• cohort
  • 129 Likewise, in a cohort of 811 aging men, subjects reporting higher stress levels scored lower on the Mini-Mental State Examination than their low-stress counterparts. (lifeextension.com)
  • We report the association of adult SBP and diastolic BP (DBP) with determinants of fetal growth, 28 size at birth, and growth in infancy and examine whether these associations were modified by factors such as current body size or socioeconomic status (SES) in extensive prospective data from the fetal period until 31 years from the Northern Finland 1966 Birth Cohort (NFBC 1966). (ahajournals.org)
  • Job demand and control in mid-life and physical and mental functioning in early old age: do childhood factors explain these associations in a British birth cohort? (bmj.com)
  • Using data from a nationally representative British birth cohort followed up across life to early old age, we were able to use prospectively collected data on job demand and control in mid-life and self-reported mental and physical functioning in early old age. (bmj.com)
  • Although this might introduce bias, the cohort have been found at age 53 to be representative in most respects of the national population born at a similar time and the distribution of occupational class and unemployment at ages 60-64 was similar to the 2001 England Census reference population. (bmj.com)
  • cognitive
  • Interestingly, depression seems to worsen cognitive dysfunction, but poorer cognitive health predisposes aging individuals to depression as well. (lifeextension.com)
  • In fact, studies designed specifically to assess age-related cognitive performance in depression show an interrelationship between the two conditions. (lifeextension.com)
  • A group of aging subjects diagnosed with depression completed various cognitive tests and their results were compared to those of age and sex - matched, non-depressed control subjects. (lifeextension.com)
  • Adjustment for childhood factors (father's and mother's educational attainment, parents' interest in school at age 7 and cognitive ability at age 8) partially explained the association between job control and physical functioning, but did not explain the association between job demand and mental functioning. (bmj.com)
  • Research on animals finds that environmental enrichment could aid the treatment and recovery of numerous brain-related dysfunctions, including Alzheimer's disease and those connected to aging, whereas a lack of stimulation might impair cognitive development. (wikipedia.org)
  • The study including reviews of autobiographical essays by the nuns upon joining the order, administration of memory and cognitive tests to the nuns (some over 100 years of age), and post-mortem examination of their brains. (wikipedia.org)
  • 1996) Linguistic ability in early life and cognitive function and Alzheimer's disease in late life: Findings from the Nun Study. (wikipedia.org)
  • diseases
  • The discovery, in 1934, that calorie restriction can extend lifespan by 50% in rats, and the existence of species having negligible senescence and potentially immortal species such as Hydra, have motivated research into delaying and preventing senescence and thus age-related diseases. (wikipedia.org)
  • On the other extreme are accelerated aging diseases, rare in humans. (wikipedia.org)
  • Senescent cells affect tumour suppression, wound healing and possibly embryonic/placental development and a pathological role in age-related diseases. (wikipedia.org)
  • The experimental elimination of senescent cells from transgenic progeroid mice and non-progeroid, naturally-aged mice led to greater resistance against aging-associated diseases. (wikipedia.org)
  • In fact, changes in liver function associated with aging or diseases such as cirrhosis, may lead to impaired clearance of nordazepam. (wikipedia.org)
  • facets
  • However, more loosely defined facets of our lives related to our psychological condition contribute to our mental fluency as well. (lifeextension.com)
  • A table of the personality dimensions measured by the NEO PI-R, including facets, is as follows: In the 1970s, Paul Costa and Robert McCrae were researching age-related changes in personality. (wikipedia.org)
  • In 1992 Costa and McCrae published a Revised NEO manual which included six facets for each factor (30 in total). (wikipedia.org)
  • risk
  • Then, I discussed briefly about what is known about the risk factors of AMD and its impact on HRQoL. (usc.edu)
  • In my first paper (chapter 2) I evaluated the risk factors associated with 4 year incidence and progression of AMD. (usc.edu)
  • The risk factors were selected based on literature review and expert clinical opinion. (usc.edu)
  • Given the equivocal results for risk factors of AMD in other population based studies and the paucity of data in Latinos, these finding will aide in our understanding of AMD in this unique ethnic group. (usc.edu)
  • Risk factors for this kind of cancer include fair complexion, blue, and green or light colored eyes, and older age. (openpr.com)
  • 13 , 14 However, whether men and women differ in response to programmed CV and renal risk and whether age augments or attenuates this sex difference are not completely clear. (ahajournals.org)
  • Thus, these studies indicate that human males exhibit greater programmed CV and renal risk compared with age-matched females, but the mechanisms responsible remain unknown. (ahajournals.org)
  • Lifestyle factors that increase the risk include excess salt in the diet, excess body weight, smoking, and alcohol use. (wikipedia.org)
  • Thus
  • Thus, an actuary can reasonably estimate the average age of death for a group of 25-year-old males, who don't smoke. (wikipedia.org)
  • A person's personality profile is thus gauged from their standing on five broad concepts which predict, among other life outcomes, behavior and the quality of interpersonal relationships. (wikipedia.org)
  • placental
  • Intrauterine growth restriction (IUGR) is a marker of impaired fetal growth and can result from a wide range of etiologic factors, including maternal conditions, placental insufficiency, and fetal genomic pathology. (ahajournals.org)
  • whereas
  • For example, the NEO PI-R consists of 240 items (questions), whereas the shorter NEO-FFI (NEO Five-Factor Inventory) has only 60 items (12 per domain). (wikipedia.org)
  • findings
  • We recently described a family with neurological findings similar to HSAN (Hereditary sensory and autonomic neuropathy) type V having a point mutation in the Nerve growth factor beta (NGFB) gene. (bmj.com)
  • The great diversity in plant life and altitudinal-determined microenvironments that surrounded the marsh helped to make it a popular place to live, as evidenced by archaeological findings. (wikipedia.org)
  • renal
  • However, insight from experimental studies indicates that hypertension programmed in response to adverse influences during critical periods of early life may involve activation of the renal nerves, 6 , 7 the renin-angiotensin system, 8 , 9 and oxidative stress. (ahajournals.org)
  • This paper discusses the effect of premature birth, LBW, intrauterine milieu, and infant feeding on the development of hypertension and renal disease in later life as well as examines the role of the kidney in developmental programming of hypertension and CKD. (biomedsearch.com)
  • This can be attributed to extremely variable hepatic and renal metabolic functions among individuals depending upon a number of factors (including age, ethnicity, disease, and current or previous use/abuse of other drugs/medicines). (wikipedia.org)
  • physiological
  • With the patient in a prone or seated position, the medical professional will look at both breasts to check the color, symmetry, dimensions according to age, lean body mass, the physiological (pregnancy and lactation) and race, looking for abnormalities, such as bulges and shrinkage. (wikipedia.org)
  • maternal
  • 29 Our a priori hypothesis was that birth measures, in particular birth weight, are linearly and inversely associated with, and change-up infant growth realignment positively associated with, adult SBP/DBP, independent of maternal and other neonatal characteristics, lifestyle factors, and SES. (ahajournals.org)
  • The major factors influencing in utero environment that are associated with a low final nephron number include uteroplacental insufficiency, maternal low-protein diet, hyperglycemia, vitamin A deficiency, exposure to or interruption of endogenous glucocorticoids, and ethanol exposure. (biomedsearch.com)
  • adult
  • Results Those with higher job control in mid-life had better physical functioning than those who reported lower job control (β 0.51, 95% CI 0.02 to 1.01, p=0.04 adjusted for adult confounders). (bmj.com)
  • The heterozygous phenotype ranged from 8 patients with Charcot arthropathy starting in adult age and associated with variable symptoms of neuropathy but without complete insensitivity to pain, anhidrosis or mental retardation, to 10 symptom-free patients. (bmj.com)
  • The NGFB mutation in its heterozygous form results in a milder disease than in homozygots with a variable clinical picture, ranging from asymptomatic cases to those with Charcot arthropathy appearing in adult age. (bmj.com)
  • The test was originally developed for use with adult men and women without overt psychopathy, but was later shown to also be useful for people at younger ages. (wikipedia.org)
  • For both the adolescent and adult sample, the item/facet correlations were higher for the revised version of the NEO than for NEO PI-R. In addition, the internal consistency, factor structure, and tests of convergent and discriminant validity suggested that the revised version could be used with middle school children. (wikipedia.org)
  • females
  • Among females, gestational age showed a stronger association with blood pressure than birth weight: gestational age higher by 7 weeks (equivalent to an average of 1 kg higher birth weight) among singletons associated with −2.9 (95% CI, −4.7, −1.1) mm Hg lower systolic blood pressure. (ahajournals.org)
  • known
  • A precise multiplier, known as the Acceleration Factor (AF) simulates long lifetime operation. (wikipedia.org)
  • Based on data from the Baltimore study, Costa and McCrae recognized two additional factors: Agreeableness (A) and Conscientiousness (C). Accordingly, in 1985 they published the first manual for the NEO that included all five factors, which are now known as the Big Five personality traits. (wikipedia.org)
  • It has long been believed that personality development is shaped by life experiences that intensify the propensities that led individuals to those experiences in the first place, which is known as the corresponsive principle. (wikipedia.org)
  • factors such as age and gender are known to impact it. (wikipedia.org)
  • include
  • contributing factors include retirees living longer (increasing the relative number of retirees), and lower birth rates (decreasing the relative number of workers, especially relative to the Post-WW2 Baby Boom). (wikipedia.org)
  • suggests
  • As such, cellular senescence represents a change in "cell state" rather than a cell becoming "aged" as the name confusingly suggests. (wikipedia.org)
  • Prospective
  • Attrition in prospective studies with follow-up across the whole of life is to be expected. (bmj.com)
  • women
  • In a study involving 36 women between the ages of 25 and 53, those with the highest work-related stress levels displayed decreased attention and visuo-spatial memory. (lifeextension.com)
  • Miriam Weber and Mark Mapstone, both memory experts at the University's Memory Disorders Clinic, have come in contact with increasing number of middle-aged women having such problems with forgetfulness. (medindia.net)
  • In addition to the yearly check by a professional, women over the age of 18 should also perform this examination monthly. (wikipedia.org)
  • cause
  • Age related macular degeneration (AMD) is a progressive, potentially irreversible disorder of the macular region of retina that can cause severe loss of central vision in the late stages. (usc.edu)
  • Despite the recent advances in the treatment of AMD, it remains the leading cause of blindness in people over the age of 60 in the Western world with significant impact on their health related quality of life (HRQoL). (usc.edu)
  • research
  • The treatment for such metastasis disease is continuously demanding more research to determine the most effective, and life saving treatments. (openpr.com)
  • The assessment at this time included six facet sub-scales for the three original factors (N, E, & O). This naming convention continued with the third version, with the Revised NEO Personality Inventory, published in 1990,[citation needed] being referred to as NEO PI-R. Research began to accumulate that indicated that the five factors were sufficiently broad and useful. (wikipedia.org)
  • Longitudinal research demonstrates that people's personality trajectories can often be explained by the social roles they espoused and relinquished throughout their life stages. (wikipedia.org)
  • Effects
  • IGF-1 has also been referred to as a "sulfation factor" and its effects were termed "nonsuppressible insulin-like activity" (NSILA) in the 1970s. (wikipedia.org)
  • Methods
  • In property and casualty insurance, there are three basic rate-making methods: Judgment Rating is used when the factors that determine potential losses are varied and cannot easily be quantified. (wikipedia.org)
  • long
  • The short term and long term impact of AMD on quality of life in Latinos has not been investigated to a great extent. (usc.edu)
  • body
  • A growing body of evidence supports the concept that changes in the intrauterine milieu during "sensitive" periods of embryonic development or in infant diet after birth affect the developing individual, resulting in general health alterations later in life. (biomedsearch.com)
  • Twenty-five premature infants (mean gestational age+/-SD, 31.4+/-1.9 weeks) were administered subcutaneously recombinant human erythropoietin (rHuEpo) at a dose of 300 u/kg of body weight three times a week beginning on the third day of life and continuing for 6 weeks. (biomedsearch.com)
  • Different parts of the body may age at different rates. (wikipedia.org)
  • higher
  • The results from these analyses revealed that older age and higher pulse pressure were independently associated with the incidence of any AMD and different early AMD lesions in this group of Latinos. (usc.edu)
  • This higher power may generate hot spots and areas of accelerated aging. (wikipedia.org)
  • individual factors
  • Approaches through social, economic and individual factors, such as brand loyalty, have been considered along with the more widely recognized geographic, physiographic, demographic and behavioral variables proposed by Philip Kotler. (wikipedia.org)
  • health
  • There was also evidence of a measurable loss in health related quality of life is associated with lesions defined as early AMD. (usc.edu)
  • Department of Life Sciences, School of Pharmacy and Health Sciences, International Medical University, Kuala Lumpur, Malaysia (I.K.S.Y. (ahajournals.org)
  • 26 patients heterozygous for the NGFB-mutation (12 men, mean age 50 (13-90) years) were examined clinically and answered a health status questionnaire, including the Michigan Neuropathy Screening Instrument (MNSI). (bmj.com)
  • relative
  • Birth weight, birth length, gestational age, ponderal index, and birth weight relative to gestational age showed a significant inverse association with blood pressure at age 31. (ahajournals.org)
  • The AF represents the accelerated aging factor relative to the useful life application conditions. (wikipedia.org)
  • The digital toggling factor (DTF) represents the number of transistors that change their state during the stress test, relative to the total number of gates in the digital portion of the IC. (wikipedia.org)
  • clinical
  • 28 relatives (15 men, mean age 44 (15-86) years) without the mutation served as controls in the clinical examination part. (bmj.com)
  • Particularly age, but perhaps also life style factors, may influence the development of clinical polyneuropathy. (bmj.com)
  • parts
  • The degrees of freedom for aligning the aging magnitude of analog parts is usually the duty-cycle, external load values and voltage stress. (wikipedia.org)
  • growth
  • It provides detailed information regarding the major factors influencing the growth of the market. (openpr.com)
  • Its primary action is mediated by binding to its specific receptor, the insulin-like growth factor 1 receptor (IGF1R), which is present on many cell types in many tissues. (wikipedia.org)
  • medical citation needed] Insulin-like growth factor 1 has been shown to bind and interact with all the IGF-1 binding proteins (IGFBPs), of which there are seven: IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP5, IGFBP6, and IGFBP7. (wikipedia.org)
  • medical citation needed] Insulin-like growth factor 1 receptor (IGF-1R) and other tyrosine kinase growth factor receptors signal through multiple pathways. (wikipedia.org)
  • current
  • Older age and current smoking were independently associated with progression of AMD. (usc.edu)
  • people
  • People wanted to know how I got back in shape at my age, what my diet was like and the exercises I did. (lifescript.com)
  • In 1950, there were 7.2 people aged 20-64 for every person of 65 or over in the OECD countries. (wikipedia.org)
  • University
  • David A. Snowdon (born 1952), is an epidemiologist and professor of neurology at the Sanders-Brown Center on Aging at the University of Kentucky. (wikipedia.org)
  • decrease
  • Organisms of some taxonomic groups, including some animals, experience chronological decrease in mortality, for all or part of their life cycle. (wikipedia.org)
  • late-life
  • The conclusion drawn from this evidence was that " late-life depression is characterized by slowed information processing, which affects all realms of cognition . (lifeextension.com)
  • data
  • 2,10,13,24 These have a number of potential limitations including retrospective data collection and an incomplete consideration of confounding factors operating throughout the life course. (ahajournals.org)
  • 1485 occupationally active study members had data available on job demand and control in mid-life and on physical and mental functioning assessed using the Short Form-36 questionnaire at 60-64 years. (bmj.com)
  • With the availability of a wealth of prospectively collected data on factors in childhood we were able to explore the influence of these on the main associations of interest which few other studies are able to do. (bmj.com)
  • changes
  • They had, in 1989, started a study of age-associated changes in cognition and function in a group of older adults in Kentucky who had agreed to brain donation at death. (wikipedia.org)
  • Researchers distinguish between mean level and rank order changes in trait standing during old age. (wikipedia.org)
  • However
  • Objectives Adverse work-related exposures have been linked with decreased physical and mental functioning in later life, however, whether childhood factors explain the associations between work exposures and functioning is unknown. (bmj.com)
  • study
  • The homogeneous life style of the nuns makes them an ideal study population. (wikipedia.org)
  • Snowdon's book on the Nun study, Aging with Grace: What the Nun Study Teaches Us About Leading Longer, Healthier, and More Meaningful Lives, won a Christopher Award in 2002. (wikipedia.org)