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DrosophilaDrosophila ProteinsDrosophila melanogasterAnimals, Genetically ModifiedInsect ProteinsGenetic LociLarvaMolecular Sequence DataMutationWingGene Expression Regulation, DevelopmentalEmbryo, NonmammalianChromosome MappingBase SequencePhenotypeAmino Acid SequencePhotoreceptor Cells, InvertebrateInsect HormonesQuantitative Trait LociCrosses, GeneticTranscription FactorsPupaGenome, InsectEyeSequence Homology, Amino AcidBody PatterningOogenesisDNA-Binding ProteinsCloning, MolecularGenes, LethalMorphogenesisChromosomesHomeodomain ProteinsModels, GeneticWnt1 ProteinX ChromosomeEvolution, MolecularNuclear ProteinsDNA Transposable ElementsSignal TransductionTranscription, GeneticGenetic LinkageSpecies SpecificityEcdysoneMushroom BodiesBlastodermGenetic VariationSense OrgansDNAIn Situ HybridizationSequence AlignmentMetamorphosis, BiologicalGenes, HomeoboxNervous SystemChromosomes, InsectRNA InterferenceReceptors, NotchRepressor ProteinsPhylogenyFat BodyTransgenesAllelesMembrane ProteinsGenetic MarkersConserved SequenceSequence Analysis, DNARNA, MessengerGenotypeHemocytesMultigene FamilyRecombination, GeneticDNA PrimersBiological EvolutionOptic Lobe, NonmammalianSelection, GeneticArmadillo Domain ProteinsNerve Tissue ProteinsSequence Homology, Nucleic AcidCentral Nervous SystemGene ExpressionDNA, ComplementaryModels, BiologicalSalivary GlandsPolymorphism, GeneticRestriction MappingMalpighian TubulesHeterochromatinMicrosatellite RepeatsGenetic Complementation TestImaginal DiscsHomozygoteEnhancer Elements, GeneticEye ProteinsCompound Eye, ArthropodFertilityCourtshipLongevityGenomeMutagenesisEcdysterone
MelanogasterMutationsGermlineProteinNeuromuscular junctionGeneticsVariationAllelesGenesChromosomePolymorphismsSpeciesEncodesMutantsPhenotypesMammalianSensitivityScreensStrainsGene expressionRegulationTranscription factorDevelopmentalAdultClusterProvenGenomicCellDiseaseMechanismsStructuralDevelopmentHumanFunctionGroup
Melanogaster18
Mutations4
  • Two independently isolated arrhythmic mutations at the per locus dramatically reduce the level of this transcript. (nih.gov)
  • Mutations at these loci result in a homologous pattern deletion in every segment and a duplication of the remaining wild-type pattern, the duplicated pattern having reversed polarity ( Nüsslein-Volhard & Wieschaus, 1980 ). (biologists.com)
  • Amitrole induced mutations at two loci in one mammalian cell line. (inchem.org)
  • [ 2 , 3 , 4 ] A full list of the described mutations is available at the TBX5 Gene Mutation Database , an online locus-specific database that contains germline and somatic mutations of the TBX5 gene. (medscape.com)
Germline1
  • Social communication of predator-induced changes in Drosophila behavior and germline physiology. (tcd.ie)
Protein6
  • In vertebrates this subfamily contains four proteins: TIF1α/TRIM24, TIF1β/TRIM28, TIF1γ/TRIM33, and TIF1δ/TRIM66, while only one protein, Bonus (Bon), is present in Drosophila , making it an attractive model to understand the conserved functions of TIF1 proteins. (elifesciences.org)
  • A C-terminal ataxin-2 disordered region promotes Huntingtin protein aggregation and neurodegeneration in Drosophila models of Huntington's disease. (tcd.ie)
  • A genome-wide resource for the analysis of protein localisation in Drosophila. (tcd.ie)
  • Gavin BA , Dolph MJ, Deleault NR, Geoghegan JC , Khurana V , Feany MB , Dolph PJ , Supattapone S . Accelerated accumulation of misfolded prion protein and spongiform degeneration in a Drosophila model of Gerstmann-Sträussler-Scheinker syndrome. (academictree.org)
  • The p19ARF protein, which is encoded by the same locus as p16, also leads to cell cycle arrest by inhibiting the ability of MDM2 to inactivate TP53. (medscape.com)
  • This locus, however, also encodes a protein from an alternative reading frame, designated p19ARF. (medscape.com)
Neuromuscular junction1
Genetics1
  • This method has been described as "a fly geneticist's Swiss army knife" and is widely used in Drosophila genetics. (wikipedia.org)
Variation2
  • Recently the genome sequences of eleven additional species of Drosophila have become available allowing us to examine variation in the structure of the Gr39a locus across a wide phylogenetic range of fly species. (st-andrews.ac.uk)
  • To test our hypotheses, we measured the critical thermal minimum (CT min ) and critical thermal maximum (CT max ) of 100 lines of the Drosophila Genetic Reference Panel (DGRP) and used GWAS to identify loci that explain variation in thermal limits. (frontiersin.org)
Alleles1
Genes5
  • In Drosophila , the BX-C cluster contains the three most posterior Hox genes, where their collinear activation incorporates progressive replacement of histone modifications, reorganization of 3D chromatin architecture and sequential activation of boundary elements and cis -regulatory regions. (biorxiv.org)
  • To generalize and quantify these promising results, a broader collection of 19 well-defined CRMs from 9 Drosophila genes known to be required for proper embryonic development was compiled. (sdbonline.org)
  • We identified 30 loci that predict tolerance, many of which are in genes involved in the regulation of immunity and metabolism. (datadryad.org)
  • Recent human GWAS finding, genes linked to sleep disorders in humans, have also led to several loci implicating metabolic processes. (uab.edu)
  • His lab is generating fruit-fly models of these risk loci, and exploiting them to identify causal genes, discover mechanistic biology and propose new therapeutic hypotheses that can be extended to humans in collaboration with Massachusetts General Hospital/Harvard. (uab.edu)
Chromosome1
  • The location of this clock gene was delimited by the molecular mapping of chromosome aberrations at or very near the per locus. (nih.gov)
Polymorphisms1
  • Our main approach has been to use population genomics to identify candidate loci and polymorphisms and then to study and validate these candidates experimentally. (unifr.ch)
Species1
  • Drosophila willistoni (Sturtevant, 1916) is a species of the willistoni group of Drosophila having wide distribution from the South of USA (Florida) and Mexico to the North of Argentina. (scielo.br)
Encodes1
Mutants1
  • In Drosophila RIM mutants, there is a large decrease in evoked synaptic transmission because of a significant reduction in both the clustering of Ca 2+ channels and the size of the readily releasable pool of synaptic vesicles at active zones. (jneurosci.org)
Phenotypes1
  • His research team has developed Drosophila cardiac and skeletal muscle disease models of laminopathies and validated Drosophila phenotypes in human muscle biopsy tissue from laminopathy patients (recently completed NIH R21 and pending R01 grants). (uab.edu)
Mammalian1
  • This important study advances our understanding of the functions and regulation of the Drosophila transcriptional regulator Bonus, an ortholog of mammalian TIF1 family members. (elifesciences.org)
Sensitivity1
  • The Drosophila SK channel (dSK) contributes to photoreceptor performance by mediating sensitivity control at the first visual network. (academictree.org)
Screens1
  • With Ram Viswanatha, he developed CRISPR/Cas9 pooled screens in Drosophila cells to facilitate large-scale screen in Drosophila and other arthropod cell lines. (wikipedia.org)
Strains1
  • Understanding the role of recombination, particularly within the mtr locus, on the fitness and expansion of strains with decreased susceptibility has important implications for the public health response to minimise gonorrhoea transmission. (cdc.gov)
Gene expression2
Regulation1
  • Glomerulus-Selective Regulation of a Critical Period for Interneuron Plasticity in the Drosophila Antennal Lobe. (tcd.ie)
Transcription factor1
Developmental1
  • Drosophila embryogenesis has proven to be an extremely powerful system for developmental gene discovery and characterization. (peerj.com)
Adult2
Cluster1
  • Here, we report that the miRNA iab-4 locus in the Drosophila Hox cluster is transcribed convergently from both DNA strands, giving rise to two distinct functional miRNAs. (nih.gov)
Proven1
  • Drosophila has proven to be a useful model system for analysis of behavior, including flight. (jove.com)
Genomic2
  • By using published DNA binding specificity data for five transcription factors active in the early Drosophila embryo, genomic regions containing unusually high concentrations of predicted binding sites were identified for these factors. (sdbonline.org)
  • Using CIS-ANALYST, the distribution of Bcd, Cad, Hb, Kr, and Kni binding sites were examined in a 1-Mb genomic region surrounding the well-characterized eve locus at a site_p value of 0.0003. (sdbonline.org)
Cell2
  • Drosophila CIAPIN1 homologue is required for follicle cell proliferation and survival. (nih.gov)
  • Cathepsin proteases mediate photoreceptor cell degeneration in Drosophila. (academictree.org)
Disease1
  • His third NIH-NHLBI MPIR01 goal is to assess the contribution of insomnia in cardiovascular disease in Drosophila and humans, to delineate biological pathways linking sleep/circadian rhythms with cardiovascular diseases. (uab.edu)
Mechanisms1
  • INTERPRETATION: Reduced azithromycin susceptibility was associated with expanding and persistent clades harbouring two well described resistance mechanisms, mosaic mtr locus and 23S rRNA variants. (cdc.gov)
Structural1
  • Identification and structural characterization of interneurons of the Drosophila brain by monoclonal antibodies of the Würzburg hybridoma library. (tcd.ie)
Development1
  • The transcription factors Bicoid (Bcd), Caudal (Cad), Hunchback (Hb), Krüppel (Kr), and Knirps (Kni) act at very early stages of Drosophila development to define the anterior-posterior axis of the embryo. (sdbonline.org)
Human1
  • We readily detected off-target alterations induced by four out of six RGENs targeted to endogenous loci in human cells by examination of partially mismatched sites. (cdc.gov)
Function2
Group1