• rats
  • Using a model of a toxic liver damage in Sprague Dawley rats, generated by repetitive intraperitoneal application of retrorsine and allyl alcohol, the ability of human ADSC to support the restoration of liver function was investigated. (hindawi.com)
  • The tRNA content and aminoacyl-tRNA synthetases of regenerating liver in the phase of rapid growth were compared with those of livers from both intact and sham-operated rats. (biochemj.org)
  • Treatment with either Gly orVE causes an elevation in total SOD activity and a decrease in TBARS levels, showing a protectiveeffect in liver regeneration on a model of ethanol-induced acute liver injury after PH in rats. (edu.mx)
  • 4. Since a high dose of tri-iodothyronine (T 3 ) was required to cause elevation of the activities of these enzymes and DNA content in 24 h-regenerating liver of TPTX rats, the relative contribution of T 3 to liver regeneration may be small. (clinsci.org)
  • Moreover, disorganization of hepatic trabecule, heterogeneity in size of hepatocytes, and increased dried liver weight were observed only in Ad5MMP-1 treated rats, suggesting that MMP-1 stimulated hepatocyte proliferation, which was confirmed by BrdU staining. (nii.ac.jp)
  • In rats, ursolic acid ameliorated high-fat diet-induced hepatic steatosis and improved metabolic disorders in high-fat diet-induced non-alcoholic fatty liver disease. (wikipedia.org)
  • It has been shown to facilitate liver regeneration in rats. (wikipedia.org)
  • Niwano et al, Acceleration of Liver Regeneration by Malotilate in Partially Hepatectomized Rats Bührer M, Le Cotonnec JY, Wermeille M, Bircher J (1986). (wikipedia.org)
  • acute liver f
  • Each year, over a million people die from chronic or acute liver failure and many patients do not survive the often extensive waiting times for a transplant organ. (healthcanal.com)
  • gene
  • The ALR gene and gene product were subsequently described, but little is known about the cellular/subcellular sites of ALR synthesis in the liver, or about the release and dissemination of the peptide. (pubmedcentralcanada.ca)
  • Gene expression of auxiliary mitogens in mouse liver was compared to patients after ALPPS or PVL. (sigmaaldrich.com)
  • Design We used siRNA delivered via nanoparticles combined with liver-specific gene knockout to study Fgfr function in liver regeneration. (bmj.com)
  • We tested this hypothesis by transiently changing the balance by using gene therapy to deliver MMP-1 in a rat model of persistent liver fibrosis. (nii.ac.jp)
  • FGF15 (and FGF19 in humans) function as hormones produced in response to bile acid absorption acting on the farnesoid X receptor FXR, are secreted into the portal venous circulation and bind onto the liver membrane receptor FGFR4/β-Klotho and repress bile acid synthesis by the Cyp7a1 gene. (wikipedia.org)
  • The enhanced expression of this gene is observed during pancreatic inflammation and liver carcinogenesis. (wikipedia.org)
  • Stem
  • The liver is thought to utilize facultative stem cells (FSCs) originating from the BECs, often referred to as "oval cells," for regeneration following toxin-based injury. (upenn.edu)
  • In the light of the persisting lack of donor organs and the risks of allotransplantations, the possibility of liver regeneration with autologous stem cells from adipose tissue (ADSC) is an intriguing alternative. (hindawi.com)
  • and most cell types could be grown and expanded outside of the body, with the exception of the liver, nerve and pancreas, as these tissue types need stem cell populations. (wikipedia.org)
  • mice
  • Both types of mice were extirpated 70% of their liver mass, and differences in regeneration process were analysed through microscopic and molecular techniques. (psychcentral.com)
  • Genetically modified mice, not expressing caveolin-1, were incapable of forming the lipidic bodies necessary in order to provide energy for the regeneration. (psychcentral.com)
  • After 48 hours of the extraction of a part of the liver, the mortality of modified mice increased, and, after 72 hours, only 22% survived, whereas normal mice survived in 89% of cases. (psychcentral.com)
  • Similar results were obtained by avoiding caveolin-1 expression with the interference RNA technique, and the administration of glucose in mice without caveolin allowed them to have an alternative energy source and were able to regenerate liver with more normality. (psychcentral.com)
  • The hypertrophy of the remnant liver after ALPPS doubled relative to PVL, whereas mice with transection alone disclosed minimal signs of regeneration. (sigmaaldrich.com)
  • Early initiators of regeneration were significantly upregulated in human and mice. (sigmaaldrich.com)
  • necrosis
  • The most common cause of chronic liver disease is chronic viral hepatitis which causes inflammation and necrosis followed by deposition of collagens in a portal and periportal fashion [ 1 ]. (hindawi.com)
  • Experimental liver necrosis may be induced by different agents, such as allyl alcohol, CCl 4 , ethionine, and galactosamine. (hindawi.com)
  • adult
  • In May 1932, L.H. McKim published a report in The Canadian Medical Association Journal, that described the regeneration of an adult digit-tip following amputation. (wikipedia.org)
  • This is one of the earliest recorded examples of adult human digit-tip regeneration. (wikipedia.org)
  • organs
  • Injury to other organs or ALPPS-plasma injection combined with PVL induced liver hypertrophy similar to ALPPS. (sigmaaldrich.com)
  • The liver is one of the few organs that have the capacity to regenerate in response to injury. (umich.edu)
  • Some tissues such as skin and large organs including the liver regrow quite readily, while others have been thought to have little or no capacity for regeneration. (wikipedia.org)
  • However ongoing research, particularly in the heart and lungs, suggests that there is hope for a variety of tissues and organs to eventually become regeneration-capable. (wikipedia.org)
  • Advances in research have enabled the induced regeneration of many more tissues and organs than previously thought possible. (wikipedia.org)
  • In 2009, the regeneration of hollow organs and tissues with a long diffusion distance, was a little more challenging. (wikipedia.org)
  • These vertebrates possess an exceptional ability to allow regeneration of entire limbs and their tails (as well as a multitude of their internal organs as well, including their spinal cord) through a process known as blastema formation. (wikipedia.org)
  • impairment
  • However, impairment of liver function still occurs in a certain percentage of patients following surgery. (healthcanal.com)
  • This liver impairment can develop into life-threatening complications and is associated with a relatively high degree of mortality. (healthcanal.com)
  • whereas
  • From these observations, we postulated that selective up‐regulation of miRNAs in the early phase after PH was involved in the priming and commitment to liver regeneration, whereas the subsequent genomewide down‐regulation of miRNAs was required for efficient recovery of liver cell mass. (umich.edu)
  • transplantation
  • For those affected, this can be life-threatening: "In such instances, patients cannot avoid organ transplantation," explains Professor Lars Zender, liver specialist at Tübingen University Hospital, who was conducting research at the HZI and Hannover Medical School until 2012. (healthcanal.com)
  • This study points towards ADSC being a promising alternative to hepatocyte or liver organ transplantation in patients with severe liver failure. (hindawi.com)
  • Currently, therapy is limited to liver organ and rarely hepatocyte transplantation. (hindawi.com)
  • remnant
  • RESULTS: After portal vein occlusion, the ratio of the future liver remnant volume to total parenchymal liver volume (FLR%) was reduced in patients receiving neoadjuvant chemotherapy (27 +/- 1% vs 32 +/- 1%, p = 0.03). (lu.se)
  • A smaller future liver remnant before portal vein occlusion resulted in a greater degree of hypertrophy (r(2) = 0.18, p. (lu.se)
  • occurs
  • In full thickness wounds that are under 2mm regeneration generally occurs before scarring. (wikipedia.org)
  • Knowing how regeneration occurs in animals such as these may have great implications for how wound-healing is tackled in medicine and research has been aimed at this area, as a result. (wikipedia.org)
  • failure
  • The result: noticeable improvements in the animals' survival rate following acute or chronic liver failure. (healthcanal.com)
  • The exact causes of liver failure are so far not fully understood. (healthcanal.com)
  • One of my dogs went into liver failure. (truthaboutpetfood.com)
  • I got lucky with a cat who'd been hospitalized for heart failure, discharged on a cardio drug that put him back into heart failure after one pill, hospitalized and discharged again and told he'd live for about 5 months (because he couldn't tolerate the drug of choice). (truthaboutpetfood.com)
  • collagenase
  • Briefly, Wistar female rat liver was perfused with collagenase A. and cells were purified by isopynic sedimentation in a two-step Percoll gradient. (nii.ac.jp)
  • injury
  • The liver can regenerate after either surgical removal or after chemical injury. (wikipedia.org)
  • Because the liver is the main site of drug detoxification, it is exposed to many chemicals in the body which may potentially induce cell death and injury. (wikipedia.org)
  • Our results suggested aprotective effect against liver injury with glycine and VE supplementation. (edu.mx)
  • myth
  • Heard a myth that if you stop drinking any alcohol for 5 weeks straight, your liver will be able to "heal" any prior alcohol-related damage (assuming you aren't an alcoholic or have other permanent liver problems). (madsci.org)
  • Cell
  • Furthermore, these changes might also be intended to negatively regulate cell-cell adhesion for structural reorganization during the process of liver regeneration. (pubmedcentralcanada.ca)
  • The activities of most, but not of all, aminoacyl-tRNA synthetases in cell sap of regenerating liver tend to be greater than normal. (biochemj.org)
  • Sedimentation analysis of cell sap in sucrose density gradients shows a shift of prolyl-tRNA synthetase activity toward the high-Mr form in regenerating liver. (biochemj.org)
  • cirrhosis
  • Liver cirrhosis on the basis of a chronic hepatitis B or C, autoimmune hepatitis, chronic alcohol abuse, primary sclerosing cholangitis, and primary biliary cirrhosis are only a few possible reasons for functional liver insufficiency. (hindawi.com)