• severe
  • Because of the severe health effects, many individuals with pyruvate dehydrogenase deficiency do not survive past childhood, although some may live into adolescence or adulthood. (wikipedia.org)
  • hyperacute
  • Another scheme defines "hyperacute" as onset within 7 days, "acute" as onset between 7 and 28 days, and "subacute" as onset between 28 days and 24 weeks. (wikipedia.org)
  • dysfunction
  • Non alcoholic fatty liver disease (NAFLD) is the leading cause of liver dysfunction worldwide and is a rapidly growing health problem in India. (medindia.net)
  • kidney failure
  • Kidney failure is common, present in more than 50% of ALF patients, either due to original insult such as paracetamol resulting in acute tubular necrosis or from hyperdynamic circulation leading to hepatorenal syndrome or functional kidney failure. (wikipedia.org)
  • They can help in determining the presence of urinary obstructions and the size and structure of the kidneys -- smaller kidneys are commonly found in cats with chronic kidney disease, while larger kidneys are associated with acute kidney failure or obstruction. (petmd.com)
  • survival
  • In pigs, treatment with the Spheroid Reservoir Bioartificial Liver has been shown to reduce the severity of liver disease and improve survival. (medindia.net)
  • hepatocyte
  • On the one hand, massive hepatocyte cell death triggers immune cell activation and recruitment to the liver, which can stimulate immune-mediated liver damage. (bmj.com)
  • Mouse models of acute liver injury revealed that liver-resident macrophages, Kupffer cells, sense hepatocyte-mediated release of alarmins, which results in Kupffer cell activation and cytokine release. (bmj.com)
  • Subsequent studies have defined LECT2 as a hepatokine, i.e. a substance made and released into the circulation by liver hepatocyte cells that regulates the function of other cells: it is a hepatocyte-derived, hormone-like, signaling protein. (wikipedia.org)
  • The liver hepatocyte is considered to be the source of the LECT2 circulating in blood. (wikipedia.org)
  • patient
  • Each eligible Acute Liver Failure patient will be given N-acetylcysteine (NAC), beginning at a dose of 150 mg/kg bodyweight in 250 ml 5% dextrose over one hour, followed by 50 mg/kg in 500 ml 5% dextrose over four hours, and 125 mg/kg in 1000 ml 5% dextrose over 19 hours, then 150 mg/kg in 1000 ml 5% dextrose per 24 hours for an additional 48 hours. (clinicaltrials.gov)
  • Over the past 35 years, the outlook for a patient presenting with acute liver failure (ALF) has changed beyond all recognition. (springer.com)
  • 1.5), all occurring within 26 weeks' duration, in a patient with previously normal liver function. (oncologynurseadvisor.com)
  • inflammation
  • On the other hand, systemic activation of inflammation, systemic inflammatory response syndrome, promotes multiple organ failure and defective antimicrobial responses. (bmj.com)
  • centers
  • Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States," Annals of Internal Medicine , vol. 137, no. 12, pp. 947-954, 2002. (hindawi.com)
  • necrosis
  • Liver damage from Amanita phalloides is related to the amanitins, powerful toxins that inhibit RNA polymerase II resulting in a deficient protein synthesis and cell necrosis. (hindawi.com)
  • mainly
  • This is a rare inherited systemic disorder of copper metabolism, affecting the liver mainly before other organs. (medindia.net)
  • Infected patients show extensive destruction of liver tissue, with steatosis of a particular type (microsteatosis, characterized by small fat droplets inside the cells), and infiltration of large numbers of inflammatory cells called morula cells, comprised mainly by macrophages containing delta virus antigens. (wikipedia.org)
  • injury
  • 3 4 However, there is ample experimental evidence that monocyte-derived macrophages change their phenotype in the liver, if injury has terminated, towards repair-promoting phagocytes. (bmj.com)
  • Hepatocytes
  • It uses healthy hepatocytes, or liver cells, from pigs to aid in digestion, removal of waste and toxins from the bloodstream. (medindia.net)
  • efficacy
  • Acharya S, Bhatia V, Sreenivas V, Khanal S, Panda S (2009) Efficacy of L-Ornithine L-Aspartate in acute liver failure: a double-blind, randomised, placebo-controlled study. (springer.com)