Lipid metabolism liver high hyperlipidemias. Medical search. Frequent questions

We show here that the AAA +ATPase Reptin is a regulator of mTOR signalling in the liver and global glucido-lipidic homeostasis. (nih.gov)
Liver X receptors (LXRs) are important regulators of cholesterol, fatty acid, and glucose homeostasis. (wikipedia.org)
LXR-RXR nuclear receptor heterodimers function as transcriptional regulators for genes involved in lipid metabolism, lipid homeostasis, and inflammation. (wikipedia.org)
Adipose tissue plays a crucial role in the regulation of energy homeostasis, insulin sensitivity, and lipid/carbohydrate metabolism. (diabetesjournals.org)
It has been suggested that continuous separation of psoriatic scales caused the permanent loss of lipids which adversely affects lipid homeostasis. (hindawi.com)
Betatrophin is a newly identified liver-derived hormone that is associated with glucose homeostasis and lipid metabolism. (biomedcentral.com)
These results demonstrate that Lkb1 plays an important role in maintaining body weight, liver and adipose tissue function, blood glucose homeostasis and survival in adult mice. (omicsdi.org)
To directly assess the role of beta cell lipolysis in insulin secretion and whole-body energy homeostasis, inducible beta cell-specific adipose triglyceride lipase (ATGL)-deficient (B-Atgl-KO) mice were studied under normal diet (ND) and high-fat diet (HFD) conditions. (omicsdi.org)
BAs are critical molecules for life, and disruption of BA homeostasis has been closely linked to hepatic, intestinal, and systemic diseases, including cholestasis, fatty liver diseases, and hepatic and colon tumors. (aspetjournals.org)
Citrus and bergamot polyphenols, in particular, may exert numerous effects on cellular and organism homeostasis, including the regulation of fat, cholesterol and carbohydrate metabolism. (bergamotaustralia.com.au)
which, when activated, stimulate expression of genes involved in energy homeostasis, specifically the metabolism of glucose and fatty acids (Blaschke et al. (bodybuilding.com)
However, larger, adequately powered, randomized, placebo-controlled, double-blind trials examining multiple measures of carbohydrate and lipid metabolism and insulin homeostasis are needed. (lww.com)

Alterations in plasma lipid and lipoprotein composition including a tendency toward an increase in total cholesterol (TC) and triglyceride (TG) and decrease in high-density lipoprotein cholesterol (HDL-C) levels suggest that psoriasis may associate with the disorders of lipid metabolism [ 25 , 26 ]. (hindawi.com)
Hypertension and disorders of lipid metabolism were the most frequent, whereas obesity, diabetes with complication, anxiety disorders, and the total number of conditions were the strongest risk factors for severe COVID-19 illness. (cdc.gov)
Essential hypertension (50.4%), disorders of lipid metabolism (49.4%), and obesity (33.0%) were the most common. (cdc.gov)
She has published over 150 peer-reviewed articles in the area of lipids-modifying drugs, cardiovascular risk stratification, and cardiovascular prevention and has lectured widely on preventive cardiology and the diagnosis and treatment of disorders of lipid metabolism. (cdc.gov)

These hormones, the pathways controlling their production, and their receptors are promising targets for managing obesity, hyperlipidemia, and insulin resistance. (diabetesjournals.org)
A recent example of the importance of adipocyte function to have profound systemic effects is provided by the report that mice specifically lacking insulin signaling in adipocytes (FIRKO mouse) are not only lean, leptin sensitive, and obesity resistant ( 1 ), but live almost 20% longer than wild-type control animals ( 2 ). (diabetesjournals.org)
Present study reports the biochemical mechanism of lipid-lowering effects of Jing-wei fu tea (JWFT), a variety of post-fermented tea on high-fat diet-induced hyperglycemia and obesity in rats. (biomedcentral.com)
While the deficiency of SCD1 increased the oxidation of fatty acid, insulin sensitivity and resistance to diet-induced obesity and liver steatosis [ 6 ]. (biomedcentral.com)
Decreased insulinaemia due to lowered GSIS protects B-Atgl-KO mice from diet-induced obesity, improves insulin sensitivity, increases lipid mobilisation from WAT and causes BAT activation. (omicsdi.org)
Hyperlipidemia, characterized by the abnormal blood lipid profiles, is one of the dominant factors of many chronic diseases such as diabetes, obesity, and cardiovascular diseases (CVD). (hindawi.com)
Apart from CVD, hyperlipidemia is also closely associated with diabetes, insulin resistance, and obesity [ 10 ]. (hindawi.com)
Other types of familial combined or dyslipidemia states may trigger increased liver very-low-density lipoprotein production in insulin-resistant states of abdominal obesity or type 2 diabetes. (contemporaryclinic.com)
Notoginsenosides can treat obesity by reducing lipid synthesis, inhibiting adipogenesis, promoting white adipose tissue browning, increasing energy consumption, and improving insulin sensitivity. (frontiersin.org)
One potential benefit of fenugreek is improving elevated blood glucose and lipid levels associated with chronic conditions such as diabetes and obesity. (lww.com)
Metabolic Syndrome (MS) is the denomination proposed by the World Health Organization (WHO) 42 , which designates a set of risk factors for cardiovascular diseases (CVDs), such as visceral obesity, dyslipidemia, high hypertension, glucose intolerance and insulin resistance 32 , which frequently are presented together. (bvsalud.org)
The relatively high prevalence of the metabolic syndrome is a worldwide phenomenon that seems to be increasing in parallel with the obesity prevalence 16 . (bvsalud.org)
The sum of inflammatory signals and deranged substrate handling induce most of the metabolic syndrome traits: insulin resistance, obesity, diabetes, liver steatosis, hyperlipidemia and their compounded combined effects. (medscape.com)

Une recherche documentaire a été effectuée dans PubMed de 1980 à 2021 en utilisant diverses combinaisons de termes MeSH comme tabac, diabète, hypertension, dyslipidémie, trouble dépressif majeur, trouble bipolaire, schizophrénie. (bvsalud.org)
Along with hypertension, diabetes, and smoking, hyperlipidemia has consistently been shown to be one of the most significant and modifiable risk factors for coronary artery disease development and progression. (medscape.com)

Sun B, Kudo M, Hayashi M, Qin LL, Wu LL, Liu TH, Gao M. YNCRG Alleviated Hepatic Steatosis in Metabolic Syndrome Model Rats by Improving Lipid Metabolism and Chronic Inflammatory Reaction. (lidsen.com)
We studied its effects and mechanism of action on a rat model of non-alcoholic fatty liver with metabolic syndrome. (lidsen.com)
We found that YNCRG can reduce the accumulation of lipids in the liver of rats with metabolic syndrome, probably by affecting lipid metabolism and the signaling pathway associated with inflammatory reactions. (lidsen.com)
The brilliant performance of BPF in clinical practice against as a treatment for hyperlipidemia and moderate hyperglycemia in metabolic syndrome, awaits a plausible mechanistic explanation. (bergamotaustralia.com.au)
Our work involves population and family-based genetic studies, high throughput sequencing to identify disease genes, with a focus on coronary artery disease (CAD) and metabolic syndrome (MetS). (yale.edu)
One of our groundbreaking discoveries was the identification of founder mutations in the DYRK1B gene, underlying atherosclerosis, metabolic syndrome, and fatty liver disease. (yale.edu)
2019. The relationship between vitamin C status, the gut-liver axis, and metabolic syndrome. . (oregonstate.edu)
This review is focused on the fate of dietary glucose under conditions of chronically high energy (largely fat) intake, evolving into the metabolic syndrome. (medscape.com)

The serum cholesterol, triglycerides, and LDL levels were significantly higher in psoriasis patients contrary to HDL level. (hindawi.com)
Patients with APOE ε 4 had significantly higher levels of total cholesterol and LDL cholesterol, whereas those with the ε 2 had higher HDL cholesterol, and triglycerides. (hindawi.com)
Secondary prevention: Prevents composite endpoint of MI and sudden death in a subgroup with triglycerides of 200 mg/dL or higher. (medscape.com)
Adding wheat germ to the high fat-cholesterol diet significantly increased high density lipoprotein (HDL) cholesterol and the HDL-serum cholesterol ratio and lowered the very low density lipoprotein (VLDL) triglycerides. (cryonet.org)
Hyperlipidemia comprises a heterogeneous group of disorders, characterized by high levels in one or more lipids and/or lipoproteins [atherogenic free fatty acids (FA), triglycerides (TG) (hypertriglyceridemia), small dense low-density lipoprotein cholesterol (LDL-C) (hypercholesterolemia), and apolipoprotein (apo) B], and/or low level in antiatherogenic high density lipoprotein cholesterol (HDL-C), in the circulation [ 1 - 3 ]. (hindawi.com)
The Lipid Panel Test Strips are intended to measure cholesterol (TC), HDL cholesterol (HDL-c) and triglycerides (TG) in whole blood. (lumigenex.com)
After the influence of hyperlipidemia, the levels of cholesterol and triglycerides in the blood exceed the standard. (growmorehealth.com)
Identification of the lipoprotein associated with lipid elevation is achieved using the gold-standard methods, which include ultracentrifugation, selective precipitation, electrophoresis, and direct measurement of cholesterol and triglycerides in isolated lipoprotein fractions. (testcatalog.org)
PPAR-alpha activation increases the expression of lipoprotein lipase and apolipoprotein A-V (apoA-V) while simultaneously decreasing expression of apoC-III in the liver, which decreases VLDL particles and lowering plasma triglycerides in chylomicrons (Staels and Fruchart 2005). (bodybuilding.com)
Triglycerides play an important role in metabolism as energy sources. (bodybuilding.com)
Levels of cholesterol and triglycerides vary considerably from day to day, due to many factors like stress, dietary habits, exercise, lifestyle, changes in metabolism. (msdmanuals.com)
Dyslipidemia Dyslipidemia is a high level of cholesterol and/or triglycerides or a low level of high-density lipoprotein (HDL) cholesterol. (msdmanuals.com)
There are 2 major types of lipids in the study comprising 1155 diabetic type 2 pa- blood: cholesterol and triglycerides. (who.int)
In the peripheral tissues, particularly adipose and muscle tissue, VLDL is cleaved by lipoprotein lipase (LPL), extracting most of the triglycerides and forming an IDL that contains apoproteins B-100 and E. IDL can be taken up by the liver through the LDL receptor, or it can be converted to the cholesterol-rich LDL that contains apoprotein B-100. (medscape.com)
elevated triglycerides - low high density lipoprotein (HDL) cholesterol - shift in low-density lipoprotein (LDL) particle density towards small, dense LDL (type B) - tendency towards postprandial lipaemia. (who.int)
A lipid profile should include measurement of total cholesterol, HDL cholesterol and triglycerides. (who.int)
hypothyroidism (symptoms, check thyroid-stimulating hormone) - obstructive liver disease (liver function tests) - chronic renal disease (renal function tests, creatinine clearance, urinalysis) - drugs (estrogen, progestins, corticosteroids, thiazides) - alcohol (raises triglycerides). (who.int)
The primary target of therapy is LDL cholesterol, unless serum triglycerides are 500 mg/dL in which case triglyceride-lowering therapy should be started immediately because of the high risk of pancreatitis. (who.int)
Using data from the second phase (1991-1994) of the Third National Health and Nutrition Examination Survey (NHANES III), we examined associations between 22 polymorphisms in 13 candidate genes and four serum lipids: high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglycerides (TG). (cdc.gov)

At the end of this experiment, hepatic lipids, serum leptin and lipids levels were determined using enzyme-linked immunosorbent assay (ELISA). (biomedcentral.com)
The results showed that JWFT inhibited the increase in the body weight, abdominal adipose weight, serum lipids and hepatic lipids, and decreased serum leptin levels of high-fat diet fed rats. (biomedcentral.com)
Serum elevations of ALT activity are rarely observed, except in parenchymal liver disease, since ALT is a more liver-specific enzyme than aspartate aminotransferase (AST). (cdc.gov)
In 2013, the American Heart Association reported that proportions of American adults aged 20 or above had abnormal blood lipid serum profile (details are shown in Table 1 ) [ 4 ]. (hindawi.com)
In some patients, increased serum lipids reflect elevated levels of intermediate-density lipoprotein, very-low-density lipoprotein, lipoprotein a (Lp[a]), or even the abnormal lipoprotein complex, LpX. (testcatalog.org)
The identification of genetic variants related to blood lipid levels within a large, population-based and nationally representative study might lead to a better understanding of the genetic contribution to serum lipid levels in the major race/ethnic groups in the U.S. population. (cdc.gov)
Results from our study contribute to a growing body of literature identifying key determinants of plasma lipoprotein concentrations and could provide insight into the biological mechanisms underlying serum lipid and cholesterol concentrations. (cdc.gov)
Decades of research have demonstrated that serum concentrations of blood lipids are associated with increased risk for cardiovascular disease and mortality [ 1 - 4 ]. (cdc.gov)

Authors Lairon D. Lacombe C. Borel P. Corraze G. Nibbelink M. Chautan M. Chanussot F. Lafont H. Title Beneficial effect of wheat germ on circulating lipoproteins and tissue lipids in rats fed a high fat, cholesterol-containing diet. (cryonet.org)
The body can regulate lipoprotein levels (and therefore lipid levels) by increasing or decreasing the production rate of lipoproteins. (msdmanuals.com)
Al lomicrons, low-density lipoproteins (LDL), Muhtaseb's study of Arab women indi- very-low-density lipoproteins (VLDL) and cated an incidence of 50% of lipid disorders high-density lipoproteins (HDL). (who.int)
Lipoproteins may be classified according to their density, as follows: chylomicrons, very-low-density lipoproteins (VLDL), intermediate-density lipoproteins (IDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL). (medscape.com)
The exogenous lipoprotein pathway refers to the metabolism of intestinal lipoproteins, the triglyceride-rich chylomicrons, primarily formed in response to dietary fat. (medscape.com)
The endogenous lipoprotein pathway refers to lipoproteins and apoproteins that are synthesized in tissues other than the intestines, predominantly in the liver. (medscape.com)

Thus the lipoprotein pattern was comparable to that obtained with the low fat diet, but the VLDL lipid composition remained altered. (cryonet.org)
The liver secretes the triglyceride-rich VLDL that contains apoproteins B-100, C-II, and E into the circulation. (medscape.com)

Angiopoietin-like 4 (ANGPTL4) is an endogenous inhibitor of lipoprotein lipase that modulates lipid levels, coronary atherosclerosis risk, and nutrient partitioning. (nature.com)
Reduction of total cholesterols (TC) and LDL-C by dietary alterations and medications that affect lipid metabolism [ 14 ] is found to reduce the occurrence of atherosclerosis in animals and clinical cardiovascular events in human [ 15 ]. (hindawi.com)
The main harm of hyperlipidemia is atherosclerosis, which leads to many related diseases, among which the most common fatal disease is coronary heart disease. (lumigenex.com)
The combined detection of three blood lipids (total cholesterol, high-density lipoprotein cholesterol and triglyceride) can help to provide clinical reference for the diagnosis and treatment of lipoprotein metabolism disorders such as diabetes, atherosclerosis, nephropathy, liver disease and coronary heart disease. (lumigenex.com)
Abnormal lipid metabolism, primar- ily of LDL cholesterol, contributes to the development of hypercholesterolemia because it's the major risk factor for the development of atherosclerosis. (contemporaryclinic.com)
Coronary atherosclerosis is usually considered to be the initial step of CAD [ 6 ], which is due to the dysregulation of lipid metabolism and abnormal accumulation of cholesterol in the subintima layer of the coronary arteries [ 7 , 8 ]. (biomedcentral.com)

Classifying the hyperlipoproteinemias into phenotypes places disorders that affect plasma lipid and lipoprotein concentrations into convenient groups for evaluation and treatment. (testcatalog.org)

High-fat diet fed rats were orally administered different doses of JWFT aqueous extract (0.5, 1.0 and 2.0 g/kg) for four weeks. (biomedcentral.com)
JWFT normalized hepatic fatty acid composition of hyperlipidemia rats by up-regulating hepatic acetyl-CoA carboxylase ( ACC ), stearoyl-CoA desaturase 1 ( SCD1 ) and fatty acid synthase ( FAS ) gene expression, and down-regulating carnitine palmitoyl transferase-1 ( CPT1 ). (biomedcentral.com)
Methods: Female Wistar rats were divided into six groups: the sham, model, and Xian-Ling-Gu-Bao capsule (XLGB) groups, and the low-, medium-, and high-dose PTE groups. (researchgate.net)
Abstract Adult male rats were fed for 7 wk either a low fat diet (3% fat) or a high fat-cholesterol diet (20% fat, 0.5% cholesterol) containing 7% wheat germ or not. (cryonet.org)
No adaptative change in lipase and colipase contents was observed in the pancreas of rats fed the wheat germ-supplemented diets, whereas the high fat diet increased these values. (cryonet.org)
High-Dietary Alpha-Tocopherol or Mixed Tocotrienols Have No Effect on Bone Mass, Density, or Turnover in Male Rats During Skeletal Maturation. (oregonstate.edu)
Finally, the nasal lesions associated with exposure to high concentrations of MeI in rats are best supported by a mode of action that involves glutathione (GSH) depletion in the nasal epithelial tissue. (cdc.gov)

When evaluating this patient and developing a management plan, it is important to consider that many endocrine diseases affect lipid metabolism . (medscape.com)

CONCLUSIONS: In this group of patients with FCHL, the major defect appeared to be overproduction of TAG by the liver due to decreased fatty acid oxidation, with fatty acids directed to TAG synthesis. (ox.ac.uk)
Anti-diabetic and dyslipidemia-correcting effects of bergamot polyphenols may be explained by their ability to activate AMP kinase (AMPK), which is a central regulator of glucose and fatty acids metabolism and inhibit cAMP phosphodiesterases (PDE), involved in regulation of lipolysis in adipocytes and liver. (bergamotaustralia.com.au)
The significant module (royal blue) identified was associated with TC, TG and non-HDL-C. GO and KEGG enrichment analyses revealed that the genes in the royal blue module were associated with carbon metabolism, steroid biosynthesis, fatty acid metabolism and biosynthesis pathways of unsaturated fatty acids. (biomedcentral.com)

Thus, prevention and treatment of hyperlipidemia are effective approaches to reduce the incident rate of chronic diseases. (hindawi.com)
There is a growing interest in TCM treatment of hyperlipidemia. (hindawi.com)
In the last few decades, hundreds of Chinese herbal medicines in the form of compounds, extracts, single herbs, or formulae have been reported to be effective for the prevention and treatment of hyperlipidemia [ 16 ], especially those high-fat diet (HFD) induced cases. (hindawi.com)
To accurately assess a patient's lipid profile, the guideline also suggests holding off treatment of hyperlipidemia in patients with hypothyroidism until they become euthyroid. (medscape.com)

Hormones produced by adipose tissue play a critical role in the regulation of energy intake, energy expenditure, and lipid and carbohydrate metabolism. (diabetesjournals.org)
Moreover, decreased insulinaemia in B-Atgl-KO mice was associated with increased energy expenditure, and lipid metabolism in brown (BAT) and white (WAT) adipose tissues, leading to reduced fat mass and body weight. (omicsdi.org)

Through the absorption and digestion of the human body, it helps to reduce blood pressure and blood lipids Cholesterol and triglyceride levels in the body, promote the stable development of blood lipids and prevent blood levels from rising. (growmorehealth.com)
Poor long-term glycemic control (AUC HbA1c), high blood pressure, and elevated triglyceride levels were correlates of CAN in subjects with type 1 diabetes. (cdc.gov)

ASP increases the efficiency of triacylglycerol synthesis in adipocytes leading to enhanced postprandial lipid clearance. (diabetesjournals.org)
Tissue-specific stable isotope measurements of postprandial lipid metabolism in familial combined hyperlipidaemia. (ox.ac.uk)

Older overweight patients with polyps, accompanied by abnormal lipid levels, are at high risk for cholesterol polyps. (biomedcentral.com)

Currently the common clinical methods to detect the content of total cholesterol and triglyceride in blood samples include enzymatic method, chemical method, and methods based on high performance liquid chromatography. (lumigenex.com)
Hyperlipidemia is an elevation of total cholesterol (TC) or non-high-density-lipoprotein (HDL) cholesterol (TC minus HDL-cholesterol). (contemporaryclinic.com)
Previous reports from the Framingham Heart Study suggested a strong positive relationship between coronary heart disease and elevated levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels, in addition to an inverse relationship between the disease and high-density lipoprotein cholesterol (HDL-C) levels [ 5 - 8 ]. (cdc.gov)

In TCM, the treatment of NAFLD mainly focused on the holism of hepatoprotection, which manifests as various forms and features in mechanism, including anti-oxidant stress, lipid metabolism modulation, anti-inflammation, anti-fibrosis and gut microbiota modulation. (biomedcentral.com)
In addition, FXR is critical in regulating lipid metabolism and reducing inflammation, processes critical in the development of cholestasis and fatty liver diseases. (aspetjournals.org)

Dietary fat and fructose, which do not increase insulin secretion, lead to reduced leptin production, suggesting a mechanism for high-fat/high-sugar diets to increase energy intake and weight gain. (diabetesjournals.org)
Taken as a whole, the present results obtained in humans are very close to those previously obtained in the rat and point out that wheat germ may play a beneficial role in the dietary management of hyperlipidemia. (cryonet.org)
The closely interwoven lifestyle elements of sedentary behaviors and high dietary intake of saturated or trans fats are the most often seen secondary causes. (contemporaryclinic.com)
Dietary lipids favor their metabolic processing, saving glucose, which additionally spares amino acids. (medscape.com)

At the same time, triglyceride and cholesterol accumulation in the liver and the triglyceride content in skin were significantly decreased. (cryonet.org)
In addition, kelp is rich in iodine, which can supplement the human body with fibrous alginic acid, inhibit the absorption of cholesterol in the stomach and intestines, reduce the accumulation of fatty substances in the body, and is more conducive to losing weight and stabilizing blood lipids. (growmorehealth.com)
2005. Alpha-tocopherol modulates Cyp3a expression, increases gamma-CEHC production, and limits tissue gamma-tocopherol accumulation in mice fed high gamma-tocopherol diets. . (oregonstate.edu)
Familial lipoprotein lipase deficiency is an example of a primary disorder in which a deficiency of lipoprotein lipase in tissue leads to a type I pattern of hyperlipidemia, with a massive accumulation of chylomicrons in the plasma. (medscape.com)
Familial LDL receptor deficiency and familial defective apoprotein B-100 are examples of primary defects that can lead to the accumulation of LDL, which corresponds to a type IIa pattern of hyperlipidemia. (medscape.com)

Glucose measurements are used in the diagnosis and treatment of pancreatic islet cell carcinoma and of carbohydrate metabolism disorders, including diabetes mellitus, neonatal hypoglycemia, and idiopathic hypoglycemia. (cdc.gov)

nephropathy, liver disease and coronary heart disease. (lumigenex.com)
Long-term failure to lower blood lipids will lead to reduced coronary blood circulation, myocardial bleeding and acute vasoconstriction, leading to angina pectoris or coronary heart disease. (growmorehealth.com)
With the development of markedly improved living standards throughout society, coronary artery disease (CAD) has emerged as a leading factor of mortality, functional deterioration, skyrocketing healthcare expenditure, disability and morbidity. (biomedcentral.com)
The "6 percent effect" of statins refers to the fact that doubling the dose of statins only decreases LDL-C levels by 6.4%, and PCSK9 inhibitors combined with statins are recommended for patients with acute coronary syndrome (ACS) with a high risk of cardiovascular events [ 14 ]. (biomedcentral.com)

modifies low density lipoprotein metabolism in cholesterol-fed guinea pigs. (webmd.com)
In univariate analysis, clinical risk factors for cholesterol polyps were age, male sex, higher body mass index (BMI), higher low-density lipoprotein (LDL), lower high-density lipoprotein (HDL), and higher aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels. (biomedcentral.com)
Liver weights and plasma ApoA-II and high-density lipoprotein concentrations were significantly elevated in curcumin-supplemented groups. (elifesciences.org)

Albumin measurements are used in the diagnosis and treatment of diseases involving the liver and/or kidneys, and are frequently used to assess nutritional status because plasma levels of albumin are dependent on protein intake. (cdc.gov)
The lipoprotein lipase (LPL) pathway has emerged as an attractive therapeutic target for reducing lipid levels and cardiovascular risk. (nature.com)
Average percentage of abnormal blood lipid levels among Americans at age 20 or above [ 4 ]. (hindawi.com)
Hyperlipidemia refers to one or more levels of blood lipid components such as plasma cholesterol, triglyceride and total fat that exceed the normal standard. (lumigenex.com)
Vasoconstriction, with the high levels of oxidized LDL, lowers the release of vasodilator nitric oxide from damaged endothelial walls and raises platelet aggregation and thromboxane release. (contemporaryclinic.com)
Metabolic speed, burning excess fat in the body, stabilizing blood lipid levels, are beneficial to health. (growmorehealth.com)
3b) Insulin helps regulate blood sugar, but it can lose effectiveness, especially when blood sugar quickly and repeatedly rises to high levels. (stackexchange.com)
A high fasting blood sugar is a real problem for those with diabetes, and it's incredibly important to keep these levels under control. (liveinnermost.com)
Age- and sex-adjusted FABP3 levels were positively associated with uric acid, urinary albumin-to-creatinine ratio, FABP1, FABP2, and fatty liver index, but negatively associated with eGFR and hemoglobin. (medsci.org)
Taken together, these results demonstrate that curcumin is a PPARα activator and may affect expression levels of proteins involved in amyloid deposition to influence amyloidosis and metabolism in a complex manner. (elifesciences.org)
Lipid levels may become abnormal because of changes that occur with aging, various disorders (including inherited ones), use of certain medications, or lifestyle (such as consuming a diet high in saturated fat, being physically inactive, or being overweight). (msdmanuals.com)
Human investigations suggest that fenugreek can be beneficial as an adjunct in controlling high blood glucose and lipid levels in people with diabetes. (lww.com)
The frequency may be decreased to every other year for patients with optimal lipid levels. (who.int)
A large meta-analysis of lipid levels in 72 studies on overt hypothyroidism assessed the magnitude of change in LDL-C and TG after treatment of hypothyroidism. (medscape.com)
Among people with genetically high cholestero l , who have very high LDL-cholesterol levels of 190 mg/dl or higher, more than 80% are underdiagnosed and, therefore, untreated. (cdc.gov)
The genetic basis for elevation in lipid levels is not well understood, but substantial heritability has been demonstrated in twin [ 9 ] and family-based [ 10 - 12 ] studies, which have estimated that approximately 43% to 83% of the variance in blood lipid and lipoprotein levels is attributable to genetic factors. (cdc.gov)
Recent candidate gene studies [ 13 - 16 ], as well as genome-wide association studies [ 17 - 25 ], have identified polymorphisms that account for a portion of the variation in blood lipid levels. (cdc.gov)

The retail health clinic setting provides a unique opportunity to identify patients with hyperlipidemia and related cardiovascular risk factors. (contemporaryclinic.com)
Their prevalence is higher in patients presenting cardiovascular risk factors.This review takes stock of the frequency, the mechanisms, and the implications of major cardiovascular risk factors in patients with serious mental disorders. (bvsalud.org)

We found that Reptin deletion completely rescued pathological phenotypes associated with IR, including glucose intolerance, hyperglycaemia, hyperlipidaemia and hepatic steatosis. (nih.gov)

RESULTS: Patients were insulin resistant as shown by higher glucose and insulin concentrations and lower muscle glucose extraction than controls. (ox.ac.uk)
Plasma triacylglycerol (TAG) concentrations were higher in patients. (ox.ac.uk)

The frequencies of alleles ε 2, ε 4, and genotypes ε 3/ ε 4 and ε 3/ ε 2 were significantly higher in psoriasis patients compared with those in controls. (hindawi.com)
High-dose PTE significantly ameliorated OVX-induced estradiol (E2) deficiency. (researchgate.net)
Curcumin supplementation for 12 weeks significantly increased AApoAII amyloid deposition relative to controls, especially in the liver and spleen. (elifesciences.org)

Nonalcoholic fatty liver disease (NAFLD) has become the world's largest chronic liver disease, while there is still no specific drug to treat NAFLD. (biomedcentral.com)

Adipocytes produce a number of hormones that have wide-ranging effects on energy intake, energy expenditure, and carbohydrate and lipid metabolism, including nutrient partitioning and fuel selection. (diabetesjournals.org)

In the liver, two major pathways carry out BA synthesis, the classic and the alternative pathway. (aspetjournals.org)
By studying diabetic dyslipid- in diabetes mellitus because insulin resist- aemia among a group of our patients we ance or deficiency affects key enzymes hoped to draw attention of the medical com- and pathways in lipid metabolism [ 1 ]. (who.int)
Many genes involved in metabolic pathways have been found to contribute to lipid level variability [ 14 , 26 , 27 ]. (cdc.gov)

We are now fully characterizing this protein and evaluating its utility as a drug target for diabetes, dyslipidemia, and fatty liver disease. (yale.edu)
Mellitus and HTN, Drug Induced Dyslipidemia, CNS disorders and any major liver and kidney disorder. (who.int)

Although dysregulated lipid metabolism results in diabetic nephropathy (DN) development in patients with type 2 diabetes mellitus (T2DM), it is not understood whether betatrophin is associated with urinary albumin excretion and renal function. (biomedcentral.com)
Young people with insulin- dependent diabetes mellitus (IDDM) may have a higher prevalence of eating disorders, such as anorexia nervosa and bulimia, and adults with longstanding diabetes and major medical complications have a higher prevalence of symptoms of depression and anxiety. (cdc.gov)
Elderly persons who have non-insulin-dependent diabetes mellitus (NIDDM) and other symptomatic medical conditions may also have a higher risk of developing psychological problems. (cdc.gov)
In addition to being the most common lipid abnormality in type 2 diabetes mellitus, hypertriglyceridaemia is also a feature of impaired glucose tolerance and impaired fasting glucose. (who.int)

Intrahepatic fat deposition has been demonstrated in patients with nonalcoholic fatty liver disease (NAFLD). (wjgnet.com)
Additionally, Lkb1 deletion reduced lipid deposition and increased expression of mitochondrial (Pgc1a, Cox5b and Cox7a) and hepatic gluconeogenesis related genes (Pepck) in liver. (omicsdi.org)
Long-term exposure to excessive blood lipids will lead to the continuous deposition of fat components in the blood vessels, resulting in blood circulation disorders, which cannot be effectively circulated everywhere and reduce the efficiency of surgery. (growmorehealth.com)
Inositol is often clinically used together with vitamin B complex, which can prevent or reduce the deposition of excess fat in the liver, and thus promoting the liver fat metabolism. (leaderbio-ingredients.com)

Consequently, the role of hepatic Reptin in the pathogenesis of insulin resistance (IR) and non-alcoholic fatty liver disease consecutive to a high-fat diet was investigated. (nih.gov)
Nonalcoholic Fatty Liver Disease (NAFLD) is defined as the fatty liver with metabolic dysfunction. (biomedcentral.com)
Alkaline phosphatase measurements are used in the diagnosis and treatment of liver, bone, and parathyroid disease. (cdc.gov)
AST measurements are used in the diagnosis and treatment of certain types of liver and heart disease. (cdc.gov)
It is currently the most sensitive enzymatic indicator of liver disease, with normal values rarely found in the presence of hepatic disease. (cdc.gov)
Environmental chemical exposure could affect liver disease development. (aspetjournals.org)
Understanding these effects will help to determine liver disease pathogenesis and provide better prevention and treatment in the future. (aspetjournals.org)
High cholesterol is significant risk factor for cardiovascular disease, along with high blood pressure and smoking. (contemporaryclinic.com)
A clear distinction must be made between primary (inherited) and secondary (liver disease, alcoholism, metabolic diseases) causes of dyslipoproteinemia. (testcatalog.org)
Most recently, we have established techniques of high throughput gene editing and multiple parallel reporter assays in my laboratory and have successfully mapped the regulatory landscape of a number of GWAS disease genes. (yale.edu)
We have developed expertise in in vivo investigation of lipid and glucose metabolism, insulin secretion and sensitivity, and vascular biology and in human physiological studies, leading to discovery of attractive drug targets that have been either patented or being investigated for their utility in treatment of fatty liver disease and diabetes in 2 clinical trials in the outlier populations of Fars/Iran. (yale.edu)
Cerebrovascular disease is characterized by high incidence rate, high recurrence rate, high disability rate and high mortality[ 1 ]. (ijpsonline.com)
Patients with CKD are at a high risk of cardiovascular disease and mortality and are associated with increased treatment costs [ 2 ]. (medsci.org)
It is extremely clear that low lipid density protein, or "bad," cholesterol (LDL-C), in the blood is a significant risk factor for heart disease and stroke, the leading causes of death among Americans. (cdc.gov)
Lipid-lowering therapy is important for secondary prevention for patients with known cardiovascular disease, as well as for primary prevention for those at increased risk. (medscape.com)

Therefore, this study recruited patients with cholesterol GBP, the dominant type of GBP, according to postoperative pathology from the four-year databases of three high-volume centers, to investigate specific risk factors for cholesterol GBP formation, and to provide a basis for its prevention and treatment. (biomedcentral.com)
Creating a link between the initiation of lipid-lowering medication (and other secondary-prevention measures) and the patient's cardiac hospitalization strength- ens the perception that this therapy is essential for the prevention of recurrent events and is an essential part of the patient's long-term treatment. (slideshare.net)
Screening is important in order to identify patients with suboptimal lipid profiles and then institute corrective measures for either primary or secondary prevention. (who.int)
The importance of surveillance and monitoring of progress made in the prevention and control of NCDs was emphasized during the High-level Meeting of the General Assembly on the Prevention and Control of Non-Communicable Diseases, which was held on 19 and 20 September 2011 in New York. (who.int)
Resolution 66/2 on the Political Declaration of the High-level Meeting of the General Assembly on the Prevention and Control of Non-Communicable Diseases was adopted by the General Assembly on 19 September 2011. (who.int)
As a public health MD focused on cardiovascular prevention, I want people to be armed with the information needed to live a long healthy life. (cdc.gov)

Leptin treatment dramatically improves metabolic abnormalities (insulin resistance and hyperlipidemia) in patients with relative leptin deficiency due to lipoatrophy. (diabetesjournals.org)
Results of lipid profile support that psoriasis is one of the independent risk factors for hyperlipidemia and emphasize the need of screening cardiovascular diseases in psoriatic patients. (hindawi.com)
Reasonable diet and exercise in daily life for patients with hyperlipidemia Combined, it can effectively assist and stabilize blood lipids in the body, play a good conditioning role, and reduce physical damage under the action of drugs. (growmorehealth.com)
Patients in the cholesterol polyp group were recruited from three high-volume centers with a diagnosis of pathologically confirmed cholesterol polyps larger than 10 mm. (biomedcentral.com)
The microarray dataset of GSE66676 obtained from patients with hyperlipidaemia was downloaded. (biomedcentral.com)
Among many common and frequently occurring diseases admitted to emergency and critical care departments, the mortality rate is high and the disability rate of surviving patients is also high. (ijpsonline.com)
With the aging population and significant improvement of living standards in China, the incidence of cerebrovascular diseases has increased at an average annual rate of 8.3 %, ranking first among the causes of death among Chinese residents and being the main cause of illness and death in patients with the nervous system[ 2 ]. (ijpsonline.com)
More recently, a pharmacy-based program that included placing lipid treat- ment reminders on the charts of patients hospitalized with CHD demonstrated an increase in treatment rates to 77% at the time of discharge.12 These and other programs have demonstrated that high rates of lipid-lowering treatment initiation can be achieved with a hospital-based system. (slideshare.net)
ABSTRACT This study investigated the patterns and determinants of lipid disorders among a group of 250 type 2 adult diabetic patients and 60 age- and sex-matched healthy controls in Sudan. (who.int)
Direct psychological consequences can arise from any one of these factors, making it harder for patients to treat their diabetes and live productive, enjoyable lives. (cdc.gov)
A fasting lipid profile is recommended on a yearly basis for patients with diabetes. (who.int)
The risk for abacavir HSR to occur is high for patients who test positive for the HLA-B*5701 allele. (who.int)
In patients with hypothyroidism , lipid metabolism is slowed, and LDL-C, TG, and HDL-C may be elevated. (medscape.com)
These data informed the Endocrine Society's 2020 Lipid Management in Patients with Endocrine Disorders clinical practice guideline . (medscape.com)

The results of the Western blotting assay showed that YNCRG did not affect the AMPK/ACC signaling pathway, but it strongly promoted the phosphorylation of PKA, ERK, and C/EBPβ in rat livers. (lidsen.com)

OBJECTIVE: The metabolic defects underlying familial combined hyperlipidaemia (FCHL) are not clearly understood. (ox.ac.uk)

The biochemical and genetic basis for the inherited disorders of lipid and lipoprotein metabolism differ considerably. (medscape.com)

Liver is the main organ for lipid uptake, de novo synthesis and fatty acid lipolysis [ 3 ]. (biomedcentral.com)
Some lipogensis and lipolysis enzymes have been known to be involved in the lipids synthesis and metabolism. (biomedcentral.com)
Farnesoid X receptor (FXR) and its regulated target networks in both the liver and the intestines are critical in suppressing BA synthesis and promoting BA transport and enterohepatic circulation. (aspetjournals.org)
BA synthesis in the liver is the primary form of cholesterol catabolism ( Fig. 1 ). (aspetjournals.org)

Xanthomas are lesions characterized by accumulations of lipid-laden macrophages. (medscape.com)

These elevations can be indicative of a genetic deficiency in lipid metabolism or transport, nephrotic syndrome, endocrine dysfunction, or even cholestasis. (testcatalog.org)

This review summarizes the recent experimental and clinical results of nine representative single Chinese herbs and seven classic TCM formulae that could improve lipid profiles so as to help understand and compare their underlying mechanisms. (hindawi.com)
The purpose of this study was to explore the potential molecular targets of hyperlipidaemia and the related molecular mechanisms. (biomedcentral.com)

Lipoprotein metabolism profile analysis adds practical information about the etiology of cholesterol and/or triglyceride elevation. (testcatalog.org)

The guideline recommends first ruling out hypothyroidism as the cause of hyperlipidemia before initiating lipid-lowering medications. (medscape.com)

The lipid abnormalities are prevalent dyslipidaemia. (who.int)

Fast Five Quiz: Lipids Management - Medscape - Jun 12, 2023. (medscape.com)

Lethal dysregulation of energy metabolism during embryonic vitamin E deficiency. (oregonstate.edu)

Anatomy5

Diseases8

Chemicals and Drugs20

Analytical, Diagnostic and Therapeutic Techniques and Equipment4

Phenomena and Processes6

Technology, Industry, Agriculture1

Health Care1

Homeostasis12

Disorders of lipid metabolism4

Obesity13

Hypertension2

Metabolic syndrome8

Triglycerides19

Serum8

Lipoproteins6

VLDL2

Atherosclerosis6

Plasma lipid and lipoprotein1

Rats7

Affect lipid metabolism1

Fatty Acids3

Treatment of hyperlipidemia4

Adipose2

Triglyceride levels2

Postprandial lipid2

Abnormal lipid levels1

Total cholesterol3

Inflammation2

Dietary4

Accumulation5

Carbohydrate metabolism1

Coronary4

Density lipoprotein3

Levels17

Cardiovascular risk2

Hepatic steatosis1

Concentrations2

Significantly3

Chronic liver d1

Energy expenditure1

Pathways3

Dyslipidemia2

Diabetes mellitus4

Deposition4

Disease15

Prevention6

Patients14

Signaling pathway1

Familial1

Differ considerably1

Synthesis4

Macrophages1

Genetic1

Mechanisms2

Elevation1

Hypothyroidism1

Abnormalities1

Fast Five Quiz1

Dysregulation1