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AdipocytesLipidsLipid Metabolism3T3-L1 CellsAdipocytes, WhiteLipid AAdipose TissueLipid BilayersLipolysisInsulinLipid PeroxidationGlucose Transporter Type 4Adipogenesis3T3 CellsAdipose Tissue, BrownMonosaccharide Transport ProteinsGlucoseLipid PeroxidesFatty AcidsCell DifferentiationTriglyceridesPPAR gammaAdipose Tissue, WhiteCells, CulturedCell MembraneDeoxyglucosePhospholipidsCholesterolObesityMembrane MicrodomainsBiological TransportInsulin ResistanceLeptinAdiponectinMuscle ProteinsSterol EsteraseRNA, MessengerReceptor, InsulinGene Expression RegulationLipid MobilizationSignal TransductionCarrier ProteinsPhosphatidylcholinesReceptors, Adrenergic, beta-3Lipoprotein LipaseKineticsEpididymisThiazolidinedionesGlycerolInsulin Receptor Substrate ProteinsMice, Inbred C57BLMice, Obese3-O-MethylglucoseGlucose Transporter Type 1Membrane ProteinsLiposomesPhosphorylationRats, Inbred StrainsFatty Acids, NonesterifiedHypoglycemic AgentsDietary FatsPhosphoproteinsIsoproterenolLipaseSubcutaneous FatFatty Acid-Binding ProteinsMethylglucosidesCell LineMitochondrial ProteinsPhenylisopropyladenosineLiverCCAAT-Enhancer-Binding Protein-alphaInsulin AntagonistsAdipokinesGene ExpressionMolecular Sequence DataCystinyl AminopeptidaseTime FactorsMembrane FluidityRats, WistarProtein TransportPhosphatidylinositol 3-KinasesThermogenesisOleic AcidDose-Response Relationship, DrugReverse Transcriptase Polymerase Chain ReactionIon ChannelsChromatography, Thin LayerProteinsRats, Sprague-DawleyBody WeightModels, BiologicalAdrenergic beta-AgonistsEnzyme ActivationBlotting, WesternLipid Metabolism DisordersMice, KnockoutLipogenesisDiet, High-Fat1-Methyl-3-isobutylxanthine
MetabolismDropletsDifferentiationAccumulationAdipose tissueObesityLipolysisMature adipocytesWhite adipocytesSynthesisProteinsInduces adipocyteHomeostasisIncrease of lipidBrown adipocytesMetabolicMediatorsCellsAdiponectinPerilipinPhosphorylationHypertrophyPhysiologyHepatocytesMoleculesTriglyceridesCatabolismUptakeSubcutaneousObeseLipogenesisMiceStromaDysregulationPPARTumor growthRegulatesFatty acidLipoproteinsMitochondrialMechanismsEnzymesTherapeutic
Metabolism23
Droplets14
  • DGAT enzymes are required for triacylglycerol synthesis and lipid droplets in adipocytes. (bvsalud.org)
  • The perilipins are a family of proteins that associate with the surface of lipid droplets. (wikipedia.org)
  • The yeast Saccharomyces cerevisiae expresses PLN1 (formerly PET10), that stabilizes lipid droplets and aids in their assembly. (wikipedia.org)
  • Perilipin is a protein that coats lipid droplets (LDs) in adipocytes, the fat-storing cells in adipose tissue. (wikipedia.org)
  • MIGA2 Links Mitochondria, the ER, and Lipid Droplets and Promotes De Novo Lipogenesis in Adipocytes. (ox.ac.uk)
  • Lipid droplets (LDs) are dynamic organelles specialized in lipid storage that interact physically with mitochondria in several cell types. (ox.ac.uk)
  • Lancemaside A and aglycon significantly reduced in lipid droplets, TG and FFA in a concentration-dependent manner. (thieme-connect.com)
  • Brown adipocytes are smaller than white adipocytes and contain multitudes of small (multilocular) lipid droplets. (news-medical.net)
  • RAB18 binds to NS5A to improve the interaction between sites of viral replication and lipid droplets [ 20 ]. (hindawi.com)
  • Lipid droplets, or LDs, are key lipid storage structures in cells. (asbmb.org)
  • Andrew Greenberg and colleagues identified perilipin as a major protein associated with lipid droplets. (asbmb.org)
  • Perilipin (stained red) binds to the surface of lipid droplets (green) and functions as a dynamic scaffolding protein that controls entry and exit of lipids from the droplets. (asbmb.org)
  • In immunocytochemical studies in differentiated adipocytes, we saw anti-perilipin immunoreactivity in well-defined ringlike patterns around both large and small intracellular lipid droplets. (asbmb.org)
  • Most adipocytes store lipid droplets, little reservoirs of fat. (ucsf.edu)
Differentiation7
  • Risperidone promotes adipocyte differentiation and lipid accumulation through Oil Red O staining and reverse transcription-polymerase chain reaction (RT-PCR). (frontiersin.org)
  • It is also related to increased adiponectin (APN) expression associated with adipocyte differentiation, as well as the expression of adipogenic genes such as peroxisome proliferator-activated receptor ( PPAR) ( 22 , 23 ). (frontiersin.org)
  • Hypoxia blocks the differentiation of adipocytes but increases the accumulation of lipids by these cells. (atlasofscience.org)
  • Results DIM, but not I3C, increased adipocyte differentiation through upregulation of peroxisome proliferator‐activated receptor γ and CCAAT/enhancer‐binding protein α. (researchgate.net)
  • AIMS/HYPOTHESIS: The thiazolidinedione (TZD) rosiglitazone is a peroxisome proliferator-activated receptor-gamma agonist that induces adipocyte differentiation and, hence, lipid accumulation. (maastrichtuniversity.nl)
  • Transfection of miR-126-3p and miR-199a-3p enhanced lipid accumulation in 3T3-L1 cells after adipocyte differentiation. (shimane-u.ac.jp)
  • Here, we report that adipocytes from tumor-invasive mammary fat undergo de-differentiation to fibroblast-like precursor cells during tumor progression and integrate into the tumor microenvironment. (usda.gov)
Accumulation14
  • Risperidone increases adipocyte lipid accumulation by plausibly inhibiting long-chain fatty acid β-oxidation through targeting MAPK14 and MAPK8. (frontiersin.org)
  • Interestingly, some studies have linked risperidone-induced weight gain with lipolysis and considered that risperidone increases lipid accumulation by altering lipolysis ( 25 ). (frontiersin.org)
  • A) In normoxia conditions, adipocytes differentiate with an increase of PPARγ2 expression and increase of lipid accumulation (B) In hypoxic conditions (mimetic), adipocytes do not express PPARγ2 but with increased lipid accumulation. (atlasofscience.org)
  • Hypoxia mimetic induces lipid accumulation through mitochondrial dysfunction and stimulates autophagy in murine preadipocyte cell line. (atlasofscience.org)
  • If the capacity of the adipocyte to store lipids is exceeded, it can no longer regulate the release of FFAs into the circulation, which ultimately leads to the abnormal accumulation of lipid in nonadipose depots. (jci.org)
  • In this study, we investigated the role of miR-126-3p and miR-199a-3p on lipid accumulation in 3T3-L1 adipocytes. (shimane-u.ac.jp)
  • In the first one, local adipose tissue hypoxia could induce fibrosis accumulation which in turn through adipocyte dysfunctions might provoke adipose tissue inflammation. (springer.com)
  • the effects of hypoxia and fibrosis may also play a role in obesity complications via notably ectopic-lipid accumulation in non-adipocyte cells. (springer.com)
  • Indeed, WAT remodeling eventually associated with a limited capacity to adequately expand might induce lipid spill over and this triglyceride accumulation in other depots such as liver or muscle. (springer.com)
  • However, lipid accumulation in non-specialized cells is deleterious and can contribute to cell death resulting in the development of pathology such as NASH (Non-Alcoholic Steatohepatitis) a liver injury associated with obesity [ 12 ]. (springer.com)
  • A new study finds that adipocyte SLC7A10 impairments may impact lipid accumulation during insulin resistance in patients with obesity. (medscape.com)
  • His master's research was focused on obesity checking the effect of flavonoids on the lipid accumulation in adipocytes. (routledge.com)
  • Finally, they revealed that the novel chromatin domains repress genes involved in lipid accumulation in preadipocytes. (u-tokyo.ac.jp)
  • Pathway defects in lipoprotein synthesis, processing, and clearance can lead to accumulation of atherogenic lipids in plasma and endothelium. (msdmanuals.com)
Adipose tissue5
Obesity8
  • Obesity can be viewed as a state of long-term lipid disequilibrium that is marked by massive adipocyte hypertrophy and is a major risk factor for developing insulin resistance and type 2 diabetes. (jci.org)
  • A recent example of the importance of adipocyte function to have profound systemic effects is provided by the report that mice specifically lacking insulin signaling in adipocytes (FIRKO mouse) are not only lean, leptin sensitive, and obesity resistant ( 1 ), but live almost 20% longer than wild-type control animals ( 2 ). (diabetesjournals.org)
  • Our results highlight the crucial role of ETP as an obesity-associated factor that promotes tumor growth in the context of adipocyte interactions with tumor and stromal cells. (jci.org)
  • RAB18 was associated with lipogenesis, lipolysis, and obesity in adipocytes [ 22 ]. (hindawi.com)
  • Hyperplasia (many small adipocytes) in both adipose regions may be protective against lipid as well as glucose/insulin abnormalities in obesity. (nih.gov)
  • Fatty tissues in our bodies contain these immature preadipocytes and the mature adipocytes they become, both of which play key roles in the development of metabolic syndrome accompanied by obesity. (u-tokyo.ac.jp)
  • But since p75NTR is found on many cell types, and especially has a role for neurons, the researchers wanted to show that its activity specifically in adipocytes accounted for the development of obesity, that it's not causing a nervous system change or hormonal change in another organ. (ucsf.edu)
  • The UCSF/UCSD team deleted p75NTR in just the mice adipocytes and saw the same effect: no obesity, no insulin resistance. (ucsf.edu)
Lipolysis5
  • The regulation of lipolysis in adipocytes involves coordinated actions of many lipid droplet (LD)-associated proteins such as perilipin, hormone sensitive lipase (HSL), adipose triglyceride lipase (ATGL), and its activator protein, CGI-58. (indexindex.com)
  • Here, we describe the cellular origin and physiological significance of micro LDs (mLDs) that emerge in the cytoplasm during active lipolysis, as well as the roles of key lipolytic proteins on mLDs in differentiated 3T3-L1 adipocytes. (indexindex.com)
  • In humans, Perilipin A is the most abundant protein associated with the adipocyte LDs and lower PLIN1 expression is related with higher rates of lipolysis. (wikipedia.org)
  • Phosphorylated perilipin changes conformation, exposing the stored lipids to hormone-sensitive lipase-mediated lipolysis. (wikipedia.org)
  • Effects of lipoic acid on lipolysis in 3T3-L1 adipocytes. (rndsystems.com)
Mature adipocytes6
  • We tested whether the action of rosiglitazone involves specific effects on mature adipocytes, which are different from those on preadipocytes. (maastrichtuniversity.nl)
  • RESULTS: Rosiglitazone does not induce an increase, but rather a decrease in the lipid content of mature adipocytes. (maastrichtuniversity.nl)
  • CONCLUSIONS/INTERPRETATION: Our findings suggest that the change of adiposity as seen in vivo reflects a shift in balance between the different effects of TZDs on preadipocytes and on mature adipocytes, while the changes in circulating adipokine levels primarily result from an effect on mature adipocytes. (maastrichtuniversity.nl)
  • We generated transgenic (TG) C57BL/6 mice expressing the Ptgs2 gene encoding cyclooxygenase-2 (COX-2) in mature adipocytes. (dtu.dk)
  • When one overeats, excess energy is stored as lipids as adipocytes are enlarged and preadipocytes are differentiated into mature adipocytes. (u-tokyo.ac.jp)
  • Specifically, we are interested in the very early changes in insulin signaling and glucose transport in mature adipocytes in relation to cell size, to unravel the cause and consequence behind adipocyte dysfunction. (lu.se)
White adipocytes6
  • Here, we report the development of a novel OoC that integrates functional mature human white adipocytes. (nature.com)
  • The platform's capability to maintain long-term viability and functionality of white adipocytes was confirmed by real-time monitoring of fatty acid uptake, by quantification of metabolite release into the effluent media as well as by an intact responsiveness to a therapeutic compound. (nature.com)
  • Endocrine functions of white adipocytes, and other WAT-resident cells in the stromal vascular fraction, are performed by the release of a variety of adipokines (adipose-associated cytokines) which affect the functioning of the brain, liver, pancreas and immune system 9 . (nature.com)
  • In fact, PLIN1 is greatly expressed in white adipocytes. (wikipedia.org)
  • The major microscopic constituent of white adipocytes is triglycerides, which are stored in a large, single (unilocular) droplet. (news-medical.net)
  • In addition, white adipocytes provide insulation and contribute to endocrine function as they secrete hormones. (news-medical.net)
Synthesis10
  • In this study, we examined the requirement for DGAT enzymes in TG synthesis and LDs in differentiated adipocytes with genetic deletions of DGAT1 and DGAT2. (bvsalud.org)
  • Adipocytes with a single deletion of either enzyme were capable of TG synthesis and LD formation. (bvsalud.org)
  • In contrast, adipocytes with deletions of both DGATs were severely lacking in TG and did not have LDs, indicating that DGAT1 and DGAT2 account for nearly all TG synthesis in adipocytes and appear to be required for LD formation during adipogenesis . (bvsalud.org)
  • Our findings show that DGAT1 and DGAT2 account for the vast majority of TG synthesis in mice , and DGAT function is required for LDs in adipocytes , but not in all cell types. (bvsalud.org)
  • We find that in adipocytes MIGA2 is involved in promoting triglyceride (TAG) synthesis from non-lipid precursors. (ox.ac.uk)
  • ASP increases the efficiency of triacylglycerol synthesis in adipocytes leading to enhanced postprandial lipid clearance. (diabetesjournals.org)
  • Effect of halofenate and clofibrate on lipid synthesis in rat adipocytes. (nih.gov)
  • Because levels of transcription factor CCAAT/enhancer binding protein-β, peroxisome proliferator-activated receptor-γ, and lipoprotein lipase are also increased, lipid transport into cells and fatty acid synthesis within cells is increased ( 8 - 15 ). (cdc.gov)
  • Thus, citric acid cycle intermedi- ates are not used for adenosine triphosphate (ATP) production and are shuttled out of the mitochondria, providing precursors for nucleotide, amino acid, and lipid synthesis path- ways for the dividing cell [13]. (who.int)
  • [ 9 ] Additionally, CLA purportedly reduces fatty acid synthesis in adipocytes, suggesting that this supplement decreases fat deposition, directly contributing to an improvement in body composition in adults and children. (medscape.com)
Proteins7
  • Regulation of mLDs and LD-associated proteins may be an attractive therapeutic target against lipid-associated metabolic diseases. (indexindex.com)
  • These actions are mediated by both the actions of a number of nonsecreted proteins and hormones produced in adipocytes. (diabetesjournals.org)
  • Adipocyte-derived factors involved in tumor progression include proteins such as adiponectin, leptin, TNF-α, monocyte chemotactic protein-1 (MCP-1), IL-6, and ECM components that control tumor cell behavior within the tumor microenvironment. (jci.org)
  • However, LDs are well-organized organelles surrounded by proteins that act as gatekeepers that tightly control lipid entry and exit. (asbmb.org)
  • More than 95% of all radiolabeled phosphate that was incorporated into cellular proteins after the PKA stimulation went into PLIN1, making it the predominant PKA substrate in adipocytes. (asbmb.org)
  • PLIN1 mainly acts as a dynamic scaffold for proteins involved in the storage and hydrolysis of neutral lipids in LDs. (asbmb.org)
  • Hydration of Lipid-binding Proteins by ten anti-parallel b-strands. (lu.se)
Induces adipocyte1
  • Collectively, the metabolic interplay between tumor cells and adipocytes induces adipocyte mesenchymal transition and contributes to reconfigure the stroma into a more tumor-friendly microenvironment. (usda.gov)
Homeostasis4
  • The adipocyte is the major site of fatty acid storage in the body and plays a critical role in maintaining normal glucose and lipid homeostasis. (jci.org)
  • Based on its presence in many tissues, MIGA2 is likely critical for lipid and energy homeostasis in a wide spectrum of cell types. (ox.ac.uk)
  • The impact of high fat palatable food and dietary lipids on endocannabinoid formation is reviewed in its pathogenetic potential for the derangement of feeding homeostasis. (frontiersin.org)
  • Invited talks will feature a broad range of topics including membrane biogenesis, protein sorting to organelles, metabolic regulation of organelle biogenesis, autophagy, protein and organelle quality control, lipid homeostasis, interorganelle contact sites, host-pathogen interactions, and the mechanism of organelle fission and fusion. (grc.org)
Increase of lipid1
  • Absence of an adipogenic effect of rosiglitazone on mature 3T3-L1 adipocytes: increase of lipid catabolism and reduction of adipokine expression. (maastrichtuniversity.nl)
Brown adipocytes4
Metabolic2
  • Thus, the repertoire is different fatty acids in adipocytes and in the blood of an individual, unique and adapted to the current metabolic state. (ukaachen.de)
  • In morbidly obese women region-specific variations in mean adipocyte size are associated with metabolic complications but not systemic or adipose inflammation. (nih.gov)
Mediators3
  • Thus, the role of midbrain dopamine is positioned at the intersection between selected hormonal signals involved in food reward information processing (namely, leptin, ghrelin, and insulin), and lipid-derived neural mediators such as endocannabinoids. (frontiersin.org)
  • The changes in iWAT were accompanied by increased levels of specific COX-derived lipid mediators and increased mRNA levels of interleukin-33, interleukin-4 and arginase-1, but not increased expression of uncoupling protein 1 or increased energy expenditure. (dtu.dk)
  • Our findings suggest a role for COX-2-derived lipid mediators from adipocytes in mediating type 2 immunity cues in subcutaneous WAT associated with decreased hepatic steatosis, but with no accompanying induction of browning and increased energy expenditure. (dtu.dk)
Cells15
  • Lipids keeps shrinking with aging and neurodegeneration I remember when my Biology teacher at the secondary school introduced us for the first time to the biochemical components of the living cells. (atlasofscience.org)
  • Mesenchymal stem/stromal cells (MSC) are the ideal source to study fat formation as they are the progenitors of adipocytes. (mdpi.com)
  • The local tumour microenvironment is the milieu within which the tumour develops, and includes tumour blood vessels, other cells types (e.g. immune cells, fibroblasts, adipocytes), soluble growth factors and signalling molecules. (otago.ac.nz)
  • We are culturing human fat cells (adipocytes) and tumour cells together, to find out how adipocytes alter tumour cell phenotype and response to therapy. (otago.ac.nz)
  • Single-cell sequencing reveals that these de-differentiated adipocytes lose their original identities and transform into multiple cell types, including myofibroblast- and macrophage-like cells, with their characteristic features involved in immune response, inflammation, and extracellular matrix remodeling. (usda.gov)
  • Can directly enter adjacent cells (adipocytes), transport into blood via albumin. (flashcardmachine.com)
  • Large fat cells in the visceral region are linked to dyslipidaemia, whereas large subcutaneous adipocytes are important for glucose and insulin abnormalities. (nih.gov)
  • A University of Tokyo research group has revealed that novel chromatin domains repress the action of genes involved in fat storage by analyzing the epigenome, the information contained in chemical changes to the genome, in a type of immature cell (preadipocytes) that will later differentiate into mature fat cells (adipocytes). (u-tokyo.ac.jp)
  • TNF-α is produced, by cells of the immune system and by adipocytes. (lww.com)
  • Your fat consists of fat cells, which biologists call adipocytes. (ucsf.edu)
  • Adipocytes do lots of things that all cells do and some things that only adipocytes do. (ucsf.edu)
  • According to the paper by lead author Dr. Bernat Baeza-Raja, from Dr. Katerina Akassoglou's lab at the Gladstone Institutes, and published in the January 12th edition of Cell Reports, removing one gene, a specific receptor found on the surface of adipocytes (as well as other cells), prevents these mice from becoming obese when fed a high-fat diet. (ucsf.edu)
  • Triglycerides primarily store energy in adipocytes and muscle cells. (msdmanuals.com)
  • The plaques contain lipids, inflammatory cells, smooth muscle. (msdmanuals.com)
  • In the capillaries of adipose and muscle tissue, apoprotein C-II (apo C-II) on the chylomicron activates endothelial lipoprotein lipase (LPL) to convert 90% of chylomicron triglyceride to fatty acids and glycerol, which are taken up by adipocytes and muscle cells for energy use or storage. (msdmanuals.com)
Adiponectin2
  • This review will address the biology, actions, and regulation of three adipocyte hormones-leptin, acylation stimulating protein (ASP), and adiponectin-with an emphasis on the most recent literature. (diabetesjournals.org)
  • Work in our laboratory has primarily focused on the biology and regulation of three key adipocyte hormones: leptin, acylation-stimulating protein, and adiponectin. (diabetesjournals.org)
Perilipin3
  • and a 4-helix bundle before the C-terminal carbon In Perilipin A, lipophile nature is conferred by the slightly hydrophobic amino acids concentrated in the central 25% of the sequence, region that anchors the protein to the core of the lipid droplet. (wikipedia.org)
  • Then, Phosphorylated HSL translocates to the LD surface and associates with Perilipin A and Adipocyte fatty acid-binding protein (AFABP). (wikipedia.org)
  • Hansen JS, de Maré S, Jones HA, Göransson O and Lindkvist-Petersson K. Visualization of lipid directed dynamics of perilipin 1 in human primary adipocytes. (lu.se)
Phosphorylation1
  • To home in on the phosphorylation/dephosphorylation mechanisms, we loaded rat adipocytes with phosphorus-32-labeled inorganic phosphate and incubated them with varying concentrations of the beta-adrenoreceptor agonist isoproterenol in the absence and presence of insulin. (asbmb.org)
Hypertrophy1
  • Classically the fat mass expansion results with an increase in the volume (hypertrophy) and the number (hyperplasia) of adipocytes [ 5 , 6 ]. (springer.com)
Physiology3
  • However, the impact of hypoxia on adipocyte physiology is not fully understood. (atlasofscience.org)
  • Effects of normoxia (A) and hypoxia mimetic (B) in the physiology of adipocyte. (atlasofscience.org)
  • Although further studies are needed for a better understanding of the effect of hypoxia in adipocyte physiology, these results highlight the importance of hypoxia in adipocyte function and provides a possible explanation for hypoxic lipogenesis. (atlasofscience.org)
Hepatocytes1
  • Furthermore, we have also performed in vitro cell (human hepatocytes and adipocytes) and in vivo (intravenous and subcutaneous administration) studies studies measuring both LNP uptake and the concurrent protein expression with the ambition to correlate LNP stucture to their biological function. (lu.se)
Molecules2
  • One might think that they simply result from lipid molecules separating out within the aqueous intracellular environment. (asbmb.org)
  • Imagine: a pill full of molecules, each one a lean, sexy adipocyte fitness trainer. (ucsf.edu)
Triglycerides1
Catabolism1
Uptake5
  • TZDs markedly stimulate the uptake of oxidized LDL (oxLDL) into adipocytes, and this requires OLR1. (jci.org)
  • Increased OLR1 expression, resulting either from TZD treatment or adenoviral gene delivery, significantly augments adipocyte cholesterol content and enhances fatty acid uptake. (jci.org)
  • This study aimed to determine whether I3C or DIM could increase glucose uptake via enhanced insulin sensitivity in 3T3‐L1 adipocytes, as well as the mechanism involved. (researchgate.net)
  • DIM also enhanced glucose uptake by increasing expression of glucose transporter 4 in adipocytes. (researchgate.net)
  • 3,3′-diindolylmethane (DIM)-a natural compound produced from indole-3-carbinol, found in cruciferous vegetables-enhances glucose uptake by increasing the activation of the insulin signaling pathway in 3T3-L1 adipocytes. (researchgate.net)
Subcutaneous2
  • Visceral, but not subcutaneous, adipocyte size was significantly associated with plasma apolipoprotein B, total cholesterol, LDL-cholesterol and triacylglycerols (p ranging from 0.002 to 0.015, partial r ranging from 0.3 to 0.4). (nih.gov)
  • Subcutaneous, but not visceral, adipocyte size was significantly associated with plasma insulin and glucose, insulin-induced glucose disposal and insulin sensitivity (p ranging from 0.002 to 0.005, partial r ranging from -0.34 to 0.35). (nih.gov)
Obese3
  • We are also studying tumour samples from normal weight and obese breast cancer patients to better understand the role adipocytes play in promoting aggressive tumour growth and spread, and identify patients likely to benefit from additional treatment during cancer therapy. (otago.ac.nz)
  • We examined the effects of Lancemaside A and aglycon, its acid hydrolysis product from Lancemaside A, isolated from Codonopsis lanceolata water extract on triglyceride and free fatty acid in primary cultured adipocytes from obese rats fed high calorie high fat diet. (thieme-connect.com)
  • Beyond its role in neurons, they saw that p75NTR is found on many cell types, including adipocytes, where a high-fat diet actually triggers the production of more p75NTR in obese mice. (ucsf.edu)
Lipogenesis1
  • Our data indicate that MIGA2 links reactions of de novo lipogenesis in mitochondria to TAG production in the ER, thereby facilitating efficient lipid storage in LDs. (ox.ac.uk)
Mice1
  • Recently, scientists at UCSF and UCSD have discovered a little trick with adipocytes in mice. (ucsf.edu)
Stroma1
  • Hence, the adipocyte, as a major constituent of the mammary tumor stroma ( 3 ), is a likely contributor to tumor growth. (jci.org)
Dysregulation1
  • These data suggest that Lancemaside A and aglycon were active compounds of Codonopsis lanceolata , and these samples improves lipid dysregulation. (thieme-connect.com)
PPAR2
  • Here we report that antidiabetic thiazolidinediones (TZDs) and other ligands for the nuclear receptor PPARγ dramatically upregulate oxidized LDL receptor 1 (OLR1) in adipocytes by facilitating the exchange of coactivators for corepressors on the OLR1 gene in cultured mouse adipocytes. (jci.org)
  • These data identify OLR1 as a novel PPARγ target gene in adipocytes. (jci.org)
Tumor growth2
  • Adipocytes represent a major cell type in the mammary tumor microenvironment and are important for tumor growth. (jci.org)
  • In contrast, promoting lipid-storage capacity in adipocytes through MitoNEET overexpression curbs tumor growth despite greater adiposity. (usda.gov)
Regulates1
  • RAB18 regulates membrane trafficking in organelles and transport vesicles, leading to a reduction in mature LDs and lipid storage [ 19 ]. (hindawi.com)
Fatty acid2
Lipoproteins1
Mitochondrial2
  • These results together suggest that hypoxia effects on adipocyte function occur through mitochondrial dysfunction and reactive oxygen species production. (atlasofscience.org)
  • Here, we discover in adipocytes that the outer mitochondrial membrane protein MIGA2 links mitochondria to LDs. (ox.ac.uk)
Mechanisms1
  • Overall, my research is focused on exploring the molecular mechanisms regulating adipocyte function, both normal and in the insulin-resistant state, using experimental cell biology methods and sophisticated microscopy techniques at a single cell level. (lu.se)
Enzymes2
  • Similarly, whether DGAT enzymes are required for lipid droplet (LD) formation is unknown. (bvsalud.org)
  • 1. Cholecystokinin: releases bile/pancreatic enzymes on gallbladder in presence of lipids. (flashcardmachine.com)
Therapeutic1
  • This has fuelled the therapeutic interest in the transformation of energy-storing into energy-dissipating adipocytes. (news-medical.net)