Lipid gene encodes alcohol aldehyde dehydrogenase. Medical search. Frequent questions

These enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. (wikipedia.org)
for example, they provide structural stability to cells and tissues, give motility to individual cells, carry messages within and between cells, and regulate gene expression and metabolism. (biologists.com)
During general alcohol metabolism, hepatocytes generate mitochondria- and cytochrome P450 2E1 (CYP2E1)-mediated reactive oxygen species (ROS) whose accumulation elicits activation of the hepatic anti-oxidant system, including glutathione (GSH). (e-cmh.org)
In addition, we address different responses of alcohol metabolism that are specific to hepatic zones ( Fig. 1 ). (e-cmh.org)
Variation in genes encoding enzymes involved in the metabolism of alcohol dehydrogenase or aldehyde dehydrogenase has been shown to influence the risk of alcohol dependence. (psychscenehub.com)
In recent years, with the development of the next generation sequencing, molecular and genetic analysis methods, lots of genes which are involved in the chlorophyll, carotenoid, cell wall, central and secondary metabolism have been identified and confirmed to regulate pigment contents, fruit softening and other aspects of fruit flavor quality. (biomedcentral.com)
However, given that tomato specialized metabolism is highly complex, in order to identify the novel genes involved in aspects of fruit quality that are associated with these metabolites still requires considerable research effort. (biomedcentral.com)
Here, we focus on the recently obtained knowledge considering structural genes as well as transcriptional and post-translational regulators involved in the metabolic pathways underlying both appearance and internal quality such as those involved in chlorophyll, carotenoid, cell wall, central and secondary metabolism (Table 1 , Figure 1 ). (biomedcentral.com)

Aldehyde dehydrogenase are a superfamily enzymes which catalyze the oxidation of a large variety of aldehydes (Jo et al. (springeropen.com)
We found significant dysregulation of genes encoding drug-metabolizing enzymes and stress response components of the NRF2- mediated oxidative damage pathway, potentially representing key genes in African-American esophageal squamous carcinogenesis. (biomedcentral.com)
Loss of activity of drug metabolizing enzymes would confer increased sensitivity of esophageal cells to xenobiotics, such as alcohol and tobacco smoke, and may account for the high incidence and aggressiveness of ESCC in this ethnic group. (biomedcentral.com)
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. (cancerindex.org)
These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. (cancerindex.org)
Hormetic pathways activated by phytochemicals may involve kinases and transcription factors that induce the expression of genes that encode antioxidant enzymes, protein chaperones, phase-2 enzymes, neurotrophic factors and other cytoprotective proteins. (psychosocialsomatic.com)

Impaired fatty alcohol oxidation in cultured fibroblasts due to deficient fatty alcohol:nicotinamide adenine dinucleotide oxidoreductase activity. (medscape.com)

Whereas, microorganic synthesis of PAA is impeded by the formation of by-product phenethyl alcohol due to quick, endogenous, and superfluous conversion of aldehydes to their corresponding alcohols, which resulted in less conversation of PAA from aldehydes. (springeropen.com)

The protein encoded by this gene is a member of subfamily 7 in the aldehyde dehydrogenase gene family. (wikipedia.org)
The protein encoded by this gene can localize to the cytosol, mitochondria, or nucleus depending on the inclusion of certain localization sequences. (wikipedia.org)
In order for a cell to respond to changes in internal and external environmental factors, a broad range of protein co- and post-translational modifications have evolved to expand upon the relatively static properties encoded in protein side-chains. (biologists.com)
This molecule serves as the template to create a protein that is responsible for the biological effect of the gene. (cheminst.ca)
What does this gene/protein do? (cancerindex.org)
What pathways are this gene/protein implicaed in? (cancerindex.org)

Accumulation of long-chain fatty alcohols and modification of macromolecules by an excess of fatty aldehydes are thought to be the pathophysiologic mechanisms causing the manifestations of Sjögren-Larsson syndrome. (medscape.com)

Aldehyde dehydrogenase 7 family, member A1, also known as ALDH7A1 or antiquitin, is an enzyme that in humans is encoded by the ALDH7A1 gene. (wikipedia.org)
Sjögren-Larsson syndrome (SLS) is diagnosed by demonstrating the enzyme deficiency or by mutation analysis of the FALDH gene. (medscape.com)
Sjögren-Larsson syndrome (SLS) is due to deficient activity of fatty aldehyde dehydrogenase (FALDH), an enzyme required to oxidize fatty alcohol to fatty acid. (medscape.com)
Young males who have experienced a traumatic event can develop low levels of MAO‑A expression (an enzyme that breaks down serotonin), and this decrease in MAO‑A levels correlates with an increase in antisocial behaviour, which is a risk factor for alcohol dependence. (psychscenehub.com)

Deficient activity of the fatty aldehyde dehydrogenase component of fatty alcohol:NAD+ oxidoreductase in cultured fibroblasts. (medscape.com)

The pathogenesis in the early stages of ALD, including alcoholic steatosis, also varies with oxidative stress, alcohol metabolite-mediated toxicity, and activation of diverse inflammatory signals. (e-cmh.org)

Furthermore, antiquitin functions as an aldehyde dehydrogenase for α-AASA in the pipecolic acid pathway of lysine catabolism. (wikipedia.org)
With numerous illustrations and tables, each of the nearly 300 sections of the Guide describes genes involved in a specific pathway, process, or structure from the molecular and cellular levels to developmental and physiological processes. (cshlpress.com)
We establish a microbial biosynthetic pathway for PAA production from the simple substrate phenylalanine in E. coli with heterologous coexpression of aminotransferase (ARO8), keto acid decarboxylase (KDC) and aldehyde dehydrogenase H (AldH) gene. (springeropen.com)
In this study, we establish a microbial biosynthetic pathway for PAA production from the simple substrate phenylalanine through overexpression of an aminotransferase gene ARO8, a keto acid decarboxylase gene KDC from S. cerevisiae and an aldehyde dehydrogenase H gene aldH from E. coli in E. coli (Fig. 1 ). (springeropen.com)
However, chronic alcohol consumption decreases GSH generation through cysteine deficiency by suppressing the methionine cycle and trans-sulfuration system, whereas it turns on an alternative defense pathway, such as the xCT transporter, to compensate for GSH shortage. (e-cmh.org)
The positive reinforcing action of alcohol comes from the activation of the dopaminergic reward pathway in the limbic system . (psychscenehub.com)

In this study, an Escherichia coli K-12 MG1655 strain with reduced aromatic aldehyde reduction (RARE) that does duty for a platform for aromatic aldehyde biosynthesis was used to prompt more PAA biosynthesis. (springeropen.com)
In contrast, Annong1589 showed a passive prevention of the spread of toxins into cells by the upregulation of genes involved in tyramine biosynthesis at the early stage (5 DPA), which may be involved in cell wall strengthening. (biomedcentral.com)

In the online version, these sections contain links to more information about proteins encoded by over 17,000 known or predicted human genes. (cshlpress.com)
It binds and inactivates the 140 kDa subunit of RNA polymerase II, blocking all gene expression leading to proteins. (helmberg.at)

Recent progress over the last two decades in the field of molecular genetics, especially with new tools such as genome-wide association studies, has helped to identify new genes and their variants, which can be used for calculations of risk, prediction of treatment efficacy, or detection of subjects prone to drug side effects. (mdpi.com)
Recent genome-wide association studies, gene expression profiling, DNA methylation and proteomic studies conducted in Japanese and Chinese ESCCs (reviewed in [ 6 ]) have identified multiple risk variants and gene signatures associated with ESCC. (biomedcentral.com)

The biosynthetic gene clusters of these linaridins lack obvious candidate genes for the dehydratase and epimerase required to introduce dehydrobutyrine and D-amino acid residues, respectively. (hokudai.ac.jp)
However, we previously demonstrated that the grisemycin (grm) cluster contained cryptic dehydratase and epimerase genes by heterologous expression of this biosynthetic gene cluster in Streptomyces lividans and proposed that two genes (grmH and grmL) with unknown functions catalyze dehydration and epimerization reactions. (hokudai.ac.jp)

A considerable amount of research has reported that fruit quality is affected by metabolic shifts which are under the coordinated regulation of both structural genes and transcriptional regulators. (biomedcentral.com)

Three transcript variants encoding different isoforms have been found for this gene. (cancerindex.org)

Alcohol dependence is characterised by deficits in the physiological dysregulation of motivation and reward systems , such as those in the limbic system, hippocampus, amygdala, caudate nucleus, frontal lobe and nucleus accumbens. (psychscenehub.com)

Specifically, few Gene Ontology biological processes (BPs) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were modulated after a short (24H) compared to a long (48H) treatment. (nature.com)

This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. (cancerindex.org)

Mutations in this gene are associated with pyridoxine-dependent epilepsy. (wikipedia.org)
Mutations in this gene cause pyridoxine-dependent epilepsy, which involves a combination of various seizure types that do not respond to standard anticonvulsants, but are treatable via administration of pyridoxine hydrochloride. (wikipedia.org)
To date, more than 70 different FALDH gene mutations have been found in patients with Sjögren-Larsson syndrome. (medscape.com)
This syndrome is a result of mutations in the gene that codes for fatty aldehyde dehydrogenase. (medscape.com)
Beyond mutations, the neurologic and other phenotypic characteristics may result from unidentified epigenetic/environmental factors, gene modifiers, or other mechanisms. (medscape.com)

Presenting the genes of the human genome in their biological context, Guide to the Human Genome is an extensive online resource (also available in print) that provides easy access to information about human genes and their roles in specific processes. (cshlpress.com)

To determine whether certain genes are uniquely altered in African-American ESCC we performed a meta-analysis of ESCC expression profiles in our African-American samples and those of several Asian samples. (biomedcentral.com)
Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
Because we showed that integration neither affects the levels of viral genes, nor those of virally disrupted human genes, a genome-wide screen was performed to identify human genes which expression is influenced by viral integration and have clinical relevance. (cancerindex.org)
Samples were taken at three different grain-filling stages (5, 10, and 15 DPA) for gene expression analysis and phenotypic observation. (biomedcentral.com)
Our study demonstrates the complexity of FHB resistance in wheat, with cultivars exhibiting unique and overlapping defense mechanisms, and highlights the importance of considering the temporal and spatial dynamics of gene expression in breeding programs for developing more resistant wheat cultivars. (biomedcentral.com)
The expression of this gene is much more abundant in stomach than liver, thus differing from the other known gene family members. (thermofisher.com)

The dysfunction of these systems is responsible for acute alcohol intoxication, alcohol dependence, and withdrawal syndrome. (psychscenehub.com)

2017 ). Recently, the high quality tomato genome and large scale transcriptomic datasets have significantly accelerated the illumination of the structural genes and transcriptional regulators underlying the formation of high quality fruit (The Tomato Genome Sequencing Consortium 2012 ). (biomedcentral.com)

of a 174-kb plasmid that bears a cluster of genes necessary for the synthesis of the polyketide toxin mycolactone. (cdc.gov)

This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. (thermofisher.com)

Moreover, to mine the other potential genes involved in fruit quality formation, we additionally carried out a weighted gene correlation network analysis of the representative genes of the fruit quality based on previously published high-resolution spatiotemporal transcriptome data for tomato fruit ripening (Shinozaki et al. (biomedcentral.com)

Chronic alcohol consumption induces the development of alcoholic steatosis in the liver, which is one of the most widespread liver diseases worldwide. (e-cmh.org)
In recent years, the tremendous increase in chronic alcohol consumption has become a global health threat. (e-cmh.org)

An additional variant encoding a different isoform has also been found for this gene. (wikipedia.org)
It was found that PAA transformation yield was up to ~94% from phenylalanine in E. coli and there was no by-product phenethyl alcohol was detected. (springeropen.com)

Alcohol alters NMDA and metabotropic MGlu5 receptors thus interfering with glutamate transmission. (psychscenehub.com)

Chronic alcohol intake leads to a broad spectrum of alcoholic liver disease (ALD) such as simple steatosis, steatohepatitis, hepatitis, fibrosis/cirrhosis, and hepatocellular carcinoma [ 2 , 4 ]. (e-cmh.org)
Alcohol dependence, or alcoholism, is a chronic and severe condition that the WHO estimates to affect 140 million individuals globally. (psychscenehub.com)

To resolve this discrepancy, this review summarizes recent advances on glutamate/mGluR5-derived alcoholic steatosis and zone-dependently different responses to alcohol intake. (e-cmh.org)

In contrast, free fatty aldehyde levels are not elevated. (medscape.com)
Alcohol reduces glutamate levels in the nucleus accumbens and suppresses glutamate-mediated signal transmission in the central nucleus of the amygdala. (psychscenehub.com)

The analysis also showed differences in selection patterns of ALDH2 between Hondo and Ryukyu, a gene recognized to be specifically targeted by selection in East Asian. (bvsalud.org)

There is evidence of a link between serotonin deficiency, impulsivity and drinking behaviour which may explain the role of SSRIs in suppressing alcohol reinforced behaviour in some alcohol-dependent patients. (psychscenehub.com)

72), including amino acid substitutions, small and large contiguous gene deletions, insertions, and splicing errors in this gene. (medscape.com)

Anatomy8

Organisms7

Diseases7

Chemicals and Drugs123

Analytical, Diagnostic and Therapeutic Techniques and Equipment12

Psychiatry and Psychology4

Phenomena and Processes33

Disciplines and Occupations1

Technology, Industry, Agriculture3

Information Science3

Health Care2

Metabolism8

Enzymes6

Oxidation1

Conversion of aldehydes1

Protein6

Alcohols1

Enzyme4

Fatty alcohol1

Oxidative1

Pathway6

Biosynthesis2

Proteins2

Genome-wide as2

Biosynthetic2

Metabolic1

Variants1

Dysregulation1

Ontology1

Chromosome1

Mutations5

Biological1

Expression6

Dysfunction1

DataSets1

Synthesis1

Family1

Correlation1

Consumption2

Found2

Receptors1

Chronic2

Intake1

Levels2

Specifically1

Deficiency1

Large1