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  • stem
  • Organ homeostasis and organismal survival are related to the ability of stem cells to sustain tissue regeneration. (telomerescience.com)
  • This suggests a direct impact of telomere length and telomerase activity on stem cell biology. (telomerescience.com)
  • Here, we demonstrate that telomerase reintroduction in mice with critically short telomeres is sufficient to correct epidermal HF stem cell defects. (telomerescience.com)
  • These mice may be useful for lineage-tracing or marking Lgr5 -expressing stem cells of the small intestine. (jax.org)
  • This variegated expression is advantageous for performing clonal lineage tracing and sorting intestinal stem cells, but may have limitations for more quantitative studies such as Lgr5-Cre driven knockout strategies. (jax.org)
  • EGFP fluorescence is observed in crypt base columnar cells in small intestine (aka stem cells of the small intestine) and colon. (jax.org)
  • This construct was inserted into the targeted gene via electroporation into male 129P2/OlaHsd-derived IB10/E14IB10 embryonic stem (ES) cells. (jax.org)
  • Those stem cells and their differentiated progeny are organized into columns named epidermal proliferation units. (wikipedia.org)
  • In humans, it is estimated that keratinocytes turnover from stem cells to desquamation every 40-56 days. (wikipedia.org)
  • Johannes Carolus (Hans) Clevers (born 27 March 1957) is a professor in molecular genetics, a geneticist, physician, medical researcher who was the first to identify stem cells in the intestine and is one of the world's leading researchers on normal stem cells and their potential for regenerative therapy. (wikipedia.org)
  • Also in 2002 he became director of the Hubrecht Institute for Developmental Biology and Stem-Cell Research at the Royal Dutch Academy of Sciences. (wikipedia.org)
  • In 2007 he received a grant of two million euros from the Dutch Cancer Society (KWF) to study the function of stem cells in the normal intestines and in colon cancer, and in 2008 and 2015 he received ERC Advanced Investigator Grants. (wikipedia.org)
  • He was the first to link Wnt signaling with adult stem cell biology, when he showed that TCF4 gene disruption leads to the abolition of crypt stem cell compartments of the gut. (wikipedia.org)
  • He went on to show that the Tcf4-driven target gene program in colorectal cancer cells is the malignant counterpart of a physiological crypt stem cell program. (wikipedia.org)
  • Play media He then described the Wnt target Lgr5 as a marker for adult stem cells including those of crypts. (wikipedia.org)
  • By the creation of several ingenious Lgr5-based transgenic mice, he established the intestinal crypt as one of the pre-eminent models to visualize and study adult stem cells in mammals. (wikipedia.org)
  • He described several counter-intuitive characteristics for crypt stem cells: Lgr5 stem cells are abundant, they cycle rapidly, they divide symmetrically, and utilize their Paneth cell-daughters as their niche. (wikipedia.org)
  • neurons
  • More recently, thresholds were shown to be insensitive to widespread loss of the inner hair cell (IHC) synapses of these neurons that can occur after noise exposures causing only temporary threshold elevations ( Kujawa and Liberman, 2009 ). (jneurosci.org)
  • Behavioral, neural, and modeling data collectively suggest that ILD sensitivity depends on binaural integration of excitation and inhibition within a ≳3 ms temporal window, significantly longer than observed in lower brainstem neurons. (jneurosci.org)
  • This result can be explained by "slow" temporal integration arising from several-millisecond-long windows of excitatory-inhibitory interaction evident in midbrain, but not brainstem, neurons. (jneurosci.org)
  • Lgr5
  • When these mice mice are bred with mice containing a loxP -flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the floxed sequences in the Lgr5 -expressing cells of the offspring. (jax.org)
  • As such, when Lgr5-EGFP-IRES-creERT2 mice are bred with mice containing loxP -flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the floxed sequences in the Lgr5 -expressing cells of the offspring. (jax.org)
  • apical
  • Myosin VI (MYO6) is found largely on the apical side of the hair cells in the region of the cuticular plate. (egms.de)
  • epidermis
  • A keratinocyte is the predominant cell type in the epidermis, the outermost layer of the skin, constituting 90% of the cells found there. (wikipedia.org)
  • Some of the transit amplifying cells continue to proliferate then commit to differentiate and migrate towards the surface of the epidermis. (wikipedia.org)
  • Within the epidermis keratinocytes are associated with other cell types such as melanocytes and Langerhans cells. (wikipedia.org)
  • Keratinocytes form tight junctions with the nerves of the skin and hold the Langerhans cells and intra-dermal lymphocytes in position within the epidermis. (wikipedia.org)
  • The salt gland continues to develop to produce two to four vacuolated cells at the level of the epidermis, the stalk cell with an almost completely cutinized wall, and at least eight terminal cells. (wikipedia.org)
  • cuticular plate
  • Striated bodies were found below the cuticular plate when the organ of Corti was sectioned in a radial plane parallel with the long axis of the hair cells. (cdc.gov)
  • molecular biology
  • The course will build upon knowledge acquired through prior studies of cell and molecular biology, general physiology and human anatomy, as we focus primarily on the central nervous system. (coursera.org)
  • stems
  • The lack of earlier reports of striated bodies in chinchilla hair cells probably stems from the difficulty of detection which requires observation made through serial sections. (cdc.gov)
  • Stems 1-4 cm long, often branched, sans hyaloderm. (wikipedia.org)
  • bundles
  • The amplification may be powered by the movement of their hair bundles, or by an electrically driven motility of their cell bodies. (wikipedia.org)
  • scales
  • All members of the family have long, tapering hairs composed of cells arranged end to end, unlike the scales characteristic of the Cyatheaceae. (wikipedia.org)
  • The pappus on top consists of scales ending in a long drawn tip and with a row of hairs along the edges. (wikipedia.org)
  • relatively
  • Calcium concentration in the stratum corneum is very high in part because those relatively dry cells are not able to dissolve the ions. (wikipedia.org)
  • We show that such responses can be accounted for by relatively long windows of bilateral excitatory-inhibitory interaction, which we explicitly measure using trains of narrowband clicks. (jneurosci.org)
  • membrane
  • The quickness of the hair cell response may also be due to the fact that it can increase the amount of neurotransmitter release in response to a change as little as 100 μV in membrane potential. (wikipedia.org)
  • These produce spheres of oily secretions, including terpenes, which pass through the cell membrane and wall to accumulate as vesicles in the secretory cavity. (wikipedia.org)
  • structures
  • b) Anatomical structures of the hair bundle corresponding to the microscopic image in (a). (egms.de)
  • found
  • In all cases for the over 70 inner hair cells sectioned, when serial sections were examined, striated bodies were found to be located in every inner hair cell. (cdc.gov)
  • A very long tuft of hair found from base of cell lying in a fold above vein 6. (wikipedia.org)
  • The salt glands of mangroves such as Acanthus, Aegiceras, Aegialitis and Avicennia are a distinctive multicellular trichome, a glandular hair found on the upper leaf surface and much more densely in the abaxial indumentum. (wikipedia.org)
  • colon cancer
  • With these insights and in a collaboration with Bert Vogelstein, he proposed that in APC-deficient colon cancer, it is the inappropriate activation of the Wnt pathway that transforms cells. (wikipedia.org)
  • inner hair
  • The consistent occurrence of a striated organelle (Friedmann body) in the inner hair cells of the normal chinchilla. (cdc.gov)
  • The consistent occurrence of the striated bodies in the inner hair cells of normal chinchillas was reported. (cdc.gov)
  • 1997
  • In 1997 the United States Food and Drug Administration approved this tactic of hair removal. (wikipedia.org)
  • Hair removal lasers have been in use since 1997 and have been approved for "permanent hair reduction" in the United States by the Food and Drug Administration (FDA). (wikipedia.org)
  • whereas
  • In lepidosaurs, the hearing organ, the basilar papilla, is generally small, with at most 2000 hair cells, whereas in archosaurs the basilar papilla can be much longer (>10mm in owls) and contain many more hair cells that show two typical size extremes, the short and the tall hair cells. (wikipedia.org)
  • permanently
  • During this differentiation process, keratinocytes permanently withdraw from the cell cycle, initiate expression of epidermal differentiation markers, and move suprabasally as they become part of the stratum spinosum, stratum granulosum and eventually become corneocytes in the stratum corneum. (wikipedia.org)
  • This means that although laser treatments with these devices will permanently reduce the total number of body hairs, they will not result in a permanent removal of all hair. (wikipedia.org)
  • short
  • The cell very short and open. (wikipedia.org)
  • While lasers may output trains of short pulses to simulate a longer pulse, IPL systems can generate pulse widths up to 250ms which is useful for larger diameter targets. (wikipedia.org)
  • body
  • Keratinocytes are the only cells in the body with the entire vitamin D metabolic pathway from vitamin D production to catabolism and Vitamin D receptor expression. (wikipedia.org)
  • damage
  • Aging, noise exposure, as well as trauma can damage the hair cells, causing the sound to distort or be completely missing. (wakemed.org)
  • Viruses that damage respiratory lining cells also damage cilia, so a runnier mucus layer is more easily propelled. (theconversation.com)
  • adult
  • Light is absorbed by dark objects but reflected by light objects and water, so laser energy can be absorbed by dark material in the hair or skin, with much more speed and intensity than just the skin without any dark adult hair or melanin. (wikipedia.org)
  • below
  • In snakes, the basilar papilla is roughly 1mm long and only responds to frequencies below about 1 kHz. (wikipedia.org)
  • In contrast, lizards tend to have two areas of hair cells, one responding below and the other above 1 kHz. (wikipedia.org)
  • terminal
  • The neurotransmitters diffuse across the narrow space between the hair cell and a nerve terminal, where they then bind to receptors and thus trigger action potentials in the nerve. (wikipedia.org)