• cancers
  • Phase I trials with paclitaxel, vinorelbine, and docetaxel have demonstrated that tariquidar (XR9576) has minimal pharmacokinetic interactions while surrogate studies have confirmed in vivo inhibition of Pgp-mediated drug transport.This study seeks to determine the pharmacokinetic interaction, if any between docetaxel and tariquidar and to evaluate the potential for activity in lung, ovarian, primary peritoneal, fallopian tube and cervical cancers. (clinicaltrials.gov)
  • Erlotinib (TarcevaTM) is a newer drug which has shown benefit for patients with lung cancers that contain an EGFR mutation. (clinicaltrials.gov)
  • They are also reported as having a "low mammary tumour incidence, but do develop other types of cancers in later life, most commonly reticular neoplasms, lung tumours, and renal tumours. (wikipedia.org)
  • Aside from the great heterogeneity seen in lung cancers (especially those occurring among tobacco smokers), the considerable variability in diagnostic and sampling techniques used in medical practice, the high relative proportion of individuals with suspected GCCL who do not undergo complete surgical resection, and the near-universal lack of complete sectioning and pathological examination of resected tumor specimens prevent high levels of quantitative accuracy. (wikipedia.org)
  • In an American study of a database of over 60,000 lung cancers, GCCL comprised between 0.3% and 0.4% of primary pulmonary malignancies, with an age-adjusted incidence rate of about 3 new cases per million persons per year. (wikipedia.org)
  • With approximately 220,000 total lung cancers diagnosed in the US each year, the proportion suggests that approximately 660 and 880 new cases are diagnosed in Americans annually. (wikipedia.org)
  • These variants are increasingly appreciated as having different genetic, biological, and clinical properties, including prognoses and responses to treatment regimens, and therefore, that correct and consistent histological classification of lung cancers are necessary to validate and implement optimum management strategies. (wikipedia.org)
  • About 1% of lung cancers are sarcomas, germ cell tumors, and hematopoietic tumors, while 99% of lung cancers are carcinoma. (wikipedia.org)
  • Approximately 95% of lung cancers are carcinoma, or tumors derived from transformed cells of epithelial lineage. (wikipedia.org)
  • pleura
  • Protecting each lung is the pleura, a two-layered membrane that envelops the lung and contains lubricating fluid between its inner and outer layers. (thefreedictionary.com)
  • It occurs when either local or generalized fibrotic changes in the lung or pleura hamper expansion and increase elastic recoil during expiration. (wikipedia.org)
  • In rounded atelectasis (Folded lung or Blesovsky syndrome), an outer portion of the lung slowly collapses as a result of scarring and shrinkage of the membrane layers covering the lungs (pleura), which would show as visceral pleural thickening and entrapment of lung tissue. (wikipedia.org)
  • renal
  • Other disease states that increase the risk of developing tuberculosis are Hodgkin lymphoma, end-stage renal disease, chronic lung disease, malnutrition, and alcoholism. (wikipedia.org)
  • Gefitinib
  • Intercalated administration of Iressa┬« (gefitinib) on days 5-18 of chemotherapy cycle improve the efficacy of Pemetrexed/platinum regimen given as first-line treatment for never-smokers with advanced (stage IIIB/IV) lung adenocarcinoma. (clinicaltrials.gov)
  • Investigators hope to show that intercalated administration of Iressa┬« (gefitinib) and Pemetrexed/platinum regimen improves the outcome of never-smokers with advanced (stage IIIB/IV) lung adenocarcinoma. (clinicaltrials.gov)
  • tissue
  • The lungs are made of elastic tissue filled with interlacing networks of tubes and sacs carrying air, and with blood vessels carrying blood. (thefreedictionary.com)
  • Although frequently described as a collapse of lung tissue, atelectasis is not synonymous with a pneumothorax, which is a more specific condition that features atelectasis. (wikipedia.org)
  • pleural
  • The lungs are surrounded by an airtight compartment, the pleural space within the pleural membrane. (thefreedictionary.com)
  • Relief of pneumothorax and collapse of the lung from accumulations of either air or fluids within the pleural space may be provided by aspiration of the air or fluid from the thoracic cavity ( thoracentesis ) or by insertion of chest tubes to provide for a gradual reexpansion of the lung. (thefreedictionary.com)
  • It is usually associated with accumulation of blood, fluid, or air within the pleural cavity, which mechanically collapses the lung. (wikipedia.org)
  • chronic
  • The blocked, contracted lung may develop pneumonia that fails to resolve completely and leads to chronic inflammation, scarring, and bronchiectasis. (wikipedia.org)
  • large
  • If a large volume of nitrogen in the lungs is replaced with oxygen, the oxygen may subsequently be absorbed into the blood, reducing the volume of the alveoli, resulting in a form of alveolar collapse known as absorption atelectasis. (wikipedia.org)