• In the homologous recombination repair-deficient population of TALAPRO-2, a placebo-controlled phase 3 trial, treatment of patients with metastatic castration-resistant prostate cancer with the poly(ADP-ribose) polymerase inhibitor talazoparib plus enzalutamide led to prolonged progression-free survival compared with placebo plus enzalutamide. (nature.com)
  • Biomarker-Directed Therapy in Black and White Men With Metastatic Castration-Resistant Prostate Cancer. (cdc.gov)
  • In this cohort study of 962 men with metastatic castration-resistant prostate cancer, mismatch repair deficiency or microsatellite instability-high was significantly more frequent in Black men than White men. (cdc.gov)
  • Genomic alterations in DNA damage response (DDR) genes are common in metastatic castration-resistant prostate cancer (mCRPC). (cdc.gov)
  • While puberty blockers have a long history of different uses, including the chemical castration of violent sex offenders, they are now most commonly recognized for the off-label treatment of gender dysphoria because of their mechanism to stop the production of estrogen and progesterone. (powerlineblog.com)
  • Aim 1: To assess preferences and barriers for de-implementation of chemical castration in prostate cancer. (biomedcentral.com)
  • Although some patients with prostate cancer benefit from ADT in terms of survival and symptom improvement, chemical castration is also commonly performed when there is no high level evidence for use and little to no health benefits to patients raising questions of low value care. (biomedcentral.com)
  • Nilutamide through its antiandrogenic activity can complement surgical castration, which suppresses only testicular androgens. (guidelinecentral.com)
  • Surgical castration of piglets is generally recognized as a painful procedure, but there is currently no gold standard for the assessment of pain behavior in piglets. (bvsalud.org)
  • In this study, we investigated the efficacy of four local anesthetics in terms of pain relief during and after surgical castration in three sequential study parts. (bvsalud.org)
  • The objective of this study was to investigate the electroencephalographic reaction pattern and FOS protein expression in male piglets undergoing surgical castration under light isoflurane anaesthesia with or without local anaesthesia. (bvsalud.org)
  • Anxiety The old-school psychoanalysts interpret that the removal of limbs usually stands for erotic and sexual anxiety that castration. (dreamsnest.com)
  • This gaze registers and enables, among other things, men's selfish desires (for sex and power, which tend to be intermingled) and their hysteria and anxiety because women signify a frightening other, inevitably calling to mind loss (involving not only castration anxiety but the disappearance of short-lived infantile unity with a nurturing mother). (sacredheart.edu)
  • Also McClintock points to racist, nationalistic and patriotic fetishes -- such as flags, crowns, maps, swastikas (or for instance chaddis) -- that can't be simply rendered equivalent to the disavowal of male castration anxiety. (cis-india.org)
  • In a broad sense, castration analogues include fears of losing something, for example, a thing that is seen as a phallic symbol, a fear of sharing one's ideas. (checkmydream.com)
  • The phallic mother childish fantasy shows denial's action in maintaining irrational beliefs and their effects on the sense of reality. (bvsalud.org)
  • There are no female fetishists, either for Freud or Lacan, for to speak of female fetishism would involve displacing the basic precepts of psychoanalysis -- namely the scene of castration leading to phallic fetishism. (cis-india.org)
  • Guided by the theoretical domains framework (TDF), urologists and patients from facilities with the highest and lowest castration rates across the VA will be interviewed to identify key preferences and de-implementation barriers for reducing castration as prostate cancer treatment. (biomedcentral.com)
  • The investigators will conduct national surveys of urologists to prioritize key barriers identified in Aim 1 for stopping incident castration as localized prostate cancer treatment using a DCE experiment design. (biomedcentral.com)
  • Aim 3: To pilot two tailored de-implementation strategies to reduce castration as localized prostate cancer treatment. (biomedcentral.com)
  • Dreams in which the surgical removal of any part of our body takes place reflect our fears about puberty and castration. (checkmydream.com)
  • In that sense, puberty orientates the child towards the binary function of reproduction and rearing of the species. (quadrant.org.au)
  • Crawford adds images of skin color dilution as a type of castration to the field of race and psychoanalysis. (cornell.edu)
  • According to some dreambooks, castration symbolically warns of loss of respect or reflects the fear of impotence. (checkmydream.com)
  • Amputation warns not only about threatening and impending losses. (dreamsnest.com)
  • Denial defends narcissism against castration threat, which is not restricted to the loss of genitals, but evokes several other narcissistic wounds. (bvsalud.org)
  • Freud couldn't resist writing about the sandman in connection with the threat of castration, which is lazy thinking in my book. (tangents.co.uk)
  • Talking to a castrato , knowing that he is a castrato, and experiencing some awkwardness, inconvenience - such a dream symbolizes the loss of something that is certainly important to you. (checkmydream.com)
  • Modern dream psychoanalysts believe, that castration symbolizes the loss of vital energy, less often it is considered to be the symbol of sense of guilt or the fear of punishment. (dream-symbols.com)
  • On the one hand, as mentioned above, castration is the symbol of fears of own sexual lacks, deprivation of masculinity or masculinity and all the responsibilities connected with it. (dream-symbols.com)
  • Genomic analysis of products of conception collected after spontaneous pregnancy loss in the first trimester reveals previously undetected chromosomal aberrations and a higher degree of mosaic chromosomal imbalances. (nature.com)
  • Neutering in a dream can also indicate fear of responsibility, fear of confrontation with real life, fear of being defeated by others, especially in competition for a woman, and, ultimately, fear of castration refers to impotence in old age. (checkmydream.com)
  • It also refers to a person's sense of personal and social identity based on those attractions, related behaviors, and membership in a community of others with similar attractions and behaviors. (msdmanuals.com)
  • In retrospect it's always difficult to make sense of why this particular incident was the catalyst. (wamc.org)
  • Both for men and women it is not uncommon to dream about loss of hair while having a personal life crises, which can be related to a sense of powerlessness. (michaelrolsen.com)
  • As a consequence of stress, behavioral changes may occur in the animal, as well as certain physical symptoms, such as hair loss or excessive scratching. (catsbuz.com)
  • Hormonal changes that occur, for example, after castration of a feline , can give rise to an abnormal loss of fur. (catsbuz.com)
  • The maintenance of the steady-state equilibrium between ROS generation and elimination is crucial for cell survival, while its loss causes cell death by different mechanisms triggered by oxidative damage. (hindawi.com)
  • As for Psychoanalytical dreambook , it gives the following explanations of dreams about castration: it can mean conflict between male and female personalities. (checkmydream.com)
  • An internal sense of being male, female, or something else, which may or may not correspond to an individual's sex assigned at birth or sex characteristics. (msdmanuals.com)
  • Castration is usually interpreted as the fear of losing sexual abilities by men. (dream-symbols.com)
  • For man the castration dream is certainly related with loss of power and sexual performance. (dreamsnest.com)
  • Dreams about castration can also be indicative of other kinds of power struggles in your life. (checkmydream.com)
  • If a man dreams that he loses his hair (either by falling off or he or someone else cuts it off), then it is perhaps a loss of strength and manliness. (michaelrolsen.com)
  • Calves castrated near weaning have a one- to two-week period of weight loss soon after castration that is never regained. (beefmagazine.com)
  • No medical authority would augment weight loss with diet pills and a gastric band. (quadrant.org.au)
  • Risk-factor modification, including lifestyle interventions (eg, exercise and weight loss) is strongly encouraged for ED patients with cardiovascular disease. (medscape.com)
  • The presence of untreated tumors or certain kidney diseases These are two pathologies that can have as their first manifestations the loss of vitality in the coat or, directly, hair loss. (catsbuz.com)
  • To dream amputated legs, foot (feet) - The meaning of amputated legs or foot in the dream, signifies that you will have some losses in your life. (dreamsnest.com)
  • he cannot find a woman to accommodate his extremely large dick, and this in concert with his aging is undercutting his sense of himself and his place in life. (correlatedcontents.com)
  • Then you may be asking yourself what's going on in your life right now - does it limit your sense of being a woman? (michaelrolsen.com)
  • A dream in which you observe a castration operation in men portends love affairs in search of a man who could fully satisfy you sexually. (checkmydream.com)
  • How to interpret a dream about castration? (dream-symbols.com)
  • When one loses one's own body part by amputation in a dream, this dream leaves a strong sense of loss. (dreamsnest.com)
  • To dream cut off or amputated finger - This dream indicates physical and mental confusion, because you have lost the ability to feel with the sense of touch. (dreamsnest.com)
  • Dream interpretation on hair and loss of hair. (michaelrolsen.com)
  • OBJECTIVE: This study assessed the use of a topical anesthetic as a feasible approach to reduce pain during piglet castration using a minimal anesthesia protocol. (bvsalud.org)
  • Those who lose fingers and then a part of the sense of touch is lost this means that you have lack of feeling to acquire knowledge through senses. (dreamsnest.com)
  • Leftists want power and money, and if you examine their policies with this in mind, they pretty much always make sense. (powerlineblog.com)
  • In that essay, Freeman argues that "we need to understand and practice time as fully incorporated, as nowhere existing outside of bodies and their pleasures," and against [or rather, alongside] the recent turn in queer studies to loss, shame, and grief [e.g. (inthemedievalmiddle.com)
  • In 1972, foreclosure couples with castration, this time not about the Wolfman, but the discourse of the capitalist. (avdelidi.gr)
  • If you have already ruled out shedding as the cause of your cat's hair loss and the process takes time or is excessive, the best solution is to go to a veterinarian to make a reliable diagnosis and recommend the best solution. (catsbuz.com)
  • Stress is one of the most frequent causes of hair loss in cats and, at the same time, more difficult to detect. (catsbuz.com)
  • Further, having a family necessarily entails a loss of focus - instead of concentrating on a problem 16 hours a day, one's time becomes split between work, spouse, children, mortgage, etc. (hackermojo.com)
  • Erotohistoriography would name a practice of tracing histories written on queer bodies-more precisely, it would trace "how queer relations complexly exceed the present," and "against pain and loss," it would "posit the value of surprise, of pleasurable interruptions and momentary fulfillments from elsewhere, other times" [p. 59]. (inthemedievalmiddle.com)
  • CLINICAL RELEVANCE: In this anesthesia model, the application of TS after skin incision significantly reduced MAP responses and nocifensive movements with spermatic cord transection compared with the application of P. However, the waiting period between TS-application and spermatic cord transection might limit the benefit of the method in conscious piglets, as pain during castration is reduced but additional stress is caused by the prolonged handling. (bvsalud.org)
  • What both do, ideally, is give the person a sense of contentment, a feeling that things are the way they should be. (hackermojo.com)
  • And therefore the cutting off, or disabling, or weakening a man's hand or finger, or striking out his eye or foretooth, or depriving him of those parts the loss of which in all animals abates their courage, are held to be mayhems. (bristol.ac.uk)
  • As a result, the English version has a better sense of accomplishment as a story than the original version. (semo.edu)
  • An undercurrent of light-skinned blackness as a type of castration emerges within an ongoing story about the feminizing of light skin and the masculinizing of dark skin. (cornell.edu)
  • This loss of focus is often welcome since it is an almost natural result of finding love. (hackermojo.com)
  • We have no loss of libido and may be keen to make love to boost our mood. (rxisk.org)
  • This article analyzes the unconscious family transmissions and their relationship with the simultaneous admission and nonadmission of castration. (bvsalud.org)
  • My childhood makes soo much more sense now that I know where the term "Bonzai" originated from. (thetruthaboutguns.com)
  • Sometimes it is also used in a slightly softer sense, to indicate fictitious and twee transgression (see the sneering term 'Mayhem Parva school' for rural murder mysteries). (bristol.ac.uk)
  • If you have recently neutered your cat, ask your vet if this could be the cause and how to control the hair loss. (catsbuz.com)
  • The prospect of the exercise of those powers by the incumbent is causing a loss of bladder control among many of the same GOP-aligned polemicists who insisted that they were perfectly safe when placed at the disposal of his predecessor. (blogspot.com)
  • To do so, we filmed 178 piglets before the applied procedures, after injection of the local anesthetic, and up to 24 h after castration (five observation times in total) in an observation arena and compared their behavior before and after castration and between treatments and control groups. (bvsalud.org)
  • The results showed significant differences in the behavior of the piglets before and after castration and between the sham-castrated control group and the control group castrated without anesthesia. (bvsalud.org)
  • Yes, one of the strengths of the film is that it shows how the parents have been coping with the loss of their daughter. (wamc.org)
  • The analysis of the response to an interdigital pinch revealed a biphasic reaction pattern in the electroencephalogram (EEG) that similarly was observed for the surgical stimuli during the castration procedure in the group without analgesia. (bvsalud.org)
  • I'm talking books that settle into my deepest sense of sorrow and fear, books that disturb me, books that expose injustice, suffering and human cruelty. (bacononthebookshelf.com)
  • Then here we will discuss the reasons for the hair loss. (catsbuz.com)
  • If your cat has dull, rough hair or abundant hair loss, the cause may be a poor or unbalanced diet that is causing nutritional deficiencies in the animal. (catsbuz.com)
  • Among the adverse reactions that can be caused by the intake of some drug or toxic food, hair loss in cats is a possibility. (catsbuz.com)
  • Thus, the cat scratches a lot, damaging its scalp and causing hair loss. (catsbuz.com)
  • Sometimes the cause of hair loss in cats is in some alteration or dysfunction of their endocrine system. (catsbuz.com)
  • So like the man, a loss of hair in women is a symbol of a loss of femininity. (michaelrolsen.com)
  • Bobby Gillespie once compared Kristofferson in his heyday to Jesus, which makes perverse sense to me. (tangents.co.uk)
  • In the Garden of Dicks, the sense of entitlement regarding female bodies is so massive that many men assume women will "let you do anything," as Donald Trump has suggested on more than one occasion. (newsweek.com)
  • the growing loss of identity, but not just identity, for that loss might really be a positive in some contexts, but the insertion of the non-self. (john-steppling.com)
  • Devastated by her loss, she travels through Europe, constantly changing her identity and taking on a series of lovers. (encyclopedia.com)
  • Dreaming of castration can also mean complete loss of energy as a result of self-confidence and loss of religious faith. (checkmydream.com)