MetastasisComponents of the tumor microenvironmentEstimated infiltrationImmunotherapyImmune cellsGenomicsPrimary tumorMetastaticSquamous Cell CarcCancersInhibited tumor growthTissuesGenesBiomarkersMalignantPrognosisSuppressorMetastasesHeterogeneitySubtypesNSCLCTissueCell ProliferationLUADPrognosticHypoxic tumorImportant role in inhibCarcinomaMolecularOncologyCellsPancreatic cancerLymphocytesMacrophagesMechanismAntigensRemains unclearDistinctBreastMutationsClinicalHuman lungGrowthFibroblastsDisease progression2019Drug resistanceContributesInteractionsInflammatoryMetabolismSurvivalMiceResearchersKrasExtracellularEpidermal
Metastasis17
- We aimed to elucidate the microenvironmental changes in the process of lymphatic metastasis of lung squamous cell carcinoma. (elsevierpure.com)
- We are applying our knowledge of how tumor cells interact with immune cells and other components of the tumor microenvironment to play a critical role in cancer initiation, progression, metastasis, and drug resistance. (janssen.com)
- However, the molecular changes driving lung cancer invasion and metastasis remain unclear. (aacrjournals.org)
- In this study, we identified fibulin-5, a vascular ligand for integrin receptors, as a suppressor of lung cancer invasion and metastasis. (aacrjournals.org)
- Furthermore, overexpression of fibulin-5 in H460 lung cancer cells inhibited metastasis in mice. (aacrjournals.org)
- Collectively, these results suggest that epigenetic silencing of fibulin-5 promotes lung cancer invasion and metastasis by activating MMP-7 expression through the ERK pathway. (aacrjournals.org)
- The 5-year survival rate of lung cancer is below 20%, with most patients dying from distant metastasis ( 1 ). (aacrjournals.org)
- However, the mechanism of lung cancer metastasis is poorly understood. (aacrjournals.org)
- Tumor metastasis is characterized by cell detachment from primary tumors and invasion of recipient tissues ( 2 ). (aacrjournals.org)
- Firstly, the transcriptome landscape of heterogeneous cell types in LUAD was analyzed and memory T cells, NK cells, and helper T cells were revealed to be the common immune cells in tumor, normal, and metastasis tissue, respectively. (aging-us.com)
- Next, the results of cell-cell communication analysis suggested that pericytes interact with broad immune cells via MDK-NCL pathways in metastasis samples, MIF-(CD74+CXCR4) and MIF-(CD74+CC44) interaction especially occurred between different cell types in tumor and normal samples. (aging-us.com)
- Cancer Network spoke with Sheila A. Stewart, PhD, on how age-related changes in the tumor microenvironment may impact progression and metastasis. (cancernetwork.com)
- Mortality from breast cancer is almost exclusively a result of tumor metastasis, and lungs are one of the main metastatic sites. (aftau.org)
- Some tumor suppressor proteins are involved in maintaining cell adhesion, preventing cells from breaking away and spreading to other parts of the body (metastasis). (pharmiweb.com)
- Welcome to the 5 th mini symposium in the Tumor immunology, Tumor microenvironment (TME) & metastasis LUCC network . (lu.se)
- RHAMM regulates MMTV-PyMT-induced lung metastasis by connecting STING-dependent DNA damage sensing to interferon/STAT1 pro-apoptosis signaling. (medscape.com)
- Noninvasive prediction of axillary lymph node breast cancer metastasis using morphometric analysis of nodal tumor microvessels in a contrast-free ultrasound approach. (medscape.com)
Components of the tumor microenvironment2
- The authors point out that while clinical studies that target components of the tumor microenvironment in this setting are still limited, the integration of preclinical findings described here may help facilitate novel clinical strategies for the prevention and treatment of brain metastases. (aacr.org)
- Plenty of research had reported that the tumor immune microenvironment (TIME) impacts cancer progression and metastases, as well as affects patient prognoses and outcomes [ 6 , 7 ], which emphasizes the important role of immune cells, vital components of the tumor microenvironment, impacting on patient survival and tumor progression [ 8 , 9 ]. (aging-us.com)
Estimated infiltration1
- With the development of bioinformatics in recent years and the acquisition of open lung cancer cohorts, it becomes possible to evaluate tumor purity content in the samples according to the estimated infiltration of stromal and immune cells ESTIMATE algorithm [ 7 ]. (hindawi.com)
Immunotherapy12
- Recent work has focused on the signaling, metabolic, and transcriptional mechanisms of T cell regulation as well as tumor-elicited innate and adaptive immune responses, and how this knowledge can be translated for novel cancer immunotherapy. (spotify.com)
- The Schalper Laboratory focuses on defining novel predictive biomarkers to identify responders and non-responders among patients who are being treated with immunotherapy for lung cancer. (yale.edu)
- The research goal of the Hata laboratory is to advance the development of novel targeted and immunotherapy approaches to benefit patients with lung cancer. (massgeneral.org)
- While checkpoint immunotherapy has revolutionized the treatment of patients with non-small cell lung cancer (NSCLC), a subset of patients develop hyperprogressive disease, yet the pathological features or underlying mechanisms for this association have yet to be fully understood. (aacr.org)
- In patients with metastatic renal cell carcinoma, neoadjuvant immunotherapy-based combinations yielded reductions in tumor size and pathologic necrosis at the time of cytoreductive nephrectomy. (cancernetwork.com)
- Immunotherapy has emerged as a major weapon in the battle against non-small cell lung cancer, which makes up 80-85 per cent of all lung cancer diagnoses. (ecancer.org)
- The research team examined the HLAs of 179 non-small cell lung cancer patients and found a strong link between the genetic makeup of the HLAs and whether the person was likely to develop side effects from immunotherapy. (ecancer.org)
- Study lead Dr Afaf Abed said this discovery would benefit all non-small cell lung cancer patients, regardless of whether they were genetically predisposed to adverse reactions to immunotherapy or not. (ecancer.org)
- Your test results will show whether you have enough PD-L1 protein in your tumor for you to benefit from a specific immunotherapy medicine. (medlineplus.gov)
- Your tumor cells have enough PD-L1 for you to use immunotherapy medicine, you may be able to start that medicine. (medlineplus.gov)
- however, it is far from ideal because PD-L1-negative tumors may respond to immunotherapy and positive tumors may not. (medscape.com)
- Other factors have been suggested to correlate with response to immunotherapy based on clinical and preclinical studies, including elevated type 1 helper T cell (Th1) tumoral gene signature, [ 11 ] and IFN-γ expression, possibly attributable to its ties to other proteins and cytokines within the tumor microenvironment. (medscape.com)
Immune cells13
- Besides, the tumor metabolic preferences vary across histologic subtypes and may correspondingly impinge on the metabolism and function of immune cells. (nih.gov)
- INTRODUCTION: Immune cells in the tumour microenvironment are associated with prognosis and response to therapy. (lu.se)
- RESULTS: CD4-Eff cells, CD8-Eff cells and M1 macrophages were the most abundant immune cells invading the tumour cell compartment and indicated a patient group with a favourable prognosis in the cluster analysis. (lu.se)
- Yellow, red, white, blue and pink: various types of immune cells including macrophages, neutrophils, dendritic cells and T cells which closely interact with the tumor. (mit.edu)
- We try to understand how immune cells control tumor growth. (mit.edu)
- We also assessed its status regarding distinct tumor-infiltrating immune cells, using the Oncomine database, TIMER databases, GEPIA, Kaplan-Meier plotter, and UALCAN database. (hindawi.com)
- Our results clarified the significant role of DOK5 in the prognosis of GC and offer a potential mechanism by which DOK5 expression might monitor tumor immunity-regulation of the infiltration of immune cells in GC. (hindawi.com)
- The Tumor Immune Estimation Resource (TIMER) platform has been used to assess the tumor-infiltrating immune cells of 32 cancer types in a comprehensive way. (hindawi.com)
- TIMER assesses a mass of tumor-infiltrating immune cells using the statistical analysis of the gene expression profiles [ 7 ]. (hindawi.com)
- The Dlk1-Dio3 locus repression mediated by Snail was found to occur specifically in several populations of tumor-infiltrating immune cells. (oncotarget.com)
- CIBERSORT and TIMER algorithms confirmed that there are significant differences in tumor-infiltrating immune cells in different risk groups. (techscience.com)
- We will therefore apply spatial single-cell transcriptomic sequencing and multiplex immunohistochemistry (mIHC) to characterize the properties and spatial distribution of tumour and immune cells in brain metastases from melanoma, breast and lung cancer patients. (lu.se)
- We reason that future therapeutic strategies should target communities of tumour and immune cells and their signalling networks rather than individual genes or cell types. (lu.se)
Genomics2
- He also consults on patients for precision oncology, partnering with the Institute for Genomic Medicine to identify therapeutic approaches based on patient tumor and germline genomics. (spotify.com)
- Our lab is also examining tumor genomics in early stage LUAD and has built a comprehensive clinically- and genomically-annotated database. (mskcc.org)
Primary tumor3
- The term "pre-metastatic niche" has been used to define a particular microenvironment suitable for tumor cell attachment and growth to which primary tumor cells metastasize. (acponline.org)
- Breast cancer patients, as well as patients with many other types of cancer, do not die from the primary tumor, but from distant metastases which have developed, sometimes after years, in essential organs such as the lungs and brain," said the study's lead researcher, Professor Neta Erez , Chair of the Department of Pathology at TAU's Sackler Faculty of Medicine . (aftau.org)
- thus, a successful metastatic colony depends on the ability of cancer cells to appropriate distinct microenvironments at each step in the metastatic cascade: the primary tumor, systemic circulation, and the final metastatic destination. (medscape.com)
Metastatic6
- these studies indicate that reciprocal interactions between tumor cells and brain stromal cells facilitate metastatic growth. (aacr.org)
- Wang H , Han G , Chen J , . Heterogeneity of tumor immune microenvironment in malignant and metastatic change in LUAD is revealed by single-cell RNA sequencing. (aging-us.com)
- We investigate BRMS1-mediated suppression of metastases in p53mut lung adenocarcinoma (LUAD), as well as the identification of a novel germline point mutation of BRMS1 variant 2, a pro-metastatic variant. (mskcc.org)
- Breast metastatic tumors in lung can be substituted by lung-derived malignant cells transformed by alternative splicing H19 lncRNA. (medscape.com)
- Metastatic tumors to the oral region are uncommon and may occur in the oral soft tissues or jawbones. (medscape.com)
- Because of their rarity, metastatic tumors to the oral region are challenging to diagnose. (medscape.com)
Squamous Cell Carc3
- In lung squamous cell carcinoma, drastic microenvironmental changes (e.g., growth factor receptor expression and proliferative capacity of tumor cells and structural changes in stromal cells) occur during both the process of lymphatic permeation and the progression into macrometastases. (elsevierpure.com)
- Prognostic value of immune-related genes in the tumor microenvironment of lung adenocarcinoma and lung squamous cell carcinoma. (cdc.gov)
- Several classes of drug have been approved for the treatment of melanoma, renal cell carcinoma, non-small cell lung cancer, bladder cancer, and head and neck squamous cell carcinoma, among others. (medscape.com)
Cancers13
- Furthermore, the Food & Drug Administration (FDA)-approved mIDH1 inhibitor ivosidenib (AG-120) dramatically inhibited tumor growth in preclinical models of pancreatic cancer, highlighting this approach as a potential therapeutic strategy against wild-type IDH1 cancers. (nature.com)
- Here we analyse 258 regions from 88 early-stage, untreated non-small-cell lung cancers using RNA sequencing and histopathology-assessed tumour-infiltrating lymphocyte estimates. (nih.gov)
- Our results suggest that the immune microenvironment exerts a strong selection pressure in early-stage, untreated non-small-cell lung cancers that produces multiple routes to immune evasion, which are clinically relevant and forecast poor disease-free survival. (nih.gov)
- PJS is autosomal-dominant condition caused by mutations of STK11, characterized by gastrointestinal polyposis, mucocutaneous pigmentation, and predisposition to a range of epithelial cancers: including colorectal, gastric, pancreatic, breast, ovarian cancers and sex cord tumors with annular tubules). (cancerindex.org)
- Most patients carry a missing or damaged p53 gene, a tumor suppressor whose activity is impaired in almost 50% of all cancers. (nature.com)
- Our focus is on understanding biological mechanisms that dictate drug sensitivity and resistance in oncogene-addicted lung cancers (those with activating genetic alterations EGFR, ALK, KRAS, etc. (massgeneral.org)
- Lung cancers that harbor activating EGFR mutations and ALK fusions are exquisitely sensitive to small molecule EGFR and ALK tyrosine kinase inhibitors, respectively. (massgeneral.org)
- Similar patterns of sensitivity and acquired resistance are also observed in other subsets of oncogene- addicted lung cancers treated with molecularly targeted therapies (e.g. (massgeneral.org)
- In collaboration with oncologists in the Mass General Center for Thoracic Cancers, we have identified acquired secondary mutations and other genomic alterations that cause drug resistance in the tumors and blood of patients progressing after initial response to targeted therapies. (massgeneral.org)
- Work by our group revealed that many KRAS mutant lung cancers exhibit decreased oncogenic dependency and a dampened apoptotic response that contributes to intrinsic resistance to KRAS targeted therapy. (massgeneral.org)
- These findings demonstrate that distinct protein isoforms may differentially contribute to diverse biological mechanisms and to the pathogenesis of cancers, potentially paving the road to identify new diagnostic markers or new therapeutic targets," said Dr. Diaz, Head of the Division of Solid Tumor Oncology at Memorial Sloan Kettering Cancer Center. (tmcnet.com)
- Report From the International Society of Urological Pathology (ISUP) Consultation Conference on Molecular Pathology of Urogenital Cancers: IV: Current and Future Utilization of Molecular-Genetic Tests for Testicular Germ Cell Tumors. (cdc.gov)
- This article focuses mainly on nonmelanoma skin cancers, with an emphasis on rare benign and malignant epithelial, dermal, and adnexal tumors. (medscape.com)
Inhibited tumor growth1
- In vivo, QRHX both inhibited tumor growth and decreased the number of tumor-associated macrophages (TAMs) in mice with lung cancer. (liankebio.com)
Tissues7
- These nontumor cells dilute the tumor purity in lung cancer tissues. (hindawi.com)
- We measured tumor purity in 486 lung carcinoma tissues from TCGA-LUAD FPKM by using the "estimate" R package. (hindawi.com)
- We are now aware that lung cancer tissues are rich in nontumor cells, of which stromal cells significantly regulate tumor proliferation, invasion, and angiogenesis [ 6 ]. (hindawi.com)
- For scRNAseq, tumor tissues are digested, causing cell death, and the resultant transcriptomic profile is incomplete. (bmj.com)
- To generate a holistic profile of CAF subtypes within NSCLC, and identify the subpopulation that promotes CTL exclusion, we have utilized the GeoMX® Digital Spatial Profiler (DSP) 14-17 , a state-of-the-art platform that allows for spatially resolved, high-plexed molecular profiling of intact tumor tissues. (bmj.com)
- It gives optional functions like differential expression analysis in tumors as well as normal tissues. (hindawi.com)
- The researchers also found that whereas the ratio of certain fungal species was similar in non-tumour tissues and some tumour tissues, other, more aggressive tumour subtypes had a greater difference in the proportion of these species. (who.int)
Genes10
- Five coexpressed genes (CD4, CD53, EVI2B, PLEK, and SASH3) were identified as tumor purity coexpressed genes that negatively correlated with tumor purity. (hindawi.com)
- Using GSEA analysis, we found that the antigen processing and presentation pathway were related to the five tumor coexpressed genes mentioned above. (hindawi.com)
- NSG data was analyzed with DESeq2 to identify genes that were differentially expressed in CAFs living in CTL-exclusive tumors. (bmj.com)
- Results We identified 441 genes that were differentially expressed in CAFs residing in CTL-exclusive tumors compared to CAFs in CTL-inclusive tumors. (bmj.com)
- Then, marker genes were calculated and 709 genes were identified to play a vital role in the microenvironment of LUAD. (aging-us.com)
- We discovered that Snail mediated the downregulation of the imprinted Dlk1-Dio3 locus, a complex genomic region containing protein-coding genes and non-coding RNAs that has been linked to tumor malignancy in lung cancer patients. (oncotarget.com)
- The researchers compared genes sequenced from healthy lungs, from lungs with micro-metastases (very small metastases which cannot be identified using existing clinical tools) and from lungs with large metastases, in a state of advanced disease. (aftau.org)
- As published in PLOS ONE , the findings show this subpopulation of cells within the tumor microenvironment communicates with the tumor and results in increased expression of certain genes involved in signaling and matrix adhesion. (uvm.edu)
- Tumor suppressor genes code for proteins that inhibit cell division and growth, acting as a control mechanism to prevent excessive cell proliferation. (pharmiweb.com)
- Tumor suppressor genes can promote cellular senescence, a state in which cells stop dividing, preventing the replication of damaged DNA. (pharmiweb.com)
Biomarkers2
- The aim of this study was to identify valuable biomarkers by searching the candidate molecules that contribute to lung adenocarcinoma pathogenesis, especially KC subtype. (cancerindex.org)
- Scientists from Seer in collaboration with Luis Diaz, M.D. from Memorial Sloan Kettering Cancer Center found previously unknown associations between four protein isoforms and non-small cell lung cancer (NSCLC) progression, constituting potential novel, disease-relevant biomarkers, or therapeutic targets. (tmcnet.com)
Malignant3
- Although studies have revealed the mechanisms involved in cancer malignant characteristics and identified reasonable therapeutic targets [ 4 ], current clinical prediction and treatment outcome of lung cancer are not satisfactory [ 5 ]. (hindawi.com)
- Lung cancer is the first leading diagnosed malignant tumor globally [ 1 ]. (medsci.org)
- As with all tumors, whether benign or malignant, the paradigm of comprehension depends on identifying the cell or cell layer of origin. (medscape.com)
Prognosis2
- In this study, we systematically assessed DOK5 expression in a variety of tumor forms involving GC, as well as its association with prognosis. (hindawi.com)
- EBV-positive tumors have a higher frequency of Crohn's disease-like lymphoid reaction that correlates with an improved prognosis in patients with gastric cancer. (medscape.com)
Suppressor3
- This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. (cancerindex.org)
- A tumor suppressor gene, also known as anti-onco gene, is an essential component of the body's defense against cancer. (pharmiweb.com)
- Many tumor suppressor proteins play a role in DNA repair, helping to correct genetic mutations and maintain the stability of the genome. (pharmiweb.com)
Metastases5
- Multiple distant metastases are the major cause of mortality in lung cancer. (aging-us.com)
- C57Bl/6 mice (n=23) were injected subcutaneously with 105 syngeneic LLCa and sacrificed 12-23 days later, before and after established lung metastases. (acponline.org)
- As a surgeon-scientist who cares for patients with earlier stage lung and esophageal cancer, my laboratory studies why patients with completely resected cancer still develop metastases and die. (mskcc.org)
- Using spatial whole transcriptomics on four lung cancer brain metastases we have previously shown that lung cancer brain metastases exhibit significant interpatient heterogeneity in their gene expression but feature consistent immune cell communities that could be clinically exploited. (lu.se)
- The prognostic and therapeutic implications of these immune and tumour communities are still unknown but will be explored in this project which includes brain metastases from 56 patients. (lu.se)
Heterogeneity2
- The diversity of histologic composition reflects the inter- and intra-tumor heterogeneity of lung adenocarcinomas (LUADs) macroscopically. (nih.gov)
- Although related treatment has improved, there are still challenges in combating tumor heterogeneity due to prognostic prediction difficulty ( Eisenstein, 2015 ). (techscience.com)
Subtypes3
- Insights into the oncological characteristics and tumor microenvironment (TME) of different histologic subtypes of LUAD at the single-cell level can help identify potential therapeutic vulnerabilities and combinational approaches to improve the survival of LUAD patients. (nih.gov)
- Recent research has classified lung adenocarcinoma patients with KRAS mutation into three subtypes by co-occurring genetic events in TP53 (KP subgroup), STK11/LKB1 (KL subgroup) and CDKN2A/B inactivation plus TTF-1 low expression (KC subgroup). (cancerindex.org)
- To unravel the role of the distinct genetic features of lung cancer subtypes among patients, new research opportunities and technologies have arisen that might contribute to different therapeutic decisions [ 4 , 5 ]. (aging-us.com)
NSCLC6
- We aimed to comprehensively characterise the spatial immune phenotypes in the mutational and clinicopathological background of non-small cell lung cancer (NSCLC). (lu.se)
- Background Cancer-associated fibroblasts (CAFs) are a major component of the non-small cell lung cancer (NSCLC) tumor microenvironment (TME). (bmj.com)
- Kilvaer TK, Khanehkenari MR, Hellevik T, Al-Saad S, Paulsen E-E, Bremnes RM, Busund L-T, Donnem T, Martinez IZ (2015) Cancer Associated Fibroblasts in Stage I-IIIA NSCLC: Prognostic Impact and Their Correlations with Tumor Molecular Markers. (bmj.com)
- Led by Balazs Halmos, MD, hematologist/oncologist with the Ireland Cancer Center, the research team followed up on their previous study, published in the New England Journal of Medicine, which found that lung cancer cells can become resistant to novel targeted agents, such as Tarceva (erlotinib), a medication in widespread use for non-small-cell lung cancer (NSCLC). (sciencedaily.com)
- In preclinical models utilizing human lung cancer cells and specific NSCLC mutational subsets, the researchers found that tumor growth was enhanced by anti-PD-1 treatment but not by anti-PD-1 F(ab) 2 fragments, which lack the Fc portion of the antibody. (aacr.org)
- Non-small cell lung cancer (NSCLC) accounts for 85-90% of cases, while lung adenocarcinoma (LUAD) is the most common subtype [ 2 ]. (medsci.org)
Tissue10
- The structure of tumor tissue is complex. (hindawi.com)
- Methods We performed digital spatial profiling on a tissue microarray (TMA) slide containing fifty-five cores of human lung tumors. (bmj.com)
- During lung cancer progression, the connective tissue of bronchial walls provides the scaffold for developing tumors, forms tissue barriers against immune responses of the host and/or constitutes the routes for the invasion of cancer cells ( 12 ). (spandidos-publications.com)
- The researchers identified these changes in the area known as "the micro-environment" of the tumor, and specifically in connective tissue known as fibroblasts which are found in the lungs among other places. (aftau.org)
- A PD-L1 test uses a sample of cancerous tumor tissue to measure how much of a protein called PD-L1 is found on the cancer cells. (medlineplus.gov)
- PD-L1 testing is used to look for the PD-L1 protein on cancer cells in a sample of tumor tissue. (medlineplus.gov)
- PD-L1 tests are done on a tissue sample from a tumor. (medlineplus.gov)
- If you aren't having the tumor removed, you may have a biopsy , which is a procedure to remove a small amount of tissue for testing. (medlineplus.gov)
- Scientists from the International Agency for Research on Cancer (IARC) and partner institutions investigated the amount of fungus present in lung adenocarcinoma tissue and found that the abundance of fungi in tumour tissue was higher than that in matched non-tumour tissue. (who.int)
- However, the progenitor cells consist of T cells isolated from resected tumor tissue. (msdmanuals.com)
Cell Proliferation1
- Direct invasion by carcinoma cells of the stromal compartment involves active proteolysis effected principally by matrix metalloproteinases (MMPs), while degrading the BM and other ECM that lie in the path of invading tumor cells, MMP-expressing cells also liberate growth factors that are sequestered there, thereby fostering cancer cell proliferation. (medscape.com)
LUAD5
- Lung adenocarcinoma (LUAD) is the most common type of non-small cell lung cancer and accounts for approximately 40% of all lung cancer cases. (aging-us.com)
- Lung adenocarcinoma (LUAD) is the most common histological type of lung cancer and has the highest cancer mortality rate worldwide [ 1 ]. (aging-us.com)
- However, the underlying functions of STARDs in lung adenocarcinoma (LUAD) have not been clarified yet. (medsci.org)
- Here, we showed that TP53 loss initiated a pharmacologically actionable secretory process that drove lung adenocarcinoma (LUAD) progression. (jci.org)
- G55-dependent secreted proteins enhanced the proliferative and invasive activities of TP53-deficient LUAD cells and promoted angiogenesis and CD8+ T cell exhaustion in the tumor microenvironment. (jci.org)
Prognostic3
- Potential mechanistic links between the asthmatic process and lung cancer progression suggest that bronchial asthma should be included in the list of potential prognostic markers for lung cancer therapy. (spandidos-publications.com)
- Prognostic value and therapeutic implications of expanded molecular testing for resected early stage lung adenocarcinoma. (cdc.gov)
- Comparison of commonly used solid tumor targeted gene sequencing panels for estimating tumor mutation burden shows analytical and prognostic concordance within the cancer genome atlas cohort. (cdc.gov)
Hypoxic tumor1
- See here how lipid loading may be involved in the paracrine crosstalk between cancer cells and stromal compartment of the hypoxic tumor microenvironment. (lu.se)
Important role in inhib1
- Thus, we draw that QRHX played a more important role in inhibiting tumor growth by regulating TAMs in mice, which was found to be associated with the inhibition of inflammation and the CXCL12/CXCR4/JAK2/STAT3 signaling pathway. (liankebio.com)
Carcinoma6
- Lung carcinoma tumor mutation burden was calculated by analyzing TCGA single nucleotide polymorphism data. (hindawi.com)
- Based on the tumor purity and lung carcinoma gene matrix, we performed weighted gene coexpression network analysis (WGCNA), and the tumor purity-related module was identified. (hindawi.com)
- Li L, Lu G, Liu Y, Gong L, Zheng X, Zheng H, Gu W, Yang L (2021) Low Infiltration of CD8+ PD-L1+ T Cells and M2 Macrophages Predicts Improved Clinical Outcomes After Immune Checkpoint Inhibitor Therapy in Non-Small Cell Lung Carcinoma. (bmj.com)
- Subcutaneous injection of the SWCNT-exposed NHLFs along with human lung carcinoma H460 cells in NSG mice resulted in a high rate of tumor formation compared with the coinjection of vehicle-exposed NHLFs and H460 cells, indicating the tumor-promoting effect of SWCNT-exposed NHLFs. (cdc.gov)
- Together, our study unveils a novel mechanism of CNT-promoted lung carcinoma through the acquisition of CAFs that regulate CSC formation. (cdc.gov)
- Skin malignancies, Merkel cell carcinoma and rare appendageal tumors. (medscape.com)
Molecular3
- Tarceva is among a new generation of cancer therapies that disrupt the molecular target responsible for stimulating tumor growth. (sciencedaily.com)
- In this latest study, that received an award at the annual American Association for Cancer Research (AACR) meeting where it was presented earlier this month, Dr. Halmos and his team were able to predict molecular changes the tumors might take next to become resistant to this new class of agents. (sciencedaily.com)
- In the Politi Laboratory, we study mechanisms of lung tumorigenesis and in particular, the molecular features of tumors that determine response and resistance to targeted drugs. (yale.edu)
Oncology1
- Our approach is highly translational, integrating assessment of clinical specimens with generation and analysis of patient-derived cell culture and mouse tumor xenograft (PDX) models, performed in close collaboration with clinicians in the MGH Thoracic Oncology group. (massgeneral.org)
Cells31
- In addition to tumor cells, there are also other components such as stromal cells, inflammatory cells, vasculature, and the extracellular matrix [ 1 ]. (hindawi.com)
- Remarkably, tumor cells from solid LUADs upregulate energy and substance metabolic activities, particularly the folate-mediated one-carbon metabolism and the key gene MTHFD2, which could serve as a potential therapeutic target. (nih.gov)
- Herein, we also demonstrate that compounds developed to target mutant IDH1 can be repurposed as wild-type IDH1 inhibitors, because these drugs surprisingly become potent inhibitors of wtIDH1 in cancer cells under conditions present in tumors: specifically, we found that wtIDH1 is critical for PDAC cell survival under low-glucose conditions, and allosteric IDH inhibitors effectively block wtIDH1 activity under low magnesium. (nature.com)
- The ED1SQ4 murine lung cancer cells were derived in our laboratory from ED1 cells 25 . (beingmedicos.com)
- Murine adenocarcinoma lung cancer 344SQ cells (0.5 × 10 5 cells) were injected subcutaneously into male 129/Sv mice (Charles River Laboratories, Wilmington, MA). (beingmedicos.com)
- We pursue a deep understanding of the relationships between cancer cells and the tumor microenvironment - the cellular environment in which tumors exist. (janssen.com)
- Researchers have developed methods for treating lung cancer cells that have become resistant to new anti-cancer agents, such as Tarceva (erlotinib). (sciencedaily.com)
- Researchers at the Ireland Cancer Center of University Hospitals Case Medical Center have developed methods for treating lung cancer cells that have become resistant to new anti-cancer agents. (sciencedaily.com)
- Carbon nanotube s promote lung tumor progression through the induction of cancer-associated fibroblasts and cancer stem-like cells. (cdc.gov)
- In the present study we investigated whether CNTs can induce CAFs and whether these cells can promote tumor formation in a xenograft mouse model. (cdc.gov)
- To estimate the effect of the asthmatic microenvironment on the invasiveness of lung cancer cells, the present study compared the behavior of human non‑small cell lung cancer A549 cells exposed to the signals from human bronchial fibroblasts (HBFs) derived from non‑asthmatic donors (NA HBFs) and from asthmatic patients (AS HBFs). (spandidos-publications.com)
- These data indicated that the interactions between lung cancer cells and HBFs in asthmatic bronchi may facilitate the colonization of lung tumors by fibroblasts. (spandidos-publications.com)
- It further stabilizes the tumor microenvironment and potentially facilitates collective colonization of novel bronchial loci by cancer cells. (spandidos-publications.com)
- However, the contribution of asthmatic bronchial fibroblasts in systemic dissemination of lung cancer cells remains unaddressed. (spandidos-publications.com)
- To elucidate the links between their function and the progression of lung cancer, we compared the behavior of human non-small cell lung cancer A549 cells exposed to the signals from monolayers of AS HBFs and from HBFs derived from non-asthmatic (NA) donors. (spandidos-publications.com)
- It has been reported that bone marrow-derived hematopoietic progenitor cells (HPC) migrate to secondary locations prior to tumor cells. (acponline.org)
- The Northern New England Clinical and Translational Research Network supported these findings through the acquisition of equipment essential for the isolation, identification, and characterization of cells from breast tumor samples. (uvm.edu)
- Cells are potent to go under abnormal growth processes and finally lead to tumor/cancer. (pharmiweb.com)
- Tumor suppressors are involved in regulating the cell cycle, ensuring that cells only divide when necessary and that the process is tightly controlled. (pharmiweb.com)
- These findings show that the presence and ratio of fungal species in cancer cells - the intratumour mycobiome - can, despite their low abundance, promote tumour progression by inducing an immunosuppressive microenvironment. (who.int)
- A number of immunologic interventions, both passive and active, can be directed against tumor cells. (msdmanuals.com)
- Lymphokine-activated killer (LAK) cells are produced from the patient's T cells which are extracted from the tumor and grown in a cell culture system with the lymphokine interleukin-2 (IL-2). (msdmanuals.com)
- Tumor-infiltrating lymphocytes (TILs) may have greater tumoricidal activity than LAK cells. (msdmanuals.com)
- This process theoretically provides a line of T cells with greater tumor specificity than those obtained from the blood. (msdmanuals.com)
- Антигени пухлин Many tumor cells produce antigens, which may be released in the bloodstream or remain on the cell surface. (msdmanuals.com)
- TAAs) with high specificity to tumor cells. (msdmanuals.com)
- Chimeric antigen receptors (CAR) recognize specific proteins on the surface of tumor cells. (msdmanuals.com)
- In contrast to TCR T cells, CAR T cells recognize only relatively large proteins on the surface of tumor cells. (msdmanuals.com)
- Concomitant use of interferon enhances the expression of major histocompatibility complex (MHC) antigens and TAAs on tumor cells, thereby augmenting the killing of tumor cells by the infused effector cells. (msdmanuals.com)
- These steps are supported by functions of the cancer cells themselves or of the tumor microenvironment. (medscape.com)
- Although tumor-associated angiogenesis has traditionally been defined as the sprouting of new vessels from preexisting vessels, it is becoming clear that the blood vessels that support tumor growth can also originate from cells recruited from the bone marrow or can even differentiate from tumor stem cells (vascular mimicry). (medscape.com)
Pancreatic cancer1
- The unique approaches used in this study, including single cell transcriptomics, provide valuable insight into the tumor microenvironment and can be utilized for the characterization of additional solid tumors including prostate, ovarian, lung, and pancreatic cancer. (uvm.edu)
Lymphocytes1
- Tumor microenvironment possesses complexity because of a mixture of growth-promoting and inhibiting growth factors, nutrients, chemokines, and other noncancer types, which interact with each other and associate with tumor growth, disease progression, drug resistance, and especially, infiltrating T lymphocytes and tumor growth [ 2 ]. (hindawi.com)
Macrophages2
- Here, we examined the effects of QRHX on lung cancer cell invasion and the potential associated mechanism(s), mainly polarization of macrophages in the tumor microenvironment. (liankebio.com)
- of 152 evaluable patients, 39 (25.7 percent) developed hyperprogressive disease, all of which showed tumor infiltration by M2-like CD163 + CD33 + PD-L1 + clustered epitheloid macrophages in pretreatment samples. (aacr.org)
Mechanism3
- We explored the coexpression factors most related to tumor purity and related biological functions and demonstrated the most relevant biological functions and mechanism of action affecting tumor purity in the lung cancer tumor microenvironment. (hindawi.com)
- The mechanism by which SWCNT-exposed fibroblasts promote tumor growth was shown to involve cancer stem cell (CSC) induction, as determined by tumor sphere formation and side population assays. (cdc.gov)
- In the present study, we used a transcriptomics approach to elucidate the mechanism of Snail-mediated tumor growth promotion in a Kras LSL-G12D/+ ;p53 fl/fl mouse model of lung adenocarcinoma. (oncotarget.com)
Antigens1
- Immune-infiltrated tumour regions exhibited ongoing immunoediting, with either loss of heterozygosity in human leukocyte antigens or depletion of expressed neoantigens. (nih.gov)
Remains unclear2
- At present, the biological processes related to the purity of lung cancer tumors remains unclear. (hindawi.com)
- The interplay between an evolving cancer and a dynamic immune microenvironment remains unclear. (nih.gov)
Distinct1
- Immune infiltration varied both between and within tumours, with different mechanisms of neoantigen presentation dysfunction enriched in distinct immune microenvironments. (nih.gov)
Breast6
- July 11, 2019 Targeted drugs for breast and lung cancer could be used together to overcome resistance to treatment in several different tumour types, a new study shows. (sciencedaily.com)
- Breast cancer may be an immunogenic tumor. (techscience.com)
- In addition to evaluating other solid tumor environments, the authors plan to utilize the breast cancer data from this study to evaluate potential patient responses to different therapeutic strategies. (uvm.edu)
- SCR-6852, an oral and highly brain-penetrating estrogen receptor degrader (SERD), effectively shrinks tumors both in intracranial and subcutaneous ER + breast cancer models. (medscape.com)
- Correction: Expression of hormone receptors is associated with specific immunological profiles of the breast cancer microenvironment. (medscape.com)
- Correction: Changes in the tumor oxygenation but not in the tumor volume and tumor vascularization reflect early response of breast cancer to neoadjuvant chemotherapy. (medscape.com)
Mutations2
- A single normal cell randomly acquires a series of mutations that allows it to proliferate and to be transformed into a cancer cell (i.e., founding clone), which initiates tumor progression and recurrence. (nature.com)
- We have previously shown that tumor founding clone mutations are able to predict tumor recurrence. (nature.com)
Clinical5
- Tumor purity-related coexpression factors in the tumor microenvironment have essential clinical, genomic, and biological significance in lung cancer. (hindawi.com)
- These coexpression factors (SASH3 and CD53) can be used to classify tumor purity phenotypes and to predict clinical outcomes. (hindawi.com)
- His primary clinical focus is on pediatric solid tumors, including neuroblastomas, tumors of the kidneys, and rare solid tumors of childhood. (spotify.com)
- We organized the 2018 Lund-Uppsala brain tumor meeting in Arild, bringing together basic and clinical research groups from both universities. (lu.se)
- The treatment and diagnosis of many cutaneous tumors is continually changing, and the role of clinicians (eg, primary care physicians, dermatologists, plastic surgeons, pathologists) focuses on an accurate diagnosis and a thorough understanding of the clinical sequelae. (medscape.com)
Human lung2
- Human lung cancer cell lines (A549, HOP62, and H1299) were purchased and authenticated by American Type Culture Collection (ATCC). (beingmedicos.com)
- We show that exposure of normal human lung fibroblasts (NHLFs) to physiological relevant concentrations of single-walled (SW) CNTs (0.08-0.15 microg/cm2) upregulated the expression of podoplanin, a known CAF marker of human lung adenocarcinoma, suggesting that SWCNTs can trigger NHLFs to initiate CAFs. (cdc.gov)
Growth7
- Pulmonary exposure to carbon nanotube s (CNTs) has recently been shown to promote the growth and neoplastic progression of lung adenocarcinoma in animals, but the underlying mechanisms are unknown. (cdc.gov)
- Accumulating evidence suggests that cancer-associated fibroblasts (CAFs) may promote tumor growth by providing appropriate tumor microenvironment. (cdc.gov)
- The communication between the MSCs and the tumor ultimately leads to cancer cell growth and disease progression. (uvm.edu)
- This finding suggests a potential correlation between fungal growth and the aggressiveness of lung adenocarcinoma. (who.int)
- This study provides the first definitive proof of the impact of within-tumour fungal infections in promoting tumour growth. (who.int)
- [ 7 ] It is well established that tumor growth beyond the size of 1-2 mm is angiogenesis dependent. (medscape.com)
- The development of the tumor vasculature is dependent on the homeostatic balance between a variety of proangiogenic and antiangiogenic (vascular endothelial growth factor and thrombospondin, respectively), inflammatory, and coagulation factors. (medscape.com)
Fibroblasts2
- Accordingly, the activation of fibroblasts/myofibroblasts, which is characteristic for the asthmatic process, may facilitate lung cancer progression. (spandidos-publications.com)
- In a normal situation, fibroblasts play a central role in healing wounds and injury to the lungs, but recent studies revealed that cancer is successful in recruiting them and causing them to produce a supportive environment for it," said Erez. (aftau.org)
Disease progression1
- This underlines an important role for Snail in influencing the immune compartment of lung tumors and thus contributing to disease progression. (oncotarget.com)
20191
- Nov. 27, 2019 Researchers have revealed why some existing cancer treatments are ineffective in tackling the early-stages of lung cancer. (sciencedaily.com)
Drug resistance1
- To functionally interrogate mechanisms of drug resistance, we have developed a robust infrastructure for generating patientderived cell lines and mouse patient-derived xenograft (PDX) models from lung cancer patients treated with targeted therapies at the MGH Cancer Center. (massgeneral.org)
Contributes2
- The epithelial-mesenchymal transition-inducing transcription factor Snail contributes to tumor progression in different malignancies. (oncotarget.com)
- This study adds to the observations that the mycobiome, as well as the microbiome, contributes towards a microenvironment that plays a critical role in promoting tumour progression, by diverting human immune-suppressing responses. (who.int)
Interactions1
Inflammatory2
- Our previous studies have shown that Qing-Re-Huo-Xue (QRHX) formulae had significant anti-inflammatory effects in chronic airway diseases such as asthma and chronic obstructive lung disease. (liankebio.com)
- Our findings furthermore point towards the contribution of Snail to an inflammatory tumor microenvironment, which is in line with our previous report of the Snail-mediated recruitment of pro-tumorigenic neutrophils to the lung tumors. (oncotarget.com)
Metabolism1
- Tumor metabolism. (nih.gov)
Survival2
- The 5-year survival rate of lung cancer is about 4-17% [ 3 ]. (hindawi.com)
- Adjuvant transarterial thromboembolization (TACE) has shown to increase overall survival in patient with microvascular invasion-HCC with tumor size ≥ 5 cm or multinodular tumors. (medscape.com)
Mice1
- Murine lung adenocarcinoma cell lines (344SQ and 393P) were obtained from Dr. Jonathan Kurie at MD Anderson Cancer Center (Houston, TX) and were originally derived from K-ras LA1/ + p53 R172HΔg/ + engineered mice 24 . (beingmedicos.com)
Researchers1
- Mar. 28, 2023 Researchers develop a 3D cell culture system to test how inhibiting fibroblast activities can help treat lung cancer. (sciencedaily.com)
Kras2
- REG4 is an indicator for KRAS mutant lung adenocarcinoma with TTF-1 low expression. (cancerindex.org)
- REG4, an important regulator of gastro-intestinal carcinogenesis, was highly expressed in KRAS mutant lung adenocarcinoma with low expression of TTF-1 (KC subtype). (cancerindex.org)
Extracellular1
- A high extracellular matrix-producing activity and contractility of myofibroblasts ( 8 ) participates in bronchial fibrosis, fibrotic remodeling of airways and lung parenchymal compartments, and a pulmonary dysfunction. (spandidos-publications.com)
Epidermal1
- The origin of cutaneous tumors can be simplistically divided into 3 major categories: epidermal, dermal, and adnexal (see image below). (medscape.com)