Liver human apolipoprotein apolipoprotein c i. Medical search. Frequent questions

ApoB100 is found in lipoproteins originating from the liver (VLDL, IDL, LDL). (wikipedia.org)
This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. (genetex.com)
Apolipoproteins are protein components of plasma lipoproteins. (thermofisher.com)
The apolipoprotein C gene family encodes four homologous proteins designated apoC-I to -IV, which specifically modulate the metabolism of triglyceride-rich lipoproteins. (thermofisher.com)
It has been suggested that defective production and/or secretion of apo B lipoproteins were highly associated with fatty degeneration of the liver and might involve impaired synthesis of very low-density lipoproteins (VLDL), resulting in the accumulation of TG in the liver [ 12 ]. (hindawi.com)
Triglycerides (TG) and cholesterol synthesized in the liver are incorporated into very low density lipoproteins (VLDLs) and released into the plasma for delivery to peripheral tissues. (nih.gov)
High density lipoproteins (HDLs), containing apolipoprotein A, are hypothesized to participate in the reverse transport of cholesterol from tissues back to the liver. (nih.gov)

[ 2 ] Research has shown that almost all patients with familial renal amyloidoses (FRA) are heterozygous for mutations in the genes for lysozyme, apolipoprotein AI, apolipoprotein AII, or fibrinogen A alpha-chain and that the amyloid fibrils in this condition are derived from the respective variant proteins. (medscape.com)
8. Effects of niacin and chromium on the expression of ATP-binding cassette transporter A1 and apolipoprotein A-1 genes in HepG2 cells. (nih.gov)
Polymorphism in Apolipoprotein C3 (APOC3) and Fatty Acid-Binding Proteins (FABP2) Genes in Nondiabetic Dyslipidemic Patients: A Tertiary Care Hospital-Based Pilot Study. (cdc.gov)
Yet, patterns are emerging by studying liver-specific genes in detail, such as the highly regulated gene for the cholesterol 7-hydroxylipase gene ( CYP7A1 ). (kent.edu)
Knowing that one of the most significant genetic risk factor s for late-onset Alzheimer's is a form of the apolipoprotein E gene called APOE4, researchers analyzed data derived from 213 brain tissue samples and identified the Alzheimer's gene expression signatures, the levels to which genes are turned on or off, specific to APOE4 carriers. (nih.gov)
It aims at suppressing genes either responsible for the development of human diseases or interfering with conventional treatment (e.g. drug resistance). (thno.org)
In this study, we aimed to identify novel HCC subtypes that resemble certain stages of liver lineages by searching for EpCAM-coexpressed genes. (gsea-msigdb.org)
The EGP catalogues single nucleotide variation (also called SNPs) in environmentally-responsive genes in the human genome and carries out research on the biological implications of such genetic variation. (nih.gov)
Moreover, the expression of PPAR-α target genes in the liver and brown adipose tissue is enhanced by a phytol-enriched diet, suggesting that phytol and phytanic acid activate PPAR-α in these organs. (nara-wu.ac.jp)
Multi-omics approach reveals posttranscriptionally regulated genes are essential for human pluripotent stem cells. (kyoto-u.ac.jp)

Apolipoprotein B (ApoB) is a protein that in humans is encoded by the APOB gene. (wikipedia.org)
It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. (genetex.com)
The analyst should use the special sampling weights in this file to analyze Apolipoprotein B (ApoB). (cdc.gov)
Clinical and pathologic studies have shown that elevated levels of total cholesterol (Total-C), low density lipoprotein cholesterol (LDL-C), and apolipoprotein B (ApoB - a membrane transport complex for LDL) promote human atherosclerosis. (nih.gov)
and the percentage change from baseline in non-high-density lipoprotein cholesterol (non-HDL-C), apolipoprotein B (ApoB), total cholesterol (TC), TC/HDL-C ratio, ApoB/apolipoprotein A1 (ApoA1) ratio, lipoprotein(a), triglycerides, HDL-C and very low-density lipoprotein cholesterol (VLDL-C). (prnewswire.com)

Similarly, decreased levels of HDL-cholesterol (HDL-C) and its transport complex, apolipoprotein A, are associated with the development of atherosclerosis. (nih.gov)
Therefore, further investigations in humans are required to determine whether dietary oxidized cholesterols found in cholesterol-rich processed foods delay the clearance of postprandial remnants, which may contribute to and exacerbate the development of atherosclerosis. (edu.au)
Clinical studies have demonstrated that elevated levels of total cholesterol (total-C), LDL-C, and apolipoprotein B (Apo B, a protein associated with LDL-C) are associated with an increased risk of atherosclerosis in humans. (pharmacycode.com)
In addition, an in vivo model of atherosclerosis was established using Apolipoprotein E (ApoE) knockout (ApoE ‑/‑ ) mice. (spandidos-publications.com)

Mice hyper-expressing Hu Apo E4 developed normally and lived normal lifespans. (nih.gov)
In this study, we began to elucidate these associations by examining the effects of apoE on PTSD severity in combat veterans, and on PTSD-like behavior in mice with human apoE. (nih.gov)
Furthermore, we measured behavioral and biological outcomes in mice expressing human apoE after a single stressful event as well as following a period of chronic variable stress, a model of combat-related trauma. (nih.gov)
15. Effect of beta-3 adrenoceptor stimulation on the levels of ApoA-I, PPARα, and PPARγ in apolipoprotein E-deficient mice. (nih.gov)
We then examined the effect of HFD on memory deficits and microglia morphology in AD model mice expressing either mouse Apoe or human APOE isoforms. (pitt.edu)
Researchers found that treating mice which expressed the human APOE4 gene reduced learning and memory deficits. (nih.gov)
Muhua Yang, Christina Gallo-Ebert, Michael Hayward, Weidong Liu, Virginia McDonough and Joseph T. Nickels, Jr . Human insulin growth factor 2 mRNA binding protein 2 increases miR-33a/b inhibition of liver ABCA1 expression and alters low-density apolipoprotein levels in mice Mol and Cell Biol. (invivotek.com)
In high-fat-diet-induced, severely obese mice, a phytol-enriched diet increases phytanic acid levels in the liver and adipose tissue, where PPAR-α is abundantly expressed. (nara-wu.ac.jp)
METHODS: Generation and characterization of apolipoprotein E-null mice carrying an additional transgenic copy of the entire Ink4/Arf locus (apoE-/-Super-Ink4/Arf) that reproduces the normal expression and regulation of the endogenous locus. (isciii.es)
RESULTS: Although liver and aorta of apoE-/-Super-Ink4/Arf mice only showed a trend towards increased Ink4/Arf transcript levels compared to apoE-/- controls, cultured macrophages with increased Ink4/Arf gene dosage exhibited augmented apoptosis induced by irradiation with ultraviolet light, indicating that low level of transgene overexpression can lead to augmented Ink4/Arf function. (isciii.es)

1. The effects of short-chain fatty acids on the transcription and secretion of apolipoprotein A-I in human hepatocytes in vitro. (nih.gov)
9. Gemfibrozil stimulates apolipoprotein A-I synthesis and secretion by stabilization of mRNA transcripts in human hepatoblastoma cell line (Hep G2). (nih.gov)
16. Linoleic acid-enriched phospholipids act through peroxisome proliferator-activated receptors alpha to stimulate hepatic apolipoprotein A-I secretion. (nih.gov)
Recently, naringenin (grapes) has been shown to inhibit apolipoprotein B-dependent secretion of HCV particles 5 . (nature.com)

It is controversial whether the apolipoprotein E epsilon 4 allele (APOE ε4) is a risk gene for human immunodeficiency virus (HIV)-related neurocognitive impairment. (nih.gov)
The ultimate goal is to gain an in depth understanding of the mechanisms by which the Apolipoprotein E e4 allele confers increased AD risk for the purpose of advancing the overall search for efficacious AD treatments and Apolipoprotein E e4-directed therapeutics in particular. (nih.gov)
The APOEε4 allele of Apolipoprotein E (APOE) is the major genetic risk factor for LOAD. (pitt.edu)
Several of our projects have revolved around the confirmed longevity gene forkhead box 3 ( FOXO3 ) and the apolipoprotein E ( APOE ) gene with its epsilon 4 'mortality' allele. (uni-kiel.de)

Daum U, Leren TP, Langer C, Chirazi A, Cullen P, Pritchard PH, Assmann G, von Eckardstein A. Multiple dysfunctions of two apolipoprotein A-I variants, apoA-I(R160L)Oslo and apoA-I(P165R), that are associated with hypoalphalipoproteinemia in heterozygous carriers. (medlineplus.gov)
Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease. (cdc.gov)
Apolipoprotein C3 Gene Variants and Risk of Developing Type 2 Diabetes in Saudi Subjects. (cdc.gov)
Identification and characterization of two functional variants in the human longevity gene FOXO3. (uni-kiel.de)
RATIONALE: Human genome-wide association studies have identified genetic variants in the chromosome 9p21 region that confer increased risk of coronary artery disease and other age-related diseases. (isciii.es)

10. Potential Contribution of Short Chain Fatty Acids to Hepatic Apolipoprotein A-I Production. (nih.gov)

T transitions has increased in recent years, probably resulting from apolipoprotein B mRNA editing enzyme catalytic polypeptide 3G (APOBEC3) deaminase editing. (cdc.gov)
Hepatic fatty acid synthase mRNA was lower in both BEE groups, whereas PPAR γ 2 mRNA and liver cholesterol were lower in 1·25 %-BEE, suggesting decreased hepatic lipid synthesis. (cambridge.org)
A notable example of RNA editing occurs with the human mRNA for apolipoprotein B. (exama2z.in)
Evolution of intestinal apolipoprotein B mRNA editing. (wustl.edu)

Apolipoprotein A‐I (ApoA‐I) related amyloidosis is a rare disease caused by missense mutations in the APOA1 gene. (jascoinc.com)
The APOA1 gene provides instructions for making a protein called apolipoprotein A-I (apoA-I). ApoA-I is a component of high-density lipoprotein (HDL). (medlineplus.gov)
Eriksson M, Schonland S, Yumlu S, Hegenbart U, von Hutten H, Gioeva Z, Lohse P, Buttner J, Schmidt H, Rocken C. Hereditary apolipoprotein AI-associated amyloidosis in surgical pathology specimens: identification of three novel mutations in the APOA1 gene. (medlineplus.gov)

18. NFkappaB regulates plasma apolipoprotein A-I and high density lipoprotein cholesterol through inhibition of peroxisome proliferator-activated receptor alpha. (nih.gov)
Gemfibrozil increases levels of high density lipoprotein (HDL) subfractions HDL 2 and HDL 3 , as well as apolipoproteins AI and AII. (nih.gov)

Apolipoprotein B is the main protein component of LDL and accounts for approximately 95% of the total protein content of LDL. (cdc.gov)
These mutations lead to protein aggregation and abnormal accumulation of ApoA‐I amyloid fibrils in heart, liver, kidneys, skin, nerves, ovaries or testes. (jascoinc.com)
The human apoC-II gene maps to chromosome 19q13.2 and encodes a 79 amino acid single chain protein that is a necessary cofactor for the activation of lipoprotein lipase, the enzyme that hydrolyzes triglycerides in plasma and transfers the fatty acids to tissues. (thermofisher.com)
The human apoC-III gene maps to chromosome 11q23 and encodes a protein that may delay catabolism of triglyceride-rich particles by inhibiting lipoprotein lipase and hepatic lipase. (thermofisher.com)
The human apoC-IV gene maps to chromosome 19q13.2 and encodes a 127 amino acid protein that is primarily expressed in the liver. (thermofisher.com)
After 16 weeks, both BEE groups had significantly lower liver weights, serum TAG, homoeostasis model assessment and serum monocyte chemoattractant protein-1 compared with HFD. (cambridge.org)
Evolocumab is an investigational fully human monoclonal antibody that inhibits proprotein convertase subtilisin/kexin type 9 (PCSK9), a protein that reduces the liver's ability to remove LDL-C from the blood. (prnewswire.com)
Afamin is a liver-produced bioactive protein and features α- and γ-tocopherol binding sites. (mdpi.com)
Well-known syntheses in the human organism are, for example, processes such as protein synthesis, fatty acid synthesis, ATP synthase and hormone synthesis. (healthandmedicineinfo.com)
Protein synthesis is one of the most important synthesis processes in the human organism. (healthandmedicineinfo.com)
The gene for this protein codes for a 456-amino-acid polypeptide, called apolipoprotein B100, which is synthesize: d in liver cells and secreted into the bloodstream where it transports lipids around the body. (exama2z.in)
A related protein, apolipoprotein B48, is made by intestinal cells. (exama2z.in)

Although mincle expressed on macrophages might be beneficial for intestinal barrier integrity, it seems to contribute to inflammation and fibrosis once the intestinal barrier becomes leaky in advanced stages of chronic liver disease. (frontiersin.org)
Our study illustrated that the gut-liver axis was a potential way for SX to ameliorate NAFLD, that is, by regulating the expression of PPAR α , apoB48, and modulating gut microbiota to protect the intestinal barrier function, and thus alleviate lipid deposition and inflammatory response in the liver. (hindawi.com)
At present, the current majority standpoint recognized that the hypothesis of "multiple-hits" could explain the pathogenesis of NAFLD more accurately, which involved factors such as liver fat deposition, insulin resistance (IR), intestinal disorders, lipotoxicity, inflammation, oxidative stress, c-Jun N-terminal kinase signaling, and epigenetic dysregulation [ 5 - 7 ]. (hindawi.com)

This meta-analysis aimed to summarize evidence of the associations between APOE ε4 and cognitive impairment in people living with HIV (PLWH). (nih.gov)
Apolipoprotein E (apoE) is an essential component of lipoprotein particles in both the brain and periphery, and exists in three isoforms in the human population: E2, E3, and E4. (nih.gov)
A genome-wide association study confirms APOE as the major gene influencing survival in long-lived individuals. (uni-kiel.de)
Apolipoprotein (apo) analysis showed that oxysterol incorporation reduced the apoE content and altered the apoC phenotype of chylomicrons, which may have an impact oil the removal of chylomicron remnants front plasma. (edu.au)

Apolipoprotein B is the primary apolipoprotein of chylomicrons, VLDL, Lp(a), IDL, and LDL particles (LDL-commonly known as "bad cholesterol" when in reference to both heart disease and vascular disease in general), which is responsible for carrying fat molecules (lipids), including cholesterol, around the body to all cells within all tissues. (wikipedia.org)
HDL is a molecule that transports cholesterol and certain fats called phospholipids through the bloodstream from the body's tissues to the liver. (medlineplus.gov)
Once in the liver, cholesterol and phospholipids are redistributed to other tissues or removed from the body. (medlineplus.gov)
In these models, the role of mincle was investigated in liver samples as well as in peripheral blood monocytes (PBMC), tissues from the kidney, spleen, small intestine, and heart. (frontiersin.org)
In this study, we found that PGC-1α was highly expressed in CRC tissues and was positively correlated with lymph node and liver metastasis. (bvsalud.org)
It has been implicated as an extracellular antioxidant, and in the transport of selenium to extra-hepatic tissues via apolipoprotein E receptor-2 (apoER2). (nih.gov)
The human leukemic oncogene MLL-AF4 promotes hyperplastic growth of hematopoietic tissues in Drosophila larvae. (iric.ca)
By immunohistochemical and Western blot analyses, we also reveal that LXRα is abundantly expressed in human oral squamous cell carcinoma (HOSCC) tissues and cell lines. (oncotarget.com)
Collectively, the results of this study suggest that the exacerbated delay in clearance of chylomicron remnants enriched with oxysterols may, be due to impaired uptake by tissues other than the liver and spleen. (edu.au)
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). (idrblab.net)

NIEHS research uses state-of-the-art science and technology to investigate the interplay between environmental exposures, human biology, genetics, and common diseases to help prevent disease and improve human health. (nih.gov)
Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study. (uni-kiel.de)
American journal of human genetics. (wustl.edu)

Apo B is necessary for the reaction with LDL receptors in the liver and on cell walls, and is thus involved in transporting cholesterol from the liver to the vessel cell. (cdc.gov)
Pathways as wide ranging as cholesterol synthesis, apolipoprotein gene expression, and cholesterol catabolism are coordinately regulated by mechanisms not clearly understood. (kent.edu)
HDL transports cholesterol mostly to the liver or steroidogenic organs such as adrenals , ovary , and testes by both direct and indirect pathways. (wikipedia.org)
Liver X receptors (LXRs) contribute not only to maintain cholesterol homeostasis but also to control cell growth. (oncotarget.com)
Mechanistically, exosomal‑mediated delivery of si‑LOC100129516 promoted cholesterol efflux by activating the peroxisome proliferator‑activated receptor γ (PPARγ)/liver X receptor α (LXRα)/phospholipid‑transporting ATPase ABCA1 (ABCA1) signaling pathway in vitro and in vivo . (spandidos-publications.com)

After most of the lipids in the chylomicron have been absorbed, ApoB48 returns to the liver as part of the chylomicron remnant, where it is endocytosed and degraded. (wikipedia.org)

ICC/IF analysis of HepG2 cells using GTX15664 Apolipoprotein B antibody [F2C4]. (genetex.com)
3. Short-Chain Fatty Acids (Except Hexanoic Acid) Lower NF-kB Transactivation, Which Rescues Inflammation-Induced Decreased Apolipoprotein A-I Transcription in HepG2 Cells. (nih.gov)
4. Link Between ER-Stress, PPAR-Alpha Activation, and BET Inhibition in Relation to Apolipoprotein A-I Transcription in HepG2 Cells. (nih.gov)
5. Large-Scale Screening of Natural Products Transactivating Peroxisome Proliferator-Activated Receptor α Identifies 9S-Hydroxy-10E,12Z,15Z-Octadecatrienoic Acid and Cymarin as Potential Compounds Capable of Increasing Apolipoprotein A-I Transcription in Human Liver Cells. (nih.gov)
11. Role of the nuclear receptors HNF4 alpha, PPAR alpha, and LXRs in the TNF alpha-mediated inhibition of human apolipoprotein A-I gene expression in HepG2 cells. (nih.gov)
12. Effects of platelet-activating factor, tumor necrosis factor, and interleukin-1alpha on the expression of apolipoprotein M in HepG2 cells. (nih.gov)
13. Pioglitazone stimulates apolipoprotein A-I production without affecting HDL removal in HepG2 cells: involvement of PPAR-alpha. (nih.gov)
14. PPARγ Represses Apolipoprotein A-I Gene but Impedes TNFα-Mediated ApoA-I Downregulation in HepG2 Cells. (nih.gov)
Curcumin (turmeric) inhibits HCV replication via suppressing the AKT SREBP-1 pathway 7 and entry of all HCV genotypes into human liver cells 8 . (nature.com)
We have previously shown that mouse and human hepatocytes can be converted to expandable liver progenitor-like cells in vitro (HepLPCs). (thno.org)
Furthermore, proliferation, migration and invasion assays, extracellular-matrix degradation assay, immunochemistry on proteins involved in migration processes and a combination of biophysical microscopy analysis of the plasma membrane organization of Hs294T human melanoma wild type, control (scrambled), ABCA1 Knockout (ABCA1 KO) and ABCA1 chemically inactivated cells were used to study the impact of ABCA1 activity on human melanoma metastasis processes. (bvsalud.org)
Notch-Mediated Expansion of Human Hematopoietic Stem and Progenitor Cells By Culture Under Hypoxia. (nih.gov)
Since an enormous number of syntheses in the human organism take place specifically in the liver cells, liver diseases or damage are also possible triggers for disturbed synthesis processes. (healthandmedicineinfo.com)
The biosynthesis of non-essential amino acids also takes place mainly in the cells of the liver. (healthandmedicineinfo.com)
Supported by the Malin och Lennart Philipson Foundation we have established a highly versatile human 3D cell culture model in which liver cells remain viable and functionally stable for multiple weeks. (molps.se)
Furthermore, we showed in a multicenter trial that liver cells in our model faithfully reproduced in vivo drug toxicity mechanisms in man. (molps.se)
A clinical-grade HLA haplobank of human induced pluripotent stem cells matching approximately 40% of the Japanese population. (kyoto-u.ac.jp)
A stress-reduced passaging technique improves the viability of human pluripotent cells. (kyoto-u.ac.jp)
Base-Resolution Methylome of Retinal Pigment Epithelial Cells Used in the First Trial of Human Induced Pluripotent Stem Cell-Based Autologous Transplantation. (kyoto-u.ac.jp)
Induced Pluripotent Stem Cells and Their Use in Human Models of Disease and Development. (kyoto-u.ac.jp)

In an immunochemical reaction, Apolipoprotein B in the human serum sample form immune complexes with specific antibodies. (cdc.gov)

liver transplantation is potentially curative in patients with fibrinogen A alpha-chain FRA and, possibly, in some patients with apolipoprotein AI amyloidosis. (medscape.com)
The liver, kidneys, and heart are commonly affected by amyloidosis. (medlineplus.gov)

Phenotypic anchoring of results from model systems by tissue dosimetry, gene expression and epigenetic mark profiling, and tissue biomarker identification should promote development of a coherent picture of mechanisms of arsenic-induced human disease. (nih.gov)
Free fatty acids (FFAs) were synthesized by excess dietary fatty acids via de novo lipogenesis (DNL) and continuously produced triglyceride (TG) in the liver, resulting in abnormally elevated level of intrahepatic TG, which could be considered a NAFLD biomarker [ 9 , 10 ]. (hindawi.com)

Mincle expression was measured in human liver samples from cirrhotic patients and donors collected at liver transplantation and in patients undergoing bariatric surgery. (frontiersin.org)
As the second most common cause of liver transplantation currently, NAFLD is predicted to be the main indication for liver transplantation and the main reason of liver-related morbidity and mortality, within 20 years [ 3 ]. (hindawi.com)
Liver Transplantation. (wustl.edu)

This FOA encouarges multidisciplinary and interdisciplinary research to elucidate how Apolipoprotein E, lipoprotein receptors and CNS lipid homeostasis influence brain aging and the transition to neurodegeneration in Alzheimers disease (AD). (nih.gov)

In light of the proliferative capacity and the heterogeneity they represented, these iHepLPCs cell lines may offer assistance in studying xenobiotic metabolism as well as liver diseases in vitro . (thno.org)
Liver lipid metabolism disorder is one of the most common initial inducement of NAFLD and continue to influence the disease progress [ 8 ]. (hindawi.com)

The human apoC-I gene maps to chromosome 19q13.2 and is expressed primarily in the liver where it is activated when monocytes differentiate into macrophages. (thermofisher.com)
Culture of Macrophage Colony-stimulating Factor Differentiated Human Monocyte-derived Macrophages. (nih.gov)

Hepatitis C virus (HCV) is one of the main causes of chronic liver disease. (nature.com)
Furthermore, mincle expression is associated with the stage of chronic liver disease. (frontiersin.org)
Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease with an increasing incidence rate but few therapies. (hindawi.com)

Nonalcoholic fatty liver disease (NAFLD) is common clinicopathological syndrome characterized by fatty degeneration of hepatocytes and lipid accumulation, of which, natural history includes nonalcoholic simple fatty liver (NAFL), nonalcoholic steatohepatitis (NASH), and associated liver cirrhosis and hepatocellular carcinoma (HCC) [ 1 , 2 ]. (hindawi.com)

Hepatitis C virus (HCV) is the causative agent of end-stage liver disease. (nature.com)
Affected individuals can have an enlarged liver (hepatomegaly), chronic kidney disease, or a form of heart disease called cardiomyopathy. (medlineplus.gov)
Methods: During a workshop, we discussed experimental systems investigating arsenic dose/exposure and phenotypic expression relationships and human disease responses to chronic arsenic exposure and identified knowledge gaps. (nih.gov)
Anchoring experimental results to specific human exposures will accelerate understanding of mechanisms of arsenic-induced human disease. (nih.gov)
We also highlight a human-specific disease end point and discuss advantages of invertebrate systems to address specific questions in a simpler background with fewer confounding factors. (nih.gov)
Active liver disease, which may include unexplained persistent elevations in hepatic transaminase levels ( 4.1 ). (nih.gov)
Association of Sst I polymorphism in apolipoprotein C3 gene with hypertriglyceridaemia in coronary atherosclerotic heart disease and type II diabetes mellitus in Chinese population. (cdc.gov)
Apolipoprotein A5 and apolipoprotein C3 single nucleotide polymorphisms are correlated with an increased risk of coronary heart disease: a case-control and meta-analysis study. (cdc.gov)
The strongest candidate was bumetanide , which is used to treat fluid retention often caused by medical problems such as heart, kidney, and liver disease. (nih.gov)
OBJECTIVE: The aim of this study was to develop a novel chronic kidney disease (CKD) risk prediction tool for young potential living kidney donors. (nih.gov)
Alcoholic liver disease: Utility of animal models. (wjgnet.com)
Interaction in Human Health and Disease. (nih.gov)
PCSK7: A novel regulator of apolipoprotein B and a potential target against non-alcoholic fatty liver disease. (iric.ca)
Liver disease in pregnancy. (medscape.com)
Building on these succefull developments, we now extend our focus to develop model systems for complex human disease. (molps.se)
Specifically we focus on type 2 diabetes mellitus (T2DM), a disease characterized by insulin resistance of muscle, liver and adipocyte tissue in combination with progressive failure of pancreatic βcells that affects more than 400 million patients globally. (molps.se)

Conclusion: A phytol-enriched diet may increase phytanic acid levels in the liver and brown adipocytes, thereby activating PPAR-α in these organs and ameliorating obesity-induced metabolic diseases. (nara-wu.ac.jp)

Involvement of other organs (eg, gastrointestinal tract, liver and spleen, heart, skin) varies somewhat depending on the specific genotype. (medscape.com)

IHC-P analysis of human liver tissue using GTX15664 Apolipoprotein B antibody [F2C4]. (genetex.com)
There are currently no references for Apolipoprotein B antibody [F2C4] (GTX15664) . (genetex.com)
Some editing events have a significant impact on the organism: in humans, editing is partly responsible for the generation of antibody diversity and has also been implicated in control of the HIV-1 infection cycle. (exama2z.in)

This selenoprotein is unique in that it contains multiple selenocysteine (Sec) residues per polypeptide (10 in human), and accounts for most of the selenium in plasma. (nih.gov)

The research team analyzed information in databases of brain tissue samples and FDA-approved drugs, performed mouse and human cell experiments, and explored human population studies to identify bumetanide as a leading drug candidate that may potentially be repurposed to treat Alzheimer's. (nih.gov)
In rat, the tissue distribution is similar in liver and intestine. (aspetjournals.org)
We have developed novel 3D tissue models that accurately reflect the biology and function of human liver. (molps.se)
Understanding human physiology, pharmacology and pathogenesis requires model systems that accurately reflect the phenotype of the tissue of interest and recapitulate its function. (molps.se)
Specifically, we integrate our liver model with microphysiological long-term stable 3D model systems for pancreas, adipose tissue and muscle and utilize this platform to investigate T2DM biology and to screen for novel anti-diabetic medications. (molps.se)

Here, we reported the generation of a novel hepatocyte model not only to provide unlimited cell sources for human hepatocytes but also to establish a tool for studying iDILI in vitro . (thno.org)
Translation of laboratory arsenic toxicology studies to human health is important but is complicated by inexact dose conversion between in vitro , murine, and human exposures and species-specific metabolic differences. (nih.gov)

Overproduction of apolipoprotein B can result in lipid-induced endoplasmic reticulum stress and insulin resistance in the liver. (wikipedia.org)

The researchers validated the data-driven discoveries by testing bumetanide in both mouse models of Alzheimer's and induced pluripotent stem cell -derived human neurons. (nih.gov)
The neutralizing effects were also confirmed in the human cell-based models, which led to the hypothesis that people already taking bumetanide should have lower rates of Alzheimer's. (nih.gov)

Chambenoit O, Hamon Y, Marguet D, Rigneault H, Rosseneu M, Chimini G. Specific docking of apolipoprotein A-I at the cell surface requires a functional ABCA1 transporter. (medlineplus.gov)
However, no direct link between human melanoma progression and ABCA1 activity has been reported yet. (bvsalud.org)

Human primary hepatocytes were isolated by modified two-step perfusion technique. (thno.org)
Furthermore, under three-dimensional culture conditions, the formed hepatic spheroids showed multiple liver functions and toxicity profiles close to those of primary human hepatocytes. (thno.org)

Error prone viral genomic replication in the hepatic micro environment permits immune evasion and facilitates viral persistence, which in turn drives the progression to liver fibrosis, cirrhosis and hepatocellular carcinoma 2 . (nature.com)

In the synthesis the human organism itself produces essential substances. (healthandmedicineinfo.com)
The liver intervenes in most of the vital metabolic pathways and is therefore involved in most of the synthesis. (healthandmedicineinfo.com)
In addition to glycogen synthesis, the synthesis of plasma proteins, coagulation factors and apolipoproteins takes place here. (healthandmedicineinfo.com)

How arsenic exposure promotes a variety of diseases is poorly understood, and specific relationships between experimental and human exposures are not established. (nih.gov)
Now showing clinical progress against liver diseases, the gene-silencing technique begins to fulfill some of its promises. (the-scientist.com)

Human results were confirmed in rodent models of cirrhosis and acute-on-chronic liver failure (ACLF). (frontiersin.org)
In human cirrhosis, mincle expression is also significantly upregulated. (frontiersin.org)

L-carnitine is made in the human brain, liver , and kidneys . (webmd.com)

This gene encodes a selenoprotein that is predominantly expressed in the liver and secreted into the plasma. (nih.gov)
Quite a lot of studies have determined the cardioprotective abilities of tocotrienols and have been shown to possess novel hypocholesterolemic effects together with an ability to reduce the atherogenic apolipoprotein and lipoprotein plasma levels. (biomedcentral.com)
and plasma concentrations of apolipoproteins have been identified as predictors for response to therapy. (hal.science)

In this review, 'specificity' is defined as the ability of an OGT agent to bind only a targeted RNA sequence in a complex mixture of biological molecules, such as those found in human body, without interacting with other biomolecules including non-targeted RNAs. (thno.org)
In April 2003, the National Human Genome Research Institute (NHGRI) and the National Institutes of Health (NIH) celebrated the 50th anniversary of Watson and Crick's Nobel Prize-winning work on the double-helical structure of DNA and the completion of a final version of the sequence of the human genome. (nih.gov)
The celebration featured a NHGRI-sponsored Scientific Symposium: From Double Helix to Human Sequence - and Beyond , and several satellite symposia on related topics. (nih.gov)

Liver enzyme abnormalities: Persistent elevations in hepatic transaminases can occur. (nih.gov)
Among all UGT isoforms identified to date, it is the only relevant bilirubin-glucuronidating enzyme in human. (aspetjournals.org)

Furthermore, we show that this element, which is conserved in the human promoter, also confers strong HNF1 responsiveness to the human UGT1A1 gene. (aspetjournals.org)

Second, an L1 transposon element, which is absent in the human promoter, is found 480 bp upstream of the transcription start site in mouse. (aspetjournals.org)
Together, these results provide evidence for a major regulatory function of this liver-enriched transcription factor in UGT1A1 activity in both rodents and human. (aspetjournals.org)

The first is synthesized exclusively by the small intestine, the second by the liver. (wikipedia.org)

Liver is the largest internal organ in the human body, responsible for metabolic homeostasis. (thno.org)
Genetic interplay between human longevity and metabolic pathways - a large-scale eQTL study. (uni-kiel.de)

However, the limited proliferation potential of human HepLPCs confines its industrial application. (thno.org)
Endotoxin contamination of apolipoprotein A-I: effect on macrophage proliferation--a cautionary tale. (nih.gov)

Objectives: We examined the use of phenotypic anchors to translate experimental data to human pathology and investigated research needs for which phenotypic anchors need to be developed. (nih.gov)

CDK8/19 inhibition plays an important role in pancreatic β-cell induction from human iPSCs. (kyoto-u.ac.jp)

Understanding the genetic profile of young AA potential living kidney donors in the context of baseline health characteristics may help to inform candidate selection and counseling. (nih.gov)

Owing to limited long-term data and lack of genetic information, current risk tools lack precision among young potential living kidney donors, particularly African Americans (AAs). (nih.gov)
Health Sciences (NIEHS) in 1998 to improve understanding of human genetic susceptibility to environmental exposure. (nih.gov)
Dr. Lynn Jorde presented an overview of the patterns of human genetic variation. (nih.gov)
In opening his talk, Dr. Jorde answered the question 'why we are interested in studying human genetic variation? (nih.gov)
Jorde pointed out that knowledge of human genetic variation is important because it has applications in medicine and forensics, and because it can be informative about the evolutionary history of the human population. (nih.gov)
Dr. Jorde studied genetic variation in human populations using a global genomic sample from Africans, Europeans and Asians in a ratio of 150:120:700. (nih.gov)

While mincle expression and downstream signaling via FC receptor gamma, SYK, and NF-kappa-B are upregulated in the liver, they are downregulated in PBMCs of these rats. (frontiersin.org)
Expression of CYP7A1 is specific to the liver and regulated by a number of factors, including bile acids and hormones. (kent.edu)
Western Blotting was used to detect apolipoprotein (apo) B48 expression. (hindawi.com)
The overlay and integration of the genotype data with other layers of information (e.g. transcriptome and methylation data) allows us to create a high-resolution molecular map of longevity and age-related processes, which improves our understanding of gene expression and regulation in human longevity. (uni-kiel.de)

Phosphatidylglucoside is expressed on human monocytes and can be converted to lysoPtdGlc. (bvsalud.org)

Anatomy9

Organisms4

Diseases22

Chemicals and Drugs64

Analytical, Diagnostic and Therapeutic Techniques and Equipment16

Psychiatry and Psychology1

Phenomena and Processes25

Technology, Industry, Agriculture1

Information Science3

Lipoproteins7

Genes10

ApoB5

Atherosclerosis4

Mice10

Secretion4

Allele4

Variants5

Hepatic apolipoprotein1

MRNA4

APOA13

High density lip2

Protein12

Intestinal3

ApoE4

Tissues10

Genetics3

Cholesterol5

Lipids1

Cells20

Serum1

Amyloidosis2

Biomarker2

Transplantation3

Receptors1

Metabolism2

Macrophages2

Chronic liver d3

Nonalcoholic fatty l1

Disease16

PPAR1

Spleen1

Antibody3

Polypeptide1

Tissue5

Vitro2

Endoplasmic reticulum stress1

Alzheimer's2

ABCA12

Hepatocytes2

Fibrosis1

Synthesis3

Diseases2

Cirrhosis2

Kidneys1

Plasma3

Sequence3

Enzyme2

Confers1

Transcription2

Small intestine1

Metabolic2

Proliferation2

Anchors1

Inhibition1

Baseline1

Genetic6

Expression4

Monocytes1