From the discovery of the first aminoamide, lidocaine, to the development of ropivacaine as a less cardiotoxic agent than racemic bupivacaine, it is evident that this field continues to search for the "Holy Grail" of local anesthetic pharmacology. (asra.com)
Lidocaine, bupivacaine, pramoxine and W 6211 also caused a lower degree of attenuation of the response to substance P than the responses to acetylcholine, histamine and barium chloride. (aspetjournals.org)
The simultaneous determination of usually employed anesthetics (procaine, lidocaine, and bupivacaine) has been developed and validated using CE with ultraviolet detection at 212 nm. (cheric.org)
Curiously, topical applications sold to combat cellulite usually contain anesthetics such as lidocaine, procaine and prilocaine, and topical anesthetics tend to suppress fat breakdown. (femininebeauty.info)
Anesthetic10
Lidocaine is the most commonly used anesthetic. (medscape.com)
If the patient is known to be allergic to lidocaine, an ester-type anesthetic, such as procaine, can be substituted. (medscape.com)
Lidocaine Ointment USP, 5% contains a local anesthetic agent and is administered topically. (nih.gov)
Lidocaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses, thereby effecting local anesthetic action. (nih.gov)
However, other quaternary lidocaine derivatives exist, such as QX-572 and QX-222 (Figure 1), whose local anesthetic utility remains unknown. (asra.com)
Lidocaine is the preferred local anesthetic nowadays. (intechopen.com)
Lidocaine, xylocaine, or lignocaine is a common local anesthetic and class-1b antiarrhythmic drug. (qualitypowders.com)
Lidocaine is used topically to relieve itching, burning, and pain from skin inflammations, injected as a dental anesthetic, or as a local anesthetic for minor surgery.It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic healthcare system. (qualitypowders.com)
The efficacy profile of lidocaine as a local anesthetic is characterized by a rapid onset of action and intermediate duration of efficacy. (qualitypowders.com)
Lidocaine Ointment USP, 5% is indicated for production of anesthesia of accessible mucous membranes of the oropharynx. (nih.gov)
Research at the Hugill Anesthesia Research Centre at The University of British Columbia (UBC) found that a quaternary derivative of lidocaine, QX-314, produces robust nociceptive, sensory, and motor blockade of long duration in animals in vivo . (asra.com)
In hypokalemic sensory overstimulation, relative insensitivity to lidocaine has been described in people who also have attention deficit hyperactivity disorder.In dental anesthesia, a relative insensitivity to lidocaine can occur for anatomical reasons due to unexpected positions of nerves. (qualitypowders.com)
While treating trigger finger by injecting steroids and lidocaine into the tendon sheath, Chiu noted that anesthesia of the entire digit was achieved. (medscape.com)
Xylocaine1
Lidocaine (Xylocaine) is the most commonly used agent. (medscape.com)
Cocaine5
article on dental anesthetics may unfortunately lead some to the erroneous conclusion that cocaine and the so-called caine anesthetics are closely related ( C&EN, June 29, page 33 ). (acs.org)
In addition, cocaine and its derivatives are Federal Schedule II drugs, whereas procaine, lidocaine, and the other "caine" drugs are unscheduled. (acs.org)
It must be the lidocaine that caused my positive for cocaine. (acs.org)
This claim is predicated on the assumption that lidocaine mimics cocaine because both end in caine. (acs.org)
This is similar to a process known as 'cutting' - in which drugs like cocaine are mixed with other substances (including laundry detergent, baking soda, procaine or lidocaine). (fitsnews.com)
Amide1
This forms the basis of classification of local anesthetics into 2 groups: the ester-type agents (eg, procaine) and the amide-type agents (eg, lidocaine). (medscape.com)
Articaine1
A cursory review of the structures for lidocaine, procaine, and articaine shows they lack the ecgonine nucleus. (acs.org)
lidocaine, though, has the advantage of a rapid onset of action. (qualitypowders.com)
Anesthetics1
Although applied in some countries, efficacy of local anesthetics based on procaine to mitigate acute responses to piglet castration remains questioned. (awionline.org)
Efficacy1
Efficacy of lidocaine topical solution in reducing discomfort reaction of horses to intramuscular vaccination. (awionline.org)
Duration2
Lidocaine may be absorbed following topical administration to mucous membranes, its rate and extent of absorption depending upon the specific site of application, duration of exposure, concentration, and total dosage. (nih.gov)
Epinephrine (adrenaline) vasoconstricts arteries, reducing bleeding and also delays the resorption of lidocaine, almost doubling the duration of anaesthesia. (qualitypowders.com)
Ointment1
Composition of Lidocaine Ointment USP, 5%: acetamide, 2-(diethylamino)- N -(2,6-dimethylphenyl)-, (lidocaine) 5% in a water miscible ointment vehicle containing polyethylene glycols. (nih.gov)
Local2
Dairy calves show behavioural responses to hot iron disbudding after local anaesthesia with procaine. (awionline.org)
Procaine caused a dose-related depression of the response to all the agonists but the response to substance P was far less susceptible to this depression. (aspetjournals.org)
Factors such as acidosis and the use of CNS stimulants and depressants affect the CNS levels of lidocaine required to produce overt systemic effects. (nih.gov)
Drugs1
In addition, gas chromatography/mass spectrometry (GC/MS) selected-ion monitoring for urine BE does not show any detectable peak for derivatized BE postingestion of drugs such as lidocaine. (acs.org)
Approximately1
Approximately 90% of lidocaine administered is excreted in the form of various metabolites, and less than 10% is excreted unchanged. (nih.gov)
Base1
At concentrations of 1 to 4 mcg of free base per mL, 60 to 80 percent of lidocaine is protein bound. (nih.gov)
Drug4
Lidocaine is also well-absorbed from the gastrointestinal tract, but little intact drug appears in the circulation because of biotransformation in the liver. (nih.gov)
Lidocaine is metabolized rapidly by the liver, and metabolites and unchanged drug are excreted by the kidneys. (nih.gov)
The plasma binding of lidocaine is dependent on drug concentration, and the fraction bound decreases with increasing concentration. (nih.gov)
The membrane-active drug procaine inhibits the phagocytosis of latex particles by normal monocytes and the proliferation of lymphocytes in an allogeneic mixed leukocyte culture [ 3361 ]. (nanomedicine.com)
Agent1
Studies of lidocaine metabolism following intravenous bolus injections have shown that the elimination half-life of this agent is typically 1.5 to 2.0 hours. (nih.gov)