• piperidine
  • The X-ray crystallographic structures of trans-[PtCl2(4-picoline)(piperidine)] and trans-[PtCl2(4-picoline)(piperazine)]center dot HCl revealed that the piperidine and piperazine ligands bind to the platinum through the equatorial position and that the ligands adopt the chair conformation. (ibp.cz)
  • Hence, to expand the database correlating structural features of platinum compounds and DNA distortions induced by these compounds, which may facilitate identification of more effective anticancer platinum drugs, we describe the DNA binding mode in a cell-free medium of trans-[PtCl2(4-picoline)(piperidine)] and trans-[PtCl2(4-picoline)(piperazine)]center dot HCl. (ibp.cz)
  • complexes
  • trans-Diaminedicholoroplatinum(II) complexes with one planar and one non-planar heterocyclic amine ligand were designed as new potential antitumor drugs. (ibp.cz)
  • hydrophobic
  • A method for the removal of a substance carrying a negative charge and being present in an aqueous liquid (I). The method comprises the steps of: (i) contacting the liquid with a matrix carrying a plurality of ligands comprising a positively charged structure and a hydrophobic structure, and (ii) desorbing. (google.com)
  • pharmacological
  • As for any pharmacological effect, pharmacodynamics and pharmacokinetics are determinants of reinforcing strength of monoamine transporter ligands. (aspetjournals.org)
  • The precise relationship between these pharmacological factors and reinforcing strength of monoamine transporter ligands remains largely speculative. (aspetjournals.org)
  • functional
  • Both have a conserved asparagine "anchor" residue which in functional bromodomains, hydrogen bonds with the carbonyl group of a bound acetyl-lysine ligand and it is crucial for the interaction. (proteopedia.org)
  • atoms
  • The nonplatinated amine of the piperazine can form hydrogen bonds with atoms that are approximately 7.5 angstrom away from the Pt binding site. (ibp.cz)
  • different
  • The bridging BNPP ligand is σ-N coordinated by both nitroso groups and shows different conformations of the piperazine ring depending on the solvent used for crystallization. (uni-muenchen.de)
  • groups
  • The results of the present work support the view that replacement of both ammine groups of transplatin by heterocyclic ligands enhances cytotoxicity probably due to the marked enhancement of the stability of intrastrand cross-links in double-helical DNA. (ibp.cz)
  • drug
  • Our goal is to provide the reader with guidelines on how to utilize the existing knowledge and ligand- and structure-based methods for the design of new 5-HT 6 R antagonists and to highlight advantages and limitations of corresponding approaches and computational modeling tools in the field of 5-HT 6 R drug design. (springer.com)
  • Quipazine is a piperazine drug used in scientific research. (wikipedia.org)
  • methods
  • We analyze existing ligand-based information and disposable pharmacophore models, quantitative structure-activity relationship methods, usable crystal structure templates, homology models, and molecular docking approaches. (springer.com)
  • known
  • It has known use in pharmacetuticals in lieu of piperazine, for example: Fasudil Bunazosin Homochlorcyclizine Homopipramol Musker, W. Kenneth (1992). (wikipedia.org)