AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesHealth Care
Partial Thromboplastin TimeProthrombin TimeBlood Coagulation TestsBlood CoagulationBlood Coagulation DisordersThrombin TimeThromboplastinHeparinAnticoagulantsHemostasisAntithrombinsBlood Coagulation FactorsDisseminated Intravascular CoagulationBleeding TimeLupus Erythematosus, SystemicThrombelastographyAntithrombin IIILupus Coagulation InhibitorHirudin TherapyHirudinsFibrinogenFactor VIIIPipecolic AcidsKaolinHemorrhagic DisordersPlatelet CountBlood Coagulation Disorders, InheritedHemorrhageFactor XIProtein CThrombinFactor XaHemophilia AProthrombinFibrinolysisHypoprothrombinemiasHemophilia BCoagulantsLupus NephritisFactor XIIInternational Normalized RatioThrombosisHeparin AntagonistsFactor IXCoagulation Protein DisordersFibrin Fibrinogen Degradation ProductsFibrinolytic AgentsFactor XI DeficiencyWhole Blood Coagulation TimeFactor XFactor VIIVitamin K DeficiencyThrombophlebitisSolar ActivityAntiphospholipid SyndromeBlood Cell CountCarotid Artery ThrombosisFactor XIaPlatelet AggregationThromboembolismPlasmaFactor VPostoperative HemorrhageActivated Protein C ResistanceHeparinoids4-HydroxycoumarinsProtein Sbeta-AlanineFactor VIIaHemostasis, SurgicalPrekallikreinFactor XIIaPlatelet Function TestsVitamin KFibrinopeptide AFactor X DeficiencyThrombophiliaAntibodies, AnticardiolipinFibrinContusionsSeaweedChromogenic CompoundsKininogensHeparin, Low-Molecular-WeightDrug MonitoringPhaeophytaAntibodies, AntiphospholipidHemodilutionThrombocytopeniaEnoxaparinFactor IXaWarfarinAfibrinogenemiaHematologic TestsAntifibrinolytic AgentsDermatan SulfateBlood PlateletsHemostatic TechniquesHydroxyethyl Starch DerivativesIndicators and Reagents
APTTSystemicProthrombinProlonged activated partGuidelines for lupus anticoagulant detAnticoagulantsAntibodiesInhibitorProlongationAntibodyKnown as Lupus anticoagulantDilute RussTissue thromboplastinThrombinCirculating lupus anticoagulantPhospholipidHeparinDeficiencyInhibitorsDiagnosisAutoantibodySymptomsPregnancyPlateletTestPatientsClinicalLaboratoryPrevalenceSyndromeClotting factorsIntrinsicClinicallyAntigenAnti-coagulantReagentPresenceNormalTests
APTT20
  • In general, healthy subjects do not have a prolonged aPTT and do not have lupus anticoagulant (LA) activity. (medscape.com)
  • The first method involves accentuating prolonged coagulation by reducing the amount of phospholipid, as is done in the tissue thromboplastin inhibition (TTI) test and the dilute aPTT test. (medscape.com)
  • The diagnosis of haemophilia C (factor XI deficiency) is centered on prolonged activated partial thromboplastin time (aPTT). (wikipedia.org)
  • in contrast, if a lupus anticoagulant is present as the cause of a prolonged aPTT, the aPTT will not correct with a 1:1 mixing study. (wikipedia.org)
  • Clotting and immunological methods were used to determine activated partial thromboplastin time (aPTT), prothrombin time (PT), thrombin time (TT), fibrinogen levels, FX activity, and FX antigen levels. (karger.com)
  • Testing to exclude lupus anticoagulant (eg, dilute Russell viper venom time and the kaolin clotting time) is indicated if aPTT values during the mixing study are similar at time 0 and after incubation at 37°C. Special testing is done if patients are already on heparin, to exclude its effect on PTT values. (medscape.com)
  • 1 They identified patients in whom the activated partial thromboplastin time (APTT) was prolonged and which did not correct on the addition of normal plasma. (bmj.com)
  • The activated partial thromboplastin time (APTT) test measures the time it takes for a blood clot to form. (redcliffelabs.com)
  • This time, prioritize your health above everything else and confirm yourself with an APTT blood test in Arrha with Redcliffe Labs. (redcliffelabs.com)
  • It is usually identified incidentally in asymptomatic patients with a prolonged activated partial thromboplastin time (aPTT). (bvsalud.org)
  • The deficit of PK is characterized by a severely prolonged aPTT and normal prothrombin time (PT) in the absence of bleeding tendency. (bvsalud.org)
  • A coagulation profile test can contain several other tests that measure prothrombin time (PT), activated partial thromboplastin time (APTT), platelets, and fibrinogen to assess bleeding problems. (flebo.in)
  • The prothrombin test can be combined with the activated partial thromboplastin time (APTT), which is also known as PTT (partial thromboplastin time). (flebo.in)
  • The APTT test examines the process of blood clot formation and also the time taken for the same when a catalyst or reagent is added in the blood sample. (flebo.in)
  • Lengthening of APTT depends on the type of heparin used, the circulating heparin concentration and the sampling time in relation to the time of heparin administration. (stago.com)
  • Lengthening of Quick's time and of APTT occurs in the presence of a specific inhibitor directed against a coagulation factor to which one of these tests is sensitive. (stago.com)
  • Treatment with vitamin K antagonists causes acquired deficiency in vitamin K-dependent coagulation factors (factors II, VII, IX and X), resulting in lengthening of Quick's time and of APTT. (stago.com)
  • Treatment with direct thrombin inhibitors (argatroban, dabigatran, hirudin derivatives) results in lengthening of Quick's time and of APTT. (stago.com)
  • Treatment with direct inhibitors of activated factor X ( rivaroxaban, apixaban ) causes lengthening of Quick's time and of APTT. (stago.com)
  • Although a coagulation profile (prothrombin time [PT], activated partial thromboplastin time [aPTT], and fibrinogen) should also be evaluated, its clinical value is unclear when the platelet count is 100,000/mm 3 or more with no evidence of bleeding. (medscape.com)
Systemic26
  • Haemophilia C is occasionally observed in individuals with systemic lupus erythematosus, because of inhibitors to the FXI protein. (wikipedia.org)
  • Overview of Systemic Lupus. (merckmanuals.com)
  • Systemic lupus erythematosus is a chronic, multisystem, inflammatory disorder of autoimmune etiology, occurring predominantly in young women. (merckmanuals.com)
  • Systemic lupus erythematosus (SLE) is more common and severe among Black and Asian patients than among White patients. (merckmanuals.com)
  • Systemic lupus erythematosus (SLE) is a chronic autoimmune connective tissue disorder, with a heterogeneous presentation. (lww.com)
  • The disorder was recognized as early as the Middle Ages, with the 12th-century physician Rogerius being the first to apply the term lupus to the classic malar rash, and in 1872, Moric Kaposi first recognized the systemic nature of the disease. (lww.com)
  • The prevalence of systemic lupus erythematosus (SLE) ranges from 7.4 to 159.4 per 100,000 of population, with the highest rates among United Kingdom residents of Afro-Caribbean descent, and non-White populations elsewhere. (lww.com)
  • Salvage therapy with cyclosporine is particularly effective in patients with underlying systemic lupus erythematosus. (medscape.com)
  • Cardiolipin antibodies (CA) are seen in a subgroup of patients with autoimmune disorders, particularly Systemic Lupus Erythematosus (SLE), who are at risk for vascular thrombosis, thrombocytopenia, cerebral infarct and/or recurrent spontaneous abortion. (dobratechnologia.pl)
  • It is often found in people with other autoimmune diseases, such as systemic lupus erythematosus (SLE). (adam.com)
  • Systemic lupus erythematosus (SLE) is an autoimmune disease. (adam.com)
  • Lupus anticoagulants (LA) were first detected in patients with systemic lupus erythematosus (SLE) in 1952 by Conley and Hartmann. (bmj.com)
  • most patients with LA do not have systemic lupus erythematosus. (strokesciences.com)
  • Antiphospholipid antibodies otherwise known as Lupus anticoagulant because it was first seen in the serum of a woman with systemic Lupus erythromatosus in 1952, is now known to be present in a variety of other clinical conditions such as recurrent venous and arterial thromboembolic disorders, habitual abortion, abruption placenta, pre-eclampsia and auto immune disorders. (ispub.com)
  • This test is not used to diagnose the autoimmune disorder known as systemic lupus erythematosus, also known simply as lupus. (laboratoriosanjose.com)
  • The pathogenetic role of anticardiolipin antibodies (aCLs) in patients with neuropsychiatric systemic lupus erythematosus (NPSLE) without cerebral infarcts remains elusive. (biomedcentral.com)
  • In this study we examined the correlation between grey and white matter magnetization transfer ratio (MTR) parameters and the presence of IgM and IgG aCLs and lupus anticoagulant in 18 patients with systemic lupus erythematosus and a history of NPSLE but without cerebral infarcts on conventional magnetic resonance imaging. (biomedcentral.com)
  • Central nervous system (CNS) involvement causes neuropsychiatric manifestations in up to 75% of patients with systemic lupus erythematosus (SLE) [ 1 ]. (biomedcentral.com)
  • The tests are not used to diagnose the chronic autoimmune disorder systemic lupus erythematosus (SLE), also known as lupus. (ganeshdiagnostic.com)
  • For women who suffer from systemic lupus erythematosus (SLE), pregnancy can be a concern, placing the mother and fetus at risk. (openrheumatologyjournal.com)
  • Pregnancy outcome, systemic lupus erythematosus (SLE), case-control. (openrheumatologyjournal.com)
  • Systemic lupus erythematosus (SLE) is a serious multi-system disease affecting predominantly women of childbearing age. (openrheumatologyjournal.com)
  • This has prognostic implications with the former being associated with a 2% incidence of systemic lupus erythematosus (SLE) versus 50% with the latter [ 1 ]. (hindawi.com)
  • Hughes Syndrome/Antiphospholipid syndrome (APS) is a systemic autoimmune, hypercoagulable, thrombo inflammatory, and thrombosis and/or pregnancy complications syndrome caused by the persistent presence of antiphospholipid antibodies (APL) in plasma of patients with vascular thrombosis and/or pregnancy morbidity along with persistent anti-phospholipid antibodies (APLA), including lupus anticoagulant (LA), anti-β2-glycoprotein I (anti-β2GPI) and/or anti-cardiolipin (ACL) antibodies. (endinglines.com)
  • Systemic lupus erythematosus (SLE) is the most common type of Lupus. (chronichealthinfo.com)
  • We found 35 cases, 15 in systemic lupus erythematosus and 12 in rheumatoid arthritis, while the remaining cases were reported in Sjögren's syndrome, polymyalgia rheumatica, systemic sclerosis, and psoriatic arthritis. (seedmedicalpublishers.com)
Prothrombin16
Prolonged activated part3
  • A child presented with excessive bruising and prolonged activated partial thromboplastin time. (bmj.com)
  • This case demonstrates a transient antiphospholipid antibody syndrome as a rare presentation of bleeding diathesis in a previously healthy child, and should be considered in children with new onset bruising and prolonged activated partial thromboplastin time. (bmj.com)
  • AHA should be suspected when a patient with no history of hemorrhages presents with bleeding and an unexplained prolonged activated partial thromboplastin time. (seedmedicalpublishers.com)
Guidelines for lupus anticoagulant det1
  • Update of the guidelines for lupus anticoagulant detection. (nih.gov)
Anticoagulants2
Antibodies14
  • One of the conclusions of the subcommittee meeting on Lupus Anticoagulant/Phospholipid dependent antibodies, held in Geneva on 2007, was the need to update the guidelines on Lupus Anticoagulant (LA) detection. (nih.gov)
  • Informed include lupus anticoagulant and anticardio- consent was obtained from patients and lipin antibodies [ 2,3 ]. (who.int)
  • In particular, retinal vascular occlusions says for anticardiolipin antibodies and lupus in patients with primary APS, i.e. with an- anticoagulant. (who.int)
  • The plasma of all the samples were subjected to kaolin clotting time and the serum of forty-three (43) of the samples were run on an enzyme-linked immunosorbent assay (ELISA) for the semi quantitative determination of IgG and IgM anticardiolipin antibodies. (ispub.com)
  • A prevalence of 9.3% was obtained for the antiphospholipid antibodies by the coagulation-based kaolin clotting time, and 2.3% by a more sensitive immunological-based ELISA test on the same set of patients. (ispub.com)
  • It is meant to detect and semi-quantify anticardiolipin antibodies in those with SLE and lupus-like disorders (antiphospholipid syndrome). (ispub.com)
  • In this study we examined the relation between brain damage as indicated by quantitative MTI parameters and the presence of aCLs, lupus anticoagulant (Lac) and antibodies directed against DNA and extractable nuclear antigen (ENA). (biomedcentral.com)
  • This test is most of the times ordered with those for any other antiphospholipid antibodies, cardiolipin antibody as well as lupus anticoagulant. (areyouhealthy.in)
  • The antiphospholipid syndrome is an autoimmune thrombophilic disease characterized by occurrence of vascular events (arterial, venous, or small vessel thrombosis) and/or pregnancy complications, in association with persistently positive antiphoshpolipid antibodies such as lupus anticoagulant, anticardiolipid antibodies, and/or anti-β2-glycoprotein I antibodies. (ghrnet.org)
  • However, at times, in certain situations, these same antibodies can instead react towards the internal body tissues and cause harm. (flebo.in)
  • For the LAC test, lupus anticoagulant antibodies are the ones that can result in an autoimmune disorder. (flebo.in)
  • With the help of a LAC test, doctors are successfully able to detect and diagnose the possibility of an autoimmune disorder that can cause the antibodies to behave this way by testing the presence of lupus anticoagulant antibodies. (flebo.in)
  • [rx] These antibodies are often referred to by different terms, including anticardiolipin antibody, lupus anticoagulant, and antiphospholipid antibody. (endinglines.com)
  • Antiphospholipid syndrome is an acquired autoimmune disorder characterized by recurrent arterial or venous thrombosis and/or pregnancy losses, in the presence of persistently elevated levels of anticardiolipin antibodies and/or evidence of circulating lupus anticoagulant (these abnormalities are detected by blood tests). (endinglines.com)
Inhibitor5
  • Immunosuppressive treatment to eradicate the FVIII inhibitor should be started as soon as the diagnosis is confirmed to reduce the time the patient is at risk of bleeding. (biomedcentral.com)
  • Mixing study revealed time-dependent inhibitor pattern that was successively identified as directed against FVIII using the Nijmegen-modified Bethesda assay. (journalmc.org)
  • We recommend considering screening for an inhibitor (by mixing study) in cases with otherwise unexplained onset hemorrhagic disorder and/or isolated activated partial thromboplastin time prolongation. (journalmc.org)
  • Reagents used to determine Quick's time contain heparin inhibitor that renders them insensitive to heparin up to a specific circulating concentration of the latter substance. (stago.com)
  • Determination of thrombin time may be used to identify the presence of a direct or indirect (heparin) thrombin inhibitor. (stago.com)
Prolongation2
Antibody2
  • Autoimmune diseases, such as antiphospholipid antibody syndrome or lupus anticoagulant syndrome. (medlineplus.gov)
  • In order to avoid false positive results, it is recommended that immunological-based ELISA test be carried out on patients that test positive to kaolin clotting time and/or have clinical features suggestive of the presence of antiphospholipid antibody before they are commenced on therapy. (ispub.com)
Known as Lupus anticoagulant1
  • A series of tests used to detect the presence of LA in the blood is known as lupus anticoagulant testing. (ganeshdiagnostic.com)
Dilute Russ2
  • Dilute Russell viper venom time (DRVVT) confirmation is only performed when the DRVVT screen is abnormally prolonged. (mayocliniclabs.com)
  • Refer to DRV1 / Dilute Russell Viper Venom Time (DRVVT), Plasma for interpretation of results. (mayocliniclabs.com)
Tissue thromboplastin1
Thrombin3
Circulating lupus anticoagulant1
  • During hemostasis pre-surgery screening it is preferable to select a reagent relatively insensitive to circulating lupus anticoagulant. (stago.com)
Phospholipid2
  • Mixing studies in plasma were positive for phospholipid dependence of the anticoagulant, confirming a diagnosis of lupus anticoagulant. (bmj.com)
  • The time required for the appearance of FIBRIN strands following the mixing of PLASMA with phospholipid platelet substitute (e.g., crude cephalins, soybean phosphatides). (lookformedical.com)
Heparin2
  • In terms of differential diagnosis, one must consider: haemophilia A, haemophilia B, lupus anticoagulant and heparin contamination. (wikipedia.org)
  • The heparin level obtained must be analyzed in the context of the treatment given to the patient (type of heparin, dosage, administration mode, time of sampling, etc) and the desired therapeutic effect. (testcatalog.org)
Deficiency4
  • Haemophilia C (also known as plasma thromboplastin antecedent (PTA) deficiency or Rosenthal syndrome) is a mild form of haemophilia affecting both sexes, due to factor XI deficiency. (wikipedia.org)
  • When an assay on a range of mixture of normal and patient's plasma is done, the presence of Lupus anticoagulant deficiency is indicated by the different patterns of response obtained. (ispub.com)
  • Furthermore, certain reagents used to determine activated partial thromboplastin time may also allow detection of deficiency of two factors involved in the contact phase of coagulation , prekallikrein (Fletcher factor) and high-molecular-weight kininogen, deficiencies of which are rare and not clinically discernible. (stago.com)
  • This feature constitutes the reason for use of Quick's time, or preferably, its expression taking into account both the degree of the induced deficiency and of the sensitivity of the reagent , INR ( I nternational N ormalized R atio), for monitoring and adjustment of the vitamin K antagonist therapy. (stago.com)
Inhibitors1
  • A mixing study was performed to eliminate the presence of coagulation factor inhibitors and lupus anticoagulant. (karger.com)
Diagnosis1
  • concerned about the adverse effects of steroids and refuse to take them at the time of diagnosis.171 Sung et al. (thrombin-inhibitor.com)
Autoantibody1
  • Antimalarials improve lupus by decreasing autoantibody production, protecting against the damaging effects of ultraviolet light from the sun. (chronichealthinfo.com)
Symptoms5
  • The clinical manifestations of drug-induced lupus erythematosus are generally milder with arthralgias and serositis being the predominant symptoms, and major organ involvement is usually absent. (lww.com)
  • At the time of the study, no active neuropsychiatric symptoms or any concurrent other neurological or psychiatric diseases were present. (biomedcentral.com)
  • Many of the symptoms of lupus are caused by inflammation. (chronichealthinfo.com)
  • It c an control some of the symptoms of lupus. (chronichealthinfo.com)
  • These medications are sometimes used when a patient does not respond to steroids or cannot tolerate a high dosage of steroids, especially when steroids have been unable to bring lupus symptoms under control, or when a person cannot tolerate high doses of steroids. (chronichealthinfo.com)
Pregnancy4
  • Our hypothesis was that pregnancy outcome in SLE is improving over time. (openrheumatologyjournal.com)
  • We searched and quantified the literature on pregnancy outcome, lupus reactivation and fertility rate. (openrheumatologyjournal.com)
  • Twenty-four percent of lupus patients had at least one preterm delivery vs 5% in controls (OR =8.32, p = 0.0008), however other pregnancy outcomes (miscarriage, therapeutic abortion, stillbirth and neonatal death rate) did not differ between the groups. (openrheumatologyjournal.com)
  • However, new strategies with respect to pregnancy timing and multidisciplinary care have improved maternal and fetal outcome in SLE. (openrheumatologyjournal.com)
Platelet1
  • Platelet count =50×10 9 /L (=25×10 9 /L if thrombocytopenia is attributable to lupus disease activity) e. (who.int)
Test10
  • A partial thromboplastin time (PTT) test uses a blood sample to measure how long it takes for your blood to make a clot . (medlineplus.gov)
  • Your PTT test results will show how much time it took for your blood to clot. (medlineplus.gov)
  • But the results of a PTT test may show a slow clotting time. (medlineplus.gov)
  • The test measures the time blood takes to clot & helps finds blood clotting problems. (redcliffelabs.com)
  • The test sample is collected from your registered address in the reserved time slot. (areyouhealthy.in)
  • The activated partial thromboplastin time test is responsible for examining the coagulation factors VII, X, V, II, and I. (flebo.in)
  • The lupus anticoagulant test, also known as the LAC test, is commonly prescribed by doctors to detect the possibility of an autoimmune disorder in a patient. (flebo.in)
  • Why is the Lupus Anticoagulant (LAC) Test done? (flebo.in)
  • There are two major reasons why the LAC test is performed and that include either finding out the cause of a particular blood clot causing discomfort to the patient or studying the prolonged partial thromboplastin time to correlate it well with the recurring miscarriages for a woman or the presence of any other autoimmune disorder. (flebo.in)
  • What does the Lupus Anticoagulant (LAC) Test Measure? (flebo.in)
Patients2
  • Although Conley and Hartmann's original description was in association with a haemorrhagic disorder, subsequent reports from the 1960s highlighted patients with thrombotic events in the presence of LA. 2 The term 'lupus anticoagulant' was introduced by Feinstein and Rapaport in 1972. (bmj.com)
  • To save time, money, and efforts of our patients, we offer the facility of downloading the outpatient laboratory reports with real-time online access. (yashodahealthcare.com)
Clinical1
  • They may also be requested with lupus anticoagulant testing to help investigate the cause of a prolonged PTT (activated partial thromboplastin time), especially if clinical findings suggest that the patient may have SLE or another autoimmune disorder. (bloodhoundonline.co.uk)
Laboratory1
  • Laboratory investigations performed before the biopsy indicated normal activity for factors VIII, IX, XI, XII, and von Willebrand factor (vWF) as well as negative lupus anticoagulant (LA) screen. (bvsalud.org)
Prevalence2
  • It is differentiated from prevalence, which refers to all cases in the population at a given time. (lecturio.com)
  • Prevalence and risk of individual thrombophilic markers with a time line representing their discovery[ 1 ] Despite the expansion of these methods, the following years brought forth discoveries of defects on a molecular basis, which posed decreasing risks of thrombosis, as can be seen in Fig 1 . (intechopen.com)
Syndrome2
Clotting factors1
Intrinsic1
  • Information provided by Quick's time and activated partial thromboplastin time concerns the extrinsic and intrinsic cascades investigated respectively by these two tests and shown in Figure 1. (stago.com)
Clinically1
  • Lupus anticoagulant is clinically the most relevant among all tests. (ghrnet.org)
Antigen1
  • No significant differences were found in MTR histogram parameters with respect to IgG aCL and lupus anticoagulant status, nor with respect to anti-dsDNA or anti-ENA (extractable nuclear antigen) status. (biomedcentral.com)
Anti-coagulant1
Reagent1
  • The degree of lengthening depends on the drug given and on the sensitivity of the reagent used , as well as the sampling time in relation to the time of drug administration. (stago.com)
Presence1
  • 2 It is worthy of note that these studies were conducted using coagulation screening techniques to determine presence or absence of Lupus Anticoagulant. (ispub.com)
Normal1
Tests1
  • The lupus anticoagulant tests are blood clotting tests. (adam.com)