AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesHealth Care
HyperoxiaLungLung DiseasesOxygenLung NeoplasmsLung InjuryPulmonary AlveoliCarcinoma, Non-Small-Cell LungAcute Lung InjuryLung TransplantationHyperbaric OxygenationAnimals, NewbornAnoxiaPartial PressureLung Volume MeasurementsBronchopulmonary DysplasiaBronchoalveolar Lavage FluidCarotid BodyPneumocytesRespiratory MechanicsChemoreceptor CellsLung Diseases, InterstitialPulmonary EdemaIon-Selective ElectrodesRetinal VesselsRats, Sprague-DawleyBlood Gas AnalysisMice, Inbred C57BLCarbon DioxideRespirationRetinopathy of PrematurityRespiratory MucosaOxygen ConsumptionOxygen Inhalation TherapyPulmonary Surfactant-Associated Protein CMicroscopy, Electrochemical, ScanningTotal Lung CapacityPulmonary CirculationExtravascular Lung WaterRespiratory Distress Syndrome, AdultPneumoniaTidal VolumeHypercapniaRNA, MessengerAirPulmonary FibrosisPulmonary VentilationOxidative StressSmall Cell Lung CarcinomaPulmonary SurfactantsRespiratory Function TestsAdenocarcinomaMacrophages, AlveolarEpithelial CellsCarcinoma, Small CellLung AbscessSuperoxide DismutaseRespiration, ArtificialVentilator-Induced Lung Injury
AcuteChronic lung diseaseAngiogenesisFibrosisOxidativeNeonatesAlveolarizationCytokinesDiseasesUmbilical cord-derivedVascularHypoxiaEndothelialNeonatal LungExposureInflammationPretermDiseasePostnatalInhalationMolecularDecreased lung injuryInfantsRatsDevelopmentPerinatalMiceInhibitionSurfactantToxicityRespiratoryMetabolismTissueRegenerativeRegenerationClinicalLipopolysaccharideLavageAsthmaSevereSuppressionCell
Acute13
  • An exact knowledge of acinar microvessel behaviour in acidosis is absolutely necessary when treating patients with diseased lungs using controlled ventilation with permissive hypercapnia, which has increasingly assumed an important place in managing acute lung injury 5 , 6 . (ersjournals.com)
  • Acute Kidney Injury is Associated with Poor Lung Outcomes in Infants Born ≥32 Weeks of Gestational Age. (seattlechildrens.org)
  • Scientists from Alnylam Pharmaceuticals and Yale University found that an RNAi therapeutic can silence angiopoietin 2 ( Ang2 ), a key mediator in acute lung injury. (genengnews.com)
  • They demonstrated inhibition of acute lung injury and cell death in animals with administration of siRNAs targeting Ang2 . (genengnews.com)
  • These results showed that we were able to design and synthesize siRNAs that following pulmonary delivery in vivo effectively silence Ang2 , a very important target associated with acute lung injury," points out Antonin de Fougerolles, Ph.D., senior director, research at Alnylam. (genengnews.com)
  • The findings demonstrate a critical role for Ang2 in the pathogenesis of hyperoxic acute lung injury and that silencing the Ang2 gene with RNAi may be therapeutically relevant. (genengnews.com)
  • The study demonstrated that acute lung injury caused by cell death, hyperoxia, and the resulting pulmonary edema may be controlled by the Ang2 protein. (genengnews.com)
  • In addition, acute lung injury was reduced to near noninjury levels as measured by statistically significant reductions in lung inflammation and cell death. (genengnews.com)
  • To investigate the effects of hydrogen-rich saline (HRS) combined with hyperbaric oxygen (HBO) on acute lung injury (ALI) and its clinical significance. (researchsquare.com)
  • Excess release and over-expression of immflammatory mediators and related immflammatory cytokines could stimulate excess immflammatory reaction, resulting in damage to alvelar-cappilary membrane and increased vascular permeability and ultimately acute lung injury (ALI) [ 5 - 7 ] . (researchsquare.com)
  • In our experiment, adult SD rat model of acute lung injury was established by injecting lipopolysaccharide (LPS) into treachea, and life signs and dry-wet ratio of pulmonary tissue were closely observed. (researchsquare.com)
  • IFN-γ Is Protective in Cytokine Release Syndrome-associated Extrapulmonary Acute Lung Injury. (yalemedicine.org)
  • Liraglutide pretreatment attenuates sepsis-induced acute lung injury. (doximity.com)
Chronic lung disease4
  • Postnatal hyperoxia exposure in rodents is a well-established model of chronic lung disease of prematurity, and also recapitulates the pulmonary vascular, cardiovascular, and renal phenotype of premature birth. (frontiersin.org)
  • Her primary research focus is in the pathogenesis of Bronchopulmonary Dysplasia, also known as Chronic Lung Disease of Prematurity. (seattlechildrens.org)
  • We will also examine how regenerative failure may contribute to development of aging-related, chronic lung disease. (karger.com)
  • Bronchopulmonary dysplasia is a chronic lung disease observed in premature infants requiring oxygen supplementation and ventilation. (johnshopkins.edu)
Angiogenesis2
Fibrosis4
  • Lung diseases such as COPD, asthma and pulmonary fibrosis, and pathogens compromise respiration, resulting in a global health and economic burden. (grc.org)
  • He is particularly interested in lung diseases leading to fibrosis, including those from exposures to foreign materials. (yalemedicine.org)
  • Thus, although some of the effects of exposure to 17 hours of more than 95 per cent oxygen are reversible, hyperoxia for even this short period lowers the structural or functional barriers that normally prevent alveolar-capillary "leak" and induces processes that can culminate in fibrosis of the alveolar wall. (nebraska.edu)
  • Idiopathic pulmonary fibrosis (IPF) is the prototypic progressive fibrotic interstitial lung disease. (lungdiseasesjournal.com)
Oxidative3
  • Compared to control rats, male rats exposed to 14 days of postnatal hyperoxia then aged to 1 year demonstrated higher skeletal muscle fatigability, lower muscle mitochondrial oxidative capacity, more mitochondrial damage, and higher glycolytic enzyme expression. (frontiersin.org)
  • HRS and HBO could all decrease the release of immflammatory cytokines in lung tissue, reduce accumulation of oxidative products and alleviate apoptosis of pulmoanry cells, and could produce good therapeutic effects on ALI induced by LPS. (researchsquare.com)
  • We characterized CL and PS oxidation products formed in a model system (cyt c/H2O2), in apoptotic cells (neurons, pulmonary artery endothelial cells) and mouse lung under inflammatory/oxidative stress conditions (hyperoxia, inhalation of single walled carbon nanotube s). (cdc.gov)
Neonates2
  • Consecutive daily administration of intratracheal surfactant and hUC-MSCs can be an effective regimen for treating hyperoxia-induced lung injury in neonates. (biomedcentral.com)
  • People exposed to hyperoxia as neonates may be at increased risk for pulmonary hypertension. (johnshopkins.edu)
Alveolarization1
Cytokines2
  • The lowered MLIs and cytokines and the increased VEGF expression and vascular density indicated that the surfactant and surfactant + hUC-MSCs (3 × 10 4 cells) treatment attenuated hyperoxia-induced lung injury. (biomedcentral.com)
  • The mRNA expression levels and protein concentrations of inflammatory cytokines in the lung tissue and mouse serum were measured using reverse transcription‑quantitative PCR and ELISA, respectively. (spandidos-publications.com)
Diseases3
  • The data published in Nature Medicine contributes to existing data demonstrating the potential for developing RNAi therapeutics that target diseases associated with the lung, such as respiratory syncytial virus (RSV) infection, influenza, and asthma. (genengnews.com)
  • The indications of HBO for the treatment of lung diseases include pulmonary edema, ARDS, etc., and the earlier the treatment is implemented, the better results will be achieved. (researchsquare.com)
  • Our lab is focused on understanding the mechanisms of lung development, injury and repair in order to design new treatments for incurable lung diseases. (ohri.ca)
Umbilical cord-derived2
  • Our previous study found that mesenchymal stem cells (MSCs) attenuated hyperoxia-induced lung injury and the combination therapy of surfactant and human umbilical cord-derived MSCs (hUC-MSCs) did not have additive effects on hyperoxia-induced lung injury in neonatal rats. (biomedcentral.com)
  • In previous study, we demonstrated that the addition of surfactant reduced the in vitro viability of human umbilical cord-derived MSCs (hUC-MSCs) through mitochondrial dysfunction and that a combination therapy of surfactant and hUC-MSCs had no additive effects on lung development in neonatal rats exposed to hyperoxia [ 14 ]. (biomedcentral.com)
Vascular4
  • The rats reared in hyperoxia and treated with NS yielded significantly higher mean linear intercepts (MLIs) and interleukin (IL)-1β and IL-6 levels and significantly lower vascular endothelial growth factors (VEGFs), platelet-derived growth factor protein expression, and vascular density than did those reared in RA and treated with NS or surfactant. (biomedcentral.com)
  • Alphonse RS, Vadivel A, Zhong S, McConaghy S, Ohls R, Yoder MC, Thébaud B . A method to isolate and culture lung vascular endothelial colony-forming cells. (ohri.ca)
  • High flow oxygen resulting in hyperoxia also has the potential to cause significant adverse cardiovascular effects with increased systemic vascular resistance and blood pressure, decreased cardiac output and reduced coronary, cerebral and renal blood flow. (bmj.com)
  • Consistent with recent literature implicating bone morphogenetic protein (BMP) signaling in pulmonary vascular disease, BMP receptors and downstream phospho-Smad1/ 5/8 were reduced in lungs of aging mice exposed to neonatal oxygen.BMPsignaling alterations were not observed in 8-week-old mice. (johnshopkins.edu)
Hypoxia1
  • and (v) the role of hypoxia-inducible factor-1 in lung development. (stanford.edu)
Endothelial2
  • While much work has focused on the failure of epithelial cell populations as a key component of the aging process, additional studies have shown that aging, as a global phenomenon in the lung, also impacts resident endothelial, mesenchymal, and immune cell populations. (karger.com)
  • Hemoglobin increases leukocyte adhesion and initiates lung microvascular endothelial activation via Toll-like receptor 4 signaling. (doximity.com)
Neonatal Lung1
  • Preventable ATII Proliferation after Hyperoxia: The "Tempo" of Folate Metabolism in the Neonatal Lung. (seattlechildrens.org)
Exposure5
  • Real-time confocal luminescence microscopy was used to measure changes in the diameter of acinar arterioles, venules and capillaries in response to stimulation with hypercapnic and isocapnic acidosis in isolated rat lungs injured by 90% oxygen exposure for 48 h. (ersjournals.com)
  • Premature birth affects more than 10% of live births, and is characterized by relative hyperoxia exposure in an immature host. (frontiersin.org)
  • The objective of this study was to evaluate whether postnatal hyperoxia exposure in rats could recapitulate the skeletal and metabolic phenotype of premature birth, and to characterize the subcellular metabolic changes associated with postnatal hyperoxia exposure, with a secondary aim to evaluate sex differences in this model. (frontiersin.org)
  • These differences were not present in female rats with the same postnatal hyperoxia exposure. (frontiersin.org)
  • The Col 4α3NC1 epitope is thought to be less accessible for anti-GBM binding in the lung, and partial denaturation of NC1 domains may be required for full exposure of this sequestered epitope to the antibody. (medscape.com)
Inflammation3
  • Background/aim: Hyperoxia- and inflammation-induced lung injury is an important cause of the development of bronchopulmonary dysplasia (BPD) in premature infants. (aybu.edu.tr)
  • We aimed to ascertain the beneficial effects of ginger (Zingiber officinale) on rat pups exposed to hyperoxia and inflammation. (aybu.edu.tr)
  • Therefore, Zn may possess protective effect as preventive and adjuvant therapy of COVID‑19 through reducing inflammation, improvement of mucociliary clearance, prevention of ventilator‑induced lung injury, modulation of antiviral and antibacterial immunity. (spandidos-publications.com)
Preterm1
  • Term-born rat models are appropriate for studying the effects of hyperoxia on preterm infants with respiratory distress because rats are born at the saccular stage, which is approximately equivalent to a human gestational age of 30 weeks [ 1 ]. (biomedcentral.com)
Disease9
  • Dr. Pryhuber's particular clinical interests are care of infants with pulmonary hypertension, lung injury, growth and developmental failure, often complicated by chronic and inflammatory disease. (rochester.edu)
  • Specifically, she is working to understand the roles of monocytes and epithelial cells in the development of this inflammatory lung disease. (seattlechildrens.org)
  • This conference aims to highlight in vitro, in vivo, and clinical studies in lung biology and how this knowledge is being translated into the development of new drugs or therapeutic strategies for the treatment of lung disease. (grc.org)
  • In particular, it will provide a platform for trainees in the lung biology field to present cutting-edge research in the areas of lung development, disease and therapeutics. (grc.org)
  • All animal models of human lung disease are available in our lab, and we correlate structural and functional changes to assess the clinical relevance of the experimental therapies we are testing. (ohri.ca)
  • This work has revealed the presence of glutathione metabolism in LLF and a novel target that can augment lung lining fluid glutathione content under oxidant stress associated with inflammatory lung disease. (bu.edu)
  • Respiratory distress syndrome (RDS), also known as hyaline membrane disease, is caused by the lack of adequate pulmonary surfactant production in an immature lung. (lecturio.com)
  • IPF is a chronic, progressive and fibrotic lung disease of unknown cause, which typically occurs in older adults. (lungdiseasesjournal.com)
  • The pathogenesis of anti-glomerular basement membrane (anti-GBM) disease (Goodpasture disease) is linked to the presence of autoantibodies that react with the alveolus in the lung and the basement membrane of the glomerulus in the kidney. (medscape.com)
Postnatal2
  • Neonatal Sprague Dawley rats were reared in either room air (RA) or hyperoxia (85% O 2 ) from postnatal days 1 to 14. (biomedcentral.com)
  • This study demonstrates detrimental mitochondrial and muscular outcomes in the adult male rat exposed to postnatal hyperoxia. (frontiersin.org)
Inhalation1
  • If true, this theory may explain why pulmonary hemorrhage is often associated with factors that increase pulmonary capillary permeability, such as active cigarette smoking, infections, recent hydrocarbon inhalation, and hyperoxia. (medscape.com)
Molecular3
  • Dr. Pryhuber trained as a post-doctoral Proctor Research Scholar and participant in the University of Cincinnati Program of Excellence in Molecular Biology of the Heart and Lung. (rochester.edu)
  • Natural lung aging is marked by molecular changes that occur during development, maturation, and late-life decline. (karger.com)
  • In this review, we examine aging as a process dependent on specific changes in molecular pathways within multiple lung cell populations. (karger.com)
Decreased lung injury1
  • In applying an RNAi approach," explains Jack Elias, M.D., chair of internal medicine at Yale University School of Medicine, "we were able to observe in mice that silencing of the Ang2 protein resulted in animals that lived longer and had evidence of decreased lung injury compared to animals with the protein intact. (genengnews.com)
Infants1
Rats4
  • Isolated perfused lungs were prepared from pathogen-free 8‐week-old male Sprague-Dawley rats weighing 250-300 g (n=87). (ersjournals.com)
  • In addition, it requested submission of full discriptions of the lung lesions seen in the new long-term rat study and of historical control data on all lung lesions in the strain of rats utilized in the study in the laboratory in which it was conducted. (inchem.org)
  • to prevent hyperoxia-induced lung injury in neonatal rats. (jefferson.edu)
  • An increase in transforming growth factor α (TGFα) and EGFR in rats with bleomycin-induced lung injury 16 has been observed. (lungdiseasesjournal.com)
Development3
  • The Gordon Research Seminar on Lung Development, Injury and Repair is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting-edge ideas. (grc.org)
  • This GRS will be held in conjunction with the "Lung Development, Injury and Repair" Gordon Research Conference (GRC). (grc.org)
  • The second edition of The Lung: Development, Aging and the Environment provides an understanding of the multi-faceted nature of lung development, aging, and how the environment influences these processes. (bookbaz.ir)
Perinatal2
  • An NIH-funded physician-scientist with expertise in human perinatal lung injury and repair, Dr. Pryhuber also served nine years as Perinatal-Neonatal Fellowship Associate Director and mentors undergraduate, graduate and post-doctoral students. (rochester.edu)
  • Jean JC, George E, Kaestner KH, Brown LA, Spira A, Joyce-Brady M. Transcription factor Klf4, induced in the lung by oxygen at birth, regulates perinatal fibroblast and myofibroblast differentiation. (bu.edu)
Mice2
  • Balog, T., Musa, M., Tartaro Bujak, I. & Sobočanec, S. (2016) The effect of 17β-estradiol on sex-dimorphic cytochrome P450 expression patterns induced by hyperoxia in the liver of male CBA/H mice . (irb.hr)
  • Here, we investigate whether neonatal hyperoxia alters pulmonary function in aging mice. (johnshopkins.edu)
Inhibition1
  • In another study, it was found that this hypercapnia-associated venule dilatation in intact lungs is significantly attenuated in hyperoxia-injured lungs due to inhibition of COX activity by excessive NO 7 . (ersjournals.com)
Surfactant2
  • The aim is to evaluate the effects of 2 consecutive days of intratracheal administration of surfactant and hUC-MSCs on hyperoxia-induced lung injury. (biomedcentral.com)
  • Although the use of exogenous surfactant and protective ventilation strategies has improved survival, the long-term pulmonary consequences of neonatal hyperoxia are unknown. (johnshopkins.edu)
Toxicity1
Respiratory1
  • To study the early changes in the lower respiratory tract in persons exposed to periods of hyperoxia usually considered safe, we evaluated 14 normal subjects by bronchoalveolar lavage before and immediately after 16.7±1.1 hours of breathing more than 95 per cent oxygen. (nebraska.edu)
Metabolism3
  • His focus is on glutathione and glutathione metabolism, particularly in the lung lining fluid that baths the surface of the lung. (bu.edu)
  • Tuzova M, Jean JC, Hughey RP, Brown LA, Cruikshank WW, Hiratake J, Joyce-Brady M. Inhibiting lung lining fluid glutathione metabolism with GGsTop as a novel treatment for asthma. (bu.edu)
  • Joyce-Brady M, Hiratake J. Inhibiting Glutathione Metabolism in Lung Lining Fluid as a Strategy to Augment Antioxidant Defense. (bu.edu)
Tissue4
  • In multiple organs, including the lungs, age-related tissue and organ dysfunction interferes with tissue regeneration, which requires functional stem cells. (karger.com)
  • Stem cells of all organs - including the lung, which harbors distinct stem cells for each separate tissue that makes up the lung as a whole - reside in niches described as a microenvironment that supports and maintains the 'stemness' of cells as a critical reservoir for maintaining tissue homeostasis and responding to injury [ 3 ]. (karger.com)
  • 3 days later, we study lung pathological, the levels of inflammatory factors, and cell apoptosis in the pulmonary tissue was detected by Tunel and cell apoptosis rate was calculated accordingly. (researchsquare.com)
  • Alveolar architecture is destroyed and healthy tissue is replaced by altered extra cellular matrix (ECM), with progressive dyspnoea and impairment of lung function ultimately leading to death 1,2 . (lungdiseasesjournal.com)
Regenerative1
  • Lung failure due to aging can be traced to loss of lung stem cell regenerative capacity within the distinctive stem cell niches found within each compartment of the lung. (karger.com)
Regeneration1
  • In this review, we will present current data on lung aging and lung regeneration, with specific attention paid to stem cell-driven regeneration within the context of aging. (karger.com)
Clinical1
  • She is a scientist at the Benaroya Research Institute and UW Center for Lung Biology and a member of the SCH Center for Clinical and Translational Research. (seattlechildrens.org)
Lipopolysaccharide1
Lavage2
  • Hyperoxia caused a significant alveolar-capillary "leak" as detected by the presence of increased plasma albumin and transferrin in lavage fluid. (nebraska.edu)
  • This treatment may also be used to provide enough oxygen to the lung during a procedure called whole lung lavage, which is used to clean an entire lung in people with certain medical conditions, like pulmonary alveolar proteinosis . (medlineplus.gov)
Asthma1
  • Severe asthma: lessons learned from the National Heart, Lung, and Blood Institute Severe Asthma Research Program. (jefferson.edu)
Severe1
  • One such gene, fibulin-5, is a regulator of elastogenesis and severe emphysema develops with fibulin-5 deficiency in the knock out lung. (bu.edu)
Suppression1
  • His laboratory has also utilized several tools to study gene expression in the developing lung, including suppression subtractive hybridization, differential display and microarrays. (bu.edu)
Cell1