If the score of only one lineage is higher than 2, the acute leukemia could be acute myeloid leukemia (AML) or acute lymphoblastic leukemia (ALL). (wikipedia.org)
Objectives: This quasi-experimental study examined the efficacy of targeted exercise training on gross motor performance and neuromuscular impairments in survivors of childhood acute lymphoblastic leukemia (ALL CCS). (bvsalud.org)
Ambiguous lineage2
These cases are characterized as acute leukemias of ambiguous lineage (ALAL). (medscape.com)
Acute leukemias of ambiguous lineage, not otherwise specified (ALAL-NOS) is a rare type of acute leukemia. (biomedcentral.com)
Leukaemia4
Biphenotypic acute leukaemia (BAL) is an uncommon type of leukemia which arises in multipotent progenitor cells which have the ability to differentiate into both myeloid and lymphoid lineages. (wikipedia.org)
About 5% of acute leukaemia cases are BAL. (wikipedia.org)
Acute biphenotypic leukaemia: immunophenotypic and cytogenetic analysis. (atlasgeneticsoncology.org)
Furthermore, I took part in the characterization of a mouse model with biphenotypic leukaemia and transdifferentiation mechanisms. (ox.ac.uk)
Myeloid leukemias1
This mechanism also applies to hematopoietic cells transformed by other HOX genes, including CDX2, which is highly expressed in a majority of acute myeloid leukemias, thus providing a molecular approach based on GSK-3 inhibitory strategies to target HOX-associated transcription in a broad spectrum of leukemias. (stanford.edu)
Lymphoid3
The cells could display both myeloid lineage and lymphoid or undifferentiated morphology. (wikipedia.org)
According to the original EGIL scoring system BAL is defined when scores are over two points for both myeloid and T- or B- lymphoid lineages. (wikipedia.org)
Subclassification of lymphoid neoplasms is often based on the presumed cell of origin based on T and B progenitor gene expression and the effect of cell lineage on influencing functional characteristics such as aggression and self-renewal capacity is largely unknown, accounted for in part, by lack of experimental models to address these questions. (refine.bio)
Phenotype2
Mixed phenotype acute leukemia (MPAL) with t(9;22)(q34;q11.2) (or BCR-ABL1 rearrangement) is also rare, accounting for less than 1% of acute leukemias. (medscape.com)
in one case, the phenotype was described: it was a case of biphenotypic acute leukemia (BAL), a B-ALL expressing CD13 (Hanson et al. (atlasgeneticsoncology.org)
Malignant2
In addition to these basic issues concerning leukemia pathogenesis, we are devising new diagnostic procedures for detecting and monitoring leukemia patients based on molecular genetic abnormalities in the malignant cells. (stanford.edu)
and (2) those in which the malignant (blast) clone coexpresses lineage-specific markers (formerly known as biphenotypic acute leukemias). (medscape.com)
Differentiation2
Our research focuses on developmental pathways that regulate hematopoietic cell growth and differentiation and are disrupted in the course of neoplastic transformation, particularly in leukemias and lymphomas. (stanford.edu)
Acute leukaemias arise through the sequential acquisition of mutations that lead to pre-leukaemic clonal expansion, followed by leukaemic transformation of lineage-restricted progenitors through their acquisition of ectopic self-renewal and impaired terminal differentiation. (ox.ac.uk)
MPAL3
however, the 2016 WHO criteria for lineage assessment in MPAL are presented in Table 1. (medscape.com)
The 2016 WHO update also emphasizes that for bilineal MPAL, it is more important that each individual blast population would meet the criteria for B, T, or myeloid leukemia, than that the specific markers below be present. (medscape.com)
This diagnosis should not be made in patients with known chronic myeloid leukemia (CML) who progress to the blast phase with features of MPAL. (medscape.com)
Classification1
Before 2008, the diagnosis of BAL was based on a score system proposed by the European Group for the Immunological Classification of Leukemias (EGIL) which could differentiate from other kinds of acute leukemia. (wikipedia.org)
If the patient has leukemia, the morphology and immunophenotype check is needed to make sure the type of leukemia. (wikipedia.org)
Transplantation1
Our work has utilized syngeneic strain zebrafish, limiting dilution cell transplantation, and the widely reported rag2-Myc transgenic model to provide new understanding of how strain differences can underlie leukemia onset in the zebrafish model. (refine.bio)
Lymphoma2
and myeloid cells are seen in stem cell leukemia/lymphoma (SCLL), which is also known as 8p11 myeloproliferative syndrome (EMS). (medscape.com)
Stem cell leukemia/lymphoma (SCLL), which is also known as the 8p11 myeloproliferative syndrome (EMS), is characterized in its typical form by the occurrence, either simultaneously or sequentially, of a bcr/abl-negative myeloproliferative disorder and a lymphoma, usually a precursor T-cell lymphoblastic lymphoma. (medscape.com)
Stem cell4
We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. (stanford.edu)
Even more importantly, our work now for the first time, has allowed assessment of cell lineage on dictating aggression and leukemia stem cell frequency independent of the underlying oncogenic driver. (refine.bio)
Furthermore, analysis of our biphenotypic B/T-ALL suggests that B cell pathways lock cells in less aggressive and lower stem cell fates and are dominant in regulating these processes when T cell pathways are co-regulated within ALL cells. (refine.bio)
The secondary objectives are to evaluate the relapse-free and overall survival after hematopoietic stem cell transplant as well as to evaluate the incidence of acute and chronic graft-versus-host disease after this preparative regimen. (mycancergenome.org)
Aggressive2
The rearrangement of MLL are related with different kinds of aggressive acute leukemias. (wikipedia.org)
In total, our work uncoveres that T-ALLs are more aggressive and have higher numbers of leukemia stem cells when compared with B-ALL and mixed phenotypic ALL. (refine.bio)
Abnormalities1
Most of biphenotypic leukemia in children is due to the rearrangement of MLL Besides them, other gene abnormalities has been reported. (wikipedia.org)
Disease2
3) We are defining the properties of cancer stem cells that initiate and sustain the unique disease features of acute leukemias through the use of various adoptive animal models. (stanford.edu)
Acute undifferentiated leukemia (AUL) is extremely rare, and little is known about the frequency of this disease. (medscape.com)
Markers1
[ 4 ] Cases of acute leukemia that may be classified in another category based on genetic or clinical features are also excluded (eg, AML with translocation t(8;21) and expression of multiple B-cell markers). (medscape.com)
Subset2
Acute leukemias induced by MLL chimeric oncoproteins are among the subset of cancers distinguished by a paradoxical dependence on GSK-3 kinase activity for sustained proliferation. (stanford.edu)
However, in a small subset of patients who present with acute leukemia, a specific lineage cannot be assigned. (medscape.com)
As with chronic myelogenous leukemia (CML) , the myeloproliferative aspect of SCLL has a chronic phase that transforms into a myeloblastic phase, typically within 1 year of diagnosis. (medscape.com)
Gene1
The hybrid gene product ABL/BCR is an oncogene which could lead several types of leukemia including BAL. (wikipedia.org)
Patients1
Findings consistent with chronic myelomonocytic leukemia have been noted in at least several patients. (medscape.com)
Cells2
Persistent fever, infection prolonged healing: Most of the white blood cells are leukemia cells, no normal function, leading to decreased immunity, susceptible to infection. (wikipedia.org)
In my project I would like to investigate the role of haematopoietic stem cells (HSCs) bias in the development of MLL-induced acute leukaemias during ageing. (ox.ac.uk)
Origin1
Uncovering a new cellular origin for acute myeloid leukemia with lineage plasticity. (ox.ac.uk)
Types1
BAL has similar symptoms to other types of leukemia, but they are usually more serious. (wikipedia.org)
Cell2
Myeloid leukemia with transdifferentiation plasticity developing from T-cell progenitors. (ox.ac.uk)
Chronic lymphocytic leukemia ( CLL ) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell ). (wikipedia.org)