Liver cell. Medical search. Frequent questions

Brain and skin cells have now been reprogrammed into heart cells using RNA, a molecule related to DNA that is crucial to the creation of proteins within a cell. (livescience.com)
This mRNA contains the instructions, derived from DNA, to create proteins, the building blocks of cells. (livescience.com)
These cells then contained much more heart mRNA than skin or brain mRNA, causing the cell to build heart-cell proteins. (livescience.com)
The presence of the heart-cell proteins influenced the expression of genes and encouraged the production of more heart-cell proteins. (livescience.com)
Our aging cells become hoarders and accumulate unnecessary proteins. (genengnews.com)
In cells, helper proteins make protein aggregates less soluble, relieving pressure on soluble, functional proteins. (genengnews.com)
The normal relation between different proteins, which is critical for proper cell function, is lost. (genengnews.com)
Evidence that widespread aggregation of surplus proteins can hasten death was presented May 7 in the journal Cell, in an article entitled, "Widespread Proteome Remodeling and Aggregation in Aging C. elegans . (genengnews.com)
Surprisingly, the long-lived worms increasingly deposited surplus and harmful proteins in insoluble aggregates, thus relieving pressure on the soluble, functional proteome. (genengnews.com)
However, in contrast to the aggregates found in short-lived animals, these deposits were enriched with helper proteins, which apparently prevented the toxic effects normally exerted by aggregates. (genengnews.com)
This mouse embryo cell moves around thanks to two proteins - actin (purple) and myosin (green) - dancing in sync. (cosmosmagazine.com)
Actin proteins (red) help this monkey cell create surface pockets (green) by which they can engulf nutrients from outside. (cosmosmagazine.com)
Actin proteins (purple) let this monkey cell form "ruffles" that help the cell crawl along a surface. (cosmosmagazine.com)
Here we describe a microscope based on light-sheet illumination 2 that allows massively parallel fluorescence correlation spectroscopy (FCS) 3 measurements and use it to visualize the diffusion and interactions of proteins in mammalian cells and in isolated fly tissue. (nature.com)
They looked at the functional properties of liver cells, such as metabolizing drugs, making the necessary proteins and taking in lipids or LDL. (stanforddaily.com)
The usage of the diffusion coefficient to quantify mobility of single particles/proteins on the cell surface is based on the assumption of Brownian motion. (igert.org)
SPT of labeled proteins on the surface of cells has developed immensely in the last 20 years. (igert.org)
The receptor also works insidethe cell as a shuttle craft, moving proteolytic enzymes to thelysosomes, a part of the cellular digestive system that breaksdown proteins into simpler compounds. (cancernetwork.com)
Being able to image the cell volume in high resolution should allow researchers to better observe the internal dynamics of cells, such as the trafficking of signalling proteins (the cell's communication) in response to encounters with pathogens. (edu.au)
Scientists at TU Darmstadt and the Leibniz Research Institute for Molecular Pharmacology (FMP) in Berlin have investigated how large functional biomolecules like proteins or antibodies can be brought into a living cell. (tu-darmstadt.de)
Linking antibodies or proteins with cell-penetrating peptides is a promising approach-but it has not yet fully led to the anticipated results. (tu-darmstadt.de)
If these peptides are also attached to the cell surface, then proteins or antibodies are transported much better into the cell interior. (tu-darmstadt.de)
Cell-penetrating peptides (green) on the cell surface act as door opener to transport proteins (blue) inside living cells. (tu-darmstadt.de)
As experiments on living cells showed, this significantly improves the intracellular uptake of functional proteins and antibodies. (tu-darmstadt.de)
This publication is the latest result of a joint funding proposal in DFG Priority Programme 1623 (Chemoselective Reactions for the Synthesis and Application of Functional Proteins) with the aim of developing novel functionalisation approaches of proteins and antibodies to make them cell-permeable, says Professor Dr. M. Cristina Cardoso from the Cell biology and epigenetics research group at the Department of Biology at TU Darmstadt. (tu-darmstadt.de)
Active cell-permeable proteins or antibodies can be used, for example, to influence signaling pathways in a cancer cell deliberately or to switch off cancer-driving gene mutations. (tu-darmstadt.de)
Likewise conceivable is the replacement of a missing enzyme in the case of a hereditary disease, for example, or the use of gene editing-that is, the genetic manipulation of cells using ready-made proteins equipped with additional properties. (tu-darmstadt.de)
However, the livers still worked as proven by human liver proteins found in the rats' blood serum. (slashgear.com)
The newly discovered 'switch' controls the activity of two proteins - 'deleted in liver cancer-1' ( DLC1 ), a tumour suppressor, and talin. (imperial.ac.uk)
Both proteins control whether or not cancer cells spread to other parts of the body, but the exact mechanisms have remained unclear. (imperial.ac.uk)
Both AP-MW induced dose- and time-dependent measures of pulmonary cytotoxicity, inflammatory cell influx, and inflammatory proteins. (cdc.gov)

The only treatment for severe liver diseases at present is a liver transplant which can lead to a lifetime of complications and for which the need for donor organs greatly outweighs the increasing demands. (kcl.ac.uk)
The research was a proof-of-concept for the process, demonstrating that in the future, we may simply grow someone a new liver rather than giving them a donor organ transplant. (slashgear.com)
The only curative treatment for ALF is liver transplantation, but there are many restrictions on the application of liver transplantation because of financial considerations, a shortage of donor livers, and immunosuppression-related complications [ 3 ]. (springer.com)
The organs were created by removing muscle cells from donor organs to leave behind tough hearts of connective tissue. (dailymail.co.uk)
Liver transplants are often an important component to treatment, but unfortunately, there aren't enough donor livers to help every child. (childrenshospital.org)

In a feat that could lead to new medical treatments, researchers have grown healthy liver cells on silicon chips. (sciencenews.org)
Rat and mouse cells do not feature such a "countdown" mechanism, and researchers from London have now shown that at least some types of rat cells from the nervous system can divide virtually forever without turning cancerous. (scientificamerican.com)
Until now, it had been a riddle to many researchers as to why cultured rodent cells did stop dividing, despite the fact that they have an enzyme called telomerase, which keeps their telomeres at a constant length. (scientificamerican.com)
The researchers, from Cortical Labs and The University of Melbourne, used DishBrain - a collection of 800,000 human neural cells learning to play Pong. (eurekalert.org)
Although NKT cells were not critical to transferring already established disease, they are extremely important in the early onset stages by helping break down the body's tolerance for infection, the researchers said. (sciencedaily.com)
Researchers uncovered the roles that different cells in the liver play in organ maintenance and regeneration after injury. (nih.gov)
When the liver experienced toxin-induced damage, the researchers again found that normal hepatocytes originating in zone 2 proliferated to replace injured tissue in zones 1 and 3. (nih.gov)
The researchers believe this technique has possibility for use in cell-based therapy for cardiovascular diseases. (livescience.com)
Heart cells created this way could be used to test treatments for heart disease and, if created from a particular patient, used to personalize treatment, according to the researchers. (livescience.com)
Researchers leveraged live-cell-based tests to assess the intracellular function of the SARS-CoV-2 target, Main 3C-like protease. (globenewswire.com)
Researchers at King's College London have used single cell RNA sequencing to identify a type of cell that may be able to regenerate liver tissue, treating liver failure without the need for transplants. (kcl.ac.uk)
Researchers at the Stanford University School of Medicine have developed a way to quickly and efficiently convert human fat stem cells into liver cells. (stanforddaily.com)
However, before the researchers can use these cells in humans, they must assure that the liver cells are safe. (stanforddaily.com)
The researchers performed careful comparisons to see how closely SCi-Heps resemble liver cells. (stanforddaily.com)
The researchers also did a detailed microarray analysis of gene expression that looked at 30,000 probes and compared the induced hepatocytes they made to liver cells and fat cells. (stanforddaily.com)
A malfunctioning 'traffic cop' gene apparently plays an important role in the formation of liver cancer, according to researchers from the Duke University Comprehensive Cancer Center and Zeneca Pharmaceuticals of Chesire, United Kingdom. (cancernetwork.com)
A malfunctioning 'traffic cop' gene apparently playsan important role in the formation of liver cancer, accordingto researchers from the Duke University Comprehensive Cancer Centerand Zeneca Pharmaceuticals of Chesire, United Kingdom. (cancernetwork.com)
The discovery that the gene-mannose 6-phosphate/insulin-like growthfactor II receptor (M6P/IGF2r)-acts as a tumor-suppressor genein human liver tumors could help researchers develop an earlydiagnostic test for liver cancer as well as new treatments, theresearchers said. (cancernetwork.com)
Because the receptor is involved both in switching on a growthinhibitor and inactivating a growth factor, the researchers hypothesizedthat losing it might well predispose a cell to cancerous growth.Their past studies showing that the protein was abundantly presentin normal liver cells but nearly absent in cancer cells strengthenedtheir suspicion. (cancernetwork.com)
Researchers from UNSW Medicine & Health and UNSW Science have developed a new method to visualise living cells in three-dimensional clarity - at the subnanometre scale - by 'focus-locking' on samples while they are being recorded. (edu.au)
The key finding: the researchers link the molecules not only to the cell-penetrating peptides but also the cell surface. (tu-darmstadt.de)
Using cells scraped from a person's skin, researchers grew miniature human livers in a lab and then successfully transplanted them into living rats. (slashgear.com)
The study was recently published in Cell Reports , where researchers detail the experiment and its results. (slashgear.com)
The researchers point out how these transplantable organs would 'dramatically' impact how liver disease is treated. (slashgear.com)
Researchers at Rice University have just unveiled a new method of 3D printing solid plastic implants that incorporate different types of living cells. (medgadget.com)
Imperial researchers have found a new cell mechanism that could be used to target tumours in the future. (imperial.ac.uk)
Researchers then injected stem cells which multiplied and grew around the structure, eventually turning into healthy heart cells. (dailymail.co.uk)
Johns Hopkins University researchers have invented dust-particle-sized devices that can be used to grab and remove living cells from hard-to-reach places without the need for electrical wires, tubes, or batteries. (campustechnology.com)
Transplanting their own (autologous) bone marrow-derived stem cells into 48 patients with end-stage liver disease resulted in therapeutic benefit to a high number of the patients, report researchers publishing in the current issue of Cell Transplantation (19:11). (medicaldaily.com)
In a new first, researchers from Wake Forest Institute for Regenerative Medicine have developed a 3D printing system that can print live cells into human-scale constructs representing bone, muscle, and ear tissue. (medgadget.com)

The LSECs contain 45% and 17% of the liver's total mass of pinocytic vesicles and lysosomes, and contain twice as many clathrin-coated pits per membrane unit, compared with two other major liver cells, Kupffer cells and hepatocytes, reflecting the high capacity clathrin-mediated endocytic activity of LSECs. (wikipedia.org)
Concurrent deletion of cyclin E1 and cyclin-dependent kinase 2 in hepatocytes inhibits DNA replication and liver regeneration in mice. (nature.com)
Cross-section of a liver lobe from a mouse in which hepatocytes from different zones are labeled. (nih.gov)
Others have implicated normal liver cells, called hepatocytes. (nih.gov)
Zhu and his team found that normal hepatocytes-not stem cells-in zone 2 did the bulk of the work of normal liver maintenance. (nih.gov)
These findings show that which hepatocytes help in recovery after liver injury depends on the location of the injury. (nih.gov)
Liver homeostasis is maintained by midlobular zone 2 hepatocytes. (nih.gov)
Surprisingly, HHyP also persists in small quantities in adults and these cells can grow into the two main cell types of the adult liver (Hepatocytes and Cholangiocytes) giving HHyPs stem cell-like properties. (kcl.ac.uk)
Scientists at the Peltz lab obtained human fat cells through liposuction, isolating the fat stem cells known as adipocyte stem cells, and through a method called spherical culture, induced these cells to become liver cells, or spherical-culture induced hepatocytes (SCi-Heps). (stanforddaily.com)
They then administered these hepatocytes in a mouse model organism and showed that these liver cells were able to reconstitute functioning human liver. (stanforddaily.com)
The analysis suggested that the hepatocytes produced through this technique have 80-90 percent resemblance to human liver cells. (stanforddaily.com)
The idea of using hepatocytes to treat liver failure depends on a simple hypothesis that liver function can be improved by supplementing exogenous hepatocytes. (springer.com)
Although liver failure can be treated via hepatocyte transplantation, it also faces multiple problems comprising the shortage of high-quality hepatocytes sources, rejection of allogeneic transplants, difficulty to expand, and losing hepatic characteristics in vitro [ 7 , 8 ]. (springer.com)

NKT cells are a unique group of T cells that share properties of both T cells and Natural Killer cells, which are naturally toxic to other cells and typically target tumor cells or cells infected with viruses. (sciencedaily.com)
There is an unmet clinical need to extract living circulating tumor cells (CTCs) for functional studies and in vitro expansion to enable drug testing and predict responses to therapy in metastatic cancer. (lu.se)
In addition to having only a 10 percent yield rate, iPS requires 30 or more days to produce liver cells and can cause tumor formation. (stanforddaily.com)
The next step is to make sure the cells we inject in human beings do not have any safety issues, meaning there is no tumor formation, and [the liver cells] won't cause extra toxicity," Xu added. (stanforddaily.com)
As a consequence, knowing something about liver tumor formationor having a handle on how one could detect these tumors when they'remuch smaller could have a significant impact on survival,'he said. (cancernetwork.com)
Usinga method to detect mismatches in genetic material, they comparedstrands of DNA from tumor cells and surrounding normal tissue,and discovered mutations in the tumor samples. (cancernetwork.com)
If you could find a small molecule that interacts with i-motif alone, then you might be able to regulate the formation of, say, tumor cells,' Wadkins says, adding that for now this is just speculation. (howstuffworks.com)
The American Joint Committee on Cancer (AJCC) tumor-node-metastasis (TNM) classification and the International Federation of Gynecology and Obstetrics (FIGO) staging system for germ cell tumors are listed below (see Tables 1 and 2). (medscape.com)

Every year, more than 7,000 people in the U.S. get a liver transplant. (nih.gov)
We now need to work quickly to unlock the recipe for converting pluripotent stem cells into HHyPs so that we could transplant those cells into patients at will. (kcl.ac.uk)
People with acute toxic insults like Tylenol induced liver toxicity need a liver transplant within two to three weeks, Peltz said. (stanforddaily.com)
Liver disease affects many people and, in a worst-case scenario, some patients require a liver transplant to survive. (slashgear.com)
Aaron is also a motivational speaker who inspires audiences with her story of being the first successful nonmatched bone marrow transplant for sickle cell disease. (cdc.gov)
The only known cure for sickle cell disease is a bone marrow transplant, and the procedure was still considered experimental. (cdc.gov)

Reduced porosity, as in liver cirrhosis, diabetes mellitus or old age may lead to prolonged postprandial lipoproteinemia and increased circulatory cholesterol levels, with increased risk for development of atherosclerosis. (wikipedia.org)
A bacteria commonly found in soil and water triggered autoimmune symptoms in mice similar to those found in an incurable liver disease called Primary Biliary Cirrhosis. (sciencedaily.com)
The team examined HHyPs and found that they resemble mouse stem cells which have been found to rapidly repair mice liver following major injury, such as occurs in cirrhosis. (kcl.ac.uk)
Symptoms of liver disease include jaundice, itching and feelings of weakness and tiredness and in more severe cases, cirrhosis. (kcl.ac.uk)
When unchecked, fibroblasts can produce scar tissue in the liver, which leads to cirrhosis and HCC. (imperial.ac.uk)
A meta-analysis of 10 studies conducted in the People's Republic of China shows that patients with liver cirrhosis who received cord blood transplantation with routine supportive therapies did better than those who received routine therapies alone. (cryo-cell.com)

The only curative treatment for acute liver failure is liver transplantation, but there are many restrictions on the application of liver transplantation. (springer.com)
The aims of this article are to review the current knowledge regarding therapeutic mechanisms of mesenchymal stem cells in acute liver failure, to discuss recent advancements in preclinical and clinical studies in the treatment of mesenchymal stem cells, and to summarize the methodological improvement of mesenchymal stem cell transplantation in treating liver failure. (springer.com)
Bone marrow or stem cell transplantation, which can cure SCD. (medlineplus.gov)
Innate immune cell dysfunction and systemic inflammation in children with chronic liver diseases undergoing transplantation. (bvsalud.org)
In this study, we examined the phenotypic and functional alterations in circulating monocyte and dendritic cells (DCs) in children with ALD undergoing liver transplantation (LT). Children were stratified into 2 clusters, C1 (mild) and C2 (severe), on the basis of laboratory parameters of ALD and compared with healthy pediatric controls. (bvsalud.org)

She was diagnosed with acute chest syndrome, a common complication of sickle cell disease that can result in lung injury, trouble breathing, low oxygen to the rest of the body and, possibly death. (cdc.gov)
Pain is the most common complication of sickle cell disease. (medlineplus.gov)

Understanding how these processes work could lead to new strategies to treat liver diseases and injuries. (nih.gov)
There is a lot of potential for [treating] different liver diseases," said Dan Xu M.S. '97, a postdoctoral fellow at Stanford, and the lead author of the study. (stanforddaily.com)
Its detection within human cells suggests it occurs naturally and may carry a biological role that could be targeted to treat diseases such as cancer . (howstuffworks.com)
1 The remaining one case had no etiology of liver diseases and showed histologically normal liver. (wjgnet.com)
Diseases, such as hepatitis and liver cancer, can put a child's life at risk. (childrenshospital.org)
When functioning normally, the Hippo pathway is important to cell growth, but when malfunctioning, the Hippo pathway can also play a role in diseases such as liver cancer and liver fibrosis. (childrenshospital.org)
The Camargo lab has recently identified chemicals that control Hippo signaling, which could be turned into novel treatments for liver cancer and other liver diseases. (childrenshospital.org)
They are now utilizing barcoding technologies to generate family trees of cancer and aging models to understand the ancestry and the function of the cells involved in these diseases. (childrenshospital.org)
It tends to occur in livers damaged by genetic defects, alcohol abuse, or chronic infection with diseases such as hepatitis B and C. (lu.se)
Advanced liver diseases (ALD) can affect immune function and compromise host defense against infections . (bvsalud.org)

The novel A2 method provides extensive elimination of WBCs combined with the gentle recovery of viable cancer cells suitable for downstream functional analyses and in vitro culture. (lu.se)
Astrocytes are a heterogeneous population of cells with distinguishing functional and morphological characteristics and are specialized to their different brain regions and locations. (news-medical.net)
This article discusses how a combination of live-cell analysis methods deliver the required flexibility to allow these highly dynamic astrocytic models to be characterized, via quantification of their growth, motility, morphology, and functional analysis. (news-medical.net)
The livers 'remained functional,' according to the study, for the four days they spent as transplants in the rats. (slashgear.com)
ES/iPS cells) and soft functional architectures (e.g., porous coordination polymers). (scienceblog.com)

Dublin, Sept. 29, 2023 (GLOBE NEWSWIRE) -- The "Live Cell Imaging Market Size & Share Analysis - Growth Trends & Forecasts (2023-2028)" report has been added to ResearchAndMarkets.com's offering. (globenewswire.com)
The Global Live Cell Imaging market is on track for substantial growth, with predictions showing an increase from USD 2.09 billion in 2023 to USD 2.94 billion by 2028, marking an impressive Compound Annual Growth Rate (CAGR) of 7.06% during the forecast period (2023-2028). (globenewswire.com)

After the research team established chronic autoimmune liver disease in mice, they performed studies to see if they could transfer the disease with spleen T cells from infected livers into a second group of mice. (sciencedaily.com)
infected guinea pig liver, spleen. (cdc.gov)

Is cell membrane living or non living? (answers.com)
Using their new movie camera and tagging technique, the team has already discovered that actin - a protein 'railway' that shuttles cargo around the cell - also helps the cell's membrane fold around and engulf molecules from outside. (cosmosmagazine.com)
SPT of QD-IgE on live cells combined with the quantification of receptor mobility using the maximum likelihood estimator for diffusion will provide significant insights into membrane protein dynamics. (igert.org)
Our cell interior is protected from unwanted visitors by a cell membrane for a good reason. (tu-darmstadt.de)
For some cells, FcCH2OH+ penetrated the cell membrane and was reduced, leading to an enhanced current known as positive feedback. (nist.gov)
For other cells, FcCH2OH diffusion was blocked by the cell membrane, leading to a lower current known as negative feedback. (nist.gov)
The talin protein attaches to the cell membrane and creates a bridge between the outside and inside of the cell. (imperial.ac.uk)
In spite of being the focus of roughly half of modern drug development due to their key role in signaling across the membrane, until now it has not been well understood how GPCRs relay signals from the outside world into cells' interiors. (scienceblog.com)
The research team, funded in part by the Japan Science and Technology Agency (JST) and the Japanese education ministry MEXT, anticipates that their findings will have a broad impact on the further study of signal transduction in the cell membrane and conceptual and methodological development for drug discovery. (scienceblog.com)

By building a living model brain, scientists will be able to experiment using real brain function rather than flawed analogous models like a computer to not only explore brain function but to test how drugs affect it. (eurekalert.org)
In general, heart-muscle cells may help repair an injured heart by replacing lost tissue, making them intriguing to scientists who study how lost or damaged tissue or organs could be regenerated . (livescience.com)
Scientists have created heart cells through other techniques before, including using embryonic stem cells and adult cells reprogrammed to an embryonic stem cell-like state. (livescience.com)
In a paper published today in Nature Communications , the scientists have identified a new type of cell called a hepatobiliary hybrid progenitor (HHyP), that forms during our early development in the womb. (kcl.ac.uk)
Scientists estimate that the average human body contains 37.2 trillion cells. (learner.org)
Using iPSC stem cells (ones acquires from skin cells), the scientists were able to create what they call mini livers that were then transplanted into rats. (slashgear.com)
The scientists stripped the cells from the dead hearts with a powerful detergent, leaving 'ghost heart' scaffolds made from the protein collagen. (dailymail.co.uk)
Scientists also need to ensure the heart cells beat in time. (dailymail.co.uk)
Studying the Hippo pathway can help scientists develop treatments which encourage a liver to heal itself, allow scientists to grow liver cells in the lab (a therapeutic approach not yet available) or study the development of liver cancer. (childrenshospital.org)
This system gives MultiPark scientists an opportunity to study single molecule dynamics in high resolution, and also allows for keeping long-term track of cell migration and cell differentiation. (lu.se)

This phenomenon is termed "replicative senescence" and prevents cells from accumulating too many genetic mutations that may turn them into cancer cells. (scientificamerican.com)
His group has developed cellular barcoding methodologies that allow for a unique genetic label to be embedded in the cells' DNA. (childrenshospital.org)

A microscopy image of neural cells where fluorescent markers show different types of cells. (eurekalert.org)
Innovations like Leica Microsystems' Leica Nano workflow, a live-cell correlative light and electron microscopy (CLEM) solution, enhance experimental success rates and simplify microscopy integration. (globenewswire.com)
There's beauty in watching the cell and then there's incredibly complex science," says Betzig, who was awarded a Nobel prize last year for his super-resolution microscopy work. (cosmosmagazine.com)

Other important receptors on LSECs are L-SIGN (liver/lymph node-specific ICAM-3 grabbing nonintegrin), LSECtin (liver and lymph node sinusoidal endothelial cell C-type lectin), Lyve-1 (lymphatic vessel endothelial hyaluronan receptor‐1), and LRP‐1 (low‐density lipoprotein receptor‐related protein‐1). (wikipedia.org)

It is therefore crucial for the development of hepatocellular carcinoma (HCC) - the most common type of liver cancer. (imperial.ac.uk)
Coloured scanning electron micrograph (SEM) of two hepatocellular carcinoma (HCC) cells, showing the numerous filopodia (hair-like projections) covering their surface. (lu.se)
Hepatocellular carcinoma is the most common type of liver cancer. (lu.se)

This, in turn, could provide a wide range of regenerative medicine applications for treating liver disease, including the possibility of bypassing the need for liver transplants. (kcl.ac.uk)
Patients given normal heart transplants must take drugs to suppress their immune systems for the rest of their lives. (dailymail.co.uk)

Aaron was first diagnosed with sickle cell disease as an infant. (cdc.gov)
When and how were you diagnosed with sickle cell disease? (medlineplus.gov)

Although the LSECs make up only about 3% of the total liver cell volume, their surface in a normal adult human liver is about 210 m2, or nearly the size of a tennis court. (wikipedia.org)
Dolly the Sheep is known as the first mammal to be cloned from an adult cell. (learner.org)
We show here that the adult mouse liver contains Lin - Sca-1 + Mac-1 + hematopoietic stem cells derived from the fetal liver. (nih.gov)
The liver is one of the few organs in the body where differentiated adult stem cells can divide to regenerate after an injury. (childrenshospital.org)

LSECs may sometimes be the initial target of injury in a condition referred to as sinusoidal obstruction syndrome (SOS, formerly hepatic veno-occlusive disease, VOD), which is described as a change of the sinusoid that may lead to hepatocyte hypoxia, with liver dysfunction and disruption of the portal circulation. (wikipedia.org)
Injecting laboratory mice with the bacterium -- Novosphingobium aromaticivorans -- prompted activation of natural killer T cells, which were critical to initiating autoimmune processes that led to liver disease. (sciencedaily.com)
This microbial activation of NKT cells was as an essential trigger of autoimmune processes that led to disease-like symptoms in mice," said Dr. Mattner, who started the study at the University of Chicago. (sciencedaily.com)
The autoimmune process was mediated by T cells (a white blood cell important to immune response), but early disease onset required the participation of Natural Killer T cells after they selectively recognized glycosphingolipid antigens on the cell wall surface of Novosphingobium aromaticivorans. (sciencedaily.com)
T cells from mice having CD1d (a glycoprotein important to activating NKT cells) caused autoimmune liver disease in recipient mice, although cells from CD1d deficient mice (which lack NKT cells) did not. (sciencedaily.com)
In the case of neural cells, protein aggregates are associated with neurodegenerative disorders such as Alzheimer's, Huntington's, and Parkinson's disease. (genengnews.com)
Liver disease is the fifth biggest killer in the UK* and the third most common cause of premature death, and the number of cases is continuing to rise. (kcl.ac.uk)
Liver cancer is one of the most common cancers worldwide,particularly because of its association with viral hepatitis,'said Dr. Randy Jirtle, professor of radiation oncology at DukeUniversity Medical Center and prinicipal investigator of the study.The lack of effective treatments also makes it a particularlydeadly disease, he said. (cancernetwork.com)
Numerous treatment strategies for acute liver failure simply prevent complications and decelerate disease progression. (springer.com)
Liver disease is mainly caused by the overconsumption of alcohol, overuse of acetaminophen or the hepatitis virus. (cryo-cell.com)
At the time, her parents were not aware of anyone else in her family who had sickle cell disease. (cdc.gov)
Her parents were frightened when Aaron was diagnosed because they didn't know much about sickle cell disease and were afraid they wouldn't know how to take care of her properly. (cdc.gov)
Having sickle cell disease nearly killed Aaron. (cdc.gov)
Her sickle cell disease was cured. (cdc.gov)
Attending Camp New Hope, a summer camp for kids with sickle cell disease, helped Aaron make friends and realize that she was not alone. (cdc.gov)
There are thousands of people with sickle cell disease in the world, and a couple out there just like me," she said. (cdc.gov)
Sickle cell disease (SCD) is a group of inherited red blood cell disorders. (medlineplus.gov)
People with the disease are born with two sickle cell genes, one from each parent. (medlineplus.gov)
Who is more likely to have sickle cell disease (SCD)? (medlineplus.gov)
What are the symptoms of sickle cell disease (SCD)? (medlineplus.gov)
How is sickle cell disease (SCD) diagnosed? (medlineplus.gov)
What are the treatments for sickle cell disease (SCD)? (medlineplus.gov)
After living with sickle cell disease for decades, Tesha Samuels underwent gene therapy at National Institutes of Health. (medlineplus.gov)
Sickle cell disease affects more than 100,000 people in the United States every year, and for three decades, Tesha Samuels was among them. (medlineplus.gov)
Now Samuels has a new outlook on life and is finally doing everything that sickle cell disease held her back from. (medlineplus.gov)
She talked with NIH MedlinePlus Magazine about her experience with sickle cell disease and her life after treatment. (medlineplus.gov)
Finally, my mom took me to a physician who questioned if I had been tested for sickle cell disease. (medlineplus.gov)
She tested positive as a carrier, and I tested positive for sickle cell disease. (medlineplus.gov)
But I'm the only one in my family who has sickle cell disease. (medlineplus.gov)
When you have sickle cell disease, you always know you're different. (medlineplus.gov)
Chronic liver disease. (cdc.gov)

The experiment is a major step towards the first 'grow-your-own' heart, and could pave the way for livers, lungs or kidneys to be made to order. (dailymail.co.uk)

Dr. Mattner said this result illustrates the importance of early microbial activation of NKT cells in the early stages of autonomous, organ-specific autoimmunity. (sciencedaily.com)
The liver is an organ essential to digestion, energy metabolism and filtration of poisons from the body. (childrenshospital.org)
One set of molecules Camargo studies extensively is the Hippo pathway, which is a system within cells that ultimately controls growth and decides how large an organ becomes. (childrenshospital.org)

This triggered chronic autoimmunity that damaged small bile ducts in the animal's livers. (sciencedaily.com)

Each mouse line was engineered to have different groups of liver cells express a fluorescent marker. (nih.gov)
Wachsmuth, M., Waldeck, W. & Langowski, J. Anomalous diffusion of fluorescent probes inside living cell nuclei investigated by spatially-resolved fluorescence correlation spectroscopy. (nature.com)
This way, the team was able to map where i-motifs were located by identifying fluorescent markers in cells' nuclei. (howstuffworks.com)
The kit uses non-fluorescent Labelling Dye Green that becomes strongly fluorescent upon entering into live cells. (abcam.com)
The hydrolysis of the non-fluorescent Labelling Dye Green by intracellular esterases generates the strongly fluorescent hydrophilic calcein that is well-retained in the cell cytoplasm. (abcam.com)

She had her first episode of pain, called a sickle cell crisis, at 8 months old and her first stroke at 8 years old. (cdc.gov)
The cells are supposed to be disc-shaped, but this changes them into a crescent, or sickle, shape. (medlineplus.gov)
The sickle-shaped cells are not flexible and cannot change shape easily. (medlineplus.gov)
The sickle cells usually only last 10 to 20 days, instead of the normal 90 to 120 days. (medlineplus.gov)
The sickle-shaped cells can also stick to vessel walls, causing a blockage that slows or stops the flow of blood. (medlineplus.gov)
The cause of SCD is a defective gene, called a sickle cell gene. (medlineplus.gov)
If you are born with one sickle cell gene, it's called sickle cell trait. (medlineplus.gov)
People with sickle cell trait are generally healthy, but they can pass the defective gene on to their children. (medlineplus.gov)
A blood test can show if you have SCD or sickle cell trait. (medlineplus.gov)
Gene therapies to treat SCD in people who are 12 years and older and have had repeated sickle cell crises. (medlineplus.gov)
Sickle cells traveling through small blood vessels can get stuck and block blood flow throughout the body, which causes pain. (medlineplus.gov)
My mom didn't know what sickle cell was at the time. (medlineplus.gov)
The trait for sickle cell is quite strong on my maternal side-my mother, grandmother, and great-grandmother all have it. (medlineplus.gov)

The cell cycle is a tightly regulated process that is controlled by the conserved cyclin-dependent kinase (CDK)-cyclin protein complex 1 . (nature.com)
It has the protein distribution (shown in green and red) indicative of a young heart-muscle cell. (livescience.com)
Worse, cells that burden themselves with toxic protein aggregates age more quickly. (genengnews.com)
In the cell, the dumpster-or rather the sequestered protein hoard-is never actually carted away. (genengnews.com)
Protein imbalances] are reduced in the long-lived daf-2 mutant but are enhanced in the short-lived daf-16 mutant," wrote the authors of the Cell article. (genengnews.com)
These findings demonstrate that the cells specifically accumulate chaperone-rich protein aggregates as a safety mechanism. (genengnews.com)
Imaging the mobility of heterochromatin protein HP1α (ref. 4 ) in cell nuclei we could provide high-resolution diffusion maps that reveal euchromatin areas with heterochromatin-like HP1α-chromatin interactions. (nature.com)
Figure 2: 1D- and 2D-FCS imaging of protein diffusion in Madin-Darby canine kidney (MDCK) cells. (nature.com)
Slaughter, B.D., Schwartz, J.W. & Li, R. Mapping dynamic protein interactions in MAP kinase signaling using live-cell fluorescence fluctuation spectroscopy and imaging. (nature.com)
The protein receptor produced by M6P/IGF2r is an attractive targetbecause it is present on the cell surface and in the plasma, Jirtlesaid, making it readily accessible for use in both liver tumortherapy and diagnosis. (cancernetwork.com)
When working properly, the M6P/IGF2r receptor protein has at leastthree distinct regulatory roles within a cell, said Jirtle. (cancernetwork.com)
This involves linking a protein or an antibody, for example, with a chemical or biochemical "tag" intended to facilitate its entry into the cell. (tu-darmstadt.de)
HLA is a protein-or marker-found on most cells in your body. (cdc.gov)
The work focuses on G protein-coupled receptors (GPCRs), a class of molecules in cell membranes that comprise the largest superfamily in the human genome. (scienceblog.com)
Hemoglobin is a protein in red blood cells that carries oxygen throughout the body. (medlineplus.gov)
The transfusions helped increase my hemoglobin (a protein in the blood that carries oxygen from the lungs to other organs) and hematocrit (the ratio of red blood cells to total blood volume). (medlineplus.gov)
In the body, these toxins inhibit protein synthesis leading to cell death. (cdc.gov)

Proliferation tracing reveals regional hepatocyte generation in liver homeostasis and repair. (nih.gov)

MSCs have the capacity of multiple differentiations and self-renewal and have been proven to be able to differentiate into a series of cell lineages, such as adipocytes, osteoblasts, chondroblasts, and hepatocyte-like cells (HLCs). (springer.com)

Our study of autoimmunity in PBC showed that NKT cells react to glycosphingolipid antigens, which promote cell attraction and immune response and are located in the bacterial cell wall of Novosphingobium aromaticivorans. (sciencedaily.com)
Even if a liver is found, recipients must take immunosuppressants-a class of drugs that reduces the strength of the body's immune system-for the rest of their lives to cope with the body's rejection of the new liver. (stanforddaily.com)
Thus, an IFN-γ-dependent loop drives liver ILC1 development in situ, highlighting the contribution of extramedullary hematopoiesis to regional immune composition within the liver. (nih.gov)
Acute liver failure (ALF) is a life-threatening clinical syndrome characterized by rapid hepatocellular necrosis due to various acute injuries induced by hepatotoxic drugs, immune-mediated attack, or viral infections. (springer.com)
Under the right conditions, such as certain gene activation or lowered immune system, cancer cells can migrate or ' metastasise ' and invade other tissues, which spreads the cancer. (imperial.ac.uk)
She completed her master's in biomedical engineering (from Czech Republic and Ireland) and has worked on diverse biomedical solutions such as immune engineering, nerve regeneration and stem cell therapy. (medgadget.com)
Alterations of innate immune cells correlated with multiple laboratory parameters of ALD, including plasma bile acids . (bvsalud.org)

Research on cell phone radiation is ongoing, as it should be, seeing the proliferation of cell phone use. (livescience.com)
Fig. 1: p38γ phosphorylates Rb and promotes liver proliferation after PHx. (nature.com)
The N-terminal phosphorylation of RB by p38 bypasses its inactivation by CDKs and prevents proliferation in cancer cells. (nature.com)

The liver has a unique capacity among organs to regenerate itself after damage. (nih.gov)
It makes sense that cells in zone 2, which are sheltered from toxic injuries affecting either end of the lobule, would be in a prime position to regenerate the liver. (nih.gov)

The cells express endocytosis receptors that mediate extremely rapid internalization of waste molecules. (wikipedia.org)
Inside every cell, billions of molecules continually writhe in an endless, carefully choreographed dance. (cosmosmagazine.com)
Diffusion processes and local dynamic equilibria inside cells lead to nonuniform spatial distributions of molecules, which are essential for processes such as nuclear organization and signaling in cell division, differentiation and migration 1 . (nature.com)
As the authors report in Nature Communications , the 3D focus-lock mechanism enables imaging beyond the surface of the cell to provide a 3D view of distinct molecules inside a cell, including living cells. (edu.au)
The research team from Darmstadt and Berlin has taken a decisive step toward transporting even large molecules into the cell interior. (tu-darmstadt.de)

Human cells, extracted from the body and grown in a culture dish, don't divide forever. (scientificamerican.com)
Why do human cells have an built-in "division clock" that some rat cells seem to lack? (scientificamerican.com)
However, more investigation is needed to understand the different cell types in the human liver," Zhu says. (nih.gov)
For the first time, we have found that cells with true stem cell-like properties may well exist in the human liver. (kcl.ac.uk)
But what had been outstanding is the validation that these structures actually exist in live human cells. (howstuffworks.com)
These are the kinds of conditions in which i-motifs had previously been detected during laboratory experiments in the 1990s, and the latest research found that the structures' prevalence increases within the human cell when the environment is made more acidic. (howstuffworks.com)
The miniature human livers looked and acted like their larger, naturally-developed counterparts, according to the report, including the ability to secrete urea and bile acids. (slashgear.com)
Previous studies have proven that rodent and human MSCs can differentiate into HLCs in vitro and in vivo , which is one of the mechanisms of MSCs in the treatment of liver failure. (springer.com)
To illustrate the point, Edmonton Journal columnist Scott Foster points out in an article in Wednesday's National Post that animal-human hybrids have been created, lived and have been permitted to develop till the 32-cell stage. (lifesitenews.com)
Using human cells and a hollowed-out cow and pig ovum, the creatures created would be mostly human but contain some mitochondrial DNA from the animals. (lifesitenews.com)
In 2007, British doctors grew a human heart valve using stem cells taken from a patient's bone marrow. (dailymail.co.uk)
One of the big challenges so far with human-sized engineered constructs has been the lack of blood vessels that nourish the cells with oxygen and nutrients, which is severely detrimental to the potential survival of cells. (medgadget.com)
The human body is derived from a single cell. (childrenshospital.org)

High-content screening has proven effective in understanding the downstream effects of various treatments on cancer cells, evaluating signaling heterogeneity, and estimating cellular responses. (globenewswire.com)
The Incucyte ® Live-Cell Analysis System delivers flexible kinetic quantification of biological phenotypes to monitor growth, motility, morphology, and cellular function. (news-medical.net)
Living cells can now be visualised in three-dimensional molecular detail, enabling new insights to cellular structure and behaviour. (edu.au)
Imagine plunging to microscopic levels and playing a game in the inside of a cell to learn organelles and basic cellular structure and function! (learner.org)
Abcam's CytoPainter Live Cell Labeling Kits are a set of tools used to label cells for fluorescence microscopic investigations and flow cytometric investigations of cellular functions. (abcam.com)
The effective labelling of cells provides a powerful method for studying cellular events in a spatial and temporal context. (abcam.com)
The live cell imaging technology platform is an important tool for studying molecular and cellular function of neuronal and non-neuronal cells and tissues. (lu.se)

Further work identified a specific cell-signaling pathway that appeared to drive zone 2 liver cells to repopulate damaged tissue. (nih.gov)
The pathways that lead to the development of tissue-resident lymphocytes, including liver type 1 innate lymphoid cells (ILC1s), remain unclear. (nih.gov)
The lab-grown organs have been created using these types of cells - the body's immature 'master cells' which have the ability to turn into different types of tissue. (dailymail.co.uk)
Presently, doctors who wish to collect cells or manipulate a bit of tissue inside a patient's body often use tethered microgrippers connected to thin wires or tubes. (campustechnology.com)
Additionally, the microgrippers are triggered to close and extricate cells from tissue when exposed to certain biochemicals or biologically relevant temperatures. (campustechnology.com)

3D printing replacement tissues and organs is still in the early stages of development, but it is clear that custom printed implants will have to integrate multiple types of cells in different locations in order to perform like native tissues. (medgadget.com)

But if a patient's liver is regenerated through the Peltz lab's technique, those side effects may be avoided. (stanforddaily.com)
If new hearts could be made using a patient's own stem cells, it is less likely they would be rejected. (dailymail.co.uk)

Two groups from University College London, led by Alison Lloyd and Martin Raff, report in ScienceExpress today that glial cells and oligodendrocyte precursor cells, both removed from the central nervous system of young rats, can divide indefinitely--in one case for more than 20 months--if the culture medium contains or lacks certain ingredients, such as hormones. (scientificamerican.com)
Astrocytes are specialized glial cells ubiquitously distributed throughout the spinal cord and brain. (news-medical.net)

Chylomicrons produced by the intestinal epithelial cells from dietary lipids have diameter up to 1000 nm which prevents them from passing through the LSEC fenestrae. (wikipedia.org)
8 Astrocytes interact with blood vessels, pericytes, and epithelial cells to organize CNS flow and modulate the blood-brain barrier (BBB). (news-medical.net)

To investigate liver cells more closely, a research team led by Dr. Hao Zhu from the Children's Medical Center Research Institute at UT Southwestern Medical Center used 14 different lines of mice, 11 of which they created for the new study. (nih.gov)
People who take an overdose of Tylenol basically destroy their liver and we hope to be able to replace it using this method-[using] the same exact procedures we use in the mice. (stanforddaily.com)

Cytopainter (ab187964) is designed to uniformly label live cells in green fluorescence. (abcam.com)
Image of CPA cells stained with CytoPainter Live Cell Labeling Kit - Green Fluorescence (ab187964) in a black wall/clear bottom 96-well plate. (abcam.com)

This advancement is set to drive the adoption of live cell imaging devices for the development of novel cancer treatments and contribute to overall market growth. (globenewswire.com)

Residential (n = 11), occupational (n = 10), and recipient (n = 1) cases of Q fever related to live cell therapy (LCT), by week of symptom onset compatible with Q fever, Rhineland-Palatinate, Germany, 2014. (cdc.gov)
The routine approach to liver therapy focuses on changes in lifestyle, including abstinence from alcohol, a reduction in non-prescription pain relievers and a low-sodium diet. (cryo-cell.com)
The meta-analysis showed that umbilical cord blood stem cell therapy 'greatly enhanced liver function' and 'improved quality of life. (cryo-cell.com)

Yet study after study, such as a massive investigation of nearly a half million cell phone users in Denmark, published last year, finds no brain cancer link. (livescience.com)
What's new about this approach for heart-cell generation is that we directly converted one cell type to another using RNA, without an intermediate step," said James Eberwine, a professor of pharmacology at the University of Pennsylvania and a study researcher. (livescience.com)
4 Research Unit for NK Cell Study, Chinese Academy of Medical Sciences, Beijing, China. (nih.gov)

Rat primary astrocytes were isolated from different brain regions (cortex, cerebellum, and hippocampus) and grown in vitro to demonstrate the utilization of live-cell analysis for monitoring and comparing the diversity of cultured astroglia phenotypes. (news-medical.net)
Stem cells grown from cells taken from a patient are then added to the ghost heart. (dailymail.co.uk)
Cells grown on black wall/clear bottom plates or slides can be stained and quantified in less than two hours at Ex/Em = 495/515 nm. (abcam.com)

Yoshikawa S, Zen Y, Fujii T, Sato Y, Ohta T, Aoyagi Y, Nakanuma Y. Characterization of CD133 + parenchymal cells in the liver: Histology and culture. (wjgnet.com)

Several factors are driving this expansion, including the impact of the COVID-19 pandemic, the rising demand for early COVID-19 diagnosis, the adoption of high-content screening in drug discovery, and technological advancements in live cell imaging. (globenewswire.com)
However, the urgent need for early COVID-19 diagnosis and effective vaccines led to a surge in demand for live cell imaging. (globenewswire.com)
Liver function tests may be useful in narrowing the differential diagnosis. (medscape.com)

Understanding how this regeneration works in more detail could lead to new treatment strategies to help repair a damaged liver. (nih.gov)
At Boston Children's Hospital, researcher Fernando Camargo, PhD , is investigating the different processes that promote liver regeneration and healing. (childrenshospital.org)

PBC results in inflammatory lesions within the portal fields and subsequent destruction of small bile ducts of the liver. (sciencedaily.com)

In the same issue of Science , a second research team from the Shanghai Institute of Biochemistry and Cell Biology reported similar results using a different method for tracking the origins of new liver cells. (nih.gov)
The increasing use of live cell imaging equipment for studying the molecular biology of the COVID-19 virus is expected to drive market growth in the coming years. (globenewswire.com)
The use of real-time, live-cell analysis provides new possibilities and cell biology workflows. (news-medical.net)
IGERT: Integrating Nanotechnology with Cell Biology and. (igert.org)
The results, appearing in the latest issue of the Journal of Cell Biology , promise to open the door to new possibilities for drug development. (scienceblog.com)
The article, "Full characterization of GPCR monomer - dimer dynamic equilibrium by single molecule imaging" by Rinshi S. Kasai, Kenichi G. N. Suzuki, Eric R. Prossnitz, Ikuko Koyama-Honda, Chieko Nakada, Takahiro K. Fujiwara, and Akihiro Kusumi, was published online in the February 7, 2011 issue of the Journal of Cell Biology . (scienceblog.com)

LSECs have been reported to play a role in the development of liver fibrosis. (wikipedia.org)
Liver fibrosis is associated with decreased LSEC fenestration, and appearance of an organized basal lamina in the space of Disse, a process called capillarization, which precedes the onset of liver fibrosis. (wikipedia.org)

These new therapies involve taking some of your blood stem cells and either adding new DNA to them or changing their existing DNA. (medlineplus.gov)

Unlike cancer cells, though, which also grow forever but are unstoppable, these cells still stop dividing if, for example, they get damaged by x-rays. (scientificamerican.com)
Do the telomeres in cancer cells get shorter each time the cell divides? (scientificamerican.com)
Here, we present a novel two-step acoustophoresis (A2) method for isolation of unfixed, viable cancer cells from red blood cell (RBC) lysed whole blood. (lu.se)
This acoustofluidic step enriches viable cancer cells in a central outlet, but a significant number of white blood cells (WBCs) remain in the central outlet fraction due to overlapping acoustophysical properties of these viable cells. (lu.se)
Using samples with 10 000 DU145 cells, we obtained 459 ± 188-fold depletion of WBC and 42% recovery of viable cancer cells. (lu.se)
He thinks Betzig's method could uncover the steps cancer cells need to assemble invadopodia. (cosmosmagazine.com)
The problem with cancer cells is they reproduce rapidly and their growth is unchecked. (howstuffworks.com)
Cells' inner structures, known as cytoskeletons, produce the forces that lead to cell migration in cancer cells. (imperial.ac.uk)

A microscopic, living robot that can heal and power itself has been created out of frog skin cells. (newscientist.com)

Figure 4: Spatially resolved HP1α mobility in 3T3 cells investigated by 2D-FCS imaging. (nature.com)

They have discovered novel genes that control blood forming stem cells and uncovered new cell populations that produce platelets. (childrenshospital.org)

The natural presence of NKT cells in the liver, combined with an accumulation of Novosphingobium aromaticivorans, likely explains why the liver is damaged during this autoimmune process, Dr. Mattner said. (sciencedaily.com)

Lack of p38γ or treatment with the p38γ inhibitor pirfenidone protects against the chemically induced formation of liver tumours. (nature.com)

In research published earlier last year in Oncogene , Jirtle'steam found that liver tumors from 64% of patients studied hadlost one copy of the gene. (cancernetwork.com)

Liver sinusoidal endothelial cells (LSECs) form the lining of the smallest blood vessels in the liver, also called the hepatic sinusoids. (wikipedia.org)
Normally differentiated LSECs prevent hepatic stellate cell activation and promote reversion to quiescence, whereas capillarized LSECs do not. (wikipedia.org)

Cord blood as a treatment option is thought to stimulate the growth of new liver cells and inhibit the death of current liver cells. (cryo-cell.com)

The liver is composed of repeating structures called lobules. (nih.gov)
Where the previous version relied on the contraction of heart muscle cells to move them forward by pushing off surfaces, these new xenobots swim around faster, being self-propelled by hair-like structures on their surface. (newscientist.com)
That's what we have now shown and it means that totally different DNA structures exist in our cells. (howstuffworks.com)
Perform scientific experimentation and observation to understand structures of cells and their relation to living things. (learner.org)
The cells then secrete and help build a supporting matrix that integrates with the body as the construct degrades, and at the end of the process the cells have sufficiently integrated into the body and no longer need the supporting structures. (medgadget.com)
Microarrays, lines, curves, and other structures can be printed in real time using the micropen, and could be used in biological or microelectronic labs, using biomaterial or conductive ink to pattern live cells or circuits. (eurasiareview.com)

Acute liver failure is a life-threatening clinical syndrome characterized by rapid development of hepatocellular necrosis leading to high mortality and resource costs. (springer.com)
In recent years, a growing number of studies have shown that stem cells can effectively treat acute liver failure. (springer.com)

The capacity of LSECs as scavengers of blood borne waste assigns an important role of these cells in innate immunity. (wikipedia.org)

Anatomy33

Organisms14

Diseases38

Chemicals and Drugs97

Analytical, Diagnostic and Therapeutic Techniques and Equipment28

Phenomena and Processes45

Disciplines and Occupations2

Information Science3

Named Groups2

Health Care2

Proteins31

Donor5

Researchers30

Hepatocytes13

Tumor8

Transplant6

Cirrhosis6

Transplantation5

Common complication of sickle cell di2

Diseases10

Functional5

20232

Spleen2

Membrane9

Scientists10

Genetic2

Microscopy3

Lymph node1

Hepatocellular carcinoma3

Transplants2

Diagnosed with sickle cell di2

Adult4

Disease31

Kidneys1

Organ3

Chronic1

Fluorescent5

Sickle13

Protein17

Reveals1

Hepatocyte1

Immune7

Proliferation3

Regenerate2

Molecules5

Human13

Cellular7

Tissue5

Organs1

Patient's2

Glial cells2

Epithelial cells2

Mice2

Fluorescence2

Treatments1

Therapy3

Study3

Grown3

Parenchymal1

Diagnosis3

Regeneration2

Bile1

Biology6

Fibrosis2

Therapies1

Cancer cells8

Microscopic1

Spatially-resolved1

Blood forming st1

Autoimmune1

Formation of liver1

Tumors1

Hepatic2

Inhibit1

Structures6

Acute2

Innate1