Lung sirolimus. Medical search. Frequent questions

Lung transplantation has matured into an accepted therapeutic alternative for children with end-stage lung disease. (medscape.com)
From 1986 through June 2016, 2330 lung and 730 heart-lung transplants in children were reported to the Registry for the International Society for Heart and Lung Transplantation (ISHLT). (medscape.com)
However, the phrase "children are not just small adults" is nowhere more true than in the field of lung transplantation. (medscape.com)
This article is meant not only to serve as an overview of the field of lung transplantation but also to highlight the unique challenges faced by pediatric lung transplant recipients, their families, and their healthcare teams. (medscape.com)
Pediatric lung transplantation actuarial survival by era. (medscape.com)
In 1963, James Hardy, MD, at the University of Mississippi, performed the first human lung transplantation in a 58-year-old convict serving a life sentence. (medscape.com)
Joel Cooper, MD, at the University of Toronto achieved success in 1983 with the transplantation of a single lung. (medscape.com)
This procedure was soon followed by successful double lung transplantation. (medscape.com)
Lastly, Bowdish et al and other groups demonstrated that living-donor lobar lung transplantation can be successfully performed. (medscape.com)
According to the International Society of Heart and Lung Transplantation (ISHLT) Registry, 2,330 pediatric lung and 730 pediatric heart-lung transplants have been performed through June 30, 2016. (medscape.com)
Furthermore, referral to centers with expertise in pulmonary hypertension on lung transplantation may be required, depending on the individual clinical context. (medscape.com)
Lung transplantation may be an option for those with end-stage lung disease. (medscape.com)
With the introduction of ciclosporin (cyclosporine) into routine clinical practice 20 years ago, lung transplantation has become an established treatment for patients with advanced lung disease. (nih.gov)
While the newer immunosuppressive drugs have been rigorously evaluated in large randomised trials in kidney, liver and cardiac transplantation, such studies are lacking in lung transplantation. (nih.gov)
This article reviews the evidence for the immunosuppressive regimens used during induction and maintenance of patients undergoing lung transplantation, and discusses current strategies in the management of chronic rejection. (nih.gov)
Renal failure induced by calcineurin-inhibitor agents is a common complication of lung transplantation. (tau.ac.il)
Lung transplantation can prolong the lives of patients with end-stage lung disease, but the median survival rate after lung transplant is less than six years, which has improved only slightly in recent decades. (sciencedaily.com)
Few outcome studies have been done in the field of lung transplantation to determine what works best. (sciencedaily.com)
Sirolimus is relatively novel in lung transplantation. (sciencedaily.com)
A 38-year-old man with cystic fibrosis had undergone bilateral lung transplantation in 1998 and had been well. (cdc.gov)
Surgical advances, in conjunction with more effective immunosuppressive strategies, have propelled the field of lung transplantation forward and have made intermediate-term survival an achievable goal. (ersjournals.com)
Initial attempts to perform lung transplantation (LTx) were marred by technical limitations that often resulted in early postoperative death. (ersjournals.com)
Treatment is with sirolimus or lung transplantation. (msdmanuals.com)
BOS remains the leading cause of death after transplantation and affects approximately 50% of all lung transplant recipients by 5 years. (itbusinessnet.com)
Progressive narrowing of these airways leads to difficulty breathing and the ultimate need for re-transplantation or death," said Steven Hays, MD, medical director of the UCSF Lung Transplant Program , and Principal Investigator of the trial. (itbusinessnet.com)
Sirolimus Long-Term Tolerability and Impact on Kidney Function in Lung Transplantation: A Single-Center Experience. (ucsd.edu)
An Unexpected Cause of Lung Disease Identified After Lung Transplantation. (ucsd.edu)
The goal of this clinical trial is to learn about the safety and effectiveness of inhaled sirolimus in patients who have developed bronchiolitis obliterans syndrome (BOS), a form of chronic rejection, after lung transplantation. (ucsf.edu)
and cardiothoracic surgeons specializing in performance of pleurodesis (procedure for pleural effusion) and lung transplantation. (utswmed.org)

Sirolimus, also known as rapamycin and sold under the brand name Rapamune among others, is a macrolide compound that is used to coat coronary stents, prevent organ transplant rejection, treat a rare lung disease called lymphangioleiomyomatosis, and treat perivascular epithelioid cell tumor (PEComa). (wikipedia.org)
In the EU, sirolimus, as Rapamune, is indicated for the prophylaxis of organ rejection in adults at low to moderate immunological risk receiving a renal transplant and, as Hyftor, is indicated for the treatment of facial angiofibroma associated with tuberous sclerosis complex. (wikipedia.org)
Dr. Reddy s Laboratories (NYSE: RDY) announced today that it has launched Sirolimus Tablets 1 mg and 2 mg, a therapeutic equivalent generic version of RAPAMUNE (Sirolimus) tablets in the US market on October 27, 2014, following the approval by the United States Food & Drug Administration (USFDA). (drreddys.com)
Rapamune is also used for treating patients with sporadic lymphangioleiomyomatosis (S-LAM) with moderate lung disease or worsening lung function. (europa.eu)
Rapamune contains the active substance sirolimus. (europa.eu)
To treat patients with S-LAM, the dose of Rapamune is 2 mg daily and after 10 to 20 days the doctor will adjust the dose to achieve appropriate levels of sirolimus in the patient's blood. (europa.eu)
The active substance in Rapamune, sirolimus, is an immunosuppressant (a medicine that reduces the activity of the immune system). (europa.eu)
Rapamune was more effective than placebo in improving lung function in a study involving 81 patients with S-LAM. (europa.eu)

Sirolimus is indicated for the prevention of organ transplant rejection and for the treatment of lymphangioleiomyomatosis (LAM). (wikipedia.org)
In May 2015, the FDA approved sirolimus to treat lymphangioleiomyomatosis (LAM), a rare, progressive lung disease that primarily affects women of childbearing age. (wikipedia.org)
Lymphangioleiomyomatosis (LAM) is a rare lung disease, resulting from proliferation in the lung, kidney, and axial lymphatics of abnormal smooth muscle-like cells (LAM cells) that exhibit features of neoplasia and neural crest origin. (medscape.com)
Lymphangioleiomyomatosis (LAM) is an indolent, progressive growth of smooth muscle cells throughout the lungs, pulmonary blood vessels, lymphatics, and pleurae. (msdmanuals.com)
Diagnosis of lymphangioleiomyomatosis is suspected in young women with dyspnea plus interstitial changes with normal or increased lung volumes on chest x-ray, spontaneous pneumothorax, or chylous effusion. (msdmanuals.com)
Sirolimus may likewise be utilized to treat a specific lung illness (lymphangioleiomyomatosis-LAM). (gm-global.in)
Safety and Efficacy of Combined Resveratrol and Sirolimus in Lymphangioleiomyomatosis. (ailam.it)
Lung-selective mRNA delivery of synthetic lipid nanoparticles for the treatment of pulmonary lymphangioleiomyomatosis. (ailam.it)
Isolation and characterisation of lymphatic endothelial cells from lung tissues affected by lymphangioleiomyomatosis. (ailam.it)
Lymphangioleiomyomatosis (LAM) is a rare, progressive lung disease that affects primarily women, usually ages 20-40 and during their childbearing years. (utswmed.org)
BACKGROUND: Lymphangioleiomyomatosis (LAM) is a rare cystic lung disease that primarily affects women. (bvsalud.org)

Recent years have seen the introduction of sirolimus and everolimus, immunosuppressive drugs that act by blocking growth factor-driven cell proliferation. (nih.gov)
Do not use FYARRO if you have had a severe allergic reaction to sirolimus or other medications that work similarly to sirolimus (eg, everolimus, temsirolimus), or human albumin. (fyarro.com)
It was sought herein, to determine 1-year clinical follow-up in patients with DM treated with the thin strut biodegradable polymer-coated sirolimus-eluting stent (BP-SES) versus durable coating everolimus-eluting stent (DP-EES). (viamedica.pl)
Everolimus is manufactured by Novartis, and is a derivative of sirolimus that inhibits mTOR. (medscape.com)

2. Inhibition of the mammalian target of rapamycin (mTOR) with sirolimus was linked to a decreased recurrence of APLS nephropathy and improved graft survival in post-renal transplant patients. (2minutemedicine.com)
This study is the first to examine the role of mTOR in APLS and whether blockade of this pathway, as achieved by sirolimus, can be linked to clinically significant vascular stenosis. (2minutemedicine.com)
phosphorylation of downstream proteins S6RP and AKT) as well as sirolimus suppression of mTOR. (2minutemedicine.com)
Sirolimus is an oral mammalian target of rapamycin (mTOR) inhibitor that is approved by the US Food and Drug Administration (FDA) for rejection prophylaxis in renal transplant patients. (cancertherapyadvisor.com)
1 Sirolimus works through mTOR to produce a blockade of B- and T-cell activation and antibody product. (cancertherapyadvisor.com)

In patients with suspected connective tissue disease (CTD)-associated interstitial lung disease (ILD) (CTD-ILD), referral to a center with expertise in management of CTD-ILD is recommended. (medscape.com)
As mentioned previously, immunosuppression is the cornerstone of the medical management of connective tissue disease (CTD)-associated interstitial lung disease (ILD) (CTD-ILD). (medscape.com)
Previously, LAM was considered an interstitial lung disease but it is now considered to be a low-grade destructive metastasizing neoplasm. (medscape.com)
Overview of Interstitial Lung Disease Interstitial lung diseases are a heterogeneous group of disorders characterized by alveolar septal thickening, fibroblast proliferation, collagen deposition, and, if the process remains unchecked. (msdmanuals.com)
The team are part of a €24 million project funded by the European Union and the European pharmaceutical industry's Innovative Medicine Initiative which is developing imaging techniques for the management of drug-induced interstitial lung disease (DIILD). (technologynetworks.com)
And the review also found that DIILD accounted for around 3-5% of all interstitial lung disease cases. (technologynetworks.com)
On the team is also Dr Nazia Chaudhuri honorary senior lecturer at The University of Manchester and a consultant physician at Wythenshawe Hospital, part of Manchester University NHS Foundation Trust, who has a specialist interest in interstitial lung disease. (technologynetworks.com)
The paper 'Drug-Induced Interstitial Lung Disease: A Systematic Review' is published in the Journal of Clinical Medicine and is available here . (technologynetworks.com)

LAM-001 is a proprietary, investigational, inhaled formulation of sirolimus, also known as rapamycin. (itbusinessnet.com)
Rapamycin (Sirolimus) is a medication that can be given to transplant patients in order to prevent rejection. (sportstimesdaily.com)
Rapamycin use has been shown to improve respiratory function, prevent or slow lung damage from exposure to pollution, and may even reduce mortality during periods of high air pollution levels. (sportstimesdaily.com)

However, if we can extend the life of a lung transplant recipient by two years, you're talking a major accomplishment. (sciencedaily.com)
We describe a case of human ehrlichiosis in a lung transplant recipient and review published reports on ehrlichiosis in immunocompromised patients. (cdc.gov)
We report a case of severe monocytic ehrlichiosis in a lung transplant recipient who had pancytopenia, acute renal failure, and encephalopathy. (cdc.gov)
This article will review the major medical complications, excluding allograft rejection, which may be encountered in the lung transplant recipient. (ersjournals.com)
Infection is an ever-present threat to the well-being of the lung transplant recipient and is a leading cause of both early and late mortality. (ersjournals.com)
Development of Host Immune Response to Bacteriophage in a Lung Transplant Recipient on Adjunctive Phage Therapy for a Multidrug-Resistant Pneumonia. (ucsd.edu)
Persistent human cosavirus infection in lung transplant recipient, Italy. (unipv.it)

However, on 7 October 2008, the FDA approved safety labeling revisions for sirolimus to warn of the risk for decreased renal function associated with its use. (wikipedia.org)
Sirolimus, a macrolide immunosuppressant with a distinct mechanism of action, may prevent renal failure but was found to have a high infectious and toxicity rate in the only relevant study conducted so far. (tau.ac.il)
Sixteen lung transplant recipients with posttransplantation renal dysfunction were allocated to receive the standard immunosuppression regimen or a combination sirolimus/low-dose calcineurin-inhibitor regimen. (tau.ac.il)
Sirolimus combined with low-dose calcineurin inhibitors appears to be a safe and effective alternative immunosuppressive therapy to sirolimus alone in lung transplant recipients with renal failure. (tau.ac.il)
Only physicians experienced in immunosuppressive therapy and management of renal transplant patients should use sirolimus. (drreddys.com)
As observed in-vitro, post-renal transplant patients with APLS who were on sirolimus also had decreased phosphorylation of S6RP and AKT on renal biopsies taken at 3 and 12 months post-op. (2minutemedicine.com)

The safety and efficacy of sirolimus treatment of LAM were investigated in clinical trials that compared sirolimus treatment with a placebo group in 89 patients for 12 months. (wikipedia.org)
The safety and efficacy of sirolimus as immunosuppressive therapy have not been established in liver or lung transplant patients, and therefore, such use is not recommended [see Warnings and Precautions. (drreddys.com)
The objective of the trial is to assess the long-term safety and efficacy of L-CsA plus Standard of Care (SoC) in the treatment of BOS in single (SLT) and double lung transplant (DLT) recipients. (ucsf.edu)

In the event that you are likewise taking cyclosporine, take sirolimus 4 hours after your cyclosporine portion. (gm-global.in)
If you also take cyclosporine, wait at least 4 hours after your cyclosporine dose before you take sirolimus. (onlinegenericmed.com)

A 2019 cohort study of nearly 10,000 lung transplant recipients in the US demonstrated significantly improved long-term survival using sirolimus + tacrolimus instead of mycophenolate mofetil + tacrolimus for immunosuppressive therapy starting at one year after transplant. (wikipedia.org)
Sirolimus can also be used alone, or in conjunction with a calcineurin inhibitor (such as tacrolimus), and/or mycophenolate mofetil, to provide steroid-free immunosuppression regimens. (wikipedia.org)
Despite a shift towards more potent immunosuppressive regimens that incorporate tacrolimus and mycophenolate mofetil, the development of chronic allograft rejection, as manifested by the bronchiolitis obliterans syndrome continues to negatively impact on the long-term survival of lung transplant recipients. (nih.gov)
The database study compared sirolimus outcomes with the most commonly used cell cycle inhibitor mycophenolate mofetil (MMF). (sciencedaily.com)

The chief advantage sirolimus has over calcineurin inhibitors is its low toxicity toward kidneys. (wikipedia.org)
The aim of the present prospective pilot study was to assess the benefit of sirolimus combined with low-dose calcineurin inhibitors in this patient population. (tau.ac.il)
They singled out an immunosuppressive drug called sirolimus, in a class of drugs called cell cycle inhibitors, based on a few small, long-term studies that found dramatically improved survival, reduced incidence of chronic rejection, and improved lung function in lung transplant patients who took sirolimus. (sciencedaily.com)
Excessive proteolytic activity, which relates to an imbalance of the elastase/alpha1-antitrypsin system or metalloprotease (MMPs) and their inhibitors (tissue inhibitors of metalloproteases [TIMPs]), may be important in lung destruction and formation of cysts. (medscape.com)

GUILFORD, Conn., Aug. 18, 2023 (GLOBE NEWSWIRE) - AI Therapeutics, Inc. , a clinical-stage biopharmaceutical company developing novel therapeutics for rare diseases, announced today the commencement of an investigator initiated Phase 2 study at UC San Francisco (UCSF) for its novel inhaled form of sirolimus, LAM-001, for the treatment of bronchiolitis obliterans syndrome (BOS) in patients post-lung transplant. (itbusinessnet.com)
Its lead drug product candidate comprises FYARRO, a form of sirolimus bound to albumin. (stockanalysis.com)

Target trough levels of sirolimus were 4 to 8 ng/mL. (tau.ac.il)
The doctor will adjust the dose to achieve appropriate levels of sirolimus in the patient's blood. (europa.eu)
Further assessments will include change in quality of life as measured by SGRQ-C over 48 weeks, change in 6-minute walk distance (6MWD) from baseline at 48 weeks, blood and BAL levels of sirolimus and various exploratory measures. (itbusinessnet.com)

Cystic lung disease is a significant cause of mortality and morbidity with a wide spectrum of radiological presentations and etiological differentials. (ijcdas.com)
The aim of the study was to identify clinical characteristics and etiological spectrum of patients manifesting with diffuse cystic lung disease radiologically. (ijcdas.com)

Sirolimus plus tacrolimus was associated with a better median survival than MMF plus tacrolimus (8.9 years vs 7.1 years). (sciencedaily.com)
The use of sirolimus in combination with tacrolimus was associated with excess mortality and graft loss in a study in de novo liver transplant patients. (drreddys.com)

Acute rejection episodes occurred in 2 patients in the sirolimus group and 1 patient in the control group (P = NS). (tau.ac.il)
To prevent chronic rejection, the most common cause of death after a lung transplant, patients must take immunosuppressive drugs for the rest of their lives. (sciencedaily.com)
The survival improvement with sirolimus was driven by fewer deaths from the top three causes: chronic rejection, infections, and cancer. (sciencedaily.com)
Tolerability and Feasibility of the Upper Esophageal Sphincter Assist Device in Preventing Acute and Chronic Allograft Rejection Among Lung Transplant Recipients. (ucsd.edu)
This study aims to investigate the clinical utility of AlloSure®-Lung for surveillance of the spectrum of rejection and infection events in concert with standard of practice (SOP) post-transplant medical care in a robust lung transplant population. (ucsf.edu)
As more experience with sirolimus has been gained, it began to be used "off-label" to prevent rejection in multiple transplant recipients and is now being studied in the treatment of GVHD. (cancertherapyadvisor.com)
As health care practitioners gained more experience with sirolimus, it began to be used "off-label" to prevent rejection in multiple transplant recipients outside of the kidney including liver, heart, and lung. (cancertherapyadvisor.com)
Rapacan 1 mg (Sirolimus Tablet) is an immunosuppressant used to prevent organ rejection after a kidney transplant. (onlinegenericmed.com)

In 2009, the FDA notified healthcare professionals that a clinical trial conducted by Wyeth showed an increased mortality in stable liver transplant patients after switching from a calcineurin inhibitor-based immunosuppressive regimen to sirolimus. (wikipedia.org)
Most lung transplant recipients routinely continue to receive a triple-drug maintenance immunosuppressive regimen consisting of a calcineurin inhibitor, an antimetabolite and corticosteroids. (nih.gov)
Recipients in both groups were randomized (based on physician preference) to immunosuppression with either a calcineurin inhibitor or sirolimus. (2minutemedicine.com)

Chest radiography, the 6-minute walk test, arterial blood gas determinations (ie, arterial oxygen tension [PaO 2 ]), and pulmonary function tests (PFTs)-especially forced vital capacity (FVC) and diffusion capacity of the lung for carbon monoxide (DLCO)-are monitored after therapy is started. (medscape.com)
We postulated that an infrequently used regimen may make a difference in outcome," said Aldo T. Iacono, MD, the Hamish S. and Christine C. Osborne Distinguished Professor in Advanced Pulmonary Care at UMSOM, Medical Director of the Lung Health Program at the University of Maryland Medical Center and senior author of the study, published in JAMA Network Open . (sciencedaily.com)
Pulmonary rehab is also helpful for patients listed for a lung transplant. (thelamfoundation.org)
This could be a blood clot in the leg (called deep vein thrombosis) or a clot that can break off and travel to the lung (called a pulmonary embolism). (nih.gov)

Immunosuppression, in turn, may predispose patients to infections and cancers, the second- and third-leading causes of post-lung transplant death. (sciencedaily.com)
Limited retrospective data in humans administered oral sirolimus post lung transplant has demonstrated improved survival in both the prevention and treatment settings of BOS. (itbusinessnet.com)

Sirolimus (Fyarro), as protein-bound particles, is indicated for the treatment of adults with locally advanced unresectable or metastatic malignant perivascular epithelioid cell tumor (PEComa). (wikipedia.org)
FYARRO ® (sirolimus protein-bound particles for injectable suspension) (albumin-bound) is a prescription medicine used to treat adults with malignant perivascular epithelioid cell tumors (PEComa) that have spread to other parts of the body (metastatic) or cannot be removed by surgery (locally advanced, unresectable). (fyarro.com)

TSC is a genetic disorder that causes tumors to form in various organs, primarily the brain, eyes, heart, kidneys, skin, and lungs, and continues over the lifetime of those who have it. (prnewswire.com)
Somatic mosaicism for TSC-2 mutations within the lungs and kidneys results in foci of disease superimposed against a background of normal cells within these tissues (although multiple discrete sites of disease might be expected). (msdmanuals.com)
This is clinically manifested in numerous systems within the body including the skin, gastrointestinal tract, liver, kidneys, and lung. (cancertherapyadvisor.com)

The majority of patients in the database, nearly 5,800, were given MMF plus tacrolimus, a combination that has become the de facto standard immunosuppression after lung transplant. (sciencedaily.com)

For patient education resources, see the Lung and Airway Center , as well as Heart and Lung Transplant and Bronchoscopy . (medscape.com)
Heart and Lung Transplant for Mixed Connective Tissue Disease: A Case Report and Implications for Pretransplant Testing. (ucsd.edu)

Prediction of Chemical Carcinogenicity in Rodents from in Vitro Genetic Toxicity Assays R AYMOND W. TENNANT, BARRY H. MARGOLIN, MICHAEL D. SHELBY, E RROL Z … As an in vivo toxicity endpoint, the acute lung inflammogenicity in a rat instillation model was compared with the in vitro toxicity endpoints comprising cytotoxicity, pro-inflammatory cytokine expression, or haemolytic potential. (holocausto.online)

The objective of the trial is to assess efficacy and safety of add-on aerosolized liposomal cyclosporine A (L-CsA) to Standard of Care (SoC) therapy as compared to SoC therapy alone in the treatment of Bronchiolitis obliterans syndrome (BOS) in single lung transplant recipients. (ucsf.edu)

Inhaled Sirolimus in Lung Transplant Recipients With Bronchiolitis Obliterans Syndrome. (ucsf.edu)

Infection rates among lung transplant recipients appear to be higher than those encountered in other solid organ transplant populations, likely related to the unique exposure of the lung allograft to the external environment and to the greater magnitude of immunosuppression employed 1 , 2 . (ersjournals.com)

These tumors can develop on the skin and vital organs, including the brain, kidney, lung, and heart, and may result in behavioral and neurological manifestations such as autism, intellectual disability, and epilepsy. (prnewswire.com)
Sirolimus is utilized with different meds to anticipate dismissal of a kidney transplant. (gm-global.in)
Sirolimus can lower blood cells that help fight infection, and may lead to serious conditions including cancer, severe brain infection causing disability or death, or a viral infection causing kidney transplant failure. (onlinegenericmed.com)
The only medications approved by the U.S. Food and Drug Administration (FDA) to treat LAM can improve lung function and shrink kidney tumors. (utswmed.org)

The guidelines give a strong recommendation for the use of vascular endothelial growth factor D testing to establish the diagnosis of LAM before considering lung biopsy in patients with cystic abnormalities on HRCT characteristic of LAM, but no other confirmatory clinical features. (medscape.com)

A scleroderma lung study that compared oral cyclophosphamide and placebo showed 1 year of cyclophosphamide was associated with a significant but modest improvement in dyspnea and lung function. (medscape.com)

Improved understanding of the mechanism of lung injury during brain death and during transition from donor to recipient may one day lead to techniques and preservation solutions that prevent ischemia-reperfusion injury. (medscape.com)

or cetuximab and sirolimus. (oncotarget.com)

What we found could improve survival of lung transplant patients on a larger scale. (sciencedaily.com)

LAM involves lung tissue infiltration with smooth muscle-like cells with mutations of the tuberous sclerosis complex gene (TSC2). (wikipedia.org)
An inhaled version of sirolimus has the promise of delivering drug directly to the lung tissue where it is needed while potentially reducing systemic exposures and concomitant toxicities. (itbusinessnet.com)
Development and Validation of a Bioanalytical LC-MS/MS Method for Simultaneous Determination of Sirolimus in Porcine Whole Blood and Lung Tissue and Pharmacokinetic Application with Coronary Stents. (uab.edu)

Single-agent EGFR inhibitor therapy is effective mainly in patients with lung cancer and EGFR mutations. (oncotarget.com)

At a mean follow up of 82 months, transplant recipients with antiphospholipid syndrome receiving sirolimus have a graft survival of 70% (7/10) versus 11% (3/27) in those not receiving sirolimus. (2minutemedicine.com)
Clinical data, functional assessments, and surveys will be collected to determine long term graft function and functional status of lung transplant recipients. (ucsf.edu)
Based on its success in the solid organ transplant world, sirolimus has also been evaluated in prevention and treatment of graft versus host disease (GVHD). (cancertherapyadvisor.com)

S-LAM is a rare lung disease that causes worsening symptoms such as shortage of breath and occurs mainly in women who are at an age when they can have children. (europa.eu)

That is, patients trade their end-stage lung disease for transplant lung disease, with the hope that it can be better managed. (medscape.com)
tell your doctor if you have or have ever had a stroke or heart or lung disease. (medlineplus.gov)
This made sirolimus the first drug approved to treat this disease. (wikipedia.org)
While offering a vital therapeutic option for patients with advanced lung disease, LTx remains fraught with complications that threaten both the quality and duration of the recipient's life. (ersjournals.com)

Many patients have experienced symptoms such as shortness of breath or lung collapses without doctors determining why - and are actually relieved to have an explanation for these health issues. (thelamfoundation.org)
The diagnosis is usually made when a computed tomography (CT) scan is performed to evaluate for unexplained shortness of breath, pleurisy, or a lung collapse (pneumothorax) and it reveals numerous lung cysts. (utswmed.org)

Although one-year survival rates have improved, long-term outcomes for children receiving lung transplants have not (see the image below). (medscape.com)
The purpose of the study is to follow participants who enrolled in the Lung Transplant Outcomes Group. (ucsf.edu)
The thin-strut biodegradable polymer coated, sirolimus-eluting stent demonstrated comparable clinical outcomes at 1-year after implantation to DP-EES. (viamedica.pl)

Using a database of over 9,000 lung transplant patients maintained by the United Network for Organ Sharing (UNOS), the researchers categorized patients by their immunosuppression regimen and compared survival rates. (sciencedaily.com)

Low dose posaconazole delayed release tablets for fungal prophylaxis in lung transplant recipients. (ucsd.edu)
Sirolimus is one such medication that can be considered an off-label second line treatment option (as well as for prophylaxis) when a patient's symptoms are refractory to steroids. (cancertherapyadvisor.com)

Revisiting Clinical Trials Using EGFR Inhibitor-Based Regimens in Patients with Advanced Non-Small Cell Lung Cancer: A Retrospective Analysis of an MD. (oncotarget.com)

You should not use sirolimus Tablet if you have ever had a lung transplant or liver transplant. (onlinegenericmed.com)
You should not use this medicine if you are allergic to sirolimus, or if you have ever had a lung transplant or liver transplant. (onlinegenericmed.com)

While retrospective analyses have shown that oral sirolimus can improve survival in BOS patients, systemic toxicities have limited its widespread adoption. (itbusinessnet.com)

It is believed that sirolimus works on T cells by blocking interleukin IL-12 from binding with its receptor," says Dr. "Sirolimus also blocks tumor necrosis factor or TNF-alpha from binding with its receptor on immune cells. (sportstimesdaily.com)

Extracorporeal photopheresis to attenuate decline in lung function due to refractory obstructive allograft dysfunction. (ucsd.edu)

Lastly, if a patient shows a progressive deterioration in lung function or shows no slowing in this decline, discontinuation of the immunosuppressive medications should be considered. (medscape.com)
It is characterized by proliferation of atypical smooth muscle cells throughout the chest, including lung parenchyma, vasculature, lymphatics, and pleurae, leading to distortion of lung architecture, cystic emphysema, and progressive deterioration of lung function. (msdmanuals.com)

Incidence of de novo malignancies in lung transplant recipients in Italy: a sinle institution experience, 1991-2008. (unipv.it)

HYFTOR™ (sirolimus topical gel) 0.2% is indicated for the treatment of facial angiofibroma associated with tuberous sclerosis in adults and children 6 years of age and older. (prnewswire.com)
While sirolimus was considered for treatment of LAM, it received orphan drug designation status because LAM is a rare condition. (wikipedia.org)
The safety of LAM treatment by sirolimus in people younger than 18 years old has not been tested. (wikipedia.org)
This study aims to discover whether earlier and longer treatment with a lower dose of sirolimus can help prevent LAM from getting worse over time. (nih.gov)
Use effective birth control to prevent pregnancy while you are taking sirolimus, and for at least 12 weeks after your treatment ends. (onlinegenericmed.com)

HYFTOR is contraindicated in patients with a history of hypersensitivity to sirolimus or any other component of the gel. (prnewswire.com)
Orsiro and Orsiro Mission are contraindicated for use in patients with a known hypersensitivity or allergy to the stent and/or stent coating materials such as amorphous silicon carbide, PLLA polymer, L-605 cobalt chromium alloy (including the major elements cobalt, chromium, tungsten and nickel), sirolimus or its derivatives. (orsiro.com)

One downside for sirolimus, though, is that it interferes with wound healing, a potentially life-threatening complication if the drug is administered in the initial days and weeks following transplant surgery. (sciencedaily.com)
BOS is a major complication in lung transplant patients for which there are no approved therapies. (itbusinessnet.com)

This study aims to identify the right dose of sirolimus to treat people who have LAM. (nih.gov)

Anatomy11

Organisms5

Diseases41

Chemicals and Drugs30

Analytical, Diagnostic and Therapeutic Techniques and Equipment44

Psychiatry and Psychology1

Phenomena and Processes13

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science1

Named Groups2

Health Care12

Transplantation29

Rapamune8

Lymphangioleiomyomatosis11

Everolimus4

MTOR5

Interstitial8

Rapamycin3

Transplant recipient7

Renal6

Safety and efficacy3

Hours after your cyclosporine2

Mycophenolate mofetil4

Inhibitors4

Form of sirolimus2

Levels of sirolimus3

Cystic lung disease2

Tacrolimus was associated2

Rejection8

Calcineurin-inhibitor3

Pulmonary4

Post-lung transplant2

Protein-bound particles2

Kidneys3

Standard immunosuppression1

Heart and Lung Transplant2

Acute1

Cyclosporine1

Bronchiolitis obliterans syndrome1

Among lung transplant recipients1

Kidney4

Considering lung biopsy1

Placebo1

Recipient1

Cetuximab1

Survival of lung transplant1

Tissue3

Mutations1

Graft3

Rare lung disease1

Disease4

Shortness of bre2

Outcomes3

Regimen1

Prophylaxis2

Clinical trials1

Liver2

Systemic1

Tumor1

Allograft dysfunction1

Progressive deterioration2

Novo1

Treatment5

Hypersensitivity2

Complication2

Dose1