• This study aims to evaluate the influences of ultraviolet radiation A and B (UVA + B) exposure on the liver and heart organs of albino rats. (nih.gov)
  • Female Wistar Albino rats, whose hair of the dorsal skin was shaved, were exposed to a combined UVA + B radiation for 2 h/day, for 4 weeks in order to be compared with the control group. (nih.gov)
  • As a result, UVA + B exposure has toxic effects, especially on the liver and the heart of Wistar albino rats. (nih.gov)
  • The acute oral toxicity test of the polyherbal was evaluated in albino rats using a single-dose based on behavioral changes and mortality. (ajol.info)
  • Agavaceae) methanolic crude extract in gentamicin-induced nephrotoxicity in male Wistar albino rats. (ugm.ac.id)
  • 2013. Green asparagus (Asparagus officinalis) prevented hypertension by an inhibitory effect on angiotensin-converting enzyme activity in the kidney of spontaneously hypertensive rats. (raysahelian.com)
  • Differential lung inflammation and injury with tobacco smoke exposure in Wistar Kyoto and spontaneously hypertensive rats. (cdc.gov)
  • This study aims to study the effect of aqueous extract of L. inermis leaves in acute ethanol induced hepatic damage in adult Wistar rats. (projectreserve.com)
  • Hepatic uptake of a modified low molecular weight heparin in rats. (jci.org)
  • Non-alcoholic fatty liver disease (NAFLD), one of the most significant forms of chronic liver disease worldwide, is characterized by hepatic steatosis. (frontiersin.org)
  • This study aimed to evaluate the effects of TQ on spatial memory and hippocampal long-term potentiation (LTP) in rats with thioacetamide (TAA)-induced liver injury and hepatic encephalopathy. (magiran.com)
  • The study's focus was to investigate if nicotine exposure during pregnancy and lactation leads to alterations in hepatic (liver) triglyceride synthesis. (naturalnews.com)
  • Biochemical analysis was carried out using liver markers enzymes, kidney markers enzymes, and lipid profiles. (ajol.info)
  • The organs (liver, kidney, and heart) were collected and prepared using standard protocols with hematoxylin and eosin for histopathological evaluation. (ajol.info)
  • Histopathological evaluation of the organs demonstrated mild degeneration in the kidney and liver while the heart revealed no pathological changes in the treated group of rats. (ajol.info)
  • Although, slight changes were observed in some biochemical parameters and histology of the kidney and liver at high doses when compared with control rats. (ajol.info)
  • We aimed to examine whether ROT-induced oxidative stress could be counteracted by cranberry juice not only in the brain but also in the liver and kidney. (cranberryinstitute.org)
  • To prevent cisplatin induced kidney toxicity we used a combination of dietary plant extracts, particularly, hydro-alcoholic extract of Tribulus terrestris (TT), Boerhaavia diffusa (BD) and Terminalia chebula (TC) in rats. (scialert.net)
  • Blood urea nitrogen (BUN), serum creatinine, malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH) and glutathione peroxidase (GPx), renal histopathology, liver fatty acid binding protein (L-FAB), kidney injury molecule-1 (Kim-1) and platinum accumulation in kidney tissue were determined. (scialert.net)
  • Male Wistar rats (225-250 g) were fed liquid diet and ethanol for 2 months. (aspetjournals.org)
  • Ethanol administration caused fatty liver, necrosis and inflammation. (aspetjournals.org)
  • 02) but not in ethanol-fed rats (20.0 ± 2.0). (aspetjournals.org)
  • and 3) the worsening of liver injury in ethanol-fed rats by HES-DFO. (aspetjournals.org)
  • This present study assessed the toxicity effect of the ethanol leaf extract of PGC in rats. (ajol.info)
  • The present study aimed at investigating the effects of curcumin on the motor coordination and the estimate of the total number of cerebellar Purkinje cells of adolescent Wistar rats exposed to ethanol. (jcimjournal.com)
  • The total of 21 male Wistar rats aged 37 d old were divided into three groups, namely ethanol, ethanol-curcumin, and control groups. (jcimjournal.com)
  • Curcumin may exert beneficial effects on the motor coordination of adolescent rats exposed to ethanol via undetermined hormetic mechanisms. (jcimjournal.com)
  • Aim: To evaluate histometrically the effect of low and high caloric value of ethanol on ligatureinduced bone loss in female rats. (bvsalud.org)
  • Methods: Sixty female rats were divided into five groups of 12 animals each: Normal Control (water), Test A (low ethanol), Control A (low iso), Test B (high ethanol) and Control B (high iso). (bvsalud.org)
  • In the presence of experimental periodontitis, a high dose of ethanol (36% of total calories in the diet) was associated with higher density of polymorphonuclear leukocytes, increasing the severity of periodontal inflammation in the ligature model of male rats 15 . (bvsalud.org)
  • Another study demonstrated that in male rats, ethanol increases ligature-induced bone loss when representing a low value (22%) in total caloric value 13 . (bvsalud.org)
  • Considering that more studies are necessary to test the hypothesis that alcohol consumption can aggravate destruction of the periodontium, the aim of this study was to evaluate histometrically the effect of low and high caloric values of ethanol consumption on alveolar bone loss associated with ligature-induced bone loss in female rats. (bvsalud.org)
  • The screening is carried according to the method of (Houghton and Raman, 1998) and exploratory tests of subacute oral toxicity are carried in vivo on Wistar albinos rats in accordance with the OECD guidelines (423). (phytojournal.com)
  • Acute toxicity and diuretic studies of the roots of Asparagus racemosus in rats. (raysahelian.com)
  • The study was carried out with an aqueous extract of the roots of Asparagus racemosus utilizing three doses viz 800 mg/kg, 1600 mg/kg and 3200 mg/kg for its diuretic activity in comparison with standard drug (furosemide) and control (normal saline) rats after doing acute toxicity study. (raysahelian.com)
  • G to T transversion mutations in codon 249 of the p53 tumour-suppressor gene have been found in human liver tumour from geographic areas with high risk of aflatoxin exposure and in AFB 1 -induced liver toxicity [ 8 ]. (hindawi.com)
  • Can cranberry juice protect against rotenone-induced toxicity in rats? (cranberryinstitute.org)
  • This research aimed to evaluate toxicity and safety of consuming chloroform extract of S. trifasciata leaf (CESTL) in acute phase using female Wistar rats as model animal. (ugm.ac.id)
  • Because it is expected that more in vivo dose-response curves for developmental toxicity of than 20% of the laboratory animals needed for REACH will be the parent glycol ethers in rat and man. (cdc.gov)
  • PBK model allows the prediction of dose-response curves for implantation rat whole-embryo culture test, the rat limb bud human developmental toxicity. (cdc.gov)
  • The PPAR alpha-humanized mouse: a model to investigate species differences in liver toxicity mediated by PPAR alpha. (who.int)
  • Objective : Using a model of carbon tetrachloride (CCl4)-induced hepatotoxicity in rats, we evaluated the effects of commercial herbal extracts used most commonly in the metropolitan area of Monterrey, Mexico. (edu.mx)
  • To our knowledge, this is the first report that liver uptake of heparins is linked to scavenger receptor mediated mechanisms in vivo. (jci.org)
  • On the basis of pharmacokinetic results obtained in rats and mice exposed to chloroform by inhalation, and of enzymatic studies in human tissues in vitro , in vivo metabolic rate constants (VmaxC = 15.7 mg/hour/kg, Km = 0.448 mg/L) were defined for humans (Corley et al. (cdc.gov)
  • This in vivo study revealed that the levels of colon CYP3A could be significantly increased in rats treated with probiotic EcN. (nel.edu)
  • response curves for rat were found to be in concordance with the 2004), in vitro and in silico alternatives for developmental embryotoxic dose levels measured in reported in vivo rat studies. (cdc.gov)
  • Finally, experimental candidiasis was evaluated in in vivo models with Wistar female rats. (who.int)
  • Methods: Pharmacokinetic parameters of riluzole were determined in Wistar rats after single-dose co-administration with ciprofloxacin and grapefruit juice. (researchgate.net)
  • Randomização de 32 ratos Wistar machos em quatro grupos: Controle (CG), Exposição à Fumaça (ESG), Antioxidante (AG) e Exposição à Fumaça+Antioxidante (ESAG). (bvsalud.org)
  • Rutin prevents experimental selenite-induced cataractogenesis in rat pups, possibly by preventing depletion of antioxidant enzymes and of GSH, and by inhibiting lipid peroxidation. (molvis.org)
  • Four weeks prior to the end of the experimental period, half of the rats in each group were randomly assigned to receive a ligature on mandibular molar, whereas the other half of group was left unligated. (bvsalud.org)
  • The control group showed normal liver and heart histology with normal adipose tissue in the pericardium. (nih.gov)
  • The disease is caused mainly by the Hantaan virus (HTNV), transmitted by the striped field mouse ( Apodemus agrarius ), and Seoul virus (SEOV), transmitted by the brown Norway rat ( Rattus norvegicus ) ( 4 , 6 ). (cdc.gov)
  • After whole-body autoradiography to study the distribution of inhaled 14C-labeled chloroform in mice, most of the radioactivity was found in fat immediately after exposure, while the concentration of radioactivity in the liver increased during the postanesthetic period, most likely due to covalent binding to lipid and protein in the liver (Cohen and Hood 1969). (cdc.gov)
  • Significant exposure to Aflatoxin B 1 (AFB 1 ), a potent hepatotoxic and hepatocarcinogenic mycotoxin, plays a major role in liver carcinogenesis through oxidative tissue damage and p53 mutation. (hindawi.com)
  • Male Wistar rats were randomized into four groups: Control Group (CG), Exposure to Smoke Group (ESG), Antioxidant Group (AG) and Exposure to Smoke plus Antioxidant Group (ESAG). (bvsalud.org)
  • Voss C, Zerban H, Bannasch P, Berger MR. Lifelong exposure to di-(2-ethylhexyl)-phthalate induces tumors in liver and testes of Sprague-Dawley rats. (who.int)
  • The varying degree of damage done to the liver and stomach is due to the masking effect of thevarious concentration of alcohol over Phyllantusamarus (hepatoprotective and gastroprotective). (journalcra.com)
  • Asparagus extract supplement has been getting a lot of attention lately for its possible role in reducing hangover symptoms or to prevent liver damage from excess alcohol use. (raysahelian.com)
  • Liver damage is always a concern for people who drink heavily. (raysahelian.com)
  • The extract should be taken prior to an evening of drinking because if it is taken after the liver damage would already have been done. (raysahelian.com)
  • AFB 1 -administered HCC-bearing rats (Group II) showed increased levels of lipid peroxides (LPOs), thiobarbituric acid substances (TBARs), and protein carbonyls (PCOs) and decreased levels of enzymic and nonenzymic antioxidants when compared to control animals (Group I). Administration of TD orally (300 mg/kg body weight/day) for 45 days to HCC-bearing animals (Group III) significantly reduced the tissue damage accompanied by restoration of the levels of antioxidants. (hindawi.com)
  • In the present study, we examined the effect of a complex rearing environment during adolescence on attention and behavioral inhibition in adult male rats. (frontiersin.org)
  • We therefore set out to examine the effect of a complex environment during adolescence -whether primed by early life adversity or not- on behavioral inhibition and impulsivity in male rats. (frontiersin.org)
  • Effects of probiotic Escherichia coli Nissle 1917 on expression of cytochromes P450 along the gastrointestinal tract of male rats. (nel.edu)
  • Live bacterial suspension of EcN was administered to healthy male Wistar rats daily for 7 days. (nel.edu)
  • Matuskova Z, Tunkova A, Anzenbacherova E, Vecera R, Siller M, Tlaskalova-Hogenova H, Zidek Z, Anzenbacher P. Effects of probiotic Escherichia coli Nissle 1917 on expression of cytochromes P450 along the gastrointestinal tract of male rats. (nel.edu)
  • The present study emphasizes the anticarcinogenic effect of Tridham (TD), a polyherbal traditional medicine, on AFB 1 -induced HCC in male Wistar rats. (hindawi.com)
  • Predator odor evokes sex-independent stress responses in male and female Wistar rats and reduces phosphorylation of cyclic-adenosine monophosphate response element binding protein in the male, but not the female hippocampus. (broadinstitute.org)
  • Histopathological findings in vital organs (liver and heart) were evaluated. (nih.gov)
  • The effect of these products given with or without CCl4in rats was evaluated by measuring the serum concentrations of aspartate amino transferase (AST) and alanine amino transferase (ALT), and histopathological analysis. (edu.mx)
  • Therefore, we verified the therapeutic effect of QHD on high-fat diet (HFD)-induced NAFLD in rats by physiological parameters and histopathological examination. (frontiersin.org)
  • One factor contributing to elevated BCAA in obesity is inhibitory phosphorylation of the branched chain keto-acid dehydrogenase complex (BCKDH) in liver. (diabetesjournals.org)
  • Proteomics analysis of liver samples from these studies revealed that both inhibition of BDK with BT2 and adenoviral mediated overexpression of PPM1K results in reduced phosphorylation of the lipogenic enzyme ATP-citrate lyase (ACL) on its regulatory serine 454. (diabetesjournals.org)
  • Furthermore, adenovirus-mediated overexpression of BDK increased ACL phosphorylation and activated de novo lipogenesis in liver of lean Wistar rats. (diabetesjournals.org)
  • This study is carried out on Wistar rats to evaluate the hepatoprotective activity of Argemone mexicana L aerial part extracts against CCL_4 induced acute liver damages. (airitilibrary.com)
  • Background : Various hepatoprotective herbal products from plants are available in Mexico, where up to 85% of patients with liver disease use some form of complementary and alternative medicine. (edu.mx)
  • Lawsonia inermis commonly known as henna has been used traditionally, especially in ayurvedic medicine, for various conditions including liver ailments, and reported to have hepatoprotective properties. (projectreserve.com)
  • To determine the hepatoprotective and antioxidant effects of hydro-alcoholic extract of Prosopis farcta ( P farcta) leaves on high fat diet-fed (HFDF) rats. (uwi.edu)
  • Argemone mexicana L. at dose 100 mg/kg indeed has a reasonable potential in healing liver parenchyma and regeneration of liver cells hence it may acts as a potent liver tonic. (airitilibrary.com)
  • It has also been used successfully by some Ayurvedic practitioners for nervous disorders, inflammation, liver diseases and certain infectious diseases. (raysahelian.com)
  • This study highlights the potent antioxidant properties of TD which contribute to its therapeutic effect in AFB 1 -induced HCC in rats. (hindawi.com)
  • Phylogenetic analysis showed that partial small segment sequences recovered from humans, laboratory rats, and local wild rats belonged to SEOV. (cdc.gov)
  • Hantavirus sequences recovered from humans and laboratory rats clustered within 1 of 3 lineages of SEOV circulating among local wild rats in Shenyang. (cdc.gov)
  • the wild rats passed the virus to laboratory rats, which then infected humans. (cdc.gov)
  • Thirty (30) female rats were equally divided into five (5) groups (I-V). Group I which served as negative control received distilled water (2 ml) for 8 days. (projectreserve.com)
  • They used female Wistar rats separated into two groups. (naturalnews.com)
  • In-vitro metabolic inhibition studies using rat and human liver microsomes and intestinal absorption studies of riluzole in a rat everted gut-sac model were conducted to elucidate the mechanism of interaction. (researchgate.net)
  • To measure impulsive action and inhibition of behavior in rats, we used the 5-choice serial reaction time task (5-CSRTT) ( Robbins, 2002 ). (frontiersin.org)
  • The researchers backtracked to determine the cascading sequence of biochemical processes that led to the liver hypertriglyceridemia in the rats' livers whose mothers were exposed to nicotine just before pregnancy , during pregnancy and while lactating. (naturalnews.com)
  • The use of rat models has been applied in the evaluation of periodontal pathogenesis 8 and regarding the influence of risk indicator/factors, such as estrogen deficiency 9-10 , alcohol consumption 11-16 , nicotine 17 and simultaneous nicotine and alcohol use 18 on disease progression. (bvsalud.org)
  • 1972). Experiments in mice, rats, and monkeys indicate that oral doses (up to 60 mg/kg) of 14C-labeled chloroform in olive oil were almost completely absorbed, as indicated by an 80-96% recovery of radioactivity in expired air, urine, and carcass (Brown et al. (cdc.gov)
  • 1990). Interspecies differences in the rate of chloroform conversion were observed in mice, rats, and squirrel monkeys, with species differences in metabolism being highly dose-dependant. (cdc.gov)
  • Previous studies have shown the presence of 2 hantaviruses carried by rodents: HTNV, carried by striped field mice, and SEOV, carried by Norway rats in Shenyang ( 18 ). (cdc.gov)
  • Since this knowledge could provide some clues about the etiology of obesity/insulin resistance, this study aimed at characterizing glucose and lipid metabolism in Lou/C vs. Wistar rats. (unige.ch)
  • Improved glucose tolerance of Lou/C rats was not related to increased insulin output but was related to improved insulin sensitivity/responsiveness in the liver and in skeletal muscles. (unige.ch)
  • 24 ] have also shown that 0.2% of G-rutin (a rutin-glucose derivative), given in a 20% casein diet for a period of one month to streptozotocin-induced diabetic rats, decreased thiobarbituric acid reactive substance (TBARS) in kidneys. (molvis.org)
  • Remarkably, these effects were accompanied by strong lowering of liver triacylglycerides and improved glucose tolerance in the absence of weight loss. (diabetesjournals.org)
  • BALB/c Mouse bone marrow cells were preincubated with Purified Rat Anti-Mouse CD16/CD32 antibody (Mouse BD Fc Block™) [Cat. (bdbiosciences.com)
  • Consumption of hibiscus sabdariffa extracts reduced obesity, abdominal fat, serum FFA and improved liver steatosis. (greenmedinfo.com)
  • Very recently, beneficial effects of naringenin have been demonstrated in old rats. (hindawi.com)
  • A very recent publication has also provided evidence that Nar has beneficial effects in the livers of old rats [ 18 ]. (hindawi.com)
  • The inbred Lou/C rat, originating from the Wistar strain, has been described as a model of resistance to diet-induced obesity, but little is known about its metabolism. (unige.ch)
  • In the inguinal adipose depot, expression of uncoupling protein-1 was detected in Lou/C but not in Wistar rats, in keeping with a higher expression of peroxisome proliferator-activated receptor-gamma coactivator-1 in these animals. (unige.ch)
  • Fat deposition was markedly lower in Lou/C than in Wistar rats, especially in visceral adipose tissue. (unige.ch)
  • No. 559864/561018) and with either BD Horizon™ RB545 Rat IgG2b, κ Isotype Control (Cat. (bdbiosciences.com)
  • Control group of rats was stressed by oral application of the saline solution daily for 7 days as well. (nel.edu)
  • The results show that the liver and the heart were injured in the UVA + B group. (nih.gov)
  • Asparagus leaves could help in the treatment of an alcohol hangover and also protect the liver from the toxic results of alcohol. (raysahelian.com)
  • These results suggest that the HFRS outbreak in Shenyang was caused by SEOV that was circulating among local wild rats and had also infected the laboratory rats. (cdc.gov)
  • The Lou/C rat: a model of spontan. (unige.ch)
  • The Lou/C rat is a valuable model of spontaneous food restriction with associated improved insulin sensitivity. (unige.ch)
  • In the present study, pharmacokinetics of CIP following IN and IV administration to rats was investigated and compared. (researchgate.net)
  • Twenty four(24) adult wistar rats of both sexes weighing 171g-250g were used for the study. (journalcra.com)
  • The aim of the study was to find whether probiotic Escherichia coli Nissle 1917 O6:K5:H1 (EcN) influences the expression of cytochromes P450 (CYP) in the rat intestine. (nel.edu)