OrganismsChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesTechnology, Industry, Agriculture
LovastatinHydroxymethylglutaryl-CoA Reductase InhibitorsMevalonic AcidAnticholesteremic AgentsProtein PrenylationPolyisoprenyl PhosphatesHydroxymethylglutaryl CoA ReductasesSimvastatinCholesterolDrug IncompatibilityPravastatinFarnesolMonascusColestipolAspergillusHydroxymethylglutaryl-CoA-Reductases, NADP-dependentFatty Acids, Monounsaturated
SimvastatinMevacorBiosynthesisPravastatinInhibitorsTake lovastatinInhibitorAspergillusUses of lovastatinEffect of lovastatinEffects of lovastatinAdministration of lovastatinProduce lovastatinPharmacokineticsLowers cholesterolSmall-moleculeTabletGrapefruit juiceStatinsBelongsInactive lactoneDissolution EnhancementLipid metabolismOralPrescriptionHepaticGemfibrozilConcentrationsFungiMedicationApoptosisMyopathyHypercholesterolemiaPathwayTabletsReduce elevatedDrugsAbsorptionEfficacyPrecautionsMildReducesWeaknessMetabolicIncidenceLevelsSide effectsSignificantly
Simvastatin5
  • As with atorvastatin, simvastatin, and other statin drugs metabolized via CYP3A4, drinking grapefruit juice during lovastatin therapy may increase the risk of side effects. (wikipedia.org)
  • The ability of lovastatin, mevastatin and simvastatin to inhibit the melanoma cell proliferation was examined using cytotoxicity and apoptosis assays. (biomedcentral.com)
  • Lovastatin, mevastatin and simvastatin inhibited the growth, cell migration and invasion of HT144, M14 and SK-MEL-28 melanoma cells. (biomedcentral.com)
  • Synthetically prepared HMG-CoA reductase inhibitor with some similarities to lovastatin, simvastatin, and pravastatin. (medscape.com)
  • Thus, atorvastatin, lovastatin and simvastatin are metabolised by isoform 3. (who.int)
Mevacor5
  • Lovastatin, sold under the brand name Mevacor among others, is a statin medication, to treat high blood cholesterol and reduce the risk of cardiovascular disease. (wikipedia.org)
  • Diet and exercise can help to keep your low density lipoprotein (bad cholesterol) and triglycerides levels low, but not everyone is successful without help from medication such as Mevacor or generic Lovastatin. (discountdrugsfromcanada.com)
  • Until you know how your body reacts to Mevacor or Lovastatin generic, you should not drive or take part in any activities that require you to be alert. (discountdrugsfromcanada.com)
  • Mevacor ( medical name Lovastatin ) is a medicine that helps patients to lower cholesterol in their body and they need to keep a suitable diet along with it. (tabletsmanual.com)
  • Now, researchers say, a study on mice may indicate that these malaria-induced cognitive impairments could be averted with a commonly used cholesterol-lowering drug lovastatin (Mevacor). (malaria.com)
Biosynthesis3
  • Mevalonate is a required building block for cholesterol biosynthesis and lovastatin interferes with its production by acting as a reversible competitive inhibitor for HMG-CoA, which binds to the HMG-CoA reductase. (wikipedia.org)
  • The effects of emodin anthrone PKS gene disruption on (+)-geodin and lovastatin biosynthesis and the production of the precursors acetyl-CoA and malonyl-CoA were investigated with cultures based on glycerol alone and in combination with lactose. (upm.edu.my)
  • The gedCΔ strain showed improved lovastatin production, particularly when cultivated on the glycerol-lactose mixture, increasing lovastatin production by 80% (113 mg/L) while simultaneously inhibiting (+)-geodin biosynthesis compared to the wild-type strain. (upm.edu.my)
Pravastatin1
Inhibitors4
  • Inhibition of HMG-CoA reductase is the basis for an assay in pharmacokinetic studies of the β-hydroxyacid metabolites (active inhibitors) and, following base hydrolysis, active plus latent inhibitors (total inhibitors) in plasma following administration of lovastatin. (nih.gov)
  • In a single dose study in four hypercholesterolemic patients, it was estimated that less than 5% of an oral dose of lovastatin reaches the general circulation as active inhibitors. (nih.gov)
  • Lovastatin belongs to the class of medications called Statins (also known as HMG-CoA reductase inhibitors). (nhcs.com.sg)
  • Lovastatin belongs to the medicine-group named HMG CoA reductase inhibitors. (tabletsmanual.com)
Take lovastatin2
  • Patients with liver disease should not take lovastatin. (wikipedia.org)
  • If you also take certain other drugs to lower your cholesterol (bile acid-binding resins such as cholestyramine or colestipol), take lovastatin at least 1 hour before or at least 4 hours after taking these medications. (healthwarehouse.com)
Inhibitor5
  • Lovastatin is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase), an enzyme that catalyzes the conversion of HMG-CoA to mevalonate. (wikipedia.org)
  • Lovastatin is a specific inhibitor of HMG-CoA reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate. (nih.gov)
  • Lovastatin is a lactone which is readily hydrolyzed in vivo to the corresponding β-hydroxyacid, a strong inhibitor of HMG-CoA reductase. (nih.gov)
  • Lovastatin (LS) is a potent HMG-CoA inhibitor used in the treatment of hypercholesterolemia. (elsevierpure.com)
  • Mevinacor (Lovastatin) is an HMG-CoA reductase inhibitor (also known as a statin) used to lower cholesterol and triglyceride levels in your blood. (comprar-medicina.com)
Aspergillus7
  • In 1982, some small-scale clinical investigations of lovastatin, a polyketide-derived natural product isolated from Aspergillus terreus, in very high-risk patients were undertaken, in which dramatic reductions in LDL cholesterol were observed, with very few adverse effects. (wikipedia.org)
  • Lovastatin, USP is a cholesterol lowering agent isolated from a strain of Aspergillus terreus. (nih.gov)
  • The present study includes the isolation of new fungal species such as Aspergillus terreus to produce lovastatin and other key secondary metabolites that can be effectively used as antimicrobial agents. (innspub.net)
  • Lovastatin was produced by Aspergillus terreus by submerged fermentation, and the levels of lovastatin produced were calculated to be 405mg/l. (innspub.net)
  • The study concludes that Aspergillus terreus is the newly isolated fungal strain that is a potent producer of lovastatin, exhibiting various other biologically important characteristics that can be used for the exploitation in various industries. (innspub.net)
  • 2004. Isolation, screening and rapid confirmation of lovastatin producing strains of Aspergillus terreus . (innspub.net)
  • Cultivation of Aspergillus terreus (ATCC 20542) with carbohydrates or low-value feedstocks such as glycerol produces lovastatin as a secondary metabolite and (+)-geodin as a by-product. (upm.edu.my)
Uses of lovastatin1
  • The primary uses of lovastatin is for the treatment of dyslipidemia and the prevention of cardiovascular disease. (wikipedia.org)
Effect of lovastatin1
  • The mechanism of the LDL-lowering effect of lovastatin may involve both reduction of VLDL-C concentration, and induction of the LDL receptor, leading to reduced production and/or increased catabolism of LDL-C. Apolipoprotein B also falls during treatment with lovastatin. (nih.gov)
Effects of lovastatin1
  • T he authors separately examined the effects of lovastatin on cholesterol level on APP processing beta-amyloid production and senile plaque deposition, in male and female mice. (nih.gov)
Administration of lovastatin1
  • The plasma concentration-time profiles of M8 were compared after oral administration of lovastatin to control rats or those treated with either ampicillin (100 mg/kg) or an antibiotic mixture consisting of cefadroxil (150 mg/kg), oxytetracycline (300 mg/kg), and erythromycin (300 mg/kg). (aspetjournals.org)
Produce lovastatin2
  • The microbial source of lovastatin was assessed by testing the ability of fungi with higher isolation frequency in the Pu-erh tea samples to produce lovastatin on Czapek yeast extract agar (CYA). (nih.gov)
  • A total of 40 strains from 3 fungal genera were selected to test their ability to produce lovastatin. (nih.gov)
Pharmacokinetics1
  • In this study, gut microbiota-mediated DDI were investigated by studying the pharmacokinetics of lovastatin in antibiotic-treated rats. (aspetjournals.org)
Lowers cholesterol1
Small-molecule1
  • In this study, we studied the enzyme that makes a small-molecule precursor to lovastatin. (bioquicknews.com)
Tablet1
Grapefruit juice2
  • Components of grapefruit juice, the flavonoid naringin, or the furanocoumarin bergamottin inhibit CYP3A4 in vitro, and may account for the in vivo effect of grapefruit juice concentrate decreasing the metabolic clearance of lovastatin, and increasing its plasma concentrations. (wikipedia.org)
  • Grapefruit and grapefruit juice may interact with lovastatin. (medicineshoppe.com)
Statins1
  • Lovastatin and other statins have been studied for their chemopreventive and chemotherapeutic effects. (wikipedia.org)
Belongs1
  • Lovastatin belongs to the family of medications known as lipid metabolism regulators . (pharmachoice.com)
Inactive lactone1
  • After oral ingestion, lovastatin, which is an inactive lactone, is hydrolyzed to the corresponding β-hydroxyacid form. (nih.gov)
Dissolution Enhancement2
  • Design and Characterization of Nanocrystals of Lovastatin for Solubility and Dissolution Enhancement. (rjptonline.org)
  • Studies on dissolution enhancement of lovastatin using soluplus by solid dispersion technique. (innspub.net)
Lipid metabolism1
  • Owing to its potential to disrupt infant lipid metabolism, lovastatin should not be taken while breastfeeding. (wikipedia.org)
Oral5
  • Following an oral dose of 14C-labeled lovastatin in man, 10% of the dose was excreted in urine and 83% in feces. (nih.gov)
  • Absorption of lovastatin, estimated relative to an intravenous reference dose, in each of four animal species tested, averaged about 30% of an oral dose. (nih.gov)
  • In animal studies, after oral dosing, lovastatin had high selectivity for the liver, where it achieved substantially higher concentrations than in non-target tissues. (nih.gov)
  • The study evaluates if a 6-month course of oral lovastatin at 80 mg/day would decrease abnormal breast duct cytology in women with a high inherited breast cancer risk. (stanford.edu)
  • Read user comments about the side effects, benefits, and effectiveness of niacin-lovastatin oral. (webmd.com)
Prescription2
  • Q: Is there a substitute for the prescription of Lovastatin? (dherbs.com)
  • Lovastatin is a prescription medication used to treat high cholesterol levels and to prevent heart disease. (medicineshoppe.com)
Hepatic1
  • As a consequence of extensive hepatic extraction of lovastatin, the availability of drug to the general circulation is low and variable. (nih.gov)
Gemfibrozil1
  • Comparison between lovastatin and gemfibrozil in treatment of primary hyperlipidemias]. (bvsalud.org)
Concentrations4
  • Lovastatin has been shown to reduce elevated LDL-C concentrations. (nih.gov)
  • Plasma concentrations of total radioactivity (lovastatin plus 14C-metabolites) peaked at 2 hours and declined rapidly to about 10% of peak by 24 hours postdose. (nih.gov)
  • After five years' storage, the lovastatin levels increased obviously in ripe Pu-erh tea samples and 55% of raw Pu-erh tea samples from 2007 were found to contain lovastatin with concentrations ranging between 28.41 ng/gdw and 228.61 ng/gdw. (nih.gov)
  • The concentrations required to inhibit proliferation of melanoma cells (0.8-2.1 μM) have previously been achieved in a phase I clinical trial of lovastatin in patients with solid tumours, (45 mg/kg/day resulted in peak plasma concentrations of approximately 3.9 μM). (biomedcentral.com)
Fungi2
  • Screening of lovastatin production by filamentous fungi. (innspub.net)
  • Bioprospecting of lovastatin producing fungi isolated from soil samples. (innspub.net)
Medication1
  • The first cases were described in 1988 in patients taking lovastatin, including several patients with a kidney transplant using concomitant cyclosporine , which is now known to be an interacting medication. (medscape.com)
Apoptosis1
  • We demonstrate that apoptosis in neuronal lovastatin treated-cells is induced by the mitochondrial pathway, with caspase-9 as the initiator and caspase-3 as the effector caspase. (unife.it)
Myopathy1
  • Lovastatin therapy should be discontinued immediately if myopathy is diagnosed or suspected. (medicineshoppe.com)
Hypercholesterolemia1
  • Homozygous Familial Hypercholesterolemia: Use of lovastatin for this rare genetic disorder (increased cholesterol levels) is not sufficient enough for treatment. (medicineshoppe.com)
Pathway3
  • Lovastatin, blocks the mevalonate pathway inhibiting the 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CR), an enzyme of the mevalonate pathway upstream the mevalonate kinase enzyme, reproducing biochemical features similar to those found in MKD. (unife.it)
  • In addition, Hh pathway blockade sensitized medulloblastoma to the effects of the proapoptotic, cholesterol-lowering agent lovastatin. (johnshopkins.edu)
  • This study thus shows that suppression of the (+)-geodin pathway increases lovastatin yield and demonstrates a practical approach of manipulating carbon flux by modulating enzyme activity. (upm.edu.my)
Tablets2
  • In the meantime there is 10 mg tablets of generic lovastatin are sold. (tabletsmanual.com)
  • Enhancement of solubility and therapeutic potential of poorly soluble lovastatin by SMEDDS formulation adsorbed on directly compressed spray dried magnesium aluminometasilicate liquid loadable tablets: A study in diet induced hyperlipidemic rabbits. (rjptonline.org)
Reduce elevated1
  • Lovastatin is widely prescribed to reduce elevated levels of cholesterol and prevent heart-related diseases. (upm.edu.my)
Drugs4
  • Compactin and lovastatin, natural products with a powerful inhibitory effect on HMG-CoA reductase, were discovered in the 1970s, and taken into clinical development as potential drugs for lowering LDL cholesterol. (wikipedia.org)
  • Lovastatin is part of a family of drugs that reduces the body's inflammatory response to infection. (malaria.com)
  • Bar, EE & Stearns, D 2008, ' New developments in medulloblastoma treatment: The potential of a cyclopamine-lovastatin combination ', Expert Opinion on Investigational Drugs , vol. 17, no. 2, pp. 185-195. (johnshopkins.edu)
  • [ 1 ] The first, lovastatin , [ 2 ] was approved about 30 years ago, and since then these drugs have been prescribed to reduce cardiovascular (CV) events and mortality in patients both with and without CV disease. (medscape.com)
Absorption1
  • These products can react with lovastatin, preventing its full absorption. (healthwarehouse.com)
Efficacy1
  • The Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS) trial to evaluate the efficacy of lovastatin for preventing coronary events, found a significantly decreased incidence of new melanomas in the lovastatin arm compared with the placebo arm. (biomedcentral.com)
Precautions1
  • Before taking Lovastatin , what precautions must I follow? (nhcs.com.sg)
Mild1
  • A very small number of people taking lovastatin may have mild memory problems or confusion. (healthwarehouse.com)
Reduces2
  • Lovastatin reduces cholesterol synthesis by inhibiting the rate-limiting step catalysed by HMG-CoA reductase. (rnpedia.com)
  • LOVASTATIN (LOE va sta tin) treats high cholesterol and reduces the risk of heart attack and stroke. (goodpillrx.com)
Weakness1
  • This can be life-threatening if not recognised and treated in time, so any unexplained muscle pain or weakness whilst on lovastatin should be promptly mentioned to the prescribing doctor. (wikipedia.org)
Metabolic1
  • Investigation of the transcriptomic and metabolic changes associated with superficial scald physiology impaired by lovastatin and 1-methylcyclopropene in pear fruit (cv. (irta.cat)
Incidence3
  • The mice that got the anti-malarial drug and the lovastatin had a dramatically, significantly reduced incidence of the late brain dysfunction," Zimmerman said. (malaria.com)
  • To elucidate the physiology underlying the development of superficial scald in pears, susceptible "Blanquilla" fruit was treated with different compounds that either promoted (ethylene) or repressed (1-methylcyclopropene and lovastatin) the incidence of this disorder after 4 months of cold storage. (irta.cat)
  • Our data show that scald was negligible for the fruit treated with 1-methylcyclopropene or lovastatin, but highly manifested in untreated (78% incidence) or ethylene-treated fruit (97% incidence). (irta.cat)
Levels2
  • This paper reports the results of an extensive survey on the levels of lovastatin in Pu-erh tea samples. (nih.gov)
  • Lovastatin is the drug used to reduce blood cholesterol serum levels. (innspub.net)
Side effects3
Significantly1
  • With increasing storage time, lovastatin concentration in ripe Pu-erh tea, and the occurrence and concentration of lovastatin for raw Pu-erh tea increased significantly. (nih.gov)