• Reduce elevated total-C, LDL-C, apo B, and TG levels and increase HDL-C in adult patients with primary hyperlipidemia (heterozygous familial and nonfamilial) and mixed dyslipidemia ( 1.2 ). (nih.gov)
  • Used as an adjunct to dietary therapy to treat primary hyperlipidemia (heterozygous familial and nonfamilial), mixed dyslipidemia and hypertriglyceridemia. (illnesshacker.com)
  • [ 49 ] High-potency statins (atorvastatin, rosuvastatin) at high doses have greater efficacy in reduction of cardiovascular events than low potency statins or high-potency statins at low doses. (medscape.com)
  • A study by Shimabukuro et al found that the impact on lipoprotein subclass profiles varies between pitavastatin and atorvastatin. (medscape.com)
  • A higher incidence of hemorrhagic stroke was seen in patients without CHD but with stroke or TIA within the previous 6 months in the atorvastatin calcium 80 mg group vs. placebo ( 5.6 ). (nih.gov)
  • Statins are often the first drug treatment for high cholesterol. (medlineplus.gov)
  • Like other members of its class (the "statins"), simvastatin lowers total serum cholesterol and particularly low density lipoprotein (LDL) cholesterol concentrations, thereby reducing the risk of atherosclerosis and its complications - myocardial infarction and stroke. (nih.gov)
  • Common side effects include muscle cramps, joint aches, abdominal pain, nausea, headache and weakness, symptoms that occur with all of the currently available statins. (nih.gov)
  • The most commonly used, and most effective drugs for treating high LDL cholesterol are called statins. (adam.com)
  • Because the benefits of statins may include prevention of serious or potentially fatal events in a small group of very high-risk pregnant patients, contraindicating these drugs in all pregnant women is not appropriate. (safemedication.com)
  • Statins are a class of prescription medicines that have been used for decades to lower low-density lipoprotein (LDL-C or "bad") cholesterol in the blood. (safemedication.com)
  • Patients who are at high risk of heart attack or stroke who require statins after giving birth should not breastfeed and should use alternatives such as infant formula. (safemedication.com)
  • Statins are one of the most widely used drugs worldwide as first-line drugs for the treatment of hyperlipidemia and the prevention and treatment of cardiovascular diseases. (e-jcpp.org)
  • Most of the side effects of statins are known to be mild, and mainly hepatotoxicity and various muscle symptoms are known. (e-jcpp.org)
  • Hepatotoxicity by statins is usually defined as an increase in alanine aminotransferase (ALT) to 2-3 times higher than the upper normal limit or more than a twofold increase in conjugated bilirubin [ 20 ]. (e-jcpp.org)
  • Pharmacotherapeutic strategies that affect the risk factor profile, such as the administration of statins for low-density lipoprotein (LDL) reduction or the administration of agents that alter atherosclerotic plaque, are of paramount importance. (medscape.com)
  • Rosuvastatin is a member of the drug class of statins, used in combination with exercise, diet, and weight-loss to treat high cholesterol and related conditions and to prevent cardiovascular disease. (illnesshacker.com)
  • Although statins are generally regarded as safe and well-tolerated, some users develop muscle symptoms that are mostly mild but in rare cases can lead to life-threatening rhabdomyolysis. (plos.org)
  • Statins are 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors which reduce the risk of coronary events and death by lowering blood concentrations of low density lipoprotein cholesterol (LDL-c). 1 , 2 , 3 , 4 They are generally regarded as safe and well tolerated. (plos.org)
  • Effects of increasing high-density lipoprotein cholesterol and decreasing low-density lipoprotein cholesterol on the incidence of first acute coronary events (from the Air Force/Texas Coronary Atherosclerosis Prevention Study). (trialresultscenter.org)
  • Low levels of high-density lipoprotein cholesterol (HDL), or hypoalphalipoproteinemia (HA), includes a variety of conditions, ranging from mild to severe, in which concentrations of alpha lipoproteins or high-density lipoprotein (HDL) are reduced. (medscape.com)
  • Dyslipidaemia is a wider terminology that also includes low levels of good cholesterol namely the high-density lipoprotein cholesterol (HDL-C). (medthical.com)
  • [10] NA also increases serum high-density lipoprotein cholesterol (HDL-C), commonly referred to as "good cholesterol," leading to a more desirable cholesterol ratio in the hyperlipidemic patient. (allergyresearchgroup.blog)
  • Beta-carotene a combination of niacin and the prescription drug simvastatin (Zocor) raises hdl (High density lipoprotein) cholesterol (Good cholesterol ) in people with coronary heart disease and low hdl levels. (foodpharmacy.blog)
  • For 126 days of mean duration of administration of pitavastatin, the % change of low density lipoprotein cholesterol indicated a dose dependent reduction: −23.4%, −29.1%, and −35.2% in the 1, 2, and 4 mg groups, respectively in patients who have not been treated with lipid lowering medications prior to study. (e-enm.org)
  • Since the prevalence of hypercholesterolemia has risen consistently increased, many guidelines recommended statin as the first drug to prevent CVD according to the CVD risk and low density lipoprotein cholesterol (LDL-C) level [ 2 ]. (e-enm.org)
  • These HMG-CoA reductase inhibitors are proven not only to reduce total cholesterol, LDL-C, and triglyceride in blood but also to increase high density lipoprotein cholesterol (HDL-C) [ 3 , 4 ]. (e-enm.org)
  • This study was designed to administer 1, 2, or 4 mg pitavastatin to patients with hyperlipidemia at the age of 20 or older for at least 8 weeks. (e-enm.org)
  • ALT elevations are clearly more frequent in patients taking higher doses of simvastatin (40 and 80 mg daily). (nih.gov)
  • Rosuvastatin also inhibits hepatic synthesis of very low density lipoprotein (VLDL). (illnesshacker.com)
  • In vivo studies in animals, and in vitro studies in cultured animal and human cells have shown rosuvastatin to have a high uptake into, and selectivity for, action in the liver, the target organ for cholesterol lowering. (illnesshacker.com)
  • High levels of cholesterol or other fats ( lipids ) in the blood ( hyperlipidemia ). (webmd.com)
  • Plasma lipoproteins are macromolecular complexes of lipids and proteins that are classified by density and electrophoretic mobility. (medscape.com)
  • The blood test will measure the lipoproteins levels which are different types of lipids in your blood to interpret the results. (medthical.com)
  • however, more than 50% of American adults have hyperlipidemia or elevated (inappropriately high) levels of lipids in their bloodstreams. (ashp.org)
  • These conditions include high blood pressure, high levels of cholesterol or other fats (lipids) in the blood (hyperlipidemia), and hardening of the arteries (atherosclerosis). (supplemented.net)
  • Hyperlipidemia, characterized by the abnormal blood lipid profiles, is one of the dominant factors of many chronic diseases such as diabetes, obesity, and cardiovascular diseases (CVD). (hindawi.com)
  • post-menopausal women with a higher serum FSH (≥78.3 IU/L) had higher serum TC and LDL-C levels than those with relatively lower FSH levels (40-78.3 IU/L), and ovariectomized mice had higher serum FSH and lipid levels and reduced hepatic LDL receptor expression. (nature.com)
  • Even without a definitive diagnosis from the workup, treatment of presumed dysbetalipoproteinemia may proceed, because other lipid disorders, such as type IIb hyperlipidemia produce similar elevations in cholesterol and triglyceride levels and will respond to the same medical interventions. (medscape.com)
  • Even with medicine, some people may continue to have high lipid levels that increase their risk for heart attack. (adam.com)
  • You have to do a fasting lipid blood test in order to know if you have high cholesterol (hyperlipidemia). (medthical.com)
  • A blood test called a lipid panel or lipid profile will show if your cholesterol is too high. (webmd.com)
  • CoQ 10 H 2 has been found to inhibit lipid peroxidation when cell membranes and low-density lipoproteins (LDL) are exposed to oxidizing conditions. (oregonstate.edu)
  • Hyperlipidemia is the term used to describe high lipid (fat) levels in your blood. (medicine.com)
  • a lipid used in the production of hormones, bile salts, and cell membranes that contributes to atherosclerotic plaque formation when levels are high. (ashp.org)
  • Familial combined hyperlipidemia is an autosomal inherited lipid abnormality and one of the most common genetic dyslipidemias , whose features partly overlap with those of the metabolic syndrome . (symptoma.com)
  • 5 At much higher intakes, NA is an effective lipid-lowering agent. (allergyresearchgroup.blog)
  • 9 To achieve beneficial effects on serum lipid values, much higher intakes (500 to 3,000 mg/day) are needed. (allergyresearchgroup.blog)
  • Niacin is obtained in the diet from a variety of whole and processed foods, with highest contents in fortified packaged foods, meat, poultry, red fish such as tuna and salmon, lesser amounts in nuts, legumes and seeds. (wikipedia.org)
  • Niacin and Hyperlipidemia: Which Form is Best? (allergyresearchgroup.blog)
  • Niacin therapy has long been recognized as a treatment option in addressing hyperlipidemia. (allergyresearchgroup.blog)
  • [1] , [2] Niacin is inexpensive and therapeutically comparable with statin drugs in cases of hyperlipidemia. (allergyresearchgroup.blog)
  • In studies, a once-daily, single-tablet combination of niacin extended-release/lovastatin showed additive LDL cholesterol lowering and was more effective than would be anticipated from doubling the component lovastatin dose. (drlauda.at)
  • Apart from CVD, hyperlipidemia is also closely associated with diabetes, insulin resistance, and obesity [ 10 ]. (hindawi.com)
  • Determining the lipoprotein subclass profile and selecting the appropriate statin in patients with diabetes and an additional cardiovascular risk, such as low HDL cholesterol or hypertriglyceridemia may be beneficial. (medscape.com)
  • Young people with insulin- dependent diabetes mellitus (IDDM) may have a higher prevalence of eating disorders, such as anorexia nervosa and bulimia, and adults with longstanding diabetes and major medical complications have a higher prevalence of symptoms of depression and anxiety. (cdc.gov)
  • Elderly persons who have non-insulin-dependent diabetes mellitus (NIDDM) and other symptomatic medical conditions may also have a higher risk of developing psychological problems. (cdc.gov)
  • Besides hyperlipidemia other risk factors for cardiovascular disease include hypertension, smoking, diabetes, kidney disease, increasing age, strong family history of heart diseases and male gender. (medthical.com)
  • Causes of hyperlipidemia can be due to familial genetic inherited condition, high fat diet, sedentary lifestyle , obesity, diabetes , alcoholism and physiological state like in pregnancy. (medthical.com)
  • It is also used for heart attack, high blood pressure, heart disease, diabetes, cancer, and many other conditions, but there is no good scientific evidence to support many of these other uses. (sona.ie)
  • Clinicians should therefore emphasize strategies to reduce cardiovascular risk even further among low-risk adults by treating modifiable risk factors (smoking, diabetes, blood pressure, hyperlipidemia, overweight, and exercise). (medscape.com)
  • People with obesity, diabetes, or a family history of heart attacks or heart disease at a young age, should be screened for high cholesterol more often. (medicine.com)
  • Silent ischemia - Patients with coronary artery disease (particularly patients with diabetes) may have ischemia without symptoms. (rxharun.com)
  • Comprehensive treatment of angina also includes controlling risk factors such as obesity, hypertension, hyperlipidemia, diabetes and cigarette smoking in order to slow the progression of atherosclerosis and decrease the risk of myocardial infarction. (deansilvermd.com)
  • This includes therapeutic lifestyle changes and the medical treatment of hypertension, hyperlipidemia, and diabetes mellitus. (medscape.com)
  • This combination of symptoms is called metabolic syndrome and it increases your risk of heart disease, stroke, diabetes and much more. (epiphanyasd.com)
  • PURPOSE OF REVIEW: To provide an overview of recent advances that have defined the first putative genes behind familial combined hyperlipidemia, the most common genetic dyslipidemia and a major risk factor for early coronary heart disease . (symptoma.com)
  • In the absence of specific and effective therapy for many types of glomerulonephritis, supportive treatments for edema, hypertension, hyperlipidemia, and intravascular thrombosis play important roles in reducing the complications associated with the disease. (basicmedicalkey.com)
  • male ≥50 years of age or female ≥60 years of age with one additional risk factor (low HDL, impaired glucose tolerance, high waist circumference, smoker, hypertension), or presence of a risk modifier (e.g. (therapeuticresearch.com)
  • Low density lipoprotein (LDL) and very low density lipoprotein (VLDL) carry cholesterol toward tissues, and elevated levels of these lipoproteins are associated with atheroma formation (fat-containing deposits in the arterial wall) and cardiovascular disease . (wikidoc.org)
  • Reduce elevated TG and VLDL-C in patients with primary dysbetalipoproteinemia (Fredrickson type lll hyperlipidemia). (globalrph.com)
  • They also have higher rates of obesity and are more likely to have glucose intolerance. (adam.com)
  • Leptin levels are high in autism and leptin resistance is feature of obesity. (epiphanyasd.com)
  • Oral supplementation of coenzyme Q 10 increases coenzyme Q 10 concentrations in plasma and lipoproteins, but it is unclear whether concentrations in peripheral tissues are increased, especially in healthy individuals. (oregonstate.edu)
  • The lysosomal membranes that separate those digestive enzymes from the rest of the cell contain relatively high concentrations of coenzyme Q 10 . (oregonstate.edu)
  • Decreased hepatic cholesterol concentrations stimulate the upregulation of hepatic low density lipoprotein (LDL) receptors which increases hepatic uptake of LDL. (illnesshacker.com)
  • Reduce elevated TG in patients with hypertriglyceridemia (Fredrickson type lV hyperlipidemia). (globalrph.com)
  • A low HDL cholesterol level is thought to accelerate the development of atherosclerosis because of impaired reverse cholesterol transport and possibly because of the absence of other protective effects of HDL, such as decreased oxidation of other lipoproteins. (medscape.com)
  • Hyperlipidemia is a factor in coronary heart disease (also called atherosclerosis). (medicine.com)
  • Symptoms of angina occur when the coronary arteries are narrowed or blocked by atherosclerosis or by a blood clot. (rxharun.com)
  • Association of coronary atherosclerosis with hyperapobetalipoproteinemia [increased protein but normal cholesterol levels in human plasma low density (beta) lipoproteins]. (symptoma.com)
  • The treatment goals for patients with coronary artery atherosclerosis are to relieve symptoms of coronary artery disease (CAD) and to prevent future cardiac events, such as unstable angina, AMI, and death. (medscape.com)
  • Familial combined hyperlipidemia is the most common genetic disorder that increases blood fats. (adam.com)
  • A higher dose increases the risk of liver function deterioration, and it is known that statin-induced liver toxicity usually occurs in the first year of statin use [ 21 ]. (e-jcpp.org)
  • In addition, the prevalence of hypercholesterolemia is significantly higher in peri-menopausal women than that in pre-menopausal women. (nature.com)
  • Moreover, blocking FSH signaling by anti-FSHβ antibody or ablating the FSH receptor ( FSHR ) gene could effectively prevent hypercholesterolemia induced by FSH injection or high-cholesterol diet feeding. (nature.com)
  • ZOCOR has not been studied in conditions where the major abnormality is elevation of chylomicrons (i.e., hyperlipidemia Fredrickson types I and V). (globalrph.com)
  • Sometimes, younger children may have mild hyperlipidemia . (adam.com)
  • Because of the lack of consistently effective treatment for primary focal segmental glomerular sclerosis, angiotensin-converting enzyme inhibitors or angiotensin receptor blockers are commonly used for patients with mild disease to control symptoms. (basicmedicalkey.com)
  • In patients with coronary heart disease (CHD) or at high risk of CHD, ZOCOR® can be started simultaneously with diet. (globalrph.com)
  • Particles in your blood called lipoproteins carry cholesterol to your body's cells that need it. (webmd.com)
  • and small, dense, low-density lipoprotein (LDL) particles, as well as the drugs that can alter the condition. (drlauda.at)
  • Low-density lipoprotein particles can be divided into subclasses with differing atherogenicity. (drlauda.at)
  • People with this condition may develop high cholesterol or high triglyceride levels as teenagers. (adam.com)
  • The levels remain high all during life. (adam.com)
  • If lifestyle changes do not change your cholesterol levels enough, or you are at very high risk for atherosclerotic heart disease, your health care provider may recommend that you take medicines. (adam.com)
  • Contact your provider if you have a personal or family history of high cholesterol levels. (adam.com)
  • A diet that is low in cholesterol and saturated fat may help to control LDL levels in people at high risk. (adam.com)
  • Hyperlipidemia is a term to describe a medical condition whereby the blood levels of cholesterol are raised. (medthical.com)
  • Having high levels of cholesterol will narrow the blood vessels with plaque (clot formation ) and increase risk of cardiovascular disease like heart diseases, stroke and peripheral vascular disease. (medthical.com)
  • Higher levels of LDL has been highly associated with cardiovascular diseases. (medthical.com)
  • If the cholesterol levels still high despite diet and exercise regimes , to prevent risk of cardiovascular diseases , medications will be started as benefits outweighs risk. (medthical.com)
  • People most commonly use red yeast rice for high levels of cholesterol and other fats in the blood. (sona.ie)
  • elevated levels of one or more lipoproteins in the blood. (ashp.org)
  • Heart disease and diet MEDICATIONS If lifestyle changes do not change your cholesterol levels, or you are at very high risk of developing atherosclerotic heart disease , your doctor may recommend medication. (symptoma.com)
  • This type of liver injury has no symptoms, represents a temporary increase in liver enzyme levels, and usually improves on its own regardless of drug interruption. (e-jcpp.org)
  • Inhibition of this enzyme in the liver stimulates LDL receptors , resulting in an increased clearance of low-density lipoprotein (LDL) from the bloodstream and a decrease in blood cholesterol levels. (wikidoc.org)
  • By reducing intracellular cholesterol levels, they cause liver cells to make more LDL receptors , leading to increased clearance of low-density lipoprotein from the bloodstream. (wikidoc.org)
  • It is prescribed by a doctor to lower cholesterol in people who have been diagnosed with high cholesterol (high levels of LDL cholesterol in the blood). (medika.life)
  • There is also uncertainty about the relationship between clinical symptoms, and levels of biochemical markers of muscle toxicity such as serum creatine kinase (CK). (plos.org)
  • 8 Rhabdomyolysis is diagnosed by CK levels substantially above 10×ULN (>50×ULN in the FDA classification), together with symptoms such as brown urine, elevated serum creatine and evidence of organ damage. (plos.org)
  • Consuming licorice daily for several weeks or longer can cause severe side effects including life-threatening high blood pressure, low potassium levels, weakness, paralysis, and occasionally brain damage in otherwise healthy people. (mymmunity.com)
  • The common problem is that in late middle age many people get overweight around their waist, they also have increased blood pressure, high blood sugar and abnormal cholesterol, or triglyceride levels. (epiphanyasd.com)
  • Health Care Professionals: Health care professionals should discontinue statin therapy in most pregnant patients, or they can consider the ongoing therapeutic needs of the individual patient, particularly those at very high risk for cardiovascular events during pregnancy. (safemedication.com)
  • In its reduced form (CoQ 10 H 2 ), coenzyme Q 10 is an effective fat-soluble antioxidant that protects cell membranes and lipoproteins from oxidation . (oregonstate.edu)
  • Thus, prevention and treatment of hyperlipidemia are effective approaches to reduce the incident rate of chronic diseases. (hindawi.com)
  • In the last few decades, hundreds of Chinese herbal medicines in the form of compounds, extracts, single herbs, or formulae have been reported to be effective for the prevention and treatment of hyperlipidemia [ 16 ], especially those high-fat diet (HFD) induced cases. (hindawi.com)
  • Because hyperlipidemia has no symptoms, the Centers for Disease Control (CDC) and prevention recommend high cholesterol should be screened for, starting from a young age. (medicine.com)
  • There is a growing interest in TCM treatment of hyperlipidemia. (hindawi.com)
  • Because of the chronic nature of cardiovascular disease, treatment of hyperlipidemia is not generally necessary during pregnancy. (safemedication.com)
  • For some people with high cholesterol, treatment is all about the medications. (webmd.com)
  • The FAQ below presents information about the treatment of hyperlipidemia. (therapeuticresearch.com)
  • List the classes of medications used in the treatment of hyperlipidemia and their basic mechanisms of action. (ashp.org)
  • 10) National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). (guiasalud.es)
  • 5 While these effects appear to be infrequent, they are serious and should be considered when approaching NA as a treatment for hyperlipidemia. (allergyresearchgroup.blog)
  • [24] While this is of very significant concern, occurrences in clinical studies are still rare, suggesting that utilizing NA at therapeutic doses of 2 to 4 g/day as a treatment for hyperlipidemia can be done safely under medical supervision and appropriate monitoring. (allergyresearchgroup.blog)
  • The usual latency to onset of symptoms of liver disease ranges from one week to as long as 3 years, but most cases have a latency of 1 to 6 months. (nih.gov)
  • Because of this, in high doses, it might cause the same side effects as this drug, including liver damage, severe muscle pain, and muscle damage. (sona.ie)
  • Lovastatin can cause liver damage. (sona.ie)
  • If ALT continues to rise to more than ten times higher than the upper normal limit, it may be associated with other diseases or interactions with other drugs metabolized via the liver. (e-jcpp.org)
  • High density lipoprotein , in contrast, carries cholesterol back to the liver and is associated with protection against cardiovascular disease. (wikidoc.org)
  • Signs and symptoms of pellagra include skin and mouth lesions, anemia, headaches, and tiredness. (wikipedia.org)
  • The signs and symptoms associated with glomerulonephritis can be nephritic in nature, characterized by inflammatory injury, or nephrotic in nature, characterized by proteinuria. (basicmedicalkey.com)
  • When symptoms appear, they may include: Chest pain (angina) or other signs of coronary artery disease may be present at a young age. (symptoma.com)
  • FDA expects removing the contraindication will enable health care professionals and patients to make individual decisions about benefit and risk, especially for those at very high risk of heart attack or stroke. (safemedication.com)
  • Hyperlipidemia does not cause any symptoms , and for some people, the first time they are diagnosed with hyperlipidemia is after they develop other conditions, such as heart disease or circulation problems, or following a heart attack or stroke. (medicine.com)
  • Myopathy and Rhabdomyolysis: Risks increase when higher doses are used concomitantly with cyclosporine and strong CYP3A4 inhibitors (e.g., clarithromycin, itraconazole, human immunodeficiency virus (HIV) or hepatitis C virus (HCV) protease inhibitors). (nih.gov)
  • Higher doses of this product seem to provide more benefits in women than men when taken over a four-year period. (supplemented.net)
  • [25] Another possible side effect of high-dose NA is a transient, modest, and reversible rise in fasting glucose and hemoglobin A1C (HbA1c), which occurs more typically in dysglycemic patients. (allergyresearchgroup.blog)
  • Genest J, Mora S, Libby P. Lipoprotein disorders and cardiovascular disease. (adam.com)
  • Oral high-dose coenzyme Q 10 is usually effective to treat mitochondrial disorders that are caused by mutations in coenzyme Q 10 biosynthetic genes . (oregonstate.edu)
  • High-dose nicotinamide does not have this medicinal effect. (wikipedia.org)
  • [21] Additionally, research has shown that eating a medium- to large-sized apple before high-dose NA intake will mitigate this benign yet bothersome cutaneous flushing. (allergyresearchgroup.blog)
  • Sudden stroke -like symptoms, such as trouble speaking, drooping on one side of the face, weakness of an arm or leg, and loss of balance. (adam.com)
  • Genetic testing is available for one type of familial combined hyperlipidemia. (adam.com)
  • It is not a disease itself, but rather a symptom of coronary artery disease, the most common type of heart disease. (rxharun.com)
  • List nonpharmacologic treatments recommended for each type of hyperlipidemia. (ashp.org)
  • Cholesterol is not water-soluble, and is therefore carried in the blood in the form of lipoproteins , the type being determined by the apoprotein , a protein coating that acts as an emulsifier . (wikidoc.org)
  • These parameters are also in relation with other biochemical abnormalities: decreased leptin and adiponectin [3] and high insulin resistance [4]. (symptoma.com)
  • The relative balance between these lipoproteins is determined by various factors, including genetics, diet, and insulin resistance . (wikidoc.org)
  • Taking garlic by mouth seems to reduce systolic blood pressure (the top number) by about 7-9 mmHg and diastolic blood pressure (the bottom number) by about 4-6 mmHg in people with high blood pressure. (supplemented.net)
  • Early clinical research suggests that taking garlic extract supplements might reduce the risk of prostate cancer or reduce symptoms associated with prostate cancer. (supplemented.net)
  • Patients first should be treated for the metabolic condition that is causing or exacerbating their hyperlipidemia. (medscape.com)
  • All high-risk patients (FRS 10-year risk ≥20%), and patients with a statin-indicated condition (above) with the following caveat regarding CKD: treat those age ≥50 years and not on dialysis. (therapeuticresearch.com)
  • Case report: Four patients are described, aged 1-13 years, with a median onset of symptoms of 5 months (IQR 0-11 months), which represents an approximate prevalence of 1 per 64,000 children under 14 years of age for our pediatric population. (bvsalud.org)
  • Combination therapy is also an effective option for improving multiple lipoprotein abnormalities. (drlauda.at)
  • The patient's low-density lipoprotein (LDL) cholesterol level response is measured in 6 weeks to 6 months, depending on the patient's cardiovascular risk factors. (medscape.com)
  • For men, a high-risk HDL cholesterol level is still less than 40 mg/dL, but for women, the high-risk HDL cholesterol level is less than 50 mg/dL. (medscape.com)
  • PCSK9 inhibitors, such as alirocumab (Praluent) and evolocumab (Repatha) These represent a newer class of drugs to treat high cholesterol. (adam.com)
  • But if you take several of them for a long time, or take one of the expensive newer drugs for high cholesterol, your out-of-pocket cost can add up. (webmd.com)