• Nine types of collectins have been defined: MBL = mannan-binding lectin (mannose-binding lectin) SP-A = surfactant protein A SP-D = surfactant protein D CL-L1 = collectin liver 1 CL-P1 = collectin placenta 1 CL-43 = Collectin of 43 kDa CL-46 = collectin of 46 kDa CL-K1 = collectin kidney 1 Conglutinin CL-43, CL-46 and conglutinin are found in bovine. (wikipedia.org)
  • 5] C1q is a member of the collectin family, which also includes surfactant A, surfactant D, and mannose-binding lectin (MBL). (medscape.com)
  • Mannose binding lectin (MBL) is a liver derived protein which plays an important role in innate immunity. (springeropen.com)
  • Mannose binding lectin (MBL) is a liver derived acute phase protein. (springeropen.com)
  • 4 SP-D is most commonly identified as a component of surfactant in the lungs, but it is not exclusive to the lungs and is significantly expressed in non-pulmonary tissues, such as skin, eye, ear, nasal compartment, epithelia of the urinary, glandular, circulatory system, gastrointestinal and reproductive tracts. (org.pk)
  • Collectins are surfactant proteins that are present in serum, lung secretions, and mucosal surfaces. (brmi.online)
  • It belongs to a family of proteins called collectins, which consists of collagenous region and a carbohydrate recognition domain (Taylor et al. (springeropen.com)
  • 2003). "Direct binding of Toll-like receptor 2 to zymosan, and zymosan-induced NF-kappa B activation and TNF-alpha secretion are down-regulated by lung collectin surfactant protein A". J. Immunol. (wikipedia.org)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Surfactant Associated Protein D (SPD) in serum, plasma, lung lavage fluid and other biological fluids. (2sars.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat Surfactant Associated Protein D (SPD) in samples from serum, plasma, lung lavage fluid and other biological fluids with no significant corss-reactivity with analogues from other species. (2sars.com)
  • Description: A sandwich ELISA kit for detection of Surfactant Associated Protein D from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (2sars.com)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human Surfactant Associated Protein D (SPD) in samples from serum, plasma, tissue homogenates, cell lysates, lung lavage fluid, cell culture supernates or other biological fluids. (2sars.com)
  • Organic barn dust inhibits surfactant protein D production through protein kinase-c alpha dependent increase of GPR116. (cdc.gov)
  • The immune surfactant or collectin surfactant protein D (SP-D) is a crucial multifunctional innate immune receptor. (cdc.gov)
  • To compare surfactant protein-D levels in type 2 diabetics and non-diabetics, and to explore its link with random blood glucose and extra-pulmonary infections. (org.pk)
  • Extra pulmonary infections, body mass index and random blood glucose levels were noted and serum surfactant protein-D was analysed using enzynme-linked immunosorbent assay. (org.pk)
  • Significant negative correlation was found between surfactant protein-D and infections (rs= -0.495, p=0.0001). (org.pk)
  • A negative association between random blood glucose and surfactant protein-D was found, but it was not significant (p=0.15). (org.pk)
  • Serum surfactant protein-D was found to have negative association with extra-pulmonary infections. (org.pk)
  • Surfactant protein-D (SP-D) is a collecting molecule responsible for immune regulation at cellular level. (org.pk)
  • Surfactant development - allows lung inflation and decreases the work of breathing and also related to immunology of the lungs. (edu.au)
  • It is also the only surface active component of lung surfactant capable of lowering surface tension to near zero levels. (absoluteastronomy.com)
  • Binding of collectins to microorganisms may trigger elimination of microorganisms by aggregation, complement activation, opsonization, activation of phagocytosis, or inhibition of microbial growth. (wikipedia.org)
  • Collectins are linked with activation of lectin pathway of complement activation. (wikipedia.org)
  • Collectin MBL is involved in activation of the lectin complement pathway. (wikipedia.org)
  • Since the appearance of life on Earth, natural immunity has been developing in all living beings in response to microbial entities (and all this without vaccines). (brmi.online)
  • Collectins (collagen-containing C-type lectins) are a part of the innate immune system. (wikipedia.org)
  • Surfactants and MBL play an important role in innate immunity. (medscape.com)
  • Other functions of collectins are modulation of inflammatory, allergic responses, adaptive immune system and clearance of apoptotic cells. (wikipedia.org)
  • There is a specific interaction between collectins and receptors on phagocytic cells which can lead to increased clearance of microorganisms. (wikipedia.org)
  • Collectins SP-A and SP-D enhance clearance of apoptotic cells by macrophages. (wikipedia.org)
  • It potentiates acute liver damage after galactosamine injection suggesting that certain types of nonparenchymal cells other than Kupffer cells are involved in zymosan action. (wikipedia.org)
  • The surface of the living cells is decorated by a complex layer of glycosylated molecules that store relevant biological information. (nature.com)
  • Affinity of interaction between microbes and collectins depends on the degree of collectin oligomerization and also on the density of ligands on the surface of the microbe. (wikipedia.org)
  • Collectins can bind to the surface of microorganisms and between carbohydrate ligands. (wikipedia.org)
  • Surfactants are compounds that lower the surface tension of a liquid, the interfacial tension between two liquids, or that between a liquid and a solid. (absoluteastronomy.com)
  • Collectins have effect on microorganism survival. (wikipedia.org)
  • Little work to date has examined the effect of such collectins in response to organic dusts. (cdc.gov)
  • Collectins SP-A and SP-D have anti-allergic effects: they inhibit IgE binding to allergens, decrease histamine release from basophils, and inhibit T-lymphocyte production in the late phase of the inflammation. (wikipedia.org)
  • Collectins (collagen-containing C-type lectins) are a part of the innate immune system. (wikipedia.org)
  • Surfactant protein (SP)-D is a large hydrophilic protein that is a member of the collagen-containing C-type lectins or collectins. (medscape.com)
  • Nine types of collectins have been defined: MBL = mannan-binding lectin (mannose-binding lectin) SP-A = surfactant protein A SP-D = surfactant protein D CL-L1 = collectin liver 1 CL-P1 = collectin placenta 1 CL-43 = Collectin of 43 kDa CL-46 = collectin of 46 kDa CL-K1 = collectin kidney 1 Conglutinin CL-43, CL-46 and conglutinin are found in bovine. (wikipedia.org)
  • Recently, "novel collectins", different from "classical collectins" consisting of mannan-binding lectin (MBL) and surfactant proteins A and D (SP-A and SP-D), have been found by reverse genetics. (nih.gov)
  • 9. Role of surfactant proteins A, D, and C1q in the clearance of apoptotic cells in vivo and in vitro: calreticulin and CD91 as a common collectin receptor complex. (nih.gov)
  • Most people have never heard of surfactant proteins, but they are now being shown to be our critical first defense in stopping viral infections such as COVID-19. (coronanlm.com)
  • Summary hoppe hj, reid kb: Collectins-soluble proteins containing nu- group can be 4. (stonecottagegardens.com)
  • Other functions of collectins are modulation of inflammatory, allergic responses, adaptive immune system and clearance of apoptotic cells. (wikipedia.org)
  • Collectins SP-A and SP-D enhance clearance of apoptotic cells by macrophages. (wikipedia.org)
  • These "novel collectins" consist of collectin liver 1 (CL-L1), collectin kidney 1 (CL-K1), and collectin placenta 1 (CL-P1) and are encoded by three separate genes. (nih.gov)
  • Furthermore, although CRP is primarily made by liver, new studies have shown that CRP is also produced by diseased tissues (eg, atherosclerotic lesions) and by various cell types including macrophages, smooth muscle cells, and endothelial cells. (ahajournals.org)
  • Collectins SP-A and SP-D have anti-allergic effects: they inhibit IgE binding to allergens, decrease histamine release from basophils, and inhibit T-lymphocyte production in the late phase of the inflammation. (wikipedia.org)
  • Affinity of interaction between microbes and collectins depends on the degree of collectin oligomerization and also on the density of ligands on the surface of the microbe. (wikipedia.org)
  • Guidance) however procedures have been established in identification of the membrane is firm, and as the force of gravity so that the direction and degree and nature of a surfactant is mixed sion is xed by the appropriate media. (stonecottagegardens.com)
  • Based on our recent results and those of others, in this paper, we summarize the new biological functions of these novel collectins in embryonic morphogenesis and development. (nih.gov)
  • It potentiates acute liver damage after galactosamine injection suggesting that certain types of nonparenchymal cells other than Kupffer cells are involved in zymosan action. (wikipedia.org)
  • Binding of collectins to microorganisms may trigger elimination of microorganisms by aggregation, complement activation, opsonization, activation of phagocytosis, or inhibition of microbial growth. (wikipedia.org)
  • Collectins are linked with activation of lectin pathway of complement activation. (wikipedia.org)
  • Collectin MBL is involved in activation of the lectin complement pathway. (wikipedia.org)
  • Find out about the exciting discoveries being made by NIEHS and NIEHS-supported researchers that are helping to improve health and save lives. (nih.gov)