• Lidocaine Hydrochloride Injection, USP is indicated for production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks, when the accepted procedures for these techniques as described in standard textbooks are observed. (pfizermedicalinformation.com)
  • Table 1 (Recommended Dosages) summarizes the recommended volumes and concentrations of Lidocaine Hydrochloride Injection, USP for various types of anesthetic procedures. (pfizermedicalinformation.com)
  • Thus, an increase in volume and concentration of Lidocaine Hydrochloride Injection will decrease the onset of anesthesia, prolong the duration of anesthesia, provide a greater degree of muscular relaxation and increase the segmental spread of anesthesia. (pfizermedicalinformation.com)
  • However, increasing the volume and concentration of Lidocaine Hydrochloride Injection may result in a more profound fall in blood pressure when used in epidural anesthesia. (pfizermedicalinformation.com)
  • For intravenous regional anesthesia, only the 50 mL single-dose vial containing 0.5% Lidocaine Hydrochloride Injection, USP should be used. (pfizermedicalinformation.com)
  • A single application should not exceed 5 g of Lidocaine Ointment 5%, containing 250 mg of lidocaine base (equivalent chemically to approximately 300 mg of lidocaine hydrochloride). (wikidoc.org)
  • Topical lidocaine/tetracaine ointment was applied to the skin for topical anesthesia, followed by intraoral nerve block and tumescent anesthesia for the face only. (cdc.gov)
  • Lidocaine Ointment 5% effects local, topical anesthesia. (nih.gov)
  • Lidocaine Ointment USP, 5% contains a local anesthetic agent and is administered topically. (nih.gov)
  • Composition of Lidocaine Ointment USP, 5%: acetamide, 2-(diethylamino)- N -(2,6-dimethylphenyl)-, (lidocaine) 5% in a water miscible ointment vehicle containing polyethylene glycols. (nih.gov)
  • Lidocaine Ointment USP, 5% is indicated for production of anesthesia of accessible mucous membranes of the oropharynx. (nih.gov)
  • Lidocaine (ointment) is an amino amide, local and anesthetic agent that is FDA approved for the treatment of temporary relief of pain associated with minor burns , including sunburn , abrasions of the skin , and insect bites . (wikidoc.org)
  • When Lidocaine Ointment 5% is used concomitantly with other products containing lidocaine, the total dose contributed by all formulations must be kept in mind. (wikidoc.org)
  • No more than one-half tube, approximately 17-20 g of ointment or 850-1000 mg lidocaine base, should be administered in any one day. (wikidoc.org)
  • Although the incidence of adverse effects with Lidocaine Ointment 5% is quite low, caution should be exercised, particularly when employing large amounts, since the incidence of adverse effects is directly proportional to the total dose of local anesthetic agent administered. (wikidoc.org)
  • There is limited information regarding Off-Label Guideline-Supported Use of Lidocaine (ointment) in adult patients. (wikidoc.org)
  • There is limited information regarding Off-Label Non-Guideline-Supported Use of Lidocaine (ointment) in adult patients. (wikidoc.org)
  • Interactions with other drugs (eg, cimetidine, beta-blockers) can also affect lidocaine drug levels. (medscape.com)
  • Renal dysfunction does not affect lidocaine kinetics but may increase the accumulation of metabolites. (nih.gov)
  • Large doses of lidocaine (up to 55 mg/kg, versus the conventional maximum of 4.5 mg/kg) are used for tumescent anesthesia, in which a dilute local anesthetic solution is injected into subcutaneous tissue until it becomes firm and tense. (medscape.com)
  • [ 3 ] Larger doses of lidocaine are generally tolerated during tumescent anesthesia for liposuction, probably due to coadministration of epinephrine, the low concentration of lidocaine in tumescent solution, and poor systemic absorption from subcutaneous fat. (medscape.com)
  • In hypokalemic sensory overstimulation, relative insensitivity to lidocaine has been described in people who also have attention deficit hyperactivity disorder.In dental anesthesia, a relative insensitivity to lidocaine can occur for anatomical reasons due to unexpected positions of nerves. (qualitypowders.com)
  • Lidocaine is used topically to relieve itching, burning, and pain from skin inflammations, injected as a dental anesthetic, or as a local anesthetic for minor surgery.It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic healthcare system. (qualitypowders.com)
  • Lidocaine is used topically to relieve itching, burning, and pain from skin inflammations, injected as a dental anesthetic, or used as a local anesthetic for minor surgery. (pharmaapis.com)
  • Lidocaine, xylocaine, or lignocaine is a common local anesthetic and class-1b antiarrhythmic drug. (qualitypowders.com)
  • Bij de beschrijving van EMLA® was al aangetoond dat amethocaine (tetracaine) een betere analgesie geeft dan EMLA® bij het plaatsen van een infuus. (richtlijnendatabase.nl)
  • Lidocaine may be absorbed following topical administration to mucous membranes, its rate and extent of absorption depending upon the specific site of application, duration of exposure, concentration, and total dosage. (nih.gov)
  • The plasma binding of lidocaine is dependent on drug concentration, and the fraction bound decreases with increasing concentration. (nih.gov)
  • As a precaution against the adverse experience sometimes observed following unintentional penetration of the subarachnoid space, a test dose such as 2 to 3 mL of 1.5% lidocaine HCl should be administered at least 5 minutes prior to injecting the total volume required for a lumbar or caudal epidural block. (pfizermedicalinformation.com)
  • Epinephrine (adrenaline) vasoconstricts arteries, reducing bleeding and also delays the resorption of lidocaine, almost doubling the duration of anaesthesia. (qualitypowders.com)
  • 1% lidocaine with 1:100K epinephrine was slowly injected into the turbinate. (medscape.com)
  • Six persons were studied while awake and during mid-thoracic (approximately a T6 sensory level) and high (approximately a T1 sensory level) lumbar EA produced by either 2% lidocaine (two persons) or 1.5% etidocaine (four persons) with 1:200,000 epinephrine. (asahq.org)
  • At concentrations of 1 to 4 mcg of free base per mL, 60 to 80 percent of lidocaine is protein bound. (nih.gov)
  • Although the incidence of side effects with lidocaine HCl is quite low, caution should be exercised when employing large volumes and concentrations, since the incidence of side effects is directly proportional to the total dose of local anesthetic agent injected. (pfizermedicalinformation.com)
  • Lidocaine is preferred for indications such as laceration repair because of its shorter duration of action. (medscape.com)
  • In the normal resting state, the nerve has a negative membrane potential of -70 mV. (medscape.com)
  • For example, because lidocaine is hepatically metabolized, liver dysfunction increases the risk of toxicity. (medscape.com)
  • 3.Lidocaine hcl in low doses can promote outflow of K+ in cardiomyocytes, reduce myocardial autonomy, and has antiarrhythmic effects. (novatismed.co)
  • The pharmacological/toxicological actions of these metabolites are similar to, but less potent than, those of lidocaine. (nih.gov)
  • Approximately 90% of lidocaine administered is excreted in the form of various metabolites, and less than 10% is excreted unchanged. (nih.gov)
  • Factors such as acidosis and the use of CNS stimulants and depressants affect the CNS levels of lidocaine required to produce overt systemic effects. (nih.gov)
  • In a 70 kg adult this dose equals 3.6 mg/kg (1.6 mg/lb) lidocaine base. (wikidoc.org)
  • For example a child of five years weighing 50 lbs., the dose of lidocaine should not exceed 75-100 mg when calculated according to Clark's rule. (wikidoc.org)
  • The efficacy profile of lidocaine as a local anesthetic is characterized by a rapid onset of action and intermediate duration of efficacy. (qualitypowders.com)
  • lidocaine, though, has the advantage of a rapid onset of action. (qualitypowders.com)
  • Lidocaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses, thereby effecting local anesthetic action. (nih.gov)
  • Buffering the pH of lidocaine makes local freezing less painful. (qualitypowders.com)
  • Lidocaine (1% or 2%) and bupivacaine (0.25%) are the 2 most commonly used local anesthetics. (medscape.com)
  • Topical lidocaine has been shown in some patients to relieve the pain of postherpetic neuralgia (a complication of shingles), though not enough study evidence exists to recommend it as a first-line treatment.ntravenous lidocaine also has uses as a temporary fix for tinnitus. (pharmaapis.com)
  • In the US, there were 278,345 trauma deaths in 2020, about 70% of which were accidental. (merckmanuals.com)
  • While the majority of children who accidental ingest teething gels remain asymptomatic, life-threatening MeHb (~70%) has occurred. (dpic.org)
  • Acidosis increases the risk because it favors dissociation of lidocaine from plasma proteins. (medscape.com)
  • Lidocaine is also well-absorbed from the gastrointestinal tract, but little intact drug appears in the circulation because of biotransformation in the liver. (nih.gov)
  • Lidocaine is metabolized rapidly by the liver, and metabolites and unchanged drug are excreted by the kidneys. (nih.gov)
  • Immediately before the procedure, the patient's skin was cleansed with 70% isopropanol. (cdc.gov)
  • Synthetic compounds like Lidocaine, for instance, quickly deadens nerves in the skin, keeping them from seeing agony. (cloveraardklop.co.za)
  • Lidocaine is the active ingredient in many skin-numbing creams, though there are others. (marbleozspa.com)
  • In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. (made-in-china.com)
  • Because of the rapid rate at which lidocaine is metabolized, any condition that affects liver function may alter lidocaine kinetics. (nih.gov)
  • In any case, the maximum amount of lidocaine administered should not exceed 4.5 mg/kg (2.0 mg/lb) of body weight. (wikidoc.org)
  • Studies of lidocaine metabolism following intravenous bolus injections have shown that the elimination half-life of this agent is typically 1.5 to 2.0 hours. (nih.gov)
  • The neck and chest were treated at 40 mJ (treatment level 7 mJ) and 25% coverage, the forehead at 60 mJ (treatment level 9 mJ) and 35% coverage, and the nose and cheeks at 70 mJ (treatment level 9 mJ) and 35% coverage (total 10.46 kJ). (cdc.gov)
  • In 1943, an alternative class of anesthetics was discovered when Lofgren developed lidocaine. (medscape.com)