• rats
  • Using a model of a toxic liver damage in Sprague Dawley rats, generated by repetitive intraperitoneal application of retrorsine and allyl alcohol, the ability of human ADSC to support the restoration of liver function was investigated. (hindawi.com)
  • The tRNA content and aminoacyl-tRNA synthetases of regenerating liver in the phase of rapid growth were compared with those of livers from both intact and sham-operated rats. (biochemj.org)
  • Treatment with either Gly orVE causes an elevation in total SOD activity and a decrease in TBARS levels, showing a protectiveeffect in liver regeneration on a model of ethanol-induced acute liver injury after PH in rats. (edu.mx)
  • It has been shown to facilitate liver regeneration in rats. (wikipedia.org)
  • Niwano et al, Acceleration of Liver Regeneration by Malotilate in Partially Hepatectomized Rats Bührer M, Le Cotonnec JY, Wermeille M, Bircher J (1986). (wikipedia.org)
  • In rats, ursolic acid ameliorated high-fat diet-induced hepatic steatosis and improved metabolic disorders in high-fat diet-induced non-alcoholic fatty liver disease. (wikipedia.org)
  • mammalian
  • These results provide direct evidence that mammalian regeneration prompts extensive and dramatic changes in cellular identity under various perturbations and thus can also serve as a cellular source for various diseases and potentially for therapy involving BEC paucity and dysfunction. (upenn.edu)
  • During mammalian liver regeneration RNA molecules of growth factors increase in number due to the addition of signaling tails. (wikipedia.org)
  • gene
  • Inhibition of the murine MKK4 gene increases the liver's potential for regeneration considerably. (healthcanal.com)
  • The ALR gene and gene product were subsequently described, but little is known about the cellular/subcellular sites of ALR synthesis in the liver, or about the release and dissemination of the peptide. (pubmedcentralcanada.ca)
  • Gene expression of auxiliary mitogens in mouse liver was compared to patients after ALPPS or PVL. (sigmaaldrich.com)
  • Aim: To identify mutants of the hepatitis B virus (HBV) X (HBx) gene and investigate the effect of the natural mutant on liver cell proliferation. (ebscohost.com)
  • FGF15 (and FGF19 in humans) function as hormones produced in response to bile acid absorption acting on the farnesoid X receptor FXR, are secreted into the portal venous circulation and bind onto the liver membrane receptor FGFR4/β-Klotho and repress bile acid synthesis by the Cyp7a1 gene. (wikipedia.org)
  • The enhanced expression of this gene is observed during pancreatic inflammation and liver carcinogenesis. (wikipedia.org)
  • adult
  • Tilghman and Belayew 1982), but is repressed to an almost sequence relative to the C3H/HeJ sequence in the low AFP- undetectable level in the adult liver (Tilghman and Belayew 1982). (deepdyve.com)
  • In May 1932, L.H. McKim published a report in The Canadian Medical Association Journal, that described the regeneration of an adult digit-tip following amputation. (wikipedia.org)
  • This is one of the earliest recorded examples of adult human digit-tip regeneration. (wikipedia.org)
  • Stem
  • The liver is thought to utilize facultative stem cells (FSCs) originating from the BECs, often referred to as "oval cells," for regeneration following toxin-based injury. (upenn.edu)
  • In the light of the persisting lack of donor organs and the risks of allotransplantations, the possibility of liver regeneration with autologous stem cells from adipose tissue (ADSC) is an intriguing alternative. (hindawi.com)
  • and most cell types could be grown and expanded outside of the body, with the exception of the liver, nerve and pancreas, as these tissue types need stem cell populations. (wikipedia.org)
  • mice
  • Both types of mice were extirpated 70% of their liver mass, and differences in regeneration process were analysed through microscopic and molecular techniques. (psychcentral.com)
  • Genetically modified mice, not expressing caveolin-1, were incapable of forming the lipidic bodies necessary in order to provide energy for the regeneration. (psychcentral.com)
  • After 48 hours of the extraction of a part of the liver, the mortality of modified mice increased, and, after 72 hours, only 22% survived, whereas normal mice survived in 89% of cases. (psychcentral.com)
  • Similar results were obtained by avoiding caveolin-1 expression with the interference RNA technique, and the administration of glucose in mice without caveolin allowed them to have an alternative energy source and were able to regenerate liver with more normality. (psychcentral.com)
  • ALPPS: from human to mice highlighting accelerated and novel mechanisms of liver regeneration. (sigmaaldrich.com)
  • The hypertrophy of the remnant liver after ALPPS doubled relative to PVL, whereas mice with transection alone disclosed minimal signs of regeneration. (sigmaaldrich.com)
  • Early initiators of regeneration were significantly upregulated in human and mice. (sigmaaldrich.com)
  • ALPPS in mice induces an unprecedented degree of liver regeneration, comparable with humans. (sigmaaldrich.com)
  • Fgf15-knock-out mice have reduced liver glycogen storage and are glucose-intolerant. (wikipedia.org)
  • Fgf15-deficient mice have impaired regeneration. (wikipedia.org)
  • In mice, ursolic acid induces neural regeneration after sciatic nerve injury. (wikipedia.org)
  • resection
  • The findings obtained from the study could make a major contribution towards the development of new treatment strategies aimed at ensuring improved liver regeneration following liver resection surgery and therefore also reducing the risk of liver failure that has to date been untreatable. (healthcanal.com)
  • ALPPS combines portal vein ligation (PVL) with liver transection (step I), followed by resection of the deportalized liver (step II) within 2 weeks after the first surgery. (sigmaaldrich.com)
  • This approach induces accelerated hypertrophy of the liver remnant to enable resection of massive tumor load. (sigmaaldrich.com)
  • organs
  • Injury to other organs or ALPPS-plasma injection combined with PVL induced liver hypertrophy similar to ALPPS. (sigmaaldrich.com)
  • The liver is one of the few organs that have the capacity to regenerate in response to injury. (umich.edu)
  • Some tissues such as skin and large organs including the liver regrow quite readily, while others have been thought to have little or no capacity for regeneration. (wikipedia.org)
  • However ongoing research, particularly in the heart and lungs, suggests that there is hope for a variety of tissues and organs to eventually become regeneration-capable. (wikipedia.org)
  • Advances in research have enabled the induced regeneration of many more tissues and organs than previously thought possible. (wikipedia.org)
  • In 2009, the regeneration of hollow organs and tissues with a long diffusion distance, was a little more challenging. (wikipedia.org)
  • These vertebrates possess an exceptional ability to allow regeneration of entire limbs and their tails (as well as a multitude of their internal organs as well, including their spinal cord) through a process known as blastema formation. (wikipedia.org)
  • whereas
  • Whereas the mechanisms and kinetics of liver regeneration in these two models are different, many of the same signaling pathways stimulate liver regeneration in both pathways. (wikipedia.org)
  • From these observations, we postulated that selective up‐regulation of miRNAs in the early phase after PH was involved in the priming and commitment to liver regeneration, whereas the subsequent genomewide down‐regulation of miRNAs was required for efficient recovery of liver cell mass. (umich.edu)
  • transplantation
  • For those affected, this can be life-threatening: "In such instances, patients cannot avoid organ transplantation," explains Professor Lars Zender, liver specialist at Tübingen University Hospital, who was conducting research at the HZI and Hannover Medical School until 2012. (healthcanal.com)
  • This study points towards ADSC being a promising alternative to hepatocyte or liver organ transplantation in patients with severe liver failure. (hindawi.com)
  • Currently, therapy is limited to liver organ and rarely hepatocyte transplantation. (hindawi.com)
  • growth
  • They can specifically secrete key growth factors at the site of the injury and therefore start the damaged tissue's regeneration processes. (healthcanal.com)
  • In the latest study, which involved collaboration between the University Department of Surgery at the MedUni Vienna led by Patrick Starlinger and the Institute of Physiology led by Alice Assinger, scientists were able to demonstrate that the specific release of growth factors from the α granules was associated with post-operative liver regeneration. (healthcanal.com)
  • The control of hepatic growth and regeneration has interested experimentalists for much of the 20th century. (pubmedcentralcanada.ca)
  • The process of regeneration in mammals is mainly compensatory growth because only the mass of the liver is replaced, not the shape. (wikipedia.org)
  • Several signaling pathways are known to stimulate regeneration in the liver including cytokines, growth factors, hormones, and nuclear receptors. (wikipedia.org)
  • remnant
  • RESULTS: After portal vein occlusion, the ratio of the future liver remnant volume to total parenchymal liver volume (FLR%) was reduced in patients receiving neoadjuvant chemotherapy (27 +/- 1% vs 32 +/- 1%, p = 0.03). (lu.se)
  • A smaller future liver remnant before portal vein occlusion resulted in a greater degree of hypertrophy (r(2) = 0.18, p. (lu.se)
  • undergo
  • Once cell proliferation is completed, the newly divided cells undergo restructuring, angiogenesis and reformation of extracellular matrix to complete the regeneration process. (wikipedia.org)
  • These cells can undergo immense proliferation in response to tissue damage before differentiating and engaging in regeneration. (wikipedia.org)
  • occurs
  • However, impairment of liver function still occurs in a certain percentage of patients following surgery. (healthcanal.com)
  • In full thickness wounds that are under 2mm regeneration generally occurs before scarring. (wikipedia.org)
  • Knowing how regeneration occurs in animals such as these may have great implications for how wound-healing is tackled in medicine and research has been aimed at this area, as a result. (wikipedia.org)
  • Cell
  • Because the liver is the main site of drug detoxification, it is exposed to many chemicals in the body which may potentially induce cell death and injury. (wikipedia.org)
  • Furthermore, these changes might also be intended to negatively regulate cell-cell adhesion for structural reorganization during the process of liver regeneration. (pubmedcentralcanada.ca)
  • The activities of most, but not of all, aminoacyl-tRNA synthetases in cell sap of regenerating liver tend to be greater than normal. (biochemj.org)
  • Sedimentation analysis of cell sap in sucrose density gradients shows a shift of prolyl-tRNA synthetase activity toward the high-Mr form in regenerating liver. (biochemj.org)
  • myth
  • Heard a myth that if you stop drinking any alcohol for 5 weeks straight, your liver will be able to "heal" any prior alcohol-related damage (assuming you aren't an alcoholic or have other permanent liver problems). (madsci.org)
  • failure
  • The result: noticeable improvements in the animals' survival rate following acute or chronic liver failure. (healthcanal.com)
  • The exact causes of liver failure are so far not fully understood. (healthcanal.com)
  • One of my dogs went into liver failure. (truthaboutpetfood.com)
  • I got lucky with a cat who'd been hospitalized for heart failure, discharged on a cardio drug that put him back into heart failure after one pill, hospitalized and discharged again and told he'd live for about 5 months (because he couldn't tolerate the drug of choice). (truthaboutpetfood.com)
  • chronic
  • In many cases, chronic or acute damage to the liver, as a direct result of hepatitis infection or poisoning, can lead to the loss of the organ's capacity to self-renew. (healthcanal.com)
  • Liver cirrhosis on the basis of a chronic hepatitis B or C, autoimmune hepatitis, chronic alcohol abuse, primary sclerosing cholangitis, and primary biliary cirrhosis are only a few possible reasons for functional liver insufficiency. (hindawi.com)
  • The most common cause of chronic liver disease is chronic viral hepatitis which causes inflammation and necrosis followed by deposition of collagens in a portal and periportal fashion [ 1 ]. (hindawi.com)
  • assay
  • Survival rates, liver weight/body weight ratios, liver weights, HE staining, transmission electron microscope imaging, nuclear-associated antigen Ki-67, enzyme-linked immunosorbent assay and signal transduction were evaluated to analyze liver regeneration. (biomedsearch.com)