• These include the major components of the glomerulus, proximal and distal tubules, loop of Henle, and collecting duct [ 1 ]. (j-organoid.org)
  • The metanephric blastema forms glomeruli, proximal and distal tubules. (esur2023.com)
  • The S3 segment of the proximal tubule, which maintains the delicate balance between high O 2 demand and low basal O 2 tension in the corticomedullary region, is the portion of the nephron most vulnerable to ischemia (Parker et al. (cellphysiolbiochem.com)
  • Later, during nephron segmentation, expression becomes restricted to the intermediate tubule region of the proximal-distal axis. (silverchair.com)
  • In contrast to earlier models that featured nephron-like structures, these advances have improved the differentiation efficiency and similarity to the human kidney. (j-organoid.org)
  • One functional component of the kidney, the nephron, carries out tasks such as filtration and reabsorption. (j-organoid.org)
  • Our studies indicate that Nek1 deficiency leads to disordered kidney maturation, and cysts throughout the nephron. (biomedcentral.com)
  • Data extracted from a individual EPO-producing cell range isolated from individual kidney showed these cells have mesenchymal features and the capability to synthesize EPO in response to hypoxia-dependent hypoxia-inducible aspect-2α (HIF-2α) stabilization and activation.7 Yet in individual renal tissues hybridization studies demonstrated EPO creation in cells of renal tubules. (cell-metabolism.com)
  • To eliminate waste products from the body, the kidney filters gigantic quantities of the plasma (over 160 quarts per day) resulting in the flow of huge quantities of water, NaCl and the base bicarbonate through the renal tubules. (yale.edu)
  • Autoradiography localized renal AVP V2 receptors to the distal tubules and collecting ducts in the medulla. (elsevierpure.com)
  • In kidneys suffering from ischemia-reperfusion and in renal tubular epithelial cells subjected to hypoxia/reoxygenation, NCX extrudes Na + in exchange for Ca 2+ influx, resulting in intracellular Ca 2+ overload and tubular epithelial cell injury (Yamashita J, S Kita, T Iwamoto et al. (cellphysiolbiochem.com)
  • Nek1 is detectable in all murine tissues but its expression in wild type and kat2J heterozygous kidneys decrease as the kidneys mature, especially in tubular epithelial cells. (biomedcentral.com)
  • LOXL2 protein expression was detected in glomerular capillary loops and tubular epithelial cells in human and mouse kidneys. (omicsdi.org)
  • Kidney stone disease (nephrolithiasis) is a common problem that can be associated with alterations in urinary solute composition including hypercalciuria. (nature.com)
  • For analysis, we excluded subjects who had missing data on serum Mg or urine albumin or urine creatinine (n = 5), those who had urinary tract infection, glomerulonephritis, nephritic syndrome, or kidney cancer (n = 17), and those who had UACR �� 300mg/g (n = 21). (trpv-antagonist.com)
  • We found that "knockout" mice lacking one of these transport proteins have a high incidence of calcium oxalate urinary stones, the same type that is most common in human patients with kidney stones. (yale.edu)
  • Advantages: often better tolerated than catheterization, decreased risk of iatrogenic urinary tract infection, prevents contamination of the urine by cells, debris, and bacteria from the lower urogenital tract, and aids in the localization of hematuria, pyuria, or bacteriuria. (dvm360.com)
  • Previous studies have reported that the levels of urinary TFF3 are significantly increased in patients with chronic kidney disease. (omicsdi.org)
  • We also determined the renal localization of TFF3 and the levels of urinary TFF3 by immunostaining and ELISA, respectively. (omicsdi.org)
  • In general, 1/3 of congenital anomalies are located within the kidneys or the urinary tract and the majority do not cause clinical problems [1]. (esur2023.com)
  • Urinary indices, urinary sediment examination, and often imaging and other tests (including sometimes a kidney biopsy) are needed to determine the cause. (msdmanuals.com)
  • Heretofore, the localization of StAR in human adult and fetal tissues has not been defined. (elsevierpure.com)
  • Highly dense tissues, such as bone or kidney stones, readily reflect echoes and, therefore, appear bright white on an ultrasound image. (medscape.com)
  • A calcium-binding protein that mediates calcium HOMEOSTASIS in KIDNEYS, BRAIN, and other tissues. (lookformedical.com)
  • Calcium-binding proteins that are found in DISTAL KIDNEY TUBULES, INTESTINES, BRAIN, and other tissues where they bind, buffer and transport cytoplasmic calcium. (lookformedical.com)
  • It is also found in LUNG, TESTIS, OVARY, KIDNEY, and BREAST, and is expressed in many tumor types found in these tissues. (lookformedical.com)
  • HGF is produced and secreted by adjacent stromal and mesenchymal cells, it contributes to the development of epithelial organs in a paracrine fashion, exerts regenerative effects on epithelia in the liver, kidney, lung, and other tissues, and promotes the regression of fibrosis in numerous organs ( 7 , 8 ). (spandidos-publications.com)
  • Although cysts only occur in 5% of the tubules in the kidney, the enormous growth of these cysts ultimately leads to the loss of normal surrounding tissues and loss of renal function. (basicmedicalkey.com)
  • We have also been studying mechanisms by which oxalate crystals induce inflammation and thereby cause damage to the kidney and other tissues. (yale.edu)
  • One approach involves the generation of isoform- and phospho-specific polyclonal and monoclonal antibodies to identify the cellular and subcellular sites of expression of ion exchangers in the kidney and other tissues, and to study their regulation. (yale.edu)
  • This finding in turn has motivated studies on the mechanisms and regulation of oxalate transporters and their roles in oxalate homeostasis, urolithiasis, and crystal-induced inflammation in the kidney and other tissues. (yale.edu)
  • The present study evaluated LOXL2 expression in human and mouse kidney tissues, as well as in cultured renal cells. (omicsdi.org)
  • TFF3 is widely expressed in multiple tissues including kidney tissue. (omicsdi.org)
  • Specifically EPO mRNA was portrayed by epithelial distal tubular cells collecting tubules and also by glomerular cells.8 High EPO amounts may also be released by tumor cells of renal carcinomas 9 thought to are based on transformed tubular or progenitor/stem cells. (cell-metabolism.com)
  • Kidney tubuloids derived from adult stem cells offer the advantage of long-term culture and expansion, but they include only tubular structures and lack glomerular components. (j-organoid.org)
  • Glomerular atrophy/hypertrophy was moderately detected in the kidneys and hydropic degeneration of tubular epithelium was more severe. (peertechzpublications.com)
  • These components have an irreplaceable role in kidney development by recruitment of mesenchymal cells to the glomerular and tubulointerstitial compartments. (omicsdi.org)
  • A role of the anion transporter SLC26A1 (Sat1) for sulfate reabsorption in the kidney is supported by the observation of hyposulfatemia and hypersulfaturia in Slc26a1-knockout mice. (bvsalud.org)
  • The primary transport protein responsible for phosphate reabsorption in the kidney is the type II sodium-phosphate cotransporter (NPT2a) localized in the proximal tubule. (hindawi.com)
  • Within the rodent anemic kidney EPO creation is fixed to interstitial peritubular fibroblast-like cells localized within the deep cortex and external medulla and coexpressing EPO mRNA as well as the mesenchymal marker Compact disc73.1-6 Within the individual kidney the complete localization of EPO-producing cells is unknown. (cell-metabolism.com)
  • Northern blot analysis revealed that hOAT3 mRNA is expressed in the kidney, brain, and skeletal muscle. (aspetjournals.org)
  • The aim of this study is to detect the TFF3 mRNA in kidney and elucidate the relationship between renal TFF3 mRNA and tubulointerstitial fibrosis in IgA nephropathy (IgAN). (omicsdi.org)
  • Increased understanding of the genetic factors contributing to kidney stone disease helps to improve our understanding of the pathogenesis of this condition. (nature.com)
  • In this review, we discuss the induction protocols for kidney organoids and tubuloids, as well as their potential applications in understanding kidney development, renal pathogenesis, and drug screening. (j-organoid.org)
  • Etiology and Pathogenesis ( Fig. 339-1 ) ADPKD is characterized by progressive formation of epithelial-lined cysts in the kidney. (basicmedicalkey.com)
  • Neks, mammalian orthologs of the fungal protein kinase never-in-mitosis A, have been implicated in the pathogenesis of polycystic kidney disease. (biomedcentral.com)
  • The embryonic kidney consists of the metanephric mesenchyme and ureteric buds. (j-organoid.org)
  • In the embryonic kidney, Nek1 expression is most prominent in cells that will become podocytes and proximal tubules. (biomedcentral.com)
  • Although urine is finally modified in subsequent tubules, the proximal tubule is the main site for both NaCl and NaHCO 3 reabsorption. (cellphysiolbiochem.com)
  • Among these organs, the kidneys play a crucial role in osmoregulation in euryhaline teleosts by modifying the amount of urine and maintaining ion and water balance according to environmental salinity/osmolality [ 1 , 2 ]. (ijbs.com)
  • The general goal of our research is to understand how the kidney regulates the composition of the urine, especially as needed to maintain the salt (NaCl) and acid-base balance of the body. (yale.edu)
  • We showed that the cause of the calcium oxalate kidney stones is a very high concentration of oxalate in the urine. (yale.edu)
  • We found that this kidney transport protein also plays a very crucial role in the intestine, where it secretes oxalate and thereby limits how much of ingested oxalate is absorbed and then excreted in the urine. (yale.edu)
  • The ureteric bud divides and branches forming the collecting system (renal pelvis, infundibulae, calyces, and tubules) for urine drainage. (esur2023.com)
  • At 9th weeks of development, the metanephros (mature kidney) starts to produce urine and the caudal end of WD is called common excretory duct. (esur2023.com)
  • Findings can be local (eg, reflecting kidney inflammation or mass), result from the systemic effects of kidney dysfunction, or affect urination (eg, changes in urine itself or in urine production). (msdmanuals.com)
  • Acute kidney injury is a rapid decrease in renal function over days to weeks, causing an accumulation of nitrogenous products in the blood (azotemia) with or without reduction in amount of urine output. (msdmanuals.com)
  • The polycystic kidney diseases are a group of genetically heterogeneous disorders and a leading cause of kidney failure. (basicmedicalkey.com)
  • The autosomal dominant form of polycystic kidney disease (ADPKD) is the most common life-threatening monogenic disease, affecting 12 million people worldwide. (basicmedicalkey.com)
  • The autosomal recessive form of polycystic kidney disease (ARPKD) is rarer but affects the pediatric population. (basicmedicalkey.com)
  • Topology of autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive polycystic kidney disease (ARPKD) proteins polycystin-1, polycystin-2, and fibrocystin/polyductin (FPC) are shown. (basicmedicalkey.com)
  • Animal models of polycystic kidney disease (PKD) have been invaluable in discovering and dissecting cellular and molecular pathways by which polycystic kidneys develop and by which progression of all types of PKD may be modified [ 1 ],[ 2 ]. (biomedcentral.com)
  • Age-related disorders such as chronic kidney disease (CKD) are increasingly prevalent globally and pose unprecedented challenges. (frontiersin.org)
  • Renal fibrosis is the hallmark of chronic kidney disease progression and is characterized by an exaggerated wound-healing process with the production of renal scar tissue. (omicsdi.org)
  • Chronic kidney disease (CKD) is long-standing, progressive deterioration of renal function. (msdmanuals.com)
  • The functional significance of the Na + /Ca 2+ exchanger (NCX) in basolateral membranes in the proximal tubule remains controversial. (cellphysiolbiochem.com)
  • We used doubly perfused bullfrog kidneys in vivo , and switched the basolateral solution (renal portal vein) to experimental solutions. (cellphysiolbiochem.com)
  • 1989), however, suggested that there is no NCX in basolateral membranes in proximal tubules but that instead, intracellular calcium pools within the mitochondria and elsewhere contribute to Na + /Ca 2+ exchange. (cellphysiolbiochem.com)
  • The localization of NCX in basolateral membranes of proximal tubules is also controversial. (cellphysiolbiochem.com)
  • We investigated coordination of the NBC and NCX on the basolateral side of bullfrog proximal tubules. (cellphysiolbiochem.com)
  • The process of secreting organic anions through the proximal tubule cells is achieved via unidirectional transcellular transport involving the uptake of organic anions into the cells from the blood across the basolateral membrane, followed by extrusion across the brush-border membrane into the proximal tubule fluid. (aspetjournals.org)
  • The hOAT3 protein was shown to be localized in the basolateral membrane of renal proximal tubules and the hOAT3 gene was determined to be located on the human chromosome 11q12-q13.3 by fluorescent in situ hybridization analysis. (aspetjournals.org)
  • The secretion of numerous organic anions, including endogenous metabolites, drugs, and xenobiotics, is an important physiological function of the renal proximal tubule. (aspetjournals.org)
  • These organoids mimic the structural similarities and developmental processes of the kidneys, while reflecting their physiological properties. (j-organoid.org)
  • In SEM imagining of different thickness paraffin sections, cartilage and secondary lamellar structure in the gills, glomerulus, and Bowman's capsule structure in the kidneys, and the structure of the pyloric cecum was observed. (peertechzpublications.com)
  • The localization of Lcn2-R in the inner medulla is intriguing considering local bacterial infections trigger toll-like receptor-4 (TLR-4)-mediated secretion of the bacteriostatic Fe 3+ -free (apo-)Lcn2. (biomedcentral.com)
  • The tubular secretion of diuretics in the proximal tubule has been shown to be critical for the action of drugs. (aspetjournals.org)
  • and renal tubular secretion of chlorothiazide and hydrochlorothiazide in the avian kidney ( Odlind and Lonnerholm, 1982 ). (aspetjournals.org)
  • Tubular secretion of acetazolamide was demonstrated to be important for the elimination of this drug in the study using the isolated rat perfused kidney ( Taft and Sweeney, 1995 ). (aspetjournals.org)
  • Increased cAMP promotes protein kinase A activity, among other effectors, and, in turn, leads to cyst growth by promoting proliferation and fluid secretion of cyst-lining cells through chloride and aquaporin channels in ADPKD kidneys. (basicmedicalkey.com)
  • Ectopic secretion of aldosterone (The ovaries and kidneys are the 2 organs described in the literature that, in the setting of neoplastic disease, can be ectopic sources of aldosterone, but this is a rare occurrence. (medscape.com)
  • Aldosterone, by inducing renal reabsorption of sodium at the distal convoluted tubule (DCT), enhances secretion of potassium and hydrogen ions, causing hypernatremia, hypokalemia, and alkalosis. (medscape.com)
  • The current study aimed to highlight histopathological findings in paraffin block sections of the liver, gill kidney, and pyloric cecum of rainbow trout ( Oncorhynchus mykiss ) by different imagining devices such as Scanning Electron (SEM) and Light Microscope (LM). (peertechzpublications.com)
  • Instead, fish hepatocytes display a diffuse or radial organization in the branching tubules that make up the liver parenchyma [8]. (peertechzpublications.com)
  • Aspergillus -derived mycotoxins, including aflatoxins and ochratoxin A, and fumonisins (members of the fusariotoxin group) can cause pathological damage to vital organs, including the kidney or liver. (frontiersin.org)
  • Tissue extracts of Mouse Testis (Lane 6) and Mouse Kidney (Lane 7) were electrophoresed using NuPAGE™ 3-8% Tris-Acetate Protein Gel (Product # EA0378BOX). (thermofisher.com)
  • A cDNA encoding a multispecific organic anion transporter 3 (hOAT3) was isolated from a human kidney cDNA library. (aspetjournals.org)
  • It is present in both the central nervous system and peripheral organs including the kidney. (degruyter.com)
  • Osmoregulation and ionoregulation in fish are mainly accomplished by the osmoregulatory organs, i.e., the gill, kidney, and gut [ 2 , 3 ]. (ijbs.com)
  • In osmoregulatory organs, including the kidneys of vertebrates, such as fishes and mammals, Na + -K + -ATPase (NKA) plays important roles in osmoregulation and ion exchange by providing a driving force for many ion-transporting systems [ 2 , 3 ]. (ijbs.com)
  • Because hOAT1 has been suggested to show rather limited capacity for organic anion transport, hOAT3 might play a large role in the human kidney. (aspetjournals.org)
  • As plasma renin is unable to cross the blood-brain barrier, it was predicted that there is the existence of brain RAS independent of the kidney. (hindawi.com)
  • In TIO most tumors overexpress the protein fibroblast growth factor-23 (FGF-23) inhibiting renal phosphate reabsorption in the proximal tubules and acting as a phosphaturic factor [ 1 , 3 , 11 ]. (hindawi.com)
  • In line with a more complex picture, multiple isoforms of the protein likely exist and non-centrosomal sites of localisation have been reported. (springer.com)
  • This protein complex has also been implicated in regulating a number of signaling pathways, including Wnt, mammalian target of rapamycin (mTOR), STAT3, cMET, phosphoinositide 3-kinase (PI3K)/AKT, G protein-coupled receptor (GPCR), and epidermal growth factor receptor (EGFR), as well as in the localization and activity of cystic fibrosis transmembrane conductance (CFTR). (basicmedicalkey.com)
  • Am J Physiol Renal Physiol 301 F1314-F1325 2011 [PMC free article] [PubMed] 36 Viallet PM Vo-Dinh T. Monitoring intracellular proteins using fluorescence techniques: from protein synthesis and localization to activity. (researchatlanta.org)
  • The presence of StAR in cells that do not express cholesterol side-chain cleavage enzyme cytochrome P450, including renal distal tubules, Sertoli cells, and fetal oocytes, suggests that StAR has roles in metabolic processes in addition to stimulating pregnenolone synthesis. (elsevierpure.com)
  • These findings illustrated and compared the regulatory roles of FXYD12 for NKA in kidneys of the two medakas in response to salinity changes. (ijbs.com)
  • All of these isoforms are commonly expressed in the kidney, and their potential roles in renal handling of organic anions have been indicated. (aspetjournals.org)
  • New Insights into the Pivotal Roles of Claudins in Proximal Tubule Electrolyte Reabsorption Aronson PS . (yale.edu)
  • New Insights into the Pivotal Roles of Claudins in Proximal Tubule Electrolyte Reabsorption Journal Of The American Society Of Nephrology 2022, 33: 659-661. (yale.edu)
  • Upon salinity challenge, the Na + -K + -ATPase (NKA) of fish kidney plays a crucial role in maintaining ion and water balance. (ijbs.com)
  • While developmental senescence and acute senescence may positively contribute to the fine-tuning of embryogenesis and injury repair, chronic senescence, when unresolved promptly, plays a crucial role in kidney fibrogenesis and CKD progression. (frontiersin.org)
  • Kidney cysts are often seen in a wide range of syndromic diseases. (basicmedicalkey.com)
  • The most common phenotype shared by many ciliopathies is kidney cysts. (basicmedicalkey.com)
  • Kidney development in kat2J homozygous mice is aberrant early, before the appearance of gross cysts: developing cortical zones are thin, populated by immature glomeruli, and characterized by excessive apoptosis of several cell types. (biomedcentral.com)
  • Here, we hypothesized that MR maintains ENaC activity in the DCT2 and early connecting tubule in the absence of aldosterone. (touro.edu)
  • METHODS: We studied AS (aldosterone synthase)-deficient (AS) mice, which were backcrossed onto the same C57BL6/J strain as kidney-specific MR knockout (KS-MR) mice. (touro.edu)
  • Carbonic anhydrase plays an important role in bicarbonate reabsorption from the proximal tubule ( Ives, 2001 ). (aspetjournals.org)
  • The first portion of each renal tubule is called the proximal tubule, and the proximal tubules are collectively responsible for reabsorbing the vast majority of the filtered NaCl, bicarbonate and water, and secreting acid in the form of ammonium ions. (yale.edu)
  • Our lab has specifically focused on identifying the proteins involved in mediating the transport of bicarbonate, NaCl and ammonium in the proximal tubule. (yale.edu)
  • FIGURE 339-1 Scheme of the primary cilium and cystic kidney disease proteins. (basicmedicalkey.com)
  • PC2 and FPC both interact with kinesin 2 (KIF 3A/B). Localization of disease proteins in the cilium, the transition zone, and the basal body is color coded. (basicmedicalkey.com)
  • These results suggest an important role of hOAT3 in the excretion/detoxification of endogenous and exogenous organic anions in the kidney. (aspetjournals.org)
  • They appear to be the key factors in driving renal fibrosis, independent of the underlying kidney disease. (omicsdi.org)
  • Identification of a monogenic cause of kidney stone disease facilitates optimal stone prevention management and identification of associated phenotypes. (nature.com)
  • Advances in our understanding of the polygenic factors contributing to risk of kidney stone disease might enable a precision medicine approach. (nature.com)
  • Fig. 1: Radiographic appearance of kidney stone disease in three patients. (nature.com)
  • Patients receiving renal transplants must be informed that anti-GBM disease can recur in the transplanted kidney, although graft loss due to this is very rare. (medscape.com)
  • Considering that Microsof company could resemble various other conditions, it should be thought within a psychologically not well patient using long-term drug abuse, wide spread nonspecific expressions and also skin-related abnormalities, like the head and neck area.Hemorrhagic temperature along with kidney affliction (HFRS) can be a zoonotic disease typically recognized in the Volga Federal Section (VFD). (mirnadatabase.com)
  • Several kidney biomarkers are used successfully in drug development, however cost-efficient, and reliable kidney biomarkers are urgently needed for monitoring farm animals for early signs of kidney disease. (frontiersin.org)
  • Cystic kidney disease may be congenital or acquired. (msdmanuals.com)
  • Taken jointly these results claim that it's the renal Compact disc133+ progenitor cells that synthesize and discharge erythropoietin under hypoxia the prolyl hydroxylase-HIF-2α axis within the individual kidney. (cell-metabolism.com)
  • As an important step in the characterization of how Nek1 may be involved in renal development and how its absence may lead to renal cystogenesis or cyst progression, we examined the expression pattern of Nek1 in normal, developing, and diseased mouse kidneys. (biomedcentral.com)
  • Lysyl oxidase?like 2 is expressed in kidney tissue and is associated with the progression of tubulointerstitial fibrosis. (omicsdi.org)
  • Tubulointerstitial fibrosis is a common end point of chronic kidney diseases, and preventing its progression is key to avoiding renal failure. (omicsdi.org)
  • At the beginning of the 4th week, at the cervical region, the pronephros (a non-functional primitive kidney) develops but it totally regresses by day 25. (esur2023.com)
  • The mesonephros is a functional primitive kidney with excretory tubules which drain into the WD for a brief period [3], Fig. 1. (esur2023.com)
  • The distal portions of the mesonephric ducts and attached ureteric buds descends inferiorly to meet the urogenital sinus and become incorporated into the posterior wall of the primitive bladder. (esur2023.com)
  • Aging kidney and CKD share many common characteristic features with increased cellular senescence, a conserved program characterized by an irreversible cell cycle arrest with altered transcriptome and secretome. (frontiersin.org)
  • In this review, we discuss current understanding of the role and mechanism of cellular senescence in kidney fibrosis. (frontiersin.org)
  • To understand the regulation of vasopressin receptors in an animal model of hypertension, localization and age-related changes in renal arginine vasopressin (AVP) receptors in spontaneously hypertensive rats (SHR) were investigated using in vitro (macro) autoradiography and a radiolabeled receptor assay. (elsevierpure.com)
  • These findings suggest that SHR have different developmental changes in kidney AVP receptors and that renal V2 receptors play a role in maintaining fluid homeostasis in SHR with established hypertension. (elsevierpure.com)
  • Prevalence of kidney stones in the United States. (nature.com)
  • Medical management of kidney stones: AUA Guideline. (nature.com)
  • For example, work with mice lacking anion exchanger Slc26a6, which can function as an oxalate transporter, revealed a phenotype of calcium oxalate kidney stones. (yale.edu)
  • Thiazides and loop diuretics exhibit their diuretic effects from the luminal side by inhibiting the Na + -Cl - cotransporter of the distal tubule and the Na + -K + -2Cl - co-transporter of the loop of Henle, respectively ( Ives, 2001 ). (aspetjournals.org)
  • FGF-23 levels were significantly increased, and total body magnetic resonance imaging (MRI) revealed a tumor mass located at the distal tibia leading to the diagnosis of tumor-induced osteomalacia (TIO). (hindawi.com)
  • To compensate, they absorb ions via the gill epithelia, excrete excess water and reabsorb filtered solutes in the kidneys [ 1 - 3 ]. (ijbs.com)
  • This fact, and the accessibility of Xenopus to genetic manipulation, makes this animal an excellent model system with which to study kidney development. (silverchair.com)
  • Our preliminary results revealed that fxyd12 was highly expressed in the kidneys of the two closely related euryhaline medaka species ( Oryzias dancena and O. latipes ) from different natural habitats (brackish water and fresh water). (ijbs.com)
  • Although the kidney functions as the major excretory system in mammals, monitoring and screening for mycotoxin induced nephrotoxicity is only now a developmental area in the field of livestock feed toxicology. (frontiersin.org)
  • The current review focuses on the role of the eCB system in normal kidney function and various diseases, such as diabetes and obesity, that directly contributes to the development of renal pathologies. (degruyter.com)
  • Among the factors that contribute to kidney fibrosis, the members of the platelet-derived growth factor (PDGF) family are among the best characterized ones. (omicsdi.org)
  • However, little is currently known regarding LOXL2 expression in the kidney and its involvement in tubulointerstitial fibrosis. (omicsdi.org)
  • Since the first publication on generating kidney-like cell aggregates from pluripotent stem cells, various modifications have been made to develop more complex and detailed kidney structures. (j-organoid.org)
  • The renal distal tubules stained with moderate to marked intensity. (elsevierpure.com)
  • Even so, towards the best our knowledge, a subcentimetric intrapancreatic pseudoaneurysm (lacking any connected pseudocyst) leading to enormous stomach hemorrhage along with distal primary pancreatic duct impediment TWS119 is a exceptional specialized medical occurrence. (peptide-solubility.com)