Lipid carriers characterization drug carriers. Medical search. Frequent questions

On the other hand, he is experienced in developing nanoparticles and nanofibers to deliver drugs effectively. (upes.ac.in)
Dr. Gunjan carries expertise in the areas of pharmaceutical product development, design, and development of novel drug delivery systems like micelle, nanoparticles, nanofibres, and other nano colloidal drug delivery systems, rate-controlled and targeted approaches for cancer chemotherapy, enhancement of drug solubility and bioavailability of poorly soluble drug, pharmacokinetics and biodistribution. (upes.ac.in)
Solid lipid nanoparticles (SLN) have emerged as a next-generation drug delivery system with potential applications in pharmaceutical field, cosmetics, research, clinical medicine and other allied sciences. (banglajol.info)
Recently more focus has been put to the development of innovative drug-delivery systems that includes liposomes and solid lipid nanoparticles (SLNs). (scialert.net)
Homogenization of solid lipid nanoparticles at 1000 bar for 20 cycles produced particles with 145.00±3.39 nm in size and zeta potential of -19.50±1.80 mv. (scialert.net)
The solid lipid nanoparticles contain a lipid matrix composed of physiologically tolerable lipids that is not toxic. (scialert.net)
Solid lipid nanoparticles (SLN) containing stabilized lipid dispersions have been designed as an alternative colloidal drug delivery system to polymer nanoparticles, emulsions and liposomes. (scialert.net)
The objective of this study was to examine the influence of component of solid lipid nanoparticles on the viability of breast cancer cells using the MTT assay. (scialert.net)
Lipid nanoparticles with a solid matrix (SLN, NLC, LDC) for oral drug delivery. (uns.ac.id)
20 Years of Lipid Nanoparticles (SLN & NLC): Present State of Development & Industrial Applications. (uns.ac.id)
Lipid Nanoparticles (Solid Lipid Nanopartocles and Nanostructured Lipid Carriers) for cosmetic, Dermal, and Transdermal Aplication. (uns.ac.id)
Tamoxifen-loaded poly(L-lactide) nanoparticles: development, characterization and in vitro evaluation of cytotoxicity. (springer.com)
Herein, we aim to review the scientific progress and perspectives for polymer-based nanoparticles as drug delivery systems for purines. (bvsalud.org)
Polymeric nanoparticles turned out to have the potential to augment antiviral and antiproliferative effects of purine derivatives by specific binding to receptors (ASGR1-liver, macrophage mannose receptor), increase in drug retention (in eye, intestines, and vagina), and permeation (intranasal to brain delivery, PEPT1 transport of acyclovir). (bvsalud.org)
The most significant achievements of polymer-based nanoparticles as drug delivery systems for purines were found for tenofovir disoproxil in protection against HIV, for acyclovir against HSV, for 6-mercaptopurine in prolongation of mice ALL model life, as well as for 6-thioguanine for increased efficacy of adoptively transferred T cells. (bvsalud.org)
Lipids have been used as raw material for nanoparticles development, mainly for the solubilization capacity of lipophilic bioactive compounds. (fortunepublish.com)
In addition, lipid nanoparticles may improve the chemical stability and permeability of bioactive compounds through the gastrointestinal tract (GIT) and may also facilitate its absorption [1-3]. (fortunepublish.com)
There are currently two types of lipid nanoparticles, solid lipid nanoparticles (SLN) developed with saturated lipids and nanostructured lipid carriers (NLC) composed of both saturated and unsaturated lipids. (fortunepublish.com)
Nanovectors, such as liposomes, micelles and lipid nanoparticles, are recognized as efficient platforms for delivering therapeutic agents, especially those with low solubility in water. (unifi.it)
Such nanoparticles, typically having a size in the order of 100 nm, are created by spontaneous electrostatic complexation of the anionic nucleic acids with cationic carrier materials, such as cationic lipids or polymers. (kuliahkaryawanmurah.com)
The carrier materials have to fulfil several requirements in order for the nanoparticles to efficiently transfect the target cells. (kuliahkaryawanmurah.com)
On this page, you will find specific research topics, for example, the generation of hexagonal flower-like wurtzite-type zinc oxide structures for energy storage purposes with microwave synthesis, and the drug delivery capability of nanoparticle systems and RNA nanoparticles for gene silencing, analyzed and investigated with dynamic light scattering (DLS) and electrophoretic light scattering (ELS). (anton-paar.com)
Nanoparticles can be utilized in drug delivery to the central nervous system (CNS). (helsinki.fi)
The characterization of BBB cells would help light on the exact mechanism of nanoparticle delivery into the brain, which would enable the design of targeted nanoparticles to deliver drugs to the CNS. (helsinki.fi)
SLN or solid lipid nanoparticles were suggested as advantageous alternatives to liposomes and other colloidal carriers for hydrophobic drug delivery, yet with limited loading capabilities and diminished tunable release profiles, especially for hydrophilic proteins and peptides. (uandes.cl)
Lipid nanoparticles (LNPs) are effective non-viral carriers, which are widely used as delivery vehicles for gene-based drugs such as messenger RNA (mRNA). (chromatographyonline.com)
Lipid-based nanoparticles (LNPs) are effective non-viral vectors for delivering messenger RNA products (mRNA), most notably used for vaccine production against the recent SARS-CoV-2 pandemic. (chromatographyonline.com)
Among them, lipid nanoparticles (LNPs) are the most clinically advanced mRNA delivery vehicles. (nanofcm.com)
It is worth pointing out that currently all SARS-CoV-2 mRNA vaccines approved for clinical use employ lipid nanoparticles (LNPs) as mRNA carriers. (nanofcm.com)

New method to form giant unilamellar vesicles was established by assisting the hydration process of a lipid film with a dextran-poly(ethylene glycol) hydrogel film. (universiteitleiden.nl)
6. Guo F, Wang J, Ma M et al (2015) Skin targeted lipid vesicles as novel nano-carrier of ketoconazole: characterization, in vitro and in vivo evaluation. (asianjpr.com)
Tween ® 80 and sodium deoxycholate, on (i) the physical, mechanical, and biological properties of ultradeformable vesicles, and (ii) the administration of naproxen sodium-loaded multidrug ultradeformable vesicles for the transdermal route in order to obtain therapeutically meaningful drug concentrations in the target tissues and to potentiate its anti-inflammatory effect by association with the antioxidant drug idebenone. (mdpi.com)

An in vitro study was conducted to determine the effect of solid lipid nanoparticle on the human breast cancer cell lines (MCF-7 and MDA-MB231). (scialert.net)
The enhanced light absorption and scattering capacity of SNPs, make them a promising candidate system for non-invasive imaging and drug delivery in nanoparticle-assisted diagnostics and therapy. (ox.ac.uk)
NanoFCM (Flow NanoAnalyzer) is a platform for comprehensive nanoparticle characterization, which covers the particle size range of 7-1000 nm, and allows the quantitative analysis of the particle size distribution, particle concentration, loading fraction, drug encapsulation efficiency and nucleic acid localization assay at the single particle level. (nanofcm.com)

These drawbacks could be mitigated by employing liposomes as carriers for AgNPs. (ox.ac.uk)
study deformable liposomes as potential carriers for transdermal drug delivery. (ddw-online.com)

Suhaimi, Effects of formulation parameters on particle size and polydispersity index of orthosiphon stamineus loaded nanostructured lipid carrier, JARAS, № 1, с. (dntb.gov.ua)

Though several studies have been carried out on various prodrugs, surprisingly very few reviews on different carriers, which can be used for prodrug synthesis were published to date. (ijpsonline.com)
In this review different types of carriers, which can be used for prodrug synthesis are summarized. (ijpsonline.com)
The objective of this review is to provide the researchers with a compilation of which carriers would be suitable for prodrug synthesis and what would be their benefits. (ijpsonline.com)
Due to the extended experience of Nawah drug delivery team, in addition to the availability of all needed equipment for synthesis, formulation and characterization of Nano-drug delivery systems (NDDSs), we are happy to assist you in preparing your nanoformulation for research or R&D work. (nawah-scientific.com)
Tumor cells require high rates of lipid synthesis to support membrane biogenesis for their exacerbated growth. (uchile.cl)
Motor protein CF0F1 reconstituted in lipid-coated hemoglobin microcapsules for ATP synthesis. (mpg.de)
[ 13 ] In cultured skin keratinocytes, elevated fatty alcohol is diverted into the synthesis of wax esters and alkyldiacylglycerol lipids. (medscape.com)

15. Qureshi MS, Jamil QA, Akhtar N, Akhtar N. Formulation and characterization of Anacyclus Pyrethrum Emulgels and its in vitro and in vivo evaluation as cosmeceutical product. (jptcp.com)

1 - 3 Various approaches have been utilized for the enhancement of solubility and dissolution rate of poorly soluble drugs such as solid dispersions preparation, 4 inclusion in cyclodextrins, 5 and particle size (PS) reduction. (dovepress.com)
Preparation and characterization of stearic acid nanostructured lipid carriers by solvent diffusion method in an aqueous system. (uns.ac.id)

7. Akhtar N, Akhtar N. Development of stable tocopherol succinate‐loaded ethosomes to enhance transdermal permeation: In vitro and in vivo characterizations. (jptcp.com)

2017). Nanostructured Lipid Carriers (NLCs): A Novel Based Nano Carrier for Drug Delivery and Drug Targeting. (uns.ac.id)

6 Although these approaches improved solubility and dissolution of poorly soluble drugs, their commercial use is limited due to stability issues of the amorphous nature of the produced drug. (dovepress.com)
Nano-drug delivery systems (NDDSs) are a class of nanomaterials that have abilities to increase the stability and water solubility of drugs, prolong the cycle time, increase the uptake rate of target cells or tissues, and reduce enzyme degradation, thereby improve the safety and effectiveness of drugs. (nawah-scientific.com)
explore how sinapic acid and its derivatives strengthen oxidative stability in different lipid systems. (ddw-online.com)

Over the past few decades, the field has seen breathtaking advancements with improved drug formulations, release mechanisms, delivery materials, and administration routes. (wikipedia.org)
Impact of dispersion media and carrier type on spray-dried proliposome powder formulations loaded with beclomethasone dipropionate for their pulmonary drug delivery via a next generation impactor Kunda NK. (ljmu.ac.uk)
A second objective was to study erosion/dispersion behavior of the formulations because it would condition release of any drug. (fhnw.ch)
Methods Different formulations containing a lipid, a polymer and different silica based inorganic carriers were produced by hot-melt extrusion at various screw speeds. (fhnw.ch)

Results Multifractal analysis indicated that inorganic carrier type and concentration as well as the screw speed affected the microstructure of the extrudates. (fhnw.ch)
The aqueous erosion/dispersion study showed that only the type and concentration of inorganic carrier were important. (fhnw.ch)
This review encompasses the significant recent advancements in drug delivery as well as molecular imaging and diagnosis of cancer exploiting polymer-based, lipid-based and inorganic nanoparticulate systems. (eurekaselect.com)

Prodrugs are derivatives of drug molecules that are pharmacologically inactive but require either chemical or enzymatic transformation to release the active drug in vivo in order to exert a pharmacological effect. (ijpsonline.com)
We have developed expertise in in vivo investigation of lipid and glucose metabolism, insulin secretion and sensitivity, and vascular biology and in human physiological studies, leading to discovery of attractive drug targets that have been either patented or being investigated for their utility in treatment of fatty liver disease and diabetes in 2 clinical trials in the outlier populations of Fars/Iran. (yale.edu)
The characterization of this protein in vivo has shown that it widely expressed in different tissues and circulates in the blood, its levels rise after food intake in humans and stimulates insulin secretion and sensitivity and inhibits platelet aggregation. (yale.edu)

Intranasal drug delivery occurs when particles are inhaled into the nasal cavity and transported directly into the nervous system. (wikipedia.org)
Drug delivery is a process of administering therapeutics to treat human diseases. (wikipedia.org)
The first drug delivery system often dates back to the 1950s, where Smith Kline & French Laboratories introduced the Spansule technology. (wikipedia.org)
Drug delivery through nasal cavity increases drug bioavailability and lowers risk of systemic exposure. (wikipedia.org)
Nasal cavity is a slightly acidic environment with enzymes which can alter degradation of drug delivery systems. (wikipedia.org)
The delivery systems between neutral to acidic pH is ideal for high drug bioavailability following intranasal administration. (wikipedia.org)
Targeting the olfactory region increases efficiency of nose-to-brain drug delivery. (wikipedia.org)
Hence, poor aqueous solubility has become the leading hurdle for formulation, and scientists are concerned in improving oral delivery of insoluble drug candidates. (dovepress.com)
His Ph.D. work was focused on designing and developing nano-drug delivery for the effective treatment of breast cancer. (upes.ac.in)
In most cases, oral drug delivery is most preferred as it is convenient, non-invasive, and easy to incorporate into a patient's lifestyle. (mdpi.com)
The delivery of drugs must overcome various obstacles, including the acidic gastric environment and the presence of intestinal efflux and influx transporters. (mdpi.com)
On the other hand, dermal/transdermal drug delivery candidates have increased in recent years in response to the development of new and optimized approaches to improve local and systemic drug delivery. (mdpi.com)
Dermal/transdermal delivery of drugs represents an effective method to deliver drugs directly to the site of action or to enhance treatment activity noninvasively. (mdpi.com)
Lipid-based drug delivery systems are one of the emerging technologies designed to address challenges such as the solubility and bioavailability of poorly water-soluble drugs. (mdpi.com)
Carrier would change a drug's physical attributes in order to increase its fat or water solubility or to allow site-directed delivery. (ijpsonline.com)
Prodrugs have better delivery properties that surpass the parent drug molecule [ 1 ]. (ijpsonline.com)
The prodrug approach is rapidly becoming a crucial part in the stratagem of delivery of drugs. (ijpsonline.com)
2016). Nano structured Lipid Carrier Based Drug Delivery System. (uns.ac.id)
Determinants of drug delivery and transport to solid tumors. (springer.com)
Novel drug delivery platforms, including dextran-albumin hydrogels and dextran-poly(ethylene glycol)-albumin hydrogels, were established in which human serum albumin acts simultaneously as an affinity-based drug carrier and crosslinker. (universiteitleiden.nl)
The obtained drug delivery platforms showed high drug loading efficiency and demonstrated sustained release of drug molecules. (universiteitleiden.nl)
It is therefore highly desirable to have a long-acting, stable, and invasive-free drug delivery system to reduce the frequency of repeated administration and increase patient compliance. (japsonline.com)
16: 7169-7180, Heptamethine Cyanine Dye MHI-148-Mediated Drug Delivery System to Enhance the Anticancer Efficiency of Paclitaxel. (bioimagingsystem.com)
Here we revise recent applications of these complementary scattering techniques in the field of drug delivery in pharmaceutics and medicine with a focus to liposomal carriers. (unifi.it)
Overall, the formulation and production technique developed in the present study has potential to contribute towards mitigating challenges associated with AgNP-mediated drug delivery and diagnostics. (ox.ac.uk)
Nowadays targeted drug delivery, as well as the early cancer diagnosis is a key research area where nanomedicine is playing a crucial role. (eurekaselect.com)
Yin, Advances in polymer-drug conjugated micelles in the delivery of anticancer drugs, Yao Xue Xue Bao, № 51, с. (dntb.gov.ua)
Therefore, exosomes have received immense attention from academia and the drug industry as a new paradigm of drug delivery. (molcells.org)
Antimicrobial peptides (AMPs) and peptides designed for drug and gene delivery currently in the drug pipeline suggest that these membrane active peptides will soon constitute a significant percentage of the drug market. (preprints.org)
BBB restricts drugs transport from blood stream to the brain, which sets challenges in drug delivery to the brain. (helsinki.fi)
12. Singla V, Saini S, Joshi B, Rana A. Emulgel: A new platform for topical drug delivery. (jptcp.com)

Exosomes are 40-100 nm soluble microvesicles with a bi-lipid membrane and a cargo abundant in proteins and RNAs, which are now believed to be important for intercellular communication 9 . (nature.com)
CPPs are another group of membrane active peptides that mainly function as cargo-carriers even though they may also show antimicrobial activity to some extent. (preprints.org)

Extraction of intracellular lipids of the oleaginous yeast Yarrowia lipolytica has been systematically studied aiming towards a sustainable extraction process for lipid recovery. (researchgate.net)
MTP mediates intracellular lipid transport in the intestine and liver and thus ensures the normal function of chylomicrons (CMs) in enterocytes and of VLDL in hepatocytes. (medscape.com)

In the light of these findings, SLN stabilized with 30% lecithin and 1% oleyl alcohol as nonionic co-surfactant in aqueous phase was found to be safe for cells and the acceptable for the incorporation lipophilic drugs. (scialert.net)
Dietary restriction has shown promise for disorders such as lysosomal acid lipase deficiency (Wolman disease), as has incorporation of lipid-lowering drugs in the regimen along with sebelipase alpha, a recombinant enzyme replacement therapy. (medscape.com)
The aim of this work was the development of nanostructured lipid carriers (NLC) using conventional fats and oils (soybean oil, SO and fully hydrogenated soybean oil, FHSO) for incorporation of free phytosterols (FP). (fortunepublish.com)
The insertion of unsaturated lipids was performed to produce less structured lipid matrices, in relation to crystallinity, obtaining a better incorporation efficiency and avoiding the release/expulsion of bioactive compounds during storage [4-5]. (fortunepublish.com)

To mitigate safety risks and ensure product efficacy, it is important to comprehensively characterize the lipids used for LNPs and their related impurities, as well as the mRNA integrity, purity and its critical quality attributes (CQAs). (chromatographyonline.com)
LNPs provide a protected compartment, sequestered from serum nuclease activity and immune components, and a drug-biodistribution profile dictated by the carrier. (nanofcm.com)

The biochemical basis of lipid storage disorders is well characterized and includes determining properties of enzymatic activities and various storage products. (medscape.com)
Advances in understanding the molecular and biochemical basis include cloning and characterization of most genes that encode specific enzymes required for sphingolipid metabolism. (medscape.com)
Scientific and technological advancements are making it easier to understand the causes of and physiological processes of diseases and how molecular and biochemical aspects of lipids play a role. (ddw-online.com)

Nowadays, crystalline nanosuspensions (nanocrystals) are considered a valuable formulation for drugs that have a poor dissolution rate and/or aqueous solubility. (dovepress.com)
Following the Biopharmaceutical Classification System, the PGZ is classified as a class II drug, which suffers from poor aqueous solubility (0.3-0.4 μg/ml at pH 6.8), slow dissolution rate, and high permeability through biomembranes after oral administration. (japsonline.com)
NLC were obtained in aqueous dispersion through the emulsification process, followed by high-pressure homogenization (HPH) using 3 and 5 cycles at 800 bar, with subsequent crystallization and stabilization of the lipid matrices (LM). (fortunepublish.com)
An aqueous phase and an ethanolic lipid phase were conveyed through two separate inlet channels, and subsequently travelled through a serpentine-shaped channel where mixing between the two phases took place. (ox.ac.uk)

Around 10 % of marketed medicines can be categorized as prodrugs currently, and also that during 2008, 33 % of approved small molecular weight drugs were prodrugs [ 5 - 7 ]. (ijpsonline.com)
Lipid storage disorders are a family of diverse diseases related by their molecular pathology. (medscape.com)
In addition to these experimental biophysical techniques, molecular dynamics simulations provided clues on the peptide-lipid interactions and dynamics of the cell entry process at atomic detail. (preprints.org)
Smart polyelectrolyte microcapsules as carriers for water-soluble small molecular drug. (mpg.de)

Because mRNA is large (104-106 Da) and negatively charged, it cannot pass through the anionic lipid bilayer of cell membranes. (nanofcm.com)

His research interest is in drug discovery involving extraction, isolation, characterization and bioactivity study of natural products from plants. (iium.edu.my)

The defective enzyme leads to lipid product accumulation, resulting in dysfunction of cellular organelles with a common storage place being the lysosome. (medscape.com)
[ 14 ] Accumulation of fatty alcohol and related lipid products disrupts formation of the intercellular membranes in the stratum corneum, which is critical for epidermal water barrier. (medscape.com)

However, there is a lack of systematic studies on production and subsequent physico-chemical characterisation of liposomal systems encapsulating SNPs. (ox.ac.uk)

Albendazole (ABZ, anti-parasitic active pharmaceutical ingredient) is a crystalline low water-soluble drug, thus the dissolution rate in gastrointestinal fluids is limited. (uchile.cl)

Intranasal administration is a potential route associated with high drug transfer from nose to brain and drug bioavailability. (wikipedia.org)
Animal studies show intranasal administration of pro-resolving lipid mediators decreased both factors, slowing pathogenesis of this disease. (wikipedia.org)

The present review is expected to be useful for scientists working in the field of drug discovery and development. (ijpsonline.com)
Drug Development and Industrial Pharmacy, 34, 1394-405. (uns.ac.id)
Any drug impairing crucial processes for bacterial life will inevitably lead to the development of drug-resistant strains, whereas the inhibition of biofilm formation might prevent the onset of bacterial resistance. (intechopen.com)
In this section, we will focus on proteins involved in biofilm formation as useful targets for the development of new drugs that can effectively and specifically impair biofilm formation with slight effects on cell survival, thus avoiding the generation of drug-resistant strains. (intechopen.com)
Thus, the combination of the characteristics from the lipid sources commonly applied in the food industry, such as vegetable oils and fats, seems to be promising for the development of nanostructured lipid systems. (fortunepublish.com)
The development of exosome treatment starts at the bench, and in order to be commercialized, it goes through the manufacturing, characterization, and formulation stages, production under Good Manufacturing Practice (GMP) conditions for clinical use, and close consultation with regulatory authorities. (molcells.org)

The first step in oral absorption of solid dosage forms is dissolution of drug compound in the gastrointestinal lumen contents. (dovepress.com)
Formulasi, karakterisasi dan Uji Penetrasi In Vitro resveratrol Solid Lipid Nanopartikel dalam krim Topikal. (uns.ac.id)

To the best of our knowledge, this is the first report depicting the formation and characterization of polyelectrolyte multi-layers on SLN and analyzing structural properties of core-shell colloids on a gold surface by QCM-D tool. (uandes.cl)

Various disorders of lipid metabolism have characteristic patterns of organ involvement and clinical history, depending on the particular substrate that is stored. (medscape.com)
these apolipoproteins have lipid-soluble segments, the beta apolipoproteins, which remain part of the lipoprotein throughout its metabolism. (medscape.com)
Two decades later, Sjögren-Larsson syndrome was shown to be an inborn error of lipid metabolism caused by deficient activity of fatty alcohol:NAD oxidoreductase. (medscape.com)

In biopharmacy and pharmaceutical technology, intensive research is aimed at developing 'intelligent' nanoscopic particles that are capable of efficiently delivering drugs to target cells. (kuliahkaryawanmurah.com)

The current study was conducted to prepare oral PGZ-loaded lipid microparticles (PGZ-LMPs) for improving PGZ's solubility and oral bioavailability and maintaining its sustained release. (japsonline.com)

When utilizing other routes of administration to target the brain, drug adsorption is low due to issues with systemic circulation effects and blood brain barrier. (wikipedia.org)
Dynamic adsorption and characterization of phospholipid and mixed phospholipid/protein layers at liquid/liquid interfaces. (mpg.de)

However, clinical researchers continually find that the involvement of drug carriers may lead to poor biocompatibility and biodegradability, low loading efficacy, and potential side effects. (nature.com)
Additionally, these biological materials from drug carriers require complex syntheses and are relatively expensive 12 , which create great obstacles for effective clinical application. (nature.com)
These studies have resulted in identifying specific disease-causing mutations and have led to improved clinical and laboratory diagnosis, prenatal diagnosis, and carrier identification. (medscape.com)
Clinical treatment currently involves the use of corticosteroids, other immunosuppressive drugs and newly developed biologics, the long term application of which are limited by serious systemic side effects and the local risk of cataracts and glaucoma 24 , 25 . (nature.com)
Despite the availability of various antidiabetic drugs in clinical use, a successful comprehensive cure of DM remains unachievable. (japsonline.com)

Recently, increasing attention has been focused on these SLN as colloidal drug carriers for incorporating hydrophilic or lipophilic drugs. (banglajol.info)

The saturated solubility and mean dissolution time, in the case of F8 and F12, were significantly higher than the coarse drug powder. (dovepress.com)

Hierarchical gold/copolymer nanostructures as hydrophobic nanotanks for drug encapsulation. (mpg.de)

The DDSolver software was employed to investigate the mechanism of the drug release and the appropriate kinetic model for describing PGZ release from LMPs. (japsonline.com)

[ 6 ] For most disorders, carrier identification and prenatal diagnosis are available as well. (medscape.com)
it can be performed for carrier testing and prenatal diagnosis. (medscape.com)

We are now fully characterizing this protein and evaluating its utility as a drug target for diabetes, dyslipidemia, and fatty liver disease. (yale.edu)

Because of the high recurrence rate for H. cinaedi bacteremia, it is recommended that patients receive prolonged treatment of at least 3 months with appropriate antimicrobial drugs ( 9 ). (cdc.gov)
We started patients on antimicrobial therapy with meropenem when H. cinaedi was suspected or gram-negative rods were identified, then changed to sulbactam/ampicillin after confirming drug sensitivity. (cdc.gov)
If other causative bacteria were identified, antimicrobial drugs were changed based on drug sensitivity results and continued for 3-6 months. (cdc.gov)

Besides being safe and non-toxic, drug carriers with improved performance should meet the requirements of (i) appropriate size and shape and (ii) cargo upload/release with unmodified properties. (unifi.it)

Between 1950s and 1980's, there were four drug release systems developed for oral and transdermal applications: dissolution, diffusion, osmosis, and ion-exchange controlled release. (wikipedia.org)

Small-angle X-ray (SAXS) and neutron (SANS) scattering techniques provide information at the nanoscale and have therefore been largely used to investigate nanovectors loaded with drugs or other biologically relevant molecules. (unifi.it)

Self-assembling natural drug hydrogels formed without structural modification and able to act as carriers are of interest for biomedical applications. (nature.com)
However, techniques with higher space and time resolution are needed for in-depth structural characterization. (unifi.it)

Anatomy4

Organisms2

Diseases2

Chemicals and Drugs51

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Phenomena and Processes30

Disciplines and Occupations5

Technology, Industry, Agriculture18

Information Science2

Named Groups1

Health Care3

Nanoparticles29

Vesicles3

Nanoparticle3

Liposomes2

Loaded nanostructured lipid1

Synthesis7

Formulation and characterization1

Preparation2

Vitro and in vivo1

20171

Stability3

Formulations4

Inorganic3

Vivo3

Delivery31

Membrane2

Intracellular2

Incorporation4

LNPs2

Biochemical3

Aqueous4

Molecular4

MRNA1

Bioactivity1

Accumulation2

Liposomal1

Water-soluble1

Intranasal2

Development6

Solid2

Polyelectrolyte1

Metabolism3

Pharmaceutical1

Bioavailability1

Adsorption2

Clinical5

Lipophilic drugs1

Solubility1

Hydrophobic1

Mechanism1

Prenatal diagnosis2

Fatty1

Antimicrobial3

Toxic1

Systems1

Molecules1

Structural2