Loop diuretics diuretics. Medical search. Frequent questions

The drugs were given to the study's loop-diuretic-resistant patients on top of furosemide . (medscape.com)
Loop diuretic efficiency, that is weight change in kg per 40 mg furosemide, "was smaller with dapagliflozin than with metolazone at each time point after randomization, although the difference was only significant at 24 hours," the published report states. (medscape.com)
Loop diuretics such as intravenous furosemide may be used carefully in pediatric patients with reduced cardiac function and/or significant mitral valve insufficiency when associated with severe aortic valve stenosis. (medscape.com)
Furosemide is a loop diuretic that increases excretion of water by interfering with the chloride-binding cotransport system, which, in turn, inhibits sodium and chloride reabsorption in the ascending loop of Henle and distal renal tubule. (medscape.com)
We found 9 trials studying the blood pressure-lowering ability of 5 different loop diuretics (furosemide, cicletanine, piretanide, indacrinone and etozolin) in 460 participants. (cochrane.org)
Nine trials evaluated the dose-related blood pressure-lowering efficacy of five drugs within the loop diuretics class (furosemide 40 mg to 60 mg, cicletanine 100 mg to 150 mg, piretanide 3 mg to 6 mg, indacrinone enantiomer -2.5 mg to -10.0/+80 mg, and etozolin 200 mg) in 460 people with baseline blood pressure of 162/103 mmHg for a mean duration of 8.8 weeks. (cochrane.org)
Carbonic anhydrase inhibitors (eg, acetazolamide) and loop diuretics (eg, furosemide) are thought to exert their effect on ICP by reducing cerebrospinal fluid (CSF) production at the choroid plexus. (medscape.com)
Furosemide inhibits the resorption of sodium and chloride in the loop of Henle and the proximal and distal tubules of the kidney. (medscape.com)
Furosemide is a loop affecting water pill/diuretic which is a kind of water pill or diuretic (heart failure drug, cardiovascular drug). (healthtap.com)
The most used loop diuretic for the treatment of heart failure is furosemide (LASIX and generics), which the Food and Drug Administration (FDA) approved in 1966. (worstpills.org)
The high dose of HWI was almost equipotent to furosemide (in terms of diuretic activity). (scialert.net)
Loop diuretic doses were titrated to a dose of at least 960 mg/day of IV furosemide equivalents before a thiazide diuretic was added. (news-medical.net)
Loop diuretics (e.g., furosemide, ethacrynic acid, bumetanide) affect the potassium gradient of the stria vascularis, as well as the electrical potential of the endocochlear structure. (medscape.com)

Bumetanide belongs to a group of medicines called loop diuretics or "water pills. (mayoclinic.org)

Several types of diuretics are available to manage hypertension. (medicalnewstoday.com)
Some types of diuretics may also help in other ways. (medlineplus.gov)
Several types of diuretics can be used increase water excretion through distinct mechanisms. (medscape.com)

The study enrolled adult patients with type 2 diabetes and an estimated glomerular filtration rate (eGFR) of at least 30 mL/min/1.73m 2 admitted to hospital with ADHF and current or planned treatment with intravenous (IV) loop diuretics. (news-medical.net)
Therefore, we treated the patient with intravenous methylprednisolone at a dose of 1 mg/kg/day (125 mg/d) and with diuretics and noninvasive ventilation (NIV). (cdc.gov)

For example, thiazides and loop diuretics can lead to low potassium, but PSDs can lead to high potassium. (medicalnewstoday.com)
Thiazides and loop diuretics exhibit their diuretic effects from the luminal side by inhibiting the Na + -Cl - cotransporter of the distal tubule and the Na + -K + -2Cl - co-transporter of the loop of Henle, respectively ( Ives, 2001 ). (aspetjournals.org)
Thiazides and loop diuretics are two common classes of diuretics used in medical treatment. (ilpi.com)
Some diuretics (thiazides and loop diuretics in particular) have antihypertensive actions that are independent of the diuretic effects. (medscape.com)

Loop diuretics are indicated and used to treat hypertension, but a systematic review of their blood pressure-lowering efficacy or effectiveness in terms of reducing cardiovascular mortality or morbidity from randomized controlled trial (RCT) evidence has not been conducted. (cochrane.org)
To determine the dose-related decrease in systolic or diastolic blood pressure, or both, as well as adverse events leading to participant withdrawal and adverse biochemical effects (serum potassium, uric acid, creatinine, glucose and lipids profile) due to loop diuretics versus placebo control in the treatment of people with primary hypertension. (cochrane.org)
We included double-blind randomized placebo-controlled trials of at least three weeks duration comparing loop diuretic with a placebo in people with primary hypertension defined as blood pressure greater than 140/90 mmHg at baseline. (cochrane.org)
Can a person treat hypertension with diuretics? (medicalnewstoday.com)
Are diuretics a suitable treatment option for hypertension? (medicalnewstoday.com)
Can diuretics help with hypertension? (medicalnewstoday.com)
Diuretics can help reduce blood pressure in people with hypertension . (medicalnewstoday.com)
A physician can recommend the most appropriate diuretic depending on a person's overall physical health and other medications in their hypertension management plan. (medicalnewstoday.com)
Loop diuretics are not a first-line treatment for hypertension. (medicalnewstoday.com)
However, loop diuretics can be helpful for managing hypertension in patients who have specific types of heart failure called heart failure preserved ejection fraction (HFpEF) and heart failure with reduced ejection fraction (HFrEF) . (medicalnewstoday.com)
However, PSDs are not as potent as other diuretics, and doctors do not recommend them as a first-line treatment for hypertension. (medicalnewstoday.com)
Hyperparathyroidism, hypertension and loop diuretic medication in renal transplant recipients. (ox.ac.uk)
Diuretics cause natriuresis and are therefore used to treat patients with volume overload, including hypertension, liver cirrhosis, nephrotic syndrome, and congestive heart failure ( Ives, 2001 ). (aspetjournals.org)
Diuretics are used in medicine to treat heart failure, liver cirrhosis, hypertension , and some kidney diseases. (ilpi.com)
Diuretics are used in the treatment of heart failure, liver cirrhosis, hypertension, and certain kidney diseases. (medscape.com)

A secondary effect of loop diuretics is to increase the production of prostaglandins, which results in vasodilation and increased blood supply to the kidney. (wikipedia.org)
Based on the limited number of published RCTs, the systolic/diastolic blood pressure-lowering effect of loop diuretics is -8/-4 mmHg, which is likely an overestimate. (cochrane.org)

Therefore, loop diuretics increase magnesium and calcium excretion. (pharmacology2000.com)
In circumstances that result in hypercalcemia, calcium excretion can be enhanced by administration of loop diuretics with saline infusion. (pharmacology2000.com)
To elucidate the molecular mechanisms for the tubular excretion of diuretics, we have elucidated the interactions of human organic anion transporters (hOATs) with diuretics using cells stably expressing hOATs. (aspetjournals.org)
In addition, because the binding of diuretics to plasma proteins is generally high (more than 90%), tubular secretion is the main route of urinary excretion of the diuretics. (aspetjournals.org)
[2] Diuretics relieve these symptoms by increasing the excretion of sodium and water from the kidneys. (worstpills.org)
Some diuretics (eg, acetazolamide) are used to make the urine more alkaline and can be efficacious for increasing the excretion of substances such as aspirin in cases of poisoning or overdose. (medscape.com)

Diuretics work by triggering the release of more urine and electrolytes, such as sodium and potassium, from the body. (medicalnewstoday.com)
Loss of calcium from urine can be increased with the use of a loop diuretic, but this therapy cannot be started until intravascular volume has been replenished. (medscape.com)
Diuretics cause or increase urine production or urine flow out of the body. (ilpi.com)
Diuretics regulate urine production by stimulating or inhibiting the body's natural hormones. (ilpi.com)
HWI also caused significant increase in specific gravity, specific conductivity, creatinine clearance, Na + and K + levels, thiazide secretion index, urine alkaline index, diuretic action, Na + and K + saliuretic indices and significant decrease in carbonic anhydrase index. (scialert.net)
A standardized protocol for IV loop diuretic dosing and titration every 12-24 hours was used for both study arms throughout the study period to target a urine output of 3-5 L/day. (news-medical.net)
A spot urine sample was collected after the initial IV loop diuretic dose, but before dapagliflozin administration, to measure baseline diuretic-induced urine sodium, potassium, and creatinine. (news-medical.net)
Regarding exploratory endpoints, dapagliflozin significantly increased both 24-hour natriuresis (p=0.025) and 24-hour urine output (p=0.005), and decreased both time to completing IV diuretic therapy (p=0.006) and time to hospital discharge (p=0.007). (news-medical.net)
The reference range value for urine diuretic screening is a negative test result. (medscape.com)
Liquid chromatography-tandem mass spectrometry screening method for the simultaneous detection of stimulants and diuretics in urine. (medscape.com)
Liquid chromatographic screening of diuretics in urine. (medscape.com)

In congestive heart failure, Amiloride Hydrochloride may be effective alone, but its principal indication is for concomitant use in patients receiving thiazides or more potent diuretic agents. (janusinfo.se)

They do not have as potent an effect as thiazides or thiazide-like diuretics on blood pressure. (medicalnewstoday.com)
Patients on multiple diuretics (n=330) were assigned to a group based on the most potent diuretic (e.g., patients treated with a non-loop diuretic and a loop diuretic were assigned to the group of patients on a loop diuretic). (pace-cme.org)
In Sri Lankan traditional medicine, in addition to some of these reported uses it is also claimed that the sharp smell of the leaves of R. graveolens promotes sexual desire in women and leaf infusion possesses potent diuretic activity ( Weragoda, 1994 ). (scialert.net)
Although Amiloride Hydrochloride may be used alone, its principal indication is as concurrent therapy with thiazides or more potent diuretics in order to conserve potassium during periods of vigorous diuresis and during long-term maintenance therapy. (janusinfo.se)
It may be used with more potent diuretics when a greater diuresis is required while maintaining a more balanced serum electrolyte pattern. (janusinfo.se)

2 Nocturnal leg cramps are a common but relatively self-limited condition of unclear pathophysiology, although associations with various medications (such as diuretics and quinine) have been proposed. (annfammed.org)
They include certain antibiotics like gentamicin, cancer treatment drugs like cisplatin and carboplatin, and pain relievers that contain salicylate like aspirin, quinine, loop diuretics. (cdc.gov)

Antihypertensive drugs from the thiazide diuretic drug class have been shown to reduce mortality and cardiovascular morbidity. (cochrane.org)

Diuretics at Cardiovascular Pharmacology. (ilpi.com)

Loop diuretics are diuretics that act on the Na-K-Cl cotransporter along the thick ascending limb of the loop of Henle in nephrons of the kidneys. (wikipedia.org)
Loop diuretics act on the Na+-K+-2Cl− symporter (NKCC2) in the thick ascending limb of the loop of Henle to inhibit sodium, chloride and potassium reabsorption. (wikipedia.org)
Loop diuretics inhibit reabsorption of sodium in the ascending limb of the loop of Henle and have a weak inhibitory action on CA. (medscape.com)
These data indicate that AP-III has a unique natriuretic effect different from frusemide, and that the main site of natriuretic action by AP-III is proximal to the ascending loop of Henle. (portlandpress.com)

Loop diuretics also inhibit magnesium and calcium reabsorption in the thick ascending limb. (wikipedia.org)

Diuretics, or water pills, are medications that help reduce the amount of water in the body. (medicalnewstoday.com)
The American Heart Association (AHA) recommends thiazide-like diuretics alongside other blood pressure medications and lifestyle adjustments. (medicalnewstoday.com)
Commonly prescribed medications for heart failure include beta-blockers , diuretics (water pills), ACE (angiotensin converting enzyme) inhibitors, and ARBs (angiotensin receptor blockers). (hdkino.org)
Diuretic medications are used to artificially elevate the urination rate. (medscape.com)

In patients with severe hypercalcemia, the individual typically is volume depleted, which means that volume should be replaced with saline prior to institution of diuretic therapy. (medscape.com)

Dapagliflozin (Farxiga) appears to be no more effective than the "thiazide-like" diuretic metolazone at improving pulmonary congestion and fluid status in patients with acute heart failure (AHF), suggests a new randomized trial. (medscape.com)
Changes in volume status and measures of pulmonary congestion and risk for serious adverse events were similar for those assigned to take dapagliflozin, an SGLT2 inhibitor, or metolazone, a quinazoline diuretic. (medscape.com)
DAPA-RESIST clinical trial - Dapagliflozin versus metolazone in heart failure with diuretic resistance. (medscape.com)

Loop diuretics cause increased uric acid reabsorption in the proximal tubule, secondary to hypovolemic states. (pharmacology2000.com)

While thiazide diuretics are more effective in patients with normal kidney function, loop diuretics are more effective in patients with impaired kidney function. (wikipedia.org)
This trial further adds to the evidence base and safety profile for using SGLT2 inhibitors in patients with acute heart failure," and "gives further confidence to clinicians that this class can be started in 'sicker' patients with HF who also have diuretic resistance," Campbell said. (medscape.com)
When all patients were stratified according to creatinine clearance, serum PTH was always greater in patients receiving loop diuretics but this difference was particularly striking in the patients with the poorest graft function. (ox.ac.uk)
In patients with HFrEF, treatment with sacubitril/valsartan resulted in a lower loop diuretic requirement, compared with enalapril [1]. (pace-cme.org)
Consequently, the ESC guidelines state that in patients with HFrEF, the use of sacubitril/valsartan may allow a reduction in loop diuretic requirement [2], but data in patients with HFpEF are lacking. (pace-cme.org)
However, it is unclear how treatment with sacubitril/valsartan affects longitudinal patterns in loop diuretic use and to what extent the efficacy and safety of sacubitril/valsartan is affected by background diuretic therapy in patients with symptomatic HFpEF. (pace-cme.org)
This post hoc analysis of data from the PARAGON-HF study examined the influence of treatment with sacubitril/valsartan on longitudinal patterns in loop diuretic use and the extent to which the efficacy and safety of sacubitril/valsartan is affected by background diuretic therapy in patients with symptomatic HFpEF. (pace-cme.org)
In this post hoc analysis, 4796 patients for whom data were available on diuretic therapy at baseline were divided into 3 groups: patients on no diuretic (n=341), a non-loop diuretic (n=698), or a loop diuretic (n=3757). (pace-cme.org)
Patients treated with a mineralocorticoid receptor antagonist alone were considered as if they were on no diuretic. (pace-cme.org)
This post hoc analysis of data from the PARAGON-HF study shows that in patients with symptomatic HFpEF, the influence of sacubitril/valsartan on longitudinal patterns in loop diuretic use is limited. (pace-cme.org)
Reduced loop diuretic use in patients taking sacubitril/valsartan compared with enalapril: the PARADIGM-HF trial. (pace-cme.org)
Joint clinical practice guidelines by the American College of Cardiology, the American Heart Association and the Heart Failure Society of America recommend treatment with loop diuretics (a type of water pills) in most heart failure patients with. (worstpills.org)
Joint clinical practice guidelines by the American College of Cardiology, the American Heart Association and the Heart Failure Society of America recommend treatment with loop diuretics (a type of water pills) in most heart failure patients with congestion or fluid buildup resulting in edema (swelling in body tissues, mainly in the feet, legs and ankles) or breathing difficulties. (worstpills.org)
The patients were hospitalized for either newly diagnosed heart failure or worsening of chronic heart failure (regardless of ejection fraction, which is a measure of the strength of the heart's pumping function), and their treatment plans included daily long-term use of loop diuretics. (worstpills.org)
Patients taking diuretics are sometimes given potassium supplements to prevent hypokalemia, but one should only take these on advice of a physician. (ilpi.com)
Little is known about the use and influence of diuretics and renin-angiotensin-aldosterone (RAAS) blockade on morbidity in those patients. (smw.ch)
The hypothesis was tested that the use of diuretics and RAAS blockade could be associated with an increased incidence of serious conditions in those patients. (smw.ch)
CONCLUSIONS: Treatment with two or more diuretics, loop diuretics, or a combination therapy with RAAS blockade and diuretics are independently associated with serious condition and therefore should be recognized as "red flags" in elderly patients presenting to the ED with NSC. (smw.ch)
Early initiation of the sodium glucose co-transporter 2 (SGLT2) inhibitor dapagliflozin did not result in a statistically significant improvement in diuretic efficiency relative to structured usual care in hospitalized patients with acute decompensated heart failure (ADHF), according to late breaking research presented in a Hot Line session today at ESC Congress 2023. (news-medical.net)
The DICTATE-AHF trial examined the efficacy and safety of dapagliflozin initiated within 24 hours of hospital presentation on diuretic response in patients with hypervolaemic ADHF. (news-medical.net)
Gradual weight reduction in cirrhotic patients is especially desirable to reduce the likelihood of untoward reactions associated with diuretic therapy. (janusinfo.se)

Loop diuretics also inhibits NKCC2 at macula densa, reducing sodium transported into macula densa cells. (wikipedia.org)
At the same time, loop diuretics inhibits the tubuloglomerular feedback mechanism so that increase in salts at the lumen near macula densa does not trigger a response that reduces the GFR. (wikipedia.org)

By disrupting the reabsorption of these ions, loop diuretics prevent the generation of a hypertonic renal medulla. (wikipedia.org)

Loop diuretics are 90% bonded to proteins and are secreted into the proximal convoluted tubule through organic anion transporter 1 (OAT-1), OAT-2, and ABCC4. (wikipedia.org)
The protein bound nature of the loop diuretic molecules causes it to be secreted via several transporter molecules along luminal wall of the proximal convoluted tubules to be able to exert its function. (wikipedia.org)
The tubular secretion of diuretics in the proximal tubule has been shown to be critical for the action of drugs. (aspetjournals.org)

Background diuretic therapy had no statistically significant impact on the effect of sacubitril/valsartan on the primary composite outcome (P-interaction=0.65). (pace-cme.org)
Background diuretic therapy had no statistically significant impact on the effect of sacubitril/valsartan on the occurrence of hypotension, serum creatinine concentration ≥2.0, ≥2.5 and ≥3.0 mg/dl and drug discontinuation. (pace-cme.org)

Most pharmaceutical drugs are detrimental to the kidneys, and "loop diuretics" are especially so. (oneradionetwork.com)

Loop diuretics are principally used in the following indications: Heart failure - Giving 2.5 times of previous oral dose twice daily for those with acute decompensated heart failure is a reasonable strategy. (wikipedia.org)

The dose-ranging effects of loop diuretics could not be evaluated. (cochrane.org)
Severe hypovolemia can develop if a person takes too high a dose of diuretics, which can lead to low blood pressure, dizziness, and fainting. (medicalnewstoday.com)
Because the trial involved a pragmatic (real-world) design, the dose and frequency of the assigned loop diuretic were determined by each patient's treating clinician. (worstpills.org)
The primary outcome was diuretic efficiency (diuretic response) expressed as the cumulative change in weight per cumulative loop diuretic dose (IV and oral) from enrolment to day 5 or discharge, if sooner. (news-medical.net)
Treatment should be started with a low dose of Amiloride, i.e. 5mg (1 tablet), plus a low dosage of the other diuretic agent. (janusinfo.se)

This study has evaluated the diuretic potential of R. graveolens leaves in rats using a Hot Water Infusion (HWI). (scialert.net)

Diuretics may also cause hypokalemia , abnormally low potassium level. (ilpi.com)
Optimal dosage is determined by diuretic response and the plasma potassium level. (janusinfo.se)

Do-administration of drugs that inhibit weak acid secretion (e.g. probenecid or indomethacin) may alter loop diuretic clearance. (pharmacology2000.com)
Thus, tubular secretion has been thought to be critical for the action of loop and thiazide diuretics. (aspetjournals.org)

The review did not provide a good estimate of the incidence of harms associated with loop diuretics because of the short duration of the trials and the lack of reporting of adverse effects in many of the trials. (cochrane.org)

Proper electrolyte balance is essential to good health, and diuretics may cause electrolyte imbalance. (ilpi.com)
The most common electrolyte imbalance, hyponatremia , having too little sodium, can result from the use of diuretics. (ilpi.com)
Care should be taken when taking diuretics to avoid dehydration (excessive body water loss) and electrolyte imbalance . (ilpi.com)

After adjusting for baseline weight, the odds ratio (OR) for diuretic efficiency with dapagliflozin versus structured care was 0.65, 95% confidence interval (CI) 0.41 to 1.01, p=0.06. (news-medical.net)

[3] However, torsemide (SOAANZ and generics) [4] - another loop diuretic that the FDA approved in 1993 - has been suggested to be more advantageous because it is more bioavailable (a large part of it is absorbed and used in the body) and it has a longer duration of action. (worstpills.org)

Use of a kind of heart medicine called loop diuretics can also cause you to be short on potassium. (stlukes-stl.com)

A pyridine and sulfonamide derivative that acts as a sodium-potassium chloride symporter inhibitor (loop diuretic). (bvsalud.org)

These diuretics inhibited organic anion uptake mediated by hOAT1, hOAT2, hOAT3, and hOAT4 in a competitive manner. (aspetjournals.org)

While more commonly used to reduce water retention, loop diuretics are are also indicated for lowering elevated blood pressure. (cochrane.org)
Thiazides, loop diuretics, and potassium sparing diuretics (PSDs) all remove water and sodium from the body. (medicalnewstoday.com)
Diuretics (Water Pills) for High Blood Pressure at WebMD. (ilpi.com)

Hypercalcemia and belongs to the drug class loop diuretics . (drugs.com)

Previous studies of diuretic combinations improved decongestion, but these diuretic combinations inherently did not optimize GDMT and were not associated with improved post-discharge outcomes. (news-medical.net)

It is postulated that loop diuretics exacerbate the hyperparathyroidism which complicates renal disease. (ox.ac.uk)

The best estimate of systolic/diastolic blood pressure-lowering efficacy of loop diuretics was -7.9 (-10.4 to -5.4) mmHg/ -4.4 (-5.9 to -2.8) mmHg. (cochrane.org)
Background diuretic therapy does not affect the efficacy and safety of sacubitril/valsartan, compared with valsartan. (pace-cme.org)

In baseline diuretic users, there was no difference on new diuretic discontinuations or treatment disruptions over the course of the trial. (pace-cme.org)

Anatomy3

Diseases8

Chemicals and Drugs42

Analytical, Diagnostic and Therapeutic Techniques and Equipment8

Phenomena and Processes6

Health Care5

Furosemide13

Bumetanide1

Types of diuretics3

Intravenous2

Thiazides and loop diuretics4

Hypertension15

Effect of loop diuretics2

Excretion6

Urine11

Congestive1

Potent5

Quinine2

Thiazide diuretic1

Pharmacology1

Henle4

Magnesium and calcium1

Medications4

Saline1

Metolazone3

Uric acid1

Patients21

Inhibits2

Reabsorption1

Proximal3

Statistically significant2

Kidneys1

Indications1

Dose5

Infusion1

Potassium level2

Secretion2

Adverse effects1

Electrolyte Imbalance3

Versus1

Torsemide1

Heart1

Inhibitor1

Anion1

Water3

Hypercalcemia1

Outcomes1

Renal disease1

Efficacy2

Baseline1