documented that Zika Virus may cause "other central nervous system abnormalities such as brain parenchymal atrophy with secondary ventriculomegaly, intracranial calcification, malformations of cortical development (such as polymicrogyria, and lissencephaly-pachygyria), agenesis/hypoplasia of the corpus callosum, cerebellar and brainstem hypoplasia, sensorineural hearing-loss , and ocular abnormalities as well as arthrogryposis in the infected fetuses. (malariamatters.org)
The cortical anomalies in the 19 fetuses were polymicrogyria (7), simplified gyral pattern (3), dysgyria (3), lissencephaly (2), cortical malformation related to tubulinopathy (1), brain atrophy (1), cortical dysplasia (1), and cobblestone malformation (1). (bvsalud.org)
Polymicrogyria is a congenital malformation of the cerebral cortex characterized by abnormal cortical layering (lamination) and an excessive number of small gyri (folds). (nih.gov)
Brain imaging findings may include reduction of the cerebral cortical volume with simplification of the gyral cortical pattern, pachygyria with cortical thickening, lissencephaly, and polymicrogyria (Jackson et al. (preventiongenetics.com)
Polymicrogyria (PMG) is a malformation of cortical development characterized by excessive small and prominent convolutions separated by shallow sulci, giving the cortical surface and cortical-white matter junction an irregular appearance ( 1 - 4 ). (ajnr.org)
Cerebellar1
This entity could be identical to "lissencephaly with cerebellar hypoplasia type B" (LCHb), and therefore linked to mutations in RELN gene. (wikipedia.org)
Syndrome5
A rare genetic syndrome with a central nervous system malformation as a major feature, characterized by cortical malformations including posterior predominant lissencephaly and diffuse pachygyria, as well as midline crossing defects, thin corpus callosum, dysplastic hippocampi, narrowing of the brainstem with small pons and midbrain, widening of the medulla, and small cerebellum. (orpha.net)
A typical combination of malformations affecting more than one body part is referred to as a malformation syndrome . (wikidoc.org)
Hennekam syndrome is an inherited disorder resulting from malformation of the lymphatic system, which is part of both the circulatory system and immune system. (beds.ac.uk)
The Currarino syndrome is an inherited congenital disorder where either the sacrum (the fused vertebrae forming the back of the pelvis ) is not formed properly, or there is a mass in the presacral space in front of the sacrum, and there are malformations of the anus or rectum . (mdwiki.org)
The management of Currarino syndrome is similar to the usual management of anorectal malformation (ARM) regarding the surgical approach and probably the prognosis that mainly depends on degree of associated sacral dysplasia. (mdwiki.org)
Corpus callosum3
Background: Brain malformations (BMs) are congenital abnormalities of the shape or structure of the brain, with corpus callosum agenesis known as the most frequent. (scirp.org)
The corpus callosum is the largest fiber tract in the central nervous system and the major interhemispheric fiber bundle in the brain. (nih.gov)
2008). Agenesis of the corpus callosum (ACC) is one of the most frequent malformations in brain with a reported incidence ranging between 0.5 and 70 in 10,000 births. (nih.gov)
Abnormal4
Their diagnoses were confirmed by autopsy, fetal or postnatal MRI, genetic findings related to cortical malformations, or an abnormal cortical imaging pattern with similar MRI findings in an affected sibling. (bvsalud.org)
A seizure is an intermittent abnormality of nervous system physiology characterised by a transient occurrence of signs and/or symptoms due to abnormal excessive or synchronous neuronal activity in the brain. (nih.gov)
Therefore, MR can be divided into nonsyndromal and syndromal forms, the latter classified with additional clinical signs such as organ malformations, abnormal body measurements, and different seizure patterns, etc. (amedes-genetics.de)
In about 50% of cases there is an association with any one of 200 genetic syndromes, defects in the central nervous system (mainly abnormal gyration, midline arachnoid cysts, Dandy-Walker complex and encephalocele) or defects in other systems (mainly cardiac, skeletal and genitourinary). (fetalmedicine.org)
Microlissencephaly (MLIS) is a rare congenital brain disorder that combines severe microcephaly (small head) with lissencephaly (smooth brain surface due to absent sulci and gyri). (wikipedia.org)
The combination of lissencephaly with severe congenital microcephaly is designated as microlissencephaly only when the cortex is abnormally thick. (wikipedia.org)
However, microcephaly peaked in October and demonstrated central nervous system abnormalities with brain dysgenesis and intracranial calcifications consistent with an intrauterine infection. (cdc.gov)
In comparison, an annual mean of 156 microcephaly cases were reported in Brazil (through the routine birth notification system) during 2010-2014, including 9 in Pernambuco ( 7 ). (cdc.gov)
Midline1
It is best thought of as being part of the holoprosencephaly spectrum (see classification system for midline malformations ). (radiopaedia.org)
A spectrum of malformations of cortical development caused by insufficient neuronal migration that subsumes the terms agyria, pachygyria and subcortical band heterotopia. (nih.gov)
Cobblestone4
Cobblestone Lissencephaly" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
This graph shows the total number of publications written about "Cobblestone Lissencephaly" by people in Harvard Catalyst Profiles by year, and whether "Cobblestone Lissencephaly" was a major or minor topic of these publication. (harvard.edu)
Below are the most recent publications written about "Cobblestone Lissencephaly" by people in Profiles. (harvard.edu)
The studied variables were clinical (age at diagnosis, sex, clinical manifestations) and CT findings (type of cerebral malformation). (scirp.org)
Neuronal migration3
Microlissencephaly is a malformation of cortical development (MCD) that occurs due to failure of neuronal migration between the third and fifth month of gestation as well as stem cell population abnormalities. (wikipedia.org)
Disorders comprising a spectrum of brain malformations representing the paradigm of a diffuse neuronal migration disorder. (bvsalud.org)
Genetic studies of human malformation and mutant mice with deficient neuronal migration have played an integral role in unveiling the existence of signalling pathways that regulate neuronal migration and neuronal detachment from the glial fibers [ 3 , 4 ]. (biomedcentral.com)
Anomalies4
Congenital disorders include minor physical anomalies (e.g., a birthmark ), severe malformations of single systems (e.g., congenital heart disease or dysmelia ), and combinations of abnormalities affecting several parts of the body. (wikidoc.org)
Patients with head circumference at least three standard deviations below the age and sex mean, with or without central nervous system anomalies, and with a family history consistent with autosomal recessive mode of inheritance (Bacino et al. (preventiongenetics.com)
Other malformations and/or chromosomal anomalies are noted in at least 60% of patients with encephalocele. (medscape.com)
Almost no publication has been made in sub-Saharan Africa on the clinical and CT scan characteristics of Brain malformations in children. (scirp.org)
Objective: The aim of this study was, in the absence of MRI, to describe the clinical and CT-scan presentations of brain malformations in children at the Yaounde Gynaeco-Obstetric and Pediatric Hospital (YGOPH). (scirp.org)
Expression of rmnd5 is strongest in neuronal ectoderm , prospective brain , eyes and ciliated cells of the skin and its suppression results in malformations of the fore- and midbrain . (xenbase.org)
Disorder1
A malformation is associated with a disorder of tissue development. (mdwiki.org)
Fetuses2
Population-based birth defects surveillance systems are critical to monitor all infants and fetuses with birth defects potentially related to Zika virus infection, regardless of known exposure or laboratory evidence of Zika virus infection during pregnancy. (cdc.gov)
In 2016, as part of the emergency response to the Zika virus outbreak in the World Health Organization’s Region of the Americas, population-based birth defects surveillance systems monitored fetuses and infants with birth defects potentially related to Zika virus infection using a standard case definition and multiple data sources. (cdc.gov)
Fetal1
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Autosomal1
An autosomal dominant sub-type of lissencephaly caused by mutation(s) in the TUBA1A gene, encoding adhesion tubulin alpha-1A chain. (nih.gov)
LYMPHATIC SYSTEM2
Peritoneal stomata constitute the principal pathways for the drainage of intraperitoneal contents from the PERITONEAL CAVITY to the LYMPHATIC SYSTEM. (bvsalud.org)
The lymphatic system consists of a network of vessels that transport lymph fluid and immune cells throughout the body. (beds.ac.uk)
Additional variants of classical (Type I) lissencephaly have been linked to RELN, the gene for reelin, and ARX, the gene for aristaless related homeobox protein. (bvsalud.org)
Noen utvikler en spesiell type anfall med plutselig tap av muskeltonus utløst av taktil- eller hørselsstimulus (Stimulus Induced Drop Attacs/SIDA). (sjelden.no)
Skeletal2
The diagnosis is possible as early as 12 weeks of gestation, due to the appearance of a thickened nuchal fold (nuchal swelling) and skeletal malformations. (radiologykey.com)
Radiographic examination of the skeletal system leads to further confirmation. (radiologykey.com)
Organ2
Large chromosomal abnormalities always produce effects on many different body parts and organ systems. (wikidoc.org)
Still, congenital conditions are often classified in a structural basis, organized when possible by primary organ system affected. (mdwiki.org)
Major1
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Structural1
A congenital malformation is a congenital physical anomaly that is deleterious, i.e. a structural defect perceived as a problem. (wikidoc.org)
Particle1
As a source, after that theology there will complete no inductive pump foundations, track magazines, final or halted outdated migration experts or Caged unique particle systems. (clearwateraudubonsociety.org)
Page1
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Term1
Birth defect is a widely-used term for a congenital malformation, i.e. a congenital, physical anomaly which is recognizable at birth, and which is significant enough to be considered a problem. (wikidoc.org)