• Lysosomes are an important component of the inner membrane system and participate in numerous cell biological processes, such as macromolecular degradation, antigen presentation, intracellular pathogen destruction, plasma membrane repair, exosome release, cell adhesion/migration and apoptosis. (biomedcentral.com)
  • 1) Materials can be recycled to the plasma membrane by Rab11-positive recycling endosomes. (biomedcentral.com)
  • 2) The remaining contents will be sequestered in Rab7-positive late endosomes, which can fuse with the plasma membrane to form exosomes. (biomedcentral.com)
  • 5) Lysosomes can also fuse with the plasma membrane to mediate membrane repair or discharge contents outside the cell, such as cathepsins or immune factors. (biomedcentral.com)
  • The effect of N3SP on NHE3 activity was evaluated in NHE3-transfected fibroblasts null for other plasma membrane NHEs, a human colon cancer cell line that models intestinal absorptive enterocytes (Caco-2/BBe), human enteroids, and mouse intestine in vitro and in vivo. (bvsalud.org)
  • Lysosome biogenesis in health and disease. (uni-bielefeld.de)
  • TRPML1-mediated lysosomal calcium release can also dephosphorylate TFEB and promote its nuclear translocation and regulate lysosome biogenesis, autophagy, and lipid metabolism. (biomedcentral.com)
  • Limb-girdle muscular dystrophy (LGMD) protein defects occur in several pathways involved in the biologic function of muscle and can be divided into groups based on cellular localization. (medscape.com)
  • Thus, lysosomes play important roles in cellular activity. (biomedcentral.com)
  • Emerging evidence suggests that lysosomes may also be the cellular center for intracellular transport (Fig. 1 ), signaling (Fig. 2 ), and metabolism. (biomedcentral.com)
  • These glycoproteins are widely involved in important biological processes, such as antigen presentation, cytokine production and glycosylation progression. (frontiersin.org)
  • In addition, previous studies have shown that lysosomes may play important roles in cancer development and progression through the abovementioned biological processes and that the functional status and spatial distribution of lysosomes are closely related to cancer cell proliferation, energy metabolism, invasion and metastasis, immune escape and tumor-associated angiogenesis. (biomedcentral.com)
  • Therefore, identifying the factors and mechanisms that regulate the functional status and spatial distribution of lysosomes and elucidating the relationship between lysosomes and the development and progression of cancer can provide important information for cancer diagnosis and prognosis prediction and may yield new therapeutic targets. (biomedcentral.com)
  • In this chapter, we describe a protocol for imaging localization and movement of T cell microvilli and surface receptors using lattice light-sheet microscopy. (bvsalud.org)
  • Comprehensive proteome analysis of lysosomes reveals the diverse function of macrophages in immune responses. (uni-bielefeld.de)
  • Microvilli are actin-based microscopic membrane protrusions that are present in a wide variety of immune cells. (bvsalud.org)
  • Quantitative Proteome Analysis of Mouse Liver Lysosomes Provides Evidence for Mannose 6-phosphate-independent Targeting Mechanisms of Acid Hydrolases in Mucolipidosis II. (uni-bielefeld.de)
  • It may also function in the protection, maintenance, and adhesion of the lysosome. (wikipedia.org)
  • The uncoated transport vesicles can fuse with autophagosome or heterophagosome to form autophagolysosome, heterophagic lysosome or phagolysosome. (biomedcentral.com)
  • Lysosomes are cell organelles found in most animal cells. (wikipedia.org)
  • Both LAMP1 and LAMP2 have been found expressed on the surface of cancerous tumors, specifically in cells of highly metastatic cancer such as colon cancer and melanoma. (wikipedia.org)
  • They are rarely found on the plasma membranes of normal cells, and are found more on highly metastatic tumors than on poorly metastatic ones. (wikipedia.org)
  • This suggests that the three glycoproteins are involved in tumor development, specifically in the processes of angiogenesis and tissue remodeling. (wikipedia.org)
  • It has also been shown that the down-regulation of LAMP2 could both reduce the resistance of breast cancer cells to the paclitaxel and could inhibit cell proliferation in multiple myeloma cells. (wikipedia.org)
  • Lysosomes are cell organelles found in most animal cells. (wikipedia.org)
  • LAMP2 has been specifically implicated in tumor cell metastasis. (wikipedia.org)
  • It has also been shown that the down-regulation of LAMP2 could both reduce the resistance of breast cancer cells to the paclitaxel and could inhibit cell proliferation in multiple myeloma cells. (wikipedia.org)
  • In a study of glial tumors, the cell membranes of glial and endothelial cells were found to contain LAMP1 and LAMP2, while YKL-40 (a different glycoprotein) was found in the cytoplasm. (wikipedia.org)
  • In this chapter, we describe a protocol for imaging localization and movement of T cell microvilli and surface receptors using lattice light-sheet microscopy. (bvsalud.org)
  • Both LAMP1 and LAMP2 have been found expressed on the surface of cancerous tumors, specifically in cells of highly metastatic cancer such as colon cancer and melanoma. (wikipedia.org)