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LysosomesGlycoproteinsCarbohydratesLysosome-Associated Membrane GlycoproteinsMembrane GlycoproteinsPlatelet Membrane GlycoproteinsCell MembraneCarbohydrate MetabolismLigandsDietary CarbohydratesCarbohydrate SequenceIntracellular MembranesOligosaccharidesFucoseMembranesLectinsMolecular Sequence DataMembrane ProteinsCell LineGlycosylationGlucosamineMembrane LipidsElectrophoresis, Polyacrylamide GelCarbohydrate ConformationMannoseMolecular WeightPolysaccharidesGlycopeptidesAmino Acid SequenceGolgi ApparatusSialic AcidsErythrocyte MembraneMembrane PotentialsGalactose OxidaseViral Envelope ProteinsMicroscopy, ElectronMembranes, ArtificialBlood PlateletsMannosyl-Glycoprotein Endo-beta-N-AcetylglucosaminidaseNeuraminidaseGalactoseCricetinaeProtein BindingChromatography, AffinityAmino SugarsCells, CulturedAntibodies, MonoclonalGlycoside HydrolasesKineticsAcetylgalactosamineReceptors, Concanavalin AWheat Germ AgglutininsImmunoelectrophoresis, Two-DimensionalN-Acetylneuraminic AcidMembrane FluidityEndoplasmic ReticulumCell FractionationViral ProteinsBlood Platelet DisordersProtein Processing, Post-TranslationalFluorescent Antibody TechniqueHydrogen-Ion ConcentrationPeriodic AcidEndosomesMutationEndocytosisBase SequenceAntigens, CDCell Membrane PermeabilityBinding SitesTunicamycinSialoglycoproteinsProtein TransportLiverPeptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine AmidaseBiological TransportLysosomal-Associated Membrane Protein 2Basement MembraneSubcellular FractionsHexosaminidasesAmino AcidsAsparagineGlycolipidsCHO CellsCattleBunyaviridaeTransfectionViral Fusion ProteinsRabbitsAntigens, SurfaceSindbis VirusProtein Structure, TertiaryMonensinChromatography, GelEpitopesTemperatureSolubilitySequence Homology, Amino AcidCloning, MolecularConcanavalin A

Lysosomal membranePlasma membraneBiogenesisSignal transductionProteinProteinsProgressionImmuneEvidenceCellularFormAnalysisFunctionPlayCellFoundDevelopmentImportantCellsVariantsHuman

Lysosomal membrane3

• These hydrolyses are stored in the lysosomal membrane, which also house lysosomal membrane glycoproteins. (wikipedia.org)
• LAMP1 and LAMP2 make up about 50% of lysosomal membrane glycoproteins. (wikipedia.org)
• Stat3-mediated alterations in lysosomal membrane protein composition. (uni-bielefeld.de)

Plasma membrane5

• The effect of N3SP on NHE3 activity was evaluated in NHE3-transfected fibroblasts null for other plasma membrane NHEs, a human colon cancer cell line that models intestinal absorptive enterocytes (Caco-2/BBe), human enteroids, and mouse intestine in vitro and in vivo. (bvsalud.org)
• Lysosomes are an important component of the inner membrane system and participate in numerous cell biological processes, such as macromolecular degradation, antigen presentation, intracellular pathogen destruction, plasma membrane repair, exosome release, cell adhesion/migration and apoptosis. (biomedcentral.com)
• 1) Materials can be recycled to the plasma membrane by Rab11-positive recycling endosomes. (biomedcentral.com)
• 2) The remaining contents will be sequestered in Rab7-positive late endosomes, which can fuse with the plasma membrane to form exosomes. (biomedcentral.com)
• 5) Lysosomes can also fuse with the plasma membrane to mediate membrane repair or discharge contents outside the cell, such as cathepsins or immune factors. (biomedcentral.com)

Biogenesis2

• Lysosome biogenesis in health and disease. (uni-bielefeld.de)
• TRPML1-mediated lysosomal calcium release can also dephosphorylate TFEB and promote its nuclear translocation and regulate lysosome biogenesis, autophagy, and lipid metabolism. (biomedcentral.com)

Signal transduction1

• Lysosomes function as an intracellular signal transduction platform. (biomedcentral.com)

Protein5

• Lysosome-associated membrane protein 2 (LAMP2), also known as CD107b (Cluster of Differentiation 107b) and Mac-3, is a human gene. (wikipedia.org)
• Its protein, LAMP2, is one of the lysosome-associated membrane glycoproteins. (wikipedia.org)
• The protein encoded by this gene is a member of a family of membrane glycoproteins. (wikipedia.org)
• Online Mendelian Inheritance in Man (OMIM): Lysosome-associated membrane protein 2 - 309060 Konecki DS, Foetisch K, Zimmer KP, Schlotter M, Lichter-Konecki U (October 1995). (wikipedia.org)
• This anti-LAMP2 antibody was produced from rabbits immunized with LAMP2 recombinant protein. (nsjbio.com)

Proteins2

• We identified a total of 587 glycoproteins, including 1239 glycopeptides, 526 monosaccharide components, and 8326 intact glycopeptides in glycoproteomics, as well as a total of 4496 proteins identified in proteomic analysis. (frontiersin.org)
• Glycosylation is an important post-translational modification of proteins, and glycoproteins are widely involved in various important cellular biological processes and diseases ( 1 ). (frontiersin.org)

Progression3

• These glycoproteins are widely involved in important biological processes, such as antigen presentation, cytokine production and glycosylation progression. (frontiersin.org)
• In addition, previous studies have shown that lysosomes may play important roles in cancer development and progression through the abovementioned biological processes and that the functional status and spatial distribution of lysosomes are closely related to cancer cell proliferation, energy metabolism, invasion and metastasis, immune escape and tumor-associated angiogenesis. (biomedcentral.com)
• Therefore, identifying the factors and mechanisms that regulate the functional status and spatial distribution of lysosomes and elucidating the relationship between lysosomes and the development and progression of cancer can provide important information for cancer diagnosis and prognosis prediction and may yield new therapeutic targets. (biomedcentral.com)

Immune2

• Microvilli are actin-based microscopic membrane protrusions that are present in a wide variety of immune cells. (bvsalud.org)
• Comprehensive proteome analysis of lysosomes reveals the diverse function of macrophages in immune responses. (uni-bielefeld.de)

Evidence2

• Quantitative Proteome Analysis of Mouse Liver Lysosomes Provides Evidence for Mannose 6-phosphate-independent Targeting Mechanisms of Acid Hydrolases in Mucolipidosis II. (uni-bielefeld.de)
• Emerging evidence suggests that lysosomes may also be the cellular center for intracellular transport (Fig. 1 ), signaling (Fig. 2 ), and metabolism. (biomedcentral.com)

Cellular1

• Thus, lysosomes play important roles in cellular activity. (biomedcentral.com)

Form1

• The uncoated transport vesicles can fuse with autophagosome or heterophagosome to form autophagolysosome, heterophagic lysosome or phagolysosome. (biomedcentral.com)

Analysis1

• Western blot analysis of anti-LAMP2 antibody and T47D lysate. (nsjbio.com)

Function1

• It may also function in the protection, maintenance, and adhesion of the lysosome. (wikipedia.org)

Play1

• Lysosomes play a crucial role in intracellular transport. (biomedcentral.com)

Cell4

• Lysosomes are cell organelles found in most animal cells. (wikipedia.org)
• LAMP2 has been specifically implicated in tumor cell metastasis. (wikipedia.org)
• The two LAMP molecules act as ligands for the cell-adhesion molecules. (wikipedia.org)
• It has also been shown that the down-regulation of LAMP2 could both reduce the resistance of breast cancer cells to the paclitaxel and could inhibit cell proliferation in multiple myeloma cells. (wikipedia.org)

Found2

• Both LAMP1 and LAMP2 have been found expressed on the surface of cancerous tumors, specifically in cells of highly metastatic cancer such as colon cancer and melanoma. (wikipedia.org)
• They are rarely found on the plasma membranes of normal cells, and are found more on highly metastatic tumors than on poorly metastatic ones. (wikipedia.org)

Development1

• This suggests that the three glycoproteins are involved in tumor development, specifically in the processes of angiogenesis and tissue remodeling. (wikipedia.org)

Important1

• Lysosomes are an important component of the inner membrane system. (biomedcentral.com)

Cells4

• LAMP2, along with LAMP1, interact with E-selectin and galectins to mediate the adhesion of some cancer cells to the ECM. (wikipedia.org)
• Lysosomes in nutrient signalling: A focus on pancreatic β-cells. (uni-bielefeld.de)
• Therefore, researchers called lysosomes the "garbage disposals" of cells [ 1 ]. (biomedcentral.com)
• 6) Lysosomes are the pools of metabolites in cells, including amino acids, sugars, lipids and nucleotides. (biomedcentral.com)

Variants1

• Across functionally tested missense variants (n = 156), the spatial proximity from the ligand was associated with loss-of-function in the GAT1 transporter activity. (bvsalud.org)

Human1

• Find LAMP2 Antibodies for a variety of species such as anti-Human LAMP2, anti-Mouse LAMP2, anti-Rat LAMP2. (antibodies-online.com)