• piperidine
  • The X-ray crystallographic structures of trans-[PtCl2(4-picoline)(piperidine)] and trans-[PtCl2(4-picoline)(piperazine)]center dot HCl revealed that the piperidine and piperazine ligands bind to the platinum through the equatorial position and that the ligands adopt the chair conformation. (ibp.cz)
  • Hence, to expand the database correlating structural features of platinum compounds and DNA distortions induced by these compounds, which may facilitate identification of more effective anticancer platinum drugs, we describe the DNA binding mode in a cell-free medium of trans-[PtCl2(4-picoline)(piperidine)] and trans-[PtCl2(4-picoline)(piperazine)]center dot HCl. (ibp.cz)
  • affinity
  • The glutamic acid residue introduces a negative charge on the side of the supposed binding pocket of BAZ1A which reduces its affinity for acetylated histone ligands . (proteopedia.org)
  • complexes
  • The synthesis, spectroscopic characterization and crystal structures of the first 1,4-bis(4-nitrosophenyl)piperazine (BNPP) (4) bridged dinuclear complexes of rhodium(III) and iridium(III) are presented. (uni-muenchen.de)
  • The main difference in the structure of the complexes is related with the diazocyclic units of the ligands: piperazine, homopiperazine, hexahydropyrimidine or hexahydropyrimidin-5-ol. (sbq.org.br)
  • Details are presented in the Article Iron Complexes Containing Electrochemically Active Diazocycle-bis(di- tert -butyl-phenol) Ligands by Lu sa L. Mendes, Christiane Fernandes, Roberto W. Franco, Leonardo M. Lube, Sheng-Hsuan Wei, Joseph H. Reibenspies, Donald J. Darensbourg and Adolfo Horn Jr . on page 1050. (sbq.org.br)
  • trans-Diaminedicholoroplatinum(II) complexes with one planar and one non-planar heterocyclic amine ligand were designed as new potential antitumor drugs. (ibp.cz)
  • hydrophobic
  • A method for the removal of a substance carrying a negative charge and being present in an aqueous liquid (I). The method comprises the steps of: (i) contacting the liquid with a matrix carrying a plurality of ligands comprising a positively charged structure and a hydrophobic structure, and (ii) desorbing. (google.com)
  • atoms
  • The nonplatinated amine of the piperazine can form hydrogen bonds with atoms that are approximately 7.5 angstrom away from the Pt binding site. (ibp.cz)
  • bound
  • Both have a conserved asparagine "anchor" residue which in functional bromodomains, hydrogen bonds with the carbonyl group of a bound acetyl-lysine ligand and it is crucial for the interaction. (proteopedia.org)
  • It features a piperazine ring with a benzhydryl (diphenylmethyl) group bound to one of the nitrogens. (wikipedia.org)
  • groups
  • The bridging BNPP ligand is σ-N coordinated by both nitroso groups and shows different conformations of the piperazine ring depending on the solvent used for crystallization. (uni-muenchen.de)
  • The results of the present work support the view that replacement of both ammine groups of transplatin by heterocyclic ligands enhances cytotoxicity probably due to the marked enhancement of the stability of intrastrand cross-links in double-helical DNA. (ibp.cz)
  • known
  • It has known use in pharmacetuticals in lieu of piperazine, for example: Fasudil Bunazosin Homochlorcyclizine Homopipramol Musker, W. Kenneth (1992). (wikipedia.org)
  • change
  • Interestingly, the overall impact of the replacement of the second ammine group in transplatin by the heterocyclic ligands appears to change the character of the global conformational changes induced in DNA towards that induced by cisplatin. (ibp.cz)
  • The macrocyclic ligand does dissociate in the course of this dramatic change in formal oxidation state of the metal. (wikipedia.org)