusFlaresOutcomesKidney functionClassificationFindingsAutoantibodiesRole in lupus
Active lupus10
  • People with active lupus should not have a transplant because the condition can occur in the transplanted kidney. (medlineplus.gov)
  • Mycophenolate mofetil or tacrolimus compared with intravenous cyclophosphamide in the induction treatment for active lupus nephritis. (suny.edu)
  • Elevated anti-double-stranded-DNA (anti-dsDNA) antibody titers and low complement (C3 and C4) levels often indicate active lupus nephritis and support the diagnosis. (msdmanuals.com)
  • This is a multi-center double-blind placebo controlled clinical trial evaluating the efficacy of VIB4920 combined with mycophenolate mofetil (MMF) and prednisone in achieving a renal response in participants with active lupus nephritis (LN). (ucsf.edu)
  • Seventy-four eligible participants with active lupus nephritis (LN) will be randomized to receive VIB4920 1500 mg or placebo intravenously at Weeks 0, 2, 4, 8, 12, 16, 20, and 24. (ucsf.edu)
  • 2. The panel recommended that all with active lupus nephritis, previously untreated undergo a renal biopsy but evidence for this was LEVEL C. (nephronpower.com)
  • Renal involvement in the form of either active lupus nephritis (LN) at the time of conception, or a LN new onset or flare during pregnancy increases the risks of preterm delivery, pre-eclampsia, maternal mortality, fetal/neonatal demise, and intrauterine growth restriction. (elsevierpure.com)
  • The US Food and Drug Administration (FDA) has expanded the indication for belimumab (Benlysta) to adults with active lupus nephritis who are receiving standard therapy. (medscape.com)
  • Benlysta is the first medicine approved to treat systemic lupus and adults with active lupus nephritis, an important treatment advance for patients with this incurable autoimmune disease," Hal Barron, MD, GlaxoSmithKline's (GSK's) chief scientific officer and president of research and development, said in a company news release . (medscape.com)
  • The data from the BLISS-LN study show that Benlysta added to standard therapy not only increased response rates over two years, but it also prevented worsening of kidney disease in patients with active lupus nephritis compared to standard therapy alone," he added. (medscape.com)
Proliferative11
  • Class IV disease (Diffuse proliferative nephritis) is both the most severe, and the most common subtype. (wikipedia.org)
  • The proliferative forms of lupus nephritis are associated with a higher risk of progression to end stage kidney disease. (wikipedia.org)
  • these are more common with focal (proliferative) and diffuse (proliferative) lupus nephritis. (medscape.com)
  • Proliferation signal inhibitors (PSI) have demonstrated efficacy in prevention and treatment in an animal model of lupus nephritis (LN) but there are no data regarding the use of PSI in human LN. We report here our experience of using PSI treatment in seven patients with severe proliferative lupus nephritis. (nih.gov)
  • This is a retrospective study on patients with proliferative lupus nephritis who had received PSI treatment. (nih.gov)
  • We identified 45 patients (38 female, seven male) who received a mean of 9 +/- 1 (range 2-23) pulses of intravenous cyclophosphamide for diffuse proliferative glomerulonephritis (n = 28), focal proliferative glomerulonephritis (n = 7), membranous nephropathy (n = 5), mesangial nephropathy with sclerosis (n = 1) or nephritis without biopsy (n = 4). (nih.gov)
  • The NOBILITY study compared standard-of-care (mycophenolate mofetil and corticosteroids) plus the anti-CD20 obinutuzumab to standard-of-care plus placebo for the treatment of proliferative lupus nephritis. (lupusresearch.org)
  • We compared in patients with proliferative lupus nephritis the diagnostic usefulness of a dsDNA-loaded nucleosome ELISA (anti-dsDNA-NcX) with ELISAs in which dsDNA or nucleosomes alone were coated. (bath.ac.uk)
  • Second, autoantibody levels were measured in these 3 ELISAs in 100 patients with proliferative lupus nephritis (LN) before immunosuppressive treatment and in 128 non-SLE disease controls. (bath.ac.uk)
  • Mycophenolate mofetil versus intravenous cyclophosphamide for induction treatment of proliferative lupus nephritis in a Japanese population: a retrospective study. (suny.edu)
  • the secondary objective was to find which components of urinary sediment can discriminate proliferative from other classes of lupus nephritis . (bvsalud.org)
Kidneys16
Systemic lupus34
  • Lupus nephritis, which is a kidney disorder, is a complication of systemic lupus erythematosus . (medlineplus.gov)
  • Systemic lupus erythematosus (SLE, or lupus) is an autoimmune disease . (medlineplus.gov)
  • Lupus nephritis is clinically evident in 50-60% of patients with systemic lupus erythematosus (SLE), and it is histologically evident in most SLE patients, even those without clinical manifestations of kidney disease. (medscape.com)
  • In the ever-perilous autoimmune disease world of systemic lupus erythematosus (SLE or lupus), up to 60% of adult patients and 80% of children will develop lupus nephritis (LN), and up to half of those will move on to end-stage renal disease. (news-medical.net)
  • You might have an autoimmune disease called systemic lupus erythematosus, or lupus, for short. (mountsinai.org)
  • Kidney inflammation caused by Systemic Lupus Erythematosus (SLE) is referred to as lupus nephritis or LN, and it is estimated that 40-50% of all SLE patients have LN requiring treatment. (pharmaphorum.com)
  • Dr. Furie added, "The strategy to target B cells (antibody-producing white blood cells responsible for producing lupus antibodies) in systemic lupus and lupus nephritis was biologically sound. (lupusresearch.org)
  • Systemic lupus erythematosus (SLE) is a complex autoimmune disorder that is challenging to diagnose and manage (1). (ashdin.com)
  • Lupus nephritis (LN) is a serious complication of systemic lupus erythematosus (SLE), more commonly known as lupus. (pipelinereview.com)
  • Autoantibodies against nucleosomes are considered a hallmark of systemic lupus erythematosus (SLE). (bath.ac.uk)
  • Systemic lupus erythematosus, commonly known as lupus, is a disease in which the the immune system produces proteins that attack the body and cause damage to the kidney, brain, joints and skin. (nephrologyspecialistsoftulsa.com)
  • Lupus nephritis is inflammation of the kidney caused by systemic lupus erythematous (SLE). (saikidneycare.com)
  • Systemic lupus erythematosus, commonly known as lupus or SLE, is an autoimmune disease in which the a patient's immune system attacks his or her own body and causes damage to the kidney, brain, joints, skin, and other organs. (cmneph.com)
  • ACR was recently awarded a $7M grant to address inequities in symptom recognition, care and disease management of systemic lupus erythematosus (lupus). (thelupusinitiative.org)
  • Lupus Nephritis (LN) develops in 40 to 60% of patients with systemic lupus erythematosus (SLE). (glomcon.org)
  • The renal domain of SLICC/ACR (Systemic Lupus International Collaborative Clinics/American College of Rheumatology) Damage Index (SDI) is associated with early mortality in SLE. (glomcon.org)
  • Lupus nephritis (LN) is among the main determinants of poor prognosis in systemic lupus erythematosus (SLE). (northwestern.edu)
  • Lupus nephritis is glomerulonephritis caused by systemic lupus erythematosus (SLE). (msdmanuals.com)
  • Systemic Lupus Erythematosus (SLE) Systemic lupus erythematosus is a chronic, multisystem, inflammatory disorder of autoimmune etiology, occurring predominantly in young women. (msdmanuals.com)
  • Lupus nephritis (LN) occurs in approximately 40% - 45% of people who have systemic lupus erythematosus (SLE). (lupusencyclopedia.com)
  • Benlysta continues to be one of our safest options for treating systemic lupus! (lupusencyclopedia.com)
  • Classification of Systemic Lupus Erythematosus (SLE) by any of the following criteria: the 1997 update of the 1982 American College of Rheumatology (ACR) criteria (1, 2), the 2012 Systemic Lupus International Collaborating Clinics (SLICC) criteria (3), or the 2019 European League Against Rheumatism (EULAR)/ACR criteria (4). (ucsf.edu)
  • Sara Gorman was diagnosed with systemic lupus at the age of 26. (blogspot.com)
  • Urinary balantidiasis in a patient with systemic lupus erythematosus and lupus nephritis: a case report. (ox.ac.uk)
  • Renal balantidiasis associated with systemic lupus erythematosus has not been reported before. (ox.ac.uk)
  • CASE PRESENTATION:We present a case of a 48-year-old Thai woman who presented with nephrotic syndrome due to systemic lupus erythematosus-related nephritis. (ox.ac.uk)
  • Background Childhood-onset systemic lupus erythematosus (SLE) is more severe than adult-onset disease, including more frequent kidney involvement. (ogu.edu.tr)
  • Researchers estimate that 200,000 1 Americans have systemic lupus erythematosus (SLE), the most common form of lupus. (cdc.gov)
  • ABSTRACT This study assessed the utility of some novel inflammatory markers compared with traditional laboratory markers in patients with systemic lupus erythematosus (SLE). (who.int)
  • Objective-- To estimate and identify factors associated with incidence of all-cause end-stage renal disease (ESRD) among newly diagnosed systemic lupus erythematosus (SLE) patients. (cdc.gov)
  • More than 5000 patients initiated treatment for end-stage renal disease (ESRD) attributed to systemic lupus erythematosus (SLE) in 2007-2011 (1). (cdc.gov)
  • These are found in hemolytic uremic syndrome, age-related macula degeneration, nephritis in systemic lupus erythematosus and recurrent pregnancy loss. (lu.se)
  • It may occur in asymptomatic individuals but it is frequently associated with autoimmune manifestations, particularly with discoid or systemic lupus erythematosus . (lu.se)
  • This may appear as a primary disorder or secondary to other diseases including infections and autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. (bvsalud.org)
Mycophenolate6
Biopsy12
American College of R2
  • American College of Rheumatology guidelines for screening, case definition, treatment and management of lupus nephritis. (medlineplus.gov)
  • In 2011, all lupus patients should receive hydroxychloroquine," Dr. David Wofsy flatly declared at a symposium sponsored by the American College of Rheumatology. (ukidney.com)
Severe8
  • Black and Hispanic people with lupus nephritis are more likely to present with severe disease at initial presentation (with more proteinuria and more extensive histopathologic changes) and progress to end stage kidney disease. (wikipedia.org)
  • Lupus nephritis is a severe disease manifestation of SLE heterogeneity. (lupusresearch.org)
  • NEW YORK , Nov. 10, 2019 /PRNewswire/ - The Lupus Research Alliance (LRA) is pleased to acknowledge positive results presented by Genentech at the American Society of Nephrology (ASN) and the 2019 ACR/ARP Annual Meeting showing the effectiveness of obinutuzumab ( Gazyva® ), a type I anti-CD20 monoclonal antibody, in the Phase 2 NOBILITY trial for the most severe form of lupus nephritis. (lupusresearch.org)
  • Lupus nephritis can be mild, moderate, or severe, and treatments plans are tailored to each patient individually. (cmneph.com)
  • We describe an uncommon case of severe lupus nephritis, presenting with terminal renal failure. (rug.nl)
  • If patients with more severe nephritis were preferentially treated with cyclophosphamide, a likely inclination among most physicians, the trial may be telling us that belimumab enhances responses only among less severely affected patients," observed Ward, who is with the National Institutes of Health, and Tektonidou, of the National and Kopodistrian University, in Athens, Greece. (medscape.com)
  • Black or African American and Hispanic/Latino women are more likely to get lupus at a younger age and have more severe symptoms. (cdc.gov)
  • Patients with C2 deficiency express many of the characteristic features of lupus, but severe nephritis, cerebritis, and aggressive arthritis are less common than in complement sufficient SLE patients. (lu.se)
Symptoms of lupus3
Autoimmune diseases6
Cyclophosphamide3
  • The medical records of patients receiving cyclophosphamide for lupus nephritis between 1987 and 1993 at the New York University/Hospital for Joint Diseases Lupus Study Group Institutions were retrospectively reviewed. (nih.gov)
  • Intermittent intravenous cyclophosphamide therapy of lupus nephritis is well tolerated and usually effective in maintaining renal function in patients unresponsive to steroids although, in our experience, 20% of patients developed ESRD and a total of 14 of 45 (30%) patients had unsatisfactory outcomes. (nih.gov)
  • Many nephrologists, myself included, are eager to find alternatives to cyclophosphamide in the management of lupus nephritis. (ukidney.com)
Imuran for lupus nephritis8
Treat lupus nephritis2
Develop lupus nephritis1
Chronic8
  • If you do have lupus, lupus is a chronic condition, but, you can control its symptoms. (mountsinai.org)
  • Lupus is a chronic, complex autoimmune disease that affects millions of people worldwide. (lupusresearch.org)
  • Lupus is a chronic (long-term) disease that can cause inflammation and pain in any part of your body. (qualmedicaresearch.com)
  • Living with a chronic illness like lupus nephritis can have a profound impact on a person's mental health. (infovitals.com)
  • Her book, "Despite Lupus: How to Live Well with a Chronic Illness", details the steps it took to reach that goal. (blogspot.com)
  • An analysis of 10-year follow-up data showed that immunosuppression may not be enough to prevent chronic kidney disease (CKD) in patients with lupus nephritis. (consultant360.com)
  • Lupus is a non-infectious and chronic autoimmune disease that affects different parts of the body. (cdc.gov)
  • Lupus is a chronic disease with no cure. (cdc.gov)
Rheumatology3
  • One of the greatest unmet needs in the treatment of patients with SLE is for safer and more efficacious treatments for lupus nephritis," commented principal investigator Richard A. Furie , MD , chief of Rheumatology at Northwell Health and a member of LRA's affiliate Lupus Therapeutics ' Lupus Clinical Investigators Network (LuCIN) . (lupusresearch.org)
  • Video - Dr. Bevra Hann professor of rheumatology at UCLA will introduce you to a person living with lupus nephritis. (thelupusinitiative.org)
  • In the four decades I have been caring for people with lupus, we have not been able to achieve remission in more than just one third of patients with lupus nephritis, and despite all of our efforts, 10% to 30% of patients with lupus kidney disease still progress to end-stage kidney disease," Furie, who is chief of the Division of Rheumatology at Northwell Health, notes in the GSK statement. (medscape.com)
Therapeutic3
  • Furthermore, using our custom lentiviral vectors and Treg transduction processes, we have genetically engineered therapeutic targeted Tregs specific for the dominant autoimmune target driving lupus nephritis (PCT patent filed). (lupusresearch.org)
  • In this 2021 LIA application, we are seeking to manufacture our targeted Tregs using GMP-ready processes and test the therapeutic efficacy on lupus nephritis patient samples. (lupusresearch.org)
  • LUPKYNIS prolongs the QTc interval in a dose-dependent manner when dosed higher than the recommended lupus nephritis therapeutic dose. (lupkynispro.com)
Immune system3
  • Individuals with lupus nephritis have a high risk for B-cell lymphoma (which begins in the immune system cells). (wikipedia.org)
  • Pathway analysis indicated that biological processes involving type 1 interferon responses and the development of the immune system were associated with nephritis in patients with SLE. (escholarship.org)
  • In a person with lupus, the immune system attacks healthy tissues and organs, instead of fighting off infection. (cdc.gov)
20202
  • Cite this: FDA Expands Belimumab Indication to Adults With Lupus Nephritis - Medscape - Dec 18, 2020. (medscape.com)
  • This study aimed to investigate baseline clinical features, treatment modalities and short- and long-term renal outcomes of paediatric patients with lupus nephritis (LN). Materials and methods This study enrolled 53 LN patients out of 102 childhood-onset SLE patients followed at Hacettepe University between 2000 and 2020. (ogu.edu.tr)
Pathophysiology1
Proteinuria1
  • In two patients treated with PSI and low-dose steroid as maintenance immunosuppression, both maintained stable lupus serology, renal function and proteinuria over 18 months. (nih.gov)
Treatment19
  • The goal of using AI to classify lupus nephritis in an automated fashion with high accuracy will translate to better treatment for lupus nephritis, according to researchers. (news-medical.net)
  • Lupus nephritis is a potentially fatal autoimmune disease for which the current treatment is ineffective and often toxic. (broadinstitute.org)
  • Proliferation signal inhibitors warrants further investigation as an alternative immunosuppressive treatment in lupus nephritis. (nih.gov)
  • Dr. Ooi has pioneered the approach of developing specialized regulatory T cells that may be used as a future treatment for lupus nephritis patients. (lupusresearch.org)
  • Current approaches, including newly approved biologicals, are ineffective at improving treatment outcomes for SLE patients with lupus nephritis. (lupusresearch.org)
  • Obinutuzumab could potentially result in a change in the lupus nephritis treatment paradigm if all goes well in future studies. (lupusresearch.org)
  • The Lupus Research Alliance aims to transform treatment while advancing toward a cure by funding the most innovative lupus research in the world. (lupusresearch.org)
  • Treatment focuses on reducing inflammation and treating the underlying cause of lupus. (nephrologyspecialistsoftulsa.com)
  • Influence of race/ethnicity on response to lupus nephritis treatment: the ALMS study. (suny.edu)
  • Once the diagnosis of lupus nephritis is established, a choice has to be made between the different induction treatment protocols. (rug.nl)
  • Lupus Nephritis Treatment - What is Next? (glomcon.org)
  • You've done your part to help further LN research and help scientists and researchers develop better diagnostic tools and treatment options for lupus nephritis patients. (blogspot.com)
  • Some of the other things the task force discusses is changing regimen when initial treatment fails, pregnancy related to SLE treatment options and monitoring of lupus nephritis. (nephronpower.com)
  • The kidney doctors at Iowa Kidney Physicians provide comprehensive kidney treatments, including diagnosis and treatment of lupus nephritis. (iowakidney.com)
  • To find out more about diagnosis and treatment of lupus nephritis, call the kidney doctors at Iowa Kidney Physicians in Des Moines, IA. (iowakidney.com)
  • The U.S. Food and Drug Administration (FDA) has granted the designation of breakthrough therapy to Gazyva ( obinutuzumab ) for the treatment of adult patients with lupus nephritis , a life-threatening kidney inflammation. (lupusnewstoday.com)
  • This means that people with lupus can manage their condition with treatment, but it will not go away. (cdc.gov)
  • Treatment can help improve symptoms, prevent flares, and prevent other health problems caused by lupus. (cdc.gov)
  • [ 99 ] In 2012, the ACR published " Guidelines for the Screening, Diagnosis, Treatment and Monitoring of Lupus Nephritis in Adults ," as well as an evidence report for lupus nephritis . (medscape.com)
Form of lupus nephritis1
Therapy for lupus nephritis3
  • Findings from this study will provide a foundation for clinical studies testing a potentially first-in-class therapy for lupus nephritis that uses specialized regulatory T cells to treat and even possibly cure this disease. (lupusresearch.org)
  • Kyverna Therapeutics Announces First Patient Enrolled in Phase 1 Clinical Trial of CD19 CAR T-cell Therapy for Lupus Nephritis in the U.S. (pipelinereview.com)
  • We are committed to developing Gazyva as a potential new therapy for lupus nephritis and plan to begin enrolling patients in a Phase 3 trial next year. (lupusnewstoday.com)
People with lupus nephritis1
Urine3
  • If you have lupus nephritis, contact your provider if you notice decreased urine output . (medlineplus.gov)
  • In a 24-week open-label induction study of 370 patients with class III-V lupus, there were no differences in the primary end-point (a prespecified decrease in urine protein/creatinine ratio and stabilization or improvement in serum creatinine) or the secondary end-point (complete renal remission, systemic disease activity and damage, and safety). (ukidney.com)
  • Conclusions Evaluation of urine sediment reflects lupus nephritis histology . (bvsalud.org)
Person with lupus nephritis1
Membranous lupus nephritis1
Foundation of America2
  • The Lupus Foundation of America works to improve the quality of life for all people affected by lupus through programs of research, education, support and advocacy. (lupus.org)
  • Take Control.TM was jointly created by the ACR and the Lupus Foundation of America (LFA) and launched in June 2018. (thelupusinitiative.org)
Different types of lupus2
Flares4
  • There is now solid evidence that hydroxychloroquine (Plaquenil) prevents lupus flares, treats the skin manifestations of the disease, protects against thromboembolic events, prevents cardiac neonatal lupus, and prolongs life. (ukidney.com)
  • Flares of lupus nephritis (LN) cause acute kidney injury (AKI), even if serum creatinine (SCr) does not increase. (biomedcentral.com)
  • Women can take steps to control symptoms, prevent lupus flares, and cope with the challenges of lupus. (cdc.gov)
  • The LUMINA (Lupus in Minorities: Nature versus Nurture) study and other trials have offered evidence of a decrease in flares and prolonged life in patients given hydroxychloroquine, making it the cornerstone of SLE management. (medscape.com)
Outcomes3
  • New study findings show women with lupus nephritis (LN, lupus-related kidney disease) - especially those with active LN - are at significantly increased risk of pregnancy complications compared to women with lupus without LN. Adverse pregnancy outcomes included fetal loss (miscarriage or stillbirth), preterm birth (childbirth that occurs before 37 weeks of pregnancy) and preeclampsia (a pregnancy complication characterized by high blood pressure and organ system damage). (lupus.org)
  • Researchers assessed data from 393 women with lupus in the United States and Canada, 37% of whom had a history of LN. Those with a history of LN had almost twice the odds of poor pregnancy outcomes compared to women without LN. (lupus.org)
  • Both CKD and lupus are risk factors for cardiovascular disease, although most studies of long-term renal outcomes in patients with lupus nephritis focus on end-stage kidney disease (ESKD) instead of CKD. (consultant360.com)
Kidney function5
Classification1
Findings2
  • Lupus nephritis is one of the most common and dangerous complications of lupus, and with no currently-approved treatments, it is truly exciting to see the promising clinical findings of the NOBILITY trial," commented Teodora Staeva, PhD , Chief Scientific Officer of the Lupus Research Alliance. (lupusresearch.org)
  • These findings have not been identified in genetic studies of lupus nephritis, suggesting that epigenome-wide association studies can help identify the genomic differences that underlie the clinical heterogeneity of SLE. (escholarship.org)
Autoantibodies1
Role in lupus1
  • the latter are thought to play a role in lupus. (medscape.com)