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  • cardiovascular disease
  • The risk of cardiovascular disease has been reported to have a linear relationship with LDL levels. (hindawi.com)
  • Conclusion: Elevated level of Lp-PLA2 is associated with periodontal inflammation, indicating that periodontal treatment could reduce the risk of cardiovascular disease in CP subjects with hyperlipidaemia. (quintpub.com)
  • The test gives results in 25 minutes with a sensitivity down to 0.04 mg/L. The risk of developing cardiovascular disease is quantified as follows: low: hs-CRP level under 1.0 mg/L average: between 1.0 and 3.0 mg/L high: above 3.0 mg/L Normal concentration in healthy human serum is between 5 and 10 mg/L, increasing with aging. (wikipedia.org)
  • Cholesterol levels may be determined as part of health screening for health insurance or occupational health, when the external physical signs such as xanthelasma, xanthoma, arcus are noticed, symptoms of cardiovascular disease develop, or a family member has been found to have FH. (wikipedia.org)
  • diabetes
  • Anti-diabetic drug A kind of medication that helps a person with diabetes control the level of glucose (sugar) in the blood so that the body works as it should. (wikipedia.org)
  • Primary hyperlipidemia is usually due to genetic causes (such as a mutation in a receptor protein), while secondary hyperlipidemia arises due to other underlying causes such as diabetes. (wikipedia.org)
  • In addition, a prospective observational study of dyslipidemic patients with diabetes or hyperglycemia showed that bezafibrate significantly reduces haemoglobin A1c (HbA1c) concentration as a function of baseline HbA1c levels, regardless of concurrent use of antidiabetic drugs. (wikipedia.org)
  • mild
  • Higher levels are found in late pregnant women, mild inflammation and viral infections (10-40 mg/L), active inflammation, bacterial infection (40-200 mg/L), severe bacterial infections and burns (>200 mg/L). CRP is a more sensitive and accurate reflection of the acute phase response than the ESR (Erythrocyte Sedimentation Rate). (wikipedia.org)
  • Mild hypoglycemia, hyperlipidemia, and hyperketosis may occur. (wikipedia.org)
  • statins
  • Nevertheless, with the new advancements in clinical medicine, it has now become possible to bring down the LDL levels to as low as 15 mg/dl using PCSK9 monoclonal antibodies alone or in combination with statins. (hindawi.com)
  • The American College of Cardiology/American Heart Association (NCEP IV) guidelines recommend prescription of evidence-based doses of statins independent of the LDL level [ 3 ]. (hindawi.com)
  • Ezetimibe is recommended as second line therapy for those intolerant of statins or unable to achieve target LDL cholesterol levels on statins alone by several major medical group practice guidelines, including the American College of Cardiology. (wikipedia.org)
  • Meta-analysis showed that rosuvastatin is able to modestly increase levels of HDL cholesterol as well, as with other statins. (wikipedia.org)
  • Heterozygous FH is normally treated with statins, bile acid sequestrants, or other lipid lowering agents that lower cholesterol levels. (wikipedia.org)
  • chronic
  • Methods: Forty chronic periodontitis (CP) subjects with hyperlipidaemia (CP/HPL group), 40 systemically healthy CP subjects (CP group) and 20 systemically and periodontally healthy subjects (control group) were enrolled. (quintpub.com)
  • Other people may develop chronic pancreatitis as a result of hereditary causes, gallstones (which block the pancreatic duct outlet), autoimmune disease such as lupus, or high triglyceride levels. (columbiasurgery.org)
  • Putative beneficial effects of rosuvastatin therapy on chronic heart failure may be negated by increases in collagen turnover markers as well as a reduction in plasma coenzyme Q10 levels in patients with chronic heart failure. (wikipedia.org)
  • patients
  • Thus, the treatment of hyperlipidemia plays a crucial role in the management of patients with CAD or those at increased risk of CAD all around the world. (hindawi.com)
  • The importance of plasma TG as an independent risk factor for CAD was recognized after the publication of a meta-analysis by Austin et al 19,20 in 2000, which provided support for the earlier observation that plasma TG levels predict relative risk in relatives of FCHL patients. (ahajournals.org)
  • The results of the JUPITER trial (2008) suggested rosuvastatin may decrease the relative risk of heart attack and stroke in patients without hyperlipidemia, but with elevated levels of highly sensitive C-reactive protein. (wikipedia.org)
  • protein
  • C-reactive protein (CRP) is an annular (ring-shaped), pentameric protein found in blood plasma, whose levels rise in response to inflammation. (wikipedia.org)
  • While there is an association between increased levels of C-reactive protein and risk of developing cancer, there is no association between genetic polymorphisms influencing circulating levels of CRP and cancer risk. (wikipedia.org)
  • It is associated with hyperlipidemia more frequently than with elevated protein. (wikipedia.org)
  • lower
  • Moreover, various studies aiming to lower the CV risk and mortality by lowering LDL levels have demonstrated encouraging results. (hindawi.com)
  • Acetohexamide A pill taken to lower the level of glucose (sugar) in the blood. (wikipedia.org)
  • The LDL is typically above the 75th percentile, that is, 75% of the healthy population would have a lower LDL level. (wikipedia.org)
  • risk
  • Hyperlipidemia has always been a topic of interest owing to the concomitant increased risk of adverse cardiovascular events. (hindawi.com)
  • Moreover, increased LDL levels are found to be positively correlated with the increased CV risk. (hindawi.com)
  • Furthermore, targeting HDL and TG levels to reduce this residual risk has been proved futile [ 5 ]. (hindawi.com)
  • In a 2004 prospective cohort study on colon cancer risk associated with CRP levels, people with colon cancer had higher average CRP concentrations than people without colon cancer. (wikipedia.org)
  • cause
  • Its half-life of 18 hours is constant, and therefore its level is determined by the rate of production and hence the severity of the precipitating cause. (wikipedia.org)
  • positively
  • Linear regression analysis showed that the serum level of Lp-PLA2 was positively associated with bleeding on probing and WBC counts. (quintpub.com)
  • significantly
  • Results: Serum Lp-PLA2 level in the CP/HPL group and the CP group was significantly higher than in the healthy group. (quintpub.com)
  • Prostacyclin/thromboxane are produced by both COX-1 and COX-2, and rofecoxib suppresses just COX-2 enzyme, so there is no reason to believe that prostacyclin levels are significantly reduced by the drug. (wikipedia.org)
  • liver
  • The assessment of plasma TG concentration as an independent predictor for CAD is complicated by the fact that (1) there is considerable interindividual and intraindividual variation in plasma TG levels and (2) circulating TRL are highly heterogeneous in size, density, and composition and may consist of intestinally derived apolipoprotein (apo) B-48-containing chylomicrons and chylomicron remnants, in addition to liver-derived apoB-100-containing VLDL and their remnants. (ahajournals.org)
  • Interferon alpha inhibits CRP production from liver cells which may explain the relatively low levels of CRP found during viral infections compared to bacterial infections Measuring and charting CRP values can prove useful in determining disease progress or the effectiveness of treatments. (wikipedia.org)
  • maintain
  • As we all know, cholesterol is an integral part of the plasma membrane, and a minimum level of LDL needs to be present to maintain structural integrity and sustain normal function of cells. (hindawi.com)
  • plasma
  • Rofecoxib crossed the placenta and blood-brain barrier, and took 1-3 hours to reach peak plasma concentration with an effective half-life (based on steady-state levels) of approximately 17 hours. (wikipedia.org)
  • target
  • The current challenge is to explore this arena to redefine the target LDL levels, if required, to avoid any suboptimal treatment. (hindawi.com)
  • If your tongue is sensitive to the spicy drops, work your way up to the target level. (healthy.co.nz)
  • heart
  • It has been found that not only elevated levels of LDL lead to coronary heart disease, but changes in composition can also result in the same. (hindawi.com)
  • cardiovascular disease
  • The risk of cardiovascular disease has been reported to have a linear relationship with LDL levels. (hindawi.com)
  • Conclusion: Elevated level of Lp-PLA2 is associated with periodontal inflammation, indicating that periodontal treatment could reduce the risk of cardiovascular disease in CP subjects with hyperlipidaemia. (quintpub.com)
  • The test gives results in 25 minutes with a sensitivity down to 0.04 mg/L. The risk of developing cardiovascular disease is quantified as follows: low: hs-CRP level under 1.0 mg/L average: between 1.0 and 3.0 mg/L high: above 3.0 mg/L Normal concentration in healthy human serum is between 5 and 10 mg/L, increasing with aging. (wikipedia.org)
  • Cholesterol levels may be determined as part of health screening for health insurance or occupational health, when the external physical signs such as xanthelasma, xanthoma, arcus are noticed, symptoms of cardiovascular disease develop, or a family member has been found to have FH. (wikipedia.org)
  • diabetes
  • Anti-diabetic drug A kind of medication that helps a person with diabetes control the level of glucose (sugar) in the blood so that the body works as it should. (wikipedia.org)
  • Primary hyperlipidemia is usually due to genetic causes (such as a mutation in a receptor protein), while secondary hyperlipidemia arises due to other underlying causes such as diabetes. (wikipedia.org)
  • In addition, a prospective observational study of dyslipidemic patients with diabetes or hyperglycemia showed that bezafibrate significantly reduces haemoglobin A1c (HbA1c) concentration as a function of baseline HbA1c levels, regardless of concurrent use of antidiabetic drugs. (wikipedia.org)
  • mild
  • Higher levels are found in late pregnant women, mild inflammation and viral infections (10-40 mg/L), active inflammation, bacterial infection (40-200 mg/L), severe bacterial infections and burns (>200 mg/L). CRP is a more sensitive and accurate reflection of the acute phase response than the ESR (Erythrocyte Sedimentation Rate). (wikipedia.org)
  • Mild hypoglycemia, hyperlipidemia, and hyperketosis may occur. (wikipedia.org)
  • statins
  • Nevertheless, with the new advancements in clinical medicine, it has now become possible to bring down the LDL levels to as low as 15 mg/dl using PCSK9 monoclonal antibodies alone or in combination with statins. (hindawi.com)
  • The American College of Cardiology/American Heart Association (NCEP IV) guidelines recommend prescription of evidence-based doses of statins independent of the LDL level [ 3 ]. (hindawi.com)
  • Ezetimibe is recommended as second line therapy for those intolerant of statins or unable to achieve target LDL cholesterol levels on statins alone by several major medical group practice guidelines, including the American College of Cardiology. (wikipedia.org)
  • Meta-analysis showed that rosuvastatin is able to modestly increase levels of HDL cholesterol as well, as with other statins. (wikipedia.org)
  • Heterozygous FH is normally treated with statins, bile acid sequestrants, or other lipid lowering agents that lower cholesterol levels. (wikipedia.org)
  • chronic
  • Methods: Forty chronic periodontitis (CP) subjects with hyperlipidaemia (CP/HPL group), 40 systemically healthy CP subjects (CP group) and 20 systemically and periodontally healthy subjects (control group) were enrolled. (quintpub.com)
  • Other people may develop chronic pancreatitis as a result of hereditary causes, gallstones (which block the pancreatic duct outlet), autoimmune disease such as lupus, or high triglyceride levels. (columbiasurgery.org)
  • Putative beneficial effects of rosuvastatin therapy on chronic heart failure may be negated by increases in collagen turnover markers as well as a reduction in plasma coenzyme Q10 levels in patients with chronic heart failure. (wikipedia.org)
  • patients
  • Thus, the treatment of hyperlipidemia plays a crucial role in the management of patients with CAD or those at increased risk of CAD all around the world. (hindawi.com)
  • The importance of plasma TG as an independent risk factor for CAD was recognized after the publication of a meta-analysis by Austin et al 19,20 in 2000, which provided support for the earlier observation that plasma TG levels predict relative risk in relatives of FCHL patients. (ahajournals.org)
  • The results of the JUPITER trial (2008) suggested rosuvastatin may decrease the relative risk of heart attack and stroke in patients without hyperlipidemia, but with elevated levels of highly sensitive C-reactive protein. (wikipedia.org)
  • protein
  • C-reactive protein (CRP) is an annular (ring-shaped), pentameric protein found in blood plasma, whose levels rise in response to inflammation. (wikipedia.org)
  • While there is an association between increased levels of C-reactive protein and risk of developing cancer, there is no association between genetic polymorphisms influencing circulating levels of CRP and cancer risk. (wikipedia.org)
  • It is associated with hyperlipidemia more frequently than with elevated protein. (wikipedia.org)
  • lower
  • Moreover, various studies aiming to lower the CV risk and mortality by lowering LDL levels have demonstrated encouraging results. (hindawi.com)
  • Acetohexamide A pill taken to lower the level of glucose (sugar) in the blood. (wikipedia.org)
  • The LDL is typically above the 75th percentile, that is, 75% of the healthy population would have a lower LDL level. (wikipedia.org)
  • risk
  • Hyperlipidemia has always been a topic of interest owing to the concomitant increased risk of adverse cardiovascular events. (hindawi.com)
  • Moreover, increased LDL levels are found to be positively correlated with the increased CV risk. (hindawi.com)
  • Furthermore, targeting HDL and TG levels to reduce this residual risk has been proved futile [ 5 ]. (hindawi.com)
  • In a 2004 prospective cohort study on colon cancer risk associated with CRP levels, people with colon cancer had higher average CRP concentrations than people without colon cancer. (wikipedia.org)
  • cause
  • Its half-life of 18 hours is constant, and therefore its level is determined by the rate of production and hence the severity of the precipitating cause. (wikipedia.org)
  • positively
  • Linear regression analysis showed that the serum level of Lp-PLA2 was positively associated with bleeding on probing and WBC counts. (quintpub.com)
  • significantly
  • Results: Serum Lp-PLA2 level in the CP/HPL group and the CP group was significantly higher than in the healthy group. (quintpub.com)
  • Prostacyclin/thromboxane are produced by both COX-1 and COX-2, and rofecoxib suppresses just COX-2 enzyme, so there is no reason to believe that prostacyclin levels are significantly reduced by the drug. (wikipedia.org)
  • liver
  • The assessment of plasma TG concentration as an independent predictor for CAD is complicated by the fact that (1) there is considerable interindividual and intraindividual variation in plasma TG levels and (2) circulating TRL are highly heterogeneous in size, density, and composition and may consist of intestinally derived apolipoprotein (apo) B-48-containing chylomicrons and chylomicron remnants, in addition to liver-derived apoB-100-containing VLDL and their remnants. (ahajournals.org)
  • Interferon alpha inhibits CRP production from liver cells which may explain the relatively low levels of CRP found during viral infections compared to bacterial infections Measuring and charting CRP values can prove useful in determining disease progress or the effectiveness of treatments. (wikipedia.org)
  • maintain
  • As we all know, cholesterol is an integral part of the plasma membrane, and a minimum level of LDL needs to be present to maintain structural integrity and sustain normal function of cells. (hindawi.com)
  • plasma
  • Rofecoxib crossed the placenta and blood-brain barrier, and took 1-3 hours to reach peak plasma concentration with an effective half-life (based on steady-state levels) of approximately 17 hours. (wikipedia.org)
  • target
  • The current challenge is to explore this arena to redefine the target LDL levels, if required, to avoid any suboptimal treatment. (hindawi.com)
  • If your tongue is sensitive to the spicy drops, work your way up to the target level. (healthy.co.nz)
  • heart
  • It has been found that not only elevated levels of LDL lead to coronary heart disease, but changes in composition can also result in the same. (hindawi.com)