• Our data suggest that miR-370 acting via miR-122 may have a causative role in the accumulation of hepatic triglycerides by modulating initially the expression of SREBP-1c, DGAT2, and Cpt1alpha and, subsequently, the expression of other genes that affect lipid metabolism. (nih.gov)
  • How does exercise affect lipid metabolism? (pfeiffertheface.com)
  • Conclusions: These results show how the uterine environment and genes both affect lipid metabolism in offspring, enhancing our understanding of the link between parental diet and metabolism in offspring. (worktribe.com)
  • Reduction of total cholesterols (TC) and LDL-C by dietary alterations and medications that affect lipid metabolism [ 14 ] is found to reduce the occurrence of atherosclerosis in animals and clinical cardiovascular events in human [ 15 ]. (hindawi.com)
  • Lipid metabolism often begins with hydrolysis, which occurs with the help of various enzymes in the digestive system. (wikipedia.org)
  • Digestion is the first step to lipid metabolism, and it is the process of breaking the triglycerides down into smaller monoglyceride units with the help of lipase enzymes. (wikipedia.org)
  • If you have one of these disorders, you may not have enough enzymes to break down lipids. (medlineplus.gov)
  • 1. Cholecystokinin: releases bile/pancreatic enzymes on gallbladder in presence of lipids. (flashcardmachine.com)
  • We found that Drosophila STING interacts with lipid synthesizing enzymes acetyl-CoA carboxylase (ACC) and fatty acid synthase (FASN). (elifesciences.org)
  • In TM6SF2 KO iPSCs, we further show a reduction in the activities of Acyl-Coenzyme A: Cholesterol Acyltransferase 1 (ACAT1) and Phosphatidylserine Synthase 1 (PSS1), two enzymes that display optimal function when specifically localized to cholesterol enriched ER lipid raft-like domains. (columbia.edu)
  • Our findings suggest that TM6SF2 may impact cholesterol localization within ER subdomains, which regulate expression levels of cholesterol synthesis genes and activities of ER lipid-raft associated enzymes. (columbia.edu)
  • nLD could be involved in nuclear-lipid homeostasis serving as an endonuclear buffering system that would provide or incorporate lipids and proteins involved in signalling pathways as transcription factors and as enzymes of lipid metabolism and nuclear processes. (unlp.edu.ar)
  • After ingested fats (lipids) are cleaved by enzymes, lipids are absorbed in the small intestine and transported via the lymphatic system into the bloodstream. (amboss.com)
  • Ingested fats (lipids) are cleaved by enzymes (e.g., pancreatic lipase ) and absorbed in the small intestine . (amboss.com)
  • We also demonstrate that HLCs express proteins essential for lipoprotein metabolism, secrete authentic VLDL particles, and respond to metabolic perturbations, supporting their value for modeling hepatosteatosis and VLDL metabolism in vitro. (columbia.edu)
  • Effect of dairy fat and milk product supplementation on plasma lipids and low-density lipoprotein metabolism in the guinea pig. (arizona.edu)
  • Pathway defects in lipoprotein synthesis, processing, and clearance can lead to accumulation of atherogenic lipids in plasma and endothelium. (msdmanuals.com)
  • One of the objectives of this thesis was to investigate the effect of various dietary n-6 to n-3 PUFA ratios on the regulation of lipid and lipoprotein metabolism using C57BL/6 mice as an animal model. (mun.ca)
  • Given the health benefits of maintaining a proper ratio of dietary n-6 to n-3 PUFA, it was of interest to understand the role of altered maternal dietary n-6 to n-3 PUFA ratio on the regulation of lipid and lipoprotein metabolism in the offspring of C57BL/6 mice at weaning. (mun.ca)
  • Offspring at weaning were selected to isolate the effects of pre-weaning diet, excluding the post weaning diet, on the offspring's lipid and lipoprotein metabolism. (mun.ca)
  • The C57BL/6 mice were selected for the current study as these have been already established as an animal model in our laboratory to study 'in utero' programming of lipid and lipoprotein metabolism in the offspring. (mun.ca)
  • In the one month feeding study, female C57BL/6 mice were fed a diet containing 20% w/w fat with n-6 to n-3 PUFA ratio of either 5:1, 15:1 or 30:1 to establish the effect on the regulation of lipid and lipoprotein metabolism. (mun.ca)
  • Feeding diets with varying n-6 to n-3 PUFA ratios to C57BL/6 mice led to the incorporation of dietary fatty acids in red blood cell (RBC) phospholipids (PL), and also altered the regulation of lipid and lipoprotein metabolism. (mun.ca)
  • A higher n-6 to n-3 PUFA ratio in the maternal diet of C57BL/6 mice led to higher plasma lipid and lipoprotein concentrations compared to a lower ratio in the offspring at weaning. (mun.ca)
  • We previously observed that treatment of mice with a dominant negative form of cJun (dn-cJun) increased the expression of genes involved in lipid metabolism and modulated the expression of nine microRNAs (miR). (nih.gov)
  • To investigate the potential effect of these miRs on the expression of the genes of lipid metabolism, we performed studies in cultured HepG2 cells. (nih.gov)
  • Flies with STING deletion are sensitive to starvation and oxidative stress, have reduced lipid storage and downregulated expression of lipid metabolism genes. (elifesciences.org)
  • Results: The analysis showed that the two possible routes for programming effects, the sperm (genes) and seminal plasma (influence on the uterine environment), both have a distinct effect on the offspring's lipid metabolism. (worktribe.com)
  • Interestingly, most mRNAs involved in lipid metabolism are overexpressed after hatching (FASN, SCD1, ACOX1), whereas genes implicated in carbohydrate metabolism (HK1, GAPDH, GLUT1) and development (HGF, IGF, FGFR2) are predominantly overexpressed from E12 to E20. (biomedcentral.com)
  • Therefore, the aim of the present study was to analyze a wide range of genes involved in liver development, cell stress, lipid and carbohydrate metabolisms throughout embryogenesis in mule ducks to better understand the ontogeny of pathways related to liver fattening. (biomedcentral.com)
  • Interestingly, carbohydrate-related genes appear to be highly expressed at the start of kinetics, while most lipid-related genes are overexpress after hatching, revealing greater sensitivity to the food transition that occurs at this stage. (biomedcentral.com)
  • Hence, the current review aimed to summarize the prominent role of lipid metabolism genes such as PCSK9, ApoB, ApoA5, ApoC3, ApoE, and ABCA1 in mediating ischemic stroke occurrence. (current-pharmaceutical-design.com)
  • Lipid catabolism is accomplished by a process known as beta oxidation which takes place in the mitochondria and peroxisome cell organelles. (wikipedia.org)
  • Noni leaf extract significantly increased physical endurance (swim time) of mice via improving lipid catabolism, carbohydrate metabolism, electron transport, antioxidant responses, energy production, and tissue glycogen stores. (noniresearch.org)
  • The production of foie gras involves different metabolic pathways in the liver of overfed ducks such as lipid synthesis and carbohydrates catabolism, but the establishment of these pathways has not yet been described with precision during embryogenesis. (biomedcentral.com)
  • Biochemistry of lipids, membrane structure, anabolism and catabolism of lipids. (up.ac.za)
  • Total ATP yield from the complete catabolism of lipids. (up.ac.za)
  • Nitrogen metabolism, amino acid biosynthesis and catabolism. (up.ac.za)
  • Physiological processes in biosynthesis (anabolism) and degradation (catabolism) of LIPIDS. (bvsalud.org)
  • LD increments were reversed on exclusion of OA and were prevented by inhibition of acyl-CoA synthetase (with Triacsin C) and thus lipid biosynthesis. (unlp.edu.ar)
  • Further, the programming effects in offspring suggest that changes in lipid distribution are more important than alterations in lipid biosynthesis. (worktribe.com)
  • Early studies that compared germ-free mice and conventionally raised mice suggested that the gut microbiota may play a role in host lipid metabolism. (news-medical.net)
  • We tested this hypothesis using an established mouse model of diet-induced obesity with pregnancy-associated loss of glucose tolerance and a novel lipid analysis tool, Lipid Traffic Analysis, that uses the temporal distribution of lipids to identify differences in the control of lipid metabolism through a time course. (cam.ac.uk)
  • Methods: We applied an updated, purpose-built computational network analysis tool to characterise control of lipid metabolism systemically (Lipid Traffic Analysis v2.3) on a known mouse model of paternal nutritional programming. (worktribe.com)
  • Our results suggest that the start of pregnancy is associated with several changes in lipid metabolism, including fewer variables associated with de novo lipogenesis and fewer PUFA-containing lipids in the circulation. (cam.ac.uk)
  • Several of the changes in lipid metabolism in healthy pregnancies were less apparent or occurred later in dams who developed GDM. (cam.ac.uk)
  • Objectives: We tested the hypothesis that the changes in lipid metabolism that are driven by paternal diet are propagated through spermatozoa and not seminal plasma. (worktribe.com)
  • In vivo and in vitro studies have shown that extracts of different pomegranate fractions (peels, flowers, juice, and seeds) regulate lipid metabolism in metabolic-disorder-associated diseases such as atherosclerosis, nonalcoholic fatty liver disease, and type 2 diabetes, helping to alleviate the development of diseases. (nih.gov)
  • We found that YNCRG can reduce the accumulation of lipids in the liver of rats with metabolic syndrome, probably by affecting lipid metabolism and the signaling pathway associated with inflammatory reactions. (lidsen.com)
  • Lipids are fats that are either absorbed from food or synthesized by the liver. (msdmanuals.com)
  • Absorbed lipids are transported in chylomicrons via the lymphatic system into the bloodstream, where they reach the liver , peripheral tissues (which have LDL receptors ) and adipose tissue (storage). (amboss.com)
  • Standardized Morinda citrifolia L. and Morinda elliptica L. leaf extracts alleviated fatigue by improving glycogen storage and lipid/carbohydrate metabolism. (noniresearch.org)
  • Glucose measurements are used in the diagnosis and treatment of pancreatic islet cell carcinoma and of carbohydrate metabolism disorders, including diabetes mellitus, neonatal hypoglycemia, and idiopathic hypoglycemia. (cdc.gov)
  • Dietary methionine influences therapy in mouse cancer models and alters human metabolism. (nature.com)
  • Sixty Angus steers (391.1+/-6.1 kg) were used to determine the effects of dietary Cu concentration on lipid metabolism and ruminal fermentation. (eurekamag.com)
  • These data indicate that replacement of 5.4% of total dietary carbohydrate with RS significantly increased post-prandial lipid oxidation and therefore could decrease fat accumulation in the long-term. (biomedcentral.com)
  • It is possible that strong physical association between RS and dietary lipid may slow the absorption, and thereby increase the oxidation, of dietary lipid. (biomedcentral.com)
  • Dietary TG metabolism begins in the stomach and duodenum, where TGs are broken into monoglycerides (MGs) and FFAs by gastric lipase, emulsification due to vigorous stomach peristalsis, and pancreatic lipase. (msdmanuals.com)
  • Background: The paternal diet affects lipid metabolism in offspring for at least two generations through nutritional programming. (worktribe.com)
  • What helps regulate lipid metabolism: LDL or HDL? (healthtap.com)
  • 2007). Emerging evidence from both epidemiological and experimental studies indicates the adverse consequences of PM2.5 exposure on diabetes, including worsening of whole-body insulin sensitivity, glucose tolerance impairment, lipid accumulation, and glucose metabolism dysfunction (Hwang et al. (deepdyve.com)
  • Lipid accumulation generally occurs in most poikilotherms during periods of feeding when plasma insulin levels are elevated. (ttu.edu)
  • Consequently, loss of autophagy causes accumulation of NCoR1, suppressing PPARα activity and resulting in impaired lipid oxidation. (elsevierpure.com)
  • The products of lipid digestion are mixed with bile salt and vitamins to form what? (flashcardmachine.com)
  • The decomposition products of lipid digestion form mixed micelles with bile acids . (amboss.com)
  • Other types of lipids found in the body are fatty acids and membrane lipids. (wikipedia.org)
  • Upregulation of stearoyl-CoA desaturase (SCD), which synthesises monounsaturated fatty acids, is required for cancer cells to proliferate in a lipid-depleted environment, and CR also impairs tumour SCD activity to cause an imbalance between unsaturated and saturated fatty acids to slow tumour growth. (nature.com)
  • By contrast, although KD also impairs tumour SCD activity, KD-driven increases in lipid availability maintain the unsaturated to saturated fatty acid ratios in tumours, and changing the KD fat composition to increase tumour saturated fatty acid levels cooperates with decreased tumour SCD activity to slow tumour growth. (nature.com)
  • Furthermore, our results are consistent with the fact that endurant individuals rely preferentially on lipid metabolism, because oxidative phosphorylation of fatty acids in muscle mitochondria produces a high yield of ATP, necessary for prolonged contraction of muscle fibers. (pfeiffertheface.com)
  • These functional deficits occurred concomitantly with the following observations in adult E- brains: decreased concentrations of and increased peroxidation of polyunsaturated fatty acids (especially docosahexaenoic acid , DHA), altered brain phospholipid and lysophospholipid composition, as well as perturbed energy (glucose/ketone), phosphatidylcholine and choline/methyl-donor metabolism. (oregonstate.edu)
  • Lipids as an energy source - TAG degradation in cells, β-oxidation of fatty acids. (wikilectures.eu)
  • Triglycerides are lipid compounds composed of a glycerol esterified to 3 fatty acid chains of varying length and composition. (medscape.com)
  • lipids are stored primarily as triacylglycerols, but various other lipid classes also are stored and constituent fatty acids tend to be more complex (longer chain, polyunsaturated). (ttu.edu)
  • Through integrated analysis of the GBM lipidome with molecular datasets, we identify CDKN2A deletion remodels the GBM lipidome , notably redistributing oxidizable polyunsaturated fatty acids into distinct lipid compartments. (bvsalud.org)
  • Lipid metabolism is the synthesis and degradation of lipids in cells, involving the breakdown and storage of fats for energy and the synthesis of structural and functional lipids, such as those involved in the construction of cell membranes. (wikipedia.org)
  • The majority of lipid digestion and absorption, however, occurs once the fats reach the small intestines. (wikipedia.org)
  • The second step in lipid metabolism is absorption of fats. (wikipedia.org)
  • Lipids are fats or fat-like substances. (medlineplus.gov)
  • Lipids are different kinds of fats circulating in the body.Metabolism is a description of how it is made,utilized and dispensed by the body. (healthtap.com)
  • Amelioration of oxidative stress and the inflammatory response is considered an important reason underlying the regulation of lipid metabolism by pomegranate extracts. (nih.gov)
  • We also observed that the earlier peak time of lipids compared to BCAAs is dependent on insulin's negative regulation of their influx. (biorxiv.org)
  • While there has been extensive research on the mathematical modeling of insulin's regulation of blood glucose 8 - 13 , there has been limited investigation of its selective regulation of blood amino acids and lipids 14 - 17 . (biorxiv.org)
  • Berberine supplementation activates the enzyme AMPK, which contributes to metabolism regulation. (dallasnews.com)
  • Poikilothermic vertebrates (fish, amphibians, reptiles) have evolved a number of life history patterns (smoltification, metamorphosis, hibernation) which present problems for lipid storage regulation. (ttu.edu)
  • Sheridan, MA 1994, ' Regulation of lipid metabolism in poikilothermic vertebrates ', Comparative Biochemistry and Physiology -- Part B: Biochemistry and , vol. 107, no. 4, pp. 495-508. (ttu.edu)
  • Lipid metabolism disorders, such as Gaucher disease and Tay-Sachs disease , involve lipids. (medlineplus.gov)
  • Imbalances in lipid metabolism are profound features of metabolic disorders. (nih.gov)
  • We therefore investigated the effects of PM2.5 exposure on insulin resistance and the disorders of hepatic glucose and lipid metabolism via hypothalamic inflammation. (deepdyve.com)
  • These lipid disorders may occur in primary (inherited) [ 5 - 7 ] or secondary form [ 8 ]. (hindawi.com)
  • Hypertension and disorders of lipid metabolism were the most frequent, whereas obesity, diabetes with complication, anxiety disorders, and the total number of conditions were the strongest risk factors for severe COVID-19 illness. (cdc.gov)
  • Essential hypertension (50.4%), disorders of lipid metabolism (49.4%), and obesity (33.0%) were the most common. (cdc.gov)
  • For example, heart disease may be due to a combination of processes such as glucose metabolism, lipid disorders, high blood pressure and inflammation. (cdc.gov)
  • 2017). The inhibition of hypothalamic inflammation by intracerebroventricular (ICV) administration of IKK2 inhibitor (IMD-0354) rectified PM2.5-induced glucose intolerance, IR, energy metabolism dysfunction, and attenuated peripheral inflammation in response to PM2.5 exposure (Song et al. (deepdyve.com)
  • In 2013, the American Heart Association reported that proportions of American adults aged 20 or above had abnormal blood lipid serum profile (details are shown in Table 1 ) [ 4 ]. (hindawi.com)
  • However, a substantial increase in serum triglyceride levels should raise the possibility of another lipid disorder. (medscape.com)
  • A study looked at the association of blood lipid levels and the microbiota of 145 European women. (news-medical.net)
  • Average percentage of abnormal blood lipid levels among Americans at age 20 or above [ 4 ]. (hindawi.com)
  • Enforcing cancer cell SCD expression or raising circulating lipid levels through a higher-fat CR diet confers resistance to the effects of CR. (nature.com)
  • This unexpected dual role of FoxO1 in promoting insulin sensitivity and lipid synthesis in addition to glucose production has the potential to explain the peculiar admixture of insulin resistance and sensitivity that is commonly observed in the metabolic syndrome. (jci.org)
  • Sun B, Kudo M, Hayashi M, Qin LL, Wu LL, Liu TH, Gao M. YNCRG Alleviated Hepatic Steatosis in Metabolic Syndrome Model Rats by Improving Lipid Metabolism and Chronic Inflammatory Reaction. (lidsen.com)
  • To evaluate the change in lipids and insulin sensitivity in 10 obese type II diabetic patients after treatment with benfluorex or placebo for 2 wk. (diabetesjournals.org)
  • Mitochondria, the major cellular site for lipid oxidation, are strongly associated with cellular oxidative and inflammatory status and are likely to be a target for pomegranate extract action. (nih.gov)
  • In the basal state, the effects of GH on protein metabolism are modest and include increased protein synthesis and decreased breakdown at the whole body level and in muscle together with decreased amino acid degradation/oxidation and decreased hepatic urea formation. (scienceopen.com)
  • Here we show that a deficiency in selective autophagy is associated with suppression of lipid oxidation. (elsevierpure.com)
  • Fig. 3: Increased SCD activity is required for cancer cells to adapt to exogenous lipid limitation. (nature.com)
  • My son had a blood test that came back with an abnormal lipid count what does that mean? (healthtap.com)
  • What is abnormal lipid metabolism? (healthtap.com)
  • Scope: To investigate the effect of sulforaphane (SFN) on the abnormal lipid metabolism and underlying mechanisms. (uea.ac.uk)
  • Methods and results: Models with abnormal lipid metabolism were established both in rats and human hepatocytes. (uea.ac.uk)
  • Conclusion: SFN improved abnormal lipid metabolism via both ER stress -dependent and -independent pathways. (uea.ac.uk)
  • Hyperlipidemia, characterized by the abnormal blood lipid profiles, is one of the dominant factors of many chronic diseases such as diabetes, obesity, and cardiovascular diseases (CVD). (hindawi.com)
  • Given that there is a link between lipid levels and obesity, it is possible that the effect of certain bacterial taxa on host lipid metabolism is the same species that affect the host's weight. (news-medical.net)
  • This study proposes to describe the basal hepatic metabolism at the level of mRNA in mule duck embryos in order to reveal potential interesting programming windows in the context of foie gras production. (biomedcentral.com)
  • Patterns of lipid storage and utilization reflect the special life histories of the animal group. (ttu.edu)
  • After extensive confirmation of successful gene editing, we explore the effect of TM6SF2 on lipid metabolism in the edited iPSCs. (columbia.edu)
  • The aim of the current study was to test the hypothesis that maternal lipid metabolism was modulated during normal pregnancy and that these modulations are altered in gestational diabetes mellitus (GDM). (cam.ac.uk)
  • To test this hypothesis, we applied high-resolution mass spectrometry analysis to lipid samples obtained from the WT and evol40 strains grown in 1 g/L glucose (glucose), 0.75 g/L phenol (low phenol), or 1.5 g/L phenol (high phenol, evol40 only) as a sole carbon source. (biomedcentral.com)
  • Lipids then continue to the stomach where chemical digestion continues by gastric lipase and mechanical digestion begins (peristalsis). (wikipedia.org)
  • Numerous studies have investigated how insulin regulates amino acids and lipids in the bloodstream 4 , 18 , 19 . (biorxiv.org)
  • Neutral lipids - involved in many cellular processes - are stored as lipid droplets (LD), those mainly cytosolic (cLD) along with a small nuclear population (nLD). (unlp.edu.ar)
  • The key roles of XBP1 and SREBP1c in SFN-reduced lipid droplets were confirmed by a timed sequence of measurement according to time points. (uea.ac.uk)
  • This review summarizes the main findings about the effects of different pomegranate fraction extracts on lipid metabolism in metabolic-disorder-associated diseases and analyses how pomegranate extracts achieve their effects. (nih.gov)
  • Lipid metabolism also occurs in plants, though the processes differ in some ways when compared to animals. (wikipedia.org)
  • These results would imply that nLD are actively involved in nuclear processes that include lipids. (unlp.edu.ar)