Levels beta catenin. Medical search. Frequent questions

Overexpressing CD82 or CD9, members of the tetraspanin family of transmembrane proteins, suppressed Wnt signaling and reduced beta-catenin protein levels. (eurekalert.org)

This library represents a selection of drug-like compounds aimed at modulating protein-protein interaction (PPI) of β-catenin with different proteins involved in significant physiological processes. (chemdiv.com)
The molecular weight of proteins were 102, 88 and 80 kDa, so they were named α, β and γ-catenin. (chemdiv.com)
In addition to ligand-regulated degradation of β-catenin, Wnt signaling is antagonized by extracellular factors that inhibit the ability of Wnt ligands to bind to Fzd and initiate signaling, such as the secreted frizzled-related proteins (SFRP1, WNT inhibitory factor (WIF) and dickkopf (DKK) [3] . (plos.org)
As part of the cell-signaling pathway, beta-catenin interacts with other proteins to control the activity (expression) of particular genes, which helps promote cell proliferation and differentiation. (medlineplus.gov)
SUMOylation is a post-translational modification of proteins that has been found to play a major role in the Wnt/β-catenin signaling pathway. (frontiersin.org)
Proteins associated with the Wnt/β-catenin pathway have been identified as SUMOylated substrates, and evidences suggested that the initiation and progression of cancers depended on the function of the SUMOylation ( 23 ). (frontiersin.org)
The ras-transformed cells reveal elevated phosphotyrosine in many proteins, including beta-catenin and p120 Cas. (rupress.org)
These results suggest that elevated tyrosine phosphorylation of proteins such as beta-catenin and p120 Cas contribute to the altered adherens junctions of ras-transformed epithelia. (rupress.org)
The aggregation of both amyloid beta (Abeta) peptides extracellularly and Tau proteins intracellularly plays key roles in the pathological consequences of AD, which lead to cholinergic neurodegeneration and eventually death. (inra.fr)
Proteins transcribed from the E1B region of ADENOVIRUSES which are involved in regulation of the levels of early and late viral gene expression. (bvsalud.org)

Mutations and overexpression of β-catenin are associated with many cancers, including hepatocellular carcinoma, colorectal carcinoma, lung cancer, malignant breast tumors, ovarian and endometrial cancer. (wikipedia.org)
Although mutations in these same genes have not been observed as recurrent genetic events in breast tumors, there is strong evidence implicating Wnt/β-catenin activity in breast tumorigenesis. (plos.org)
Mutations in the APC gene that cause desmoid tumors lead to a short APC protein that is unable to interact with beta-catenin. (medlineplus.gov)
Excess beta-catenin, whether caused by CTNNB1 or APC gene mutations, promotes uncontrolled growth and division of cells, allowing the formation of desmoid tumors. (medlineplus.gov)
Methods: Escalating doses of PF-04691502 were administered to 23 patients with advanced solid tumors in sequential cohorts across the following dose levels: 2 mg, 4 mg, 8 mg, and 11 mg. 14 additional patients were enrolled in an expansion cohort at the MTD to ensure at least five matched pre- and post-treatment biopsies for biomarkers of PI3K activity. (researchgate.net)
Analysis of Wnt/Beta catenin signalling in desmoid tumors. (firebaseapp.com)
However, studies have identified the beta-catenin pathway as playing a potential role in the pathogenesis of these tumors. (medscape.com)

β-catenin is a component of the complex cadherin complex whose stabilization is required to activate Wnt/β-catenin signaling. (chemdiv.com)
Canonical Wnt/β-catenin signaling is initiated by binding of Wnt ligands to Frizzled (Fzd)-LRP5/6 receptor complexes, leading to inactivation of the destruction complex and stabilization of β-catenin. (plos.org)
Wnts bind to the cell surface Frizzled family receptors in conjunction with low-density lipoprotein receptor-related protein family receptors (LRP5 or 6) resulting in the stabilization of intracellular beta -catenin levels (2). (novusbio.com)
Wnts bind Frizzled receptors and forms complex with low-density lipoprotein receptor-related protein (LRP5 or LRP6) which results in the stabilization of intracellular beta-catenin levels. (biolegend.com)
Mutagenesis experiments demonstrate that substitution of the serine residues in the glycogen synthase kinase 3beta (GSK3beta) phosphorylation consensus motif of beta-catenin inhibits ubiquitination and results in stabilization of the protein. (bioseek.eu)

Catenin beta-1, also known as β-catenin (beta-catenin), is a protein that in humans is encoded by the CTNNB1 gene. (wikipedia.org)
Loss-of-function mutations in APC or AXIN or activating mutations in the gene encoding β-catenin, CTNNB1 , lead to aberrant activation of Wnt/β-catenin signaling and have been causally linked to tumorigenesis of the colon, liver and skin [1] , [4] . (plos.org)
The CTNNB1 gene provides instructions for making a protein called beta-catenin. (medlineplus.gov)
CTNNB1 gene mutations lead to an abnormally stable beta-catenin protein that is not broken down when it is no longer needed. (medlineplus.gov)

Building on previous work, Dr. Alman will focus on drugs that inhibit DT cell growth presumably by blocking Beta catenin signaling in mesenchymal cells. (dtrf.org)
Nefopam targets β-catenin protein level in mesenchymal cells in-vitro and in-vivo. (dcchemicals.com)

In colon-derived cell lines where Yap is overabundant, its depletion strongly reduces beta-catenin and Notch signaling and inhibits proliferation and survival. (harvard.edu)
E-7386 (E7386) is a potent, orally active modulator of CBP/beta-catenin, disrupts the interaction and inhibits canonical Wnt signaling pathway /TCF reporter gene activity in LiCl-stimulated HEK-293 and MDA-MB-231 with IC50 of 55 and 73 nM, respectively. (dcchemicals.com)
ZW4864 (free base) inhibits β catenin/BCL9 PPI with a Ki value of 0.76 μM and an IC50 value of 0.87 μM. (dcchemicals.com)

Intracellular accumulation of beta-catenin increases translocation of the protein into the nucleus, where it binds to TCF/LEF transcription factors to promote expression of Wnt target genes. (biolegend.com)
beta-catenin, but not E-cadherin, p120(cas) or alpha-catenin, becomes stabilized when proteasome-mediated proteolysis is inhibited and this leads to the accumulation of multi-ubiquitinated forms of beta-catenin. (bioseek.eu)
One study showed that the accumulation of nuclear beta-catenin as measured immunohistochemically was able to help differentiate craniopharyngiomas from Rathke cleft cysts. (medscape.com)

β-Catenin is a dual function protein, involved in regulation and coordination of cell-cell adhesion and gene transcription. (wikipedia.org)
Not only their ARM domains resemble each other in both architecture and ligand binding capacity, but the N-terminal β-TrCP-binding motif is also conserved in plakoglobin, implying common ancestry and shared regulation with β-catenin. (wikipedia.org)
The recently described role of the Wnt/β-catenin pathway in the regulation of immune cell infiltration of microenvironment tumor resumes interest because of its potential impact to rection of immune therapy. (chemdiv.com)
Studies have shown that the Wnt/β-catenin signaling pathway controls cell fate and function through the transcriptional and post-translational regulation of omics networks. (frontiersin.org)
Therefore, precise regulation of Wnt/β-catenin signaling as a cancer-targeting strategy may contribute to the treatment of some malignancies. (frontiersin.org)
Here, we review the complex regulation of Wnt/β-catenin signaling by SUMOylation and discuss the potential targets of SUMOylation therapy. (frontiersin.org)
They found bated levels of beta-catenin, a macromolecule concerned in hair growth and therefore the method of generation and regulation of follicles. (dailybayonet.com)
Here we show that the ubiquitin-dependent proteolysis system is involved in the regulation of beta-catenin turnover. (bioseek.eu)
We show that ubiquitination of beta-catenin is greatly reduced in Wnt-expressing cells, providing the first evidence that the ubiquitin-proteasome degradation pathway may act downstream of GSK3beta in the regulation of beta-catenin. (bioseek.eu)
[ 3 ] Beta-catenin is a downstream component of the Wnt signal transduction pathway that plays critical roles in the regulation of cellular proliferation, morphology, and development. (medscape.com)

But very soon, it was realized that the Drosophila protein armadillo - implicated in mediating the morphogenic effects of Wingless/Wnt - is homologous to the mammalian β-catenin, not just in structure but also in function. (wikipedia.org)
In the current model of this pathway, the amount of beta-catenin (or its invertebrate homolog Armadillo) is tightly regulated and its steady-state level outside the cadherin-catenin complex is low in the absence of Wingless/Wnt signal. (bioseek.eu)

Notably, the C-terminal segment of β-catenin can mimic the effects of the entire Wnt pathway if artificially fused to the DNA binding domain of LEF1 transcription factor. (wikipedia.org)
Here we identify CSNK1E , the gene encoding casein kinase 1 epsilon (CK1ε) as required specifically for the proliferation of breast cancer cells with activated β-catenin and confirm its role as a positive regulator of β-catenin-driven transcription. (plos.org)
Once stabilized, β-catenin accumulates and translocates to the nucleus, where it complexes with TCF/LEF to activate transcription of target genes, such as MYC and CCND1 . (plos.org)
Wnt-beta catenin activity is required for transcription of many target genes in the oral territory, including two Brachyury orthologues necessary for gastrulation. (cam.ac.uk)
ICG-001 is a small-molecule antagonist of b-catenin/TCF-mediated transcription (IC50 = 3 uM) and specifically downregulates the expression of a subset of b-catenin/TCF-responsive genes. (dcchemicals.com)
iCRT3 is an inhibitor of both Wnt and β-catenin-responsive transcription. (dcchemicals.com)
We further wanted to ascertain whether this protein interaction was direct using recombinant versions of purified b-catenin and WT1 protein but failed to detect any association ( Online Supplementary Figure S1B, C ). This suggested that perhaps the interaction is mediated through a post-translational modification, common partners such as WTX, 8 or cellular structures like DNA, given their well-documented roles in transcription. (haematologica.org)

In conclusion, our data showed that β-catenin expression in fibroids occurs independently of MED12 mutations. (embies.com)

In cardiac muscle, β-catenin localizes to adherens junctions in intercalated disc structures, which are critical for electrical and mechanical coupling between adjacent cardiomyocytes. (wikipedia.org)
Contributing to the modified adherens junctions of the transformed cells are decreased interactions among beta-catenin, E-cadherin, and the actin cytoskeleton. (rupress.org)

Components of the canonical wingless (WNT) pathway, including WNT8b, WNT10a, WNT10b, frizzled 1 and 2 and TCF4 were upregulated at the messenger RNA and protein levels following Cyclin A2 depletion. (cnrs.fr)
We were successful in reducing the cellular beta-catenin protein levels and both the chitosan/siRNA and PEGylated chitosan/siRNA approaches were successful in reducing beta catenin protein levels after 48 h. (txst.edu)
Another significant result was that the chitosan/siRNA had a similar ability as Lipofectamine/siRNA to reduce beta catenin protein levels when administered at a sufficient concentration of siRNA. (txst.edu)

Speaking more specifically, β-catenin is an integral structural component of cadherin-based adhesive junctions as well as it a key nuclear effector of canonical in nucleus Wnt signaling. (chemdiv.com)
The Wnt pathway mediates the biological processes of the canonical or non-canonical pathway, depending on the involvement of β-catenin in signal transduction. (chemdiv.com)
The canonical signaling pathway is initiated upon Wnt binding to a Frizzled family receptor and an LRP5/LRP6 coreceptor, which leads to activation of the beta-catenin cascade. (thermofisher.com)
LF3 is a specific inhibitor of canonical Wnt signaling by disrupting the interaction between β-catenin and TCF4 with an IC50 less than 2 μM. (dcchemicals.com)
Recent studies showed that genetic aberrations in the MED12 gene, probably through the canonical WNT/β-catenin pathway, lead to the pathogenesis of uterine fibroids. (embies.com)

The Wnt/β-catenin pathway plays a critical role in embryonic development, maintenance of multipotent progenitor cell populations and proliferation of many tissue types [1] , [2] . (plos.org)
Abnormally activated Wnt/β-catenin signaling pathway plays a crucial role in promoting malignant tumor occurrence, development, recurrence, and metastasis, particularly in cancer stem cells. (frontiersin.org)

A representative example of a 'druggable' 'hot spots' included specific topological features of the β -catenin interaction. (chemdiv.com)
In particular, decreased tyrosine phosphorylation of beta-catenin is accompanied by increased interaction with both E-cadherin and the detergent insoluble cytoskeletal fraction. (rupress.org)
PRI-724 (C-82 prodrug, ICG-001 analog) is a potent and specific inhibitor that disrupts the interaction of β-catenin and CBP. (dcchemicals.com)
ZW4864 (free base) is an orally active and selective β catenin/B-Cell lymphoma 9 protein−protein interaction (β catenin/BCL9 PPI) inhibitor. (dcchemicals.com)
GB1874 is an inhibitor of the Wnt pathway that targets the β-catenin-TCF4 interaction.GB1874 affected the proliferation and stemness of Wnt-addicted colorectal cancer (CRC) cells in vitro.GB1874 inhibited the growth of CRC tumor xenografts in vivo. (dcchemicals.com)
Our data are consistent with an epistatic model of interaction where discordant levels of GSK3B and MAPT gene expression can lead to altered beta-catenin levels and pathogenicity. (ox.ac.uk)
WT1 is an RNA-binding protein, 6 and β-catenin has also been shown to bind RNA, 7 so to confirm this interaction was not indirect via RNA binding we repeated WT1 Co-IP (with or without CHIR99021) after first confirming complete digestion of RNA through RNase A pre-treatment of cell lysates ( Figure 1E ). (haematologica.org)
As shown in Figure 1F-H, the b-catenin:WT1 interaction remained in K562, HEL and KG-1 cells under both basal (DMSO) and stimulated (CHIR99021) Wnt signaling. (haematologica.org)

We demonstrated that the patients with higher levels of Notch3 expression commonly had a poor prognosis. (oncotarget.com)
b-Catenin is the central mediator of Wnt signaling and is frequently overexpressed in AML in which it is associated with poor prognosis. (haematologica.org)

Furthermore, the Wnt/β-catenin can crosstalk with other signaling pathways including Notch, FGF, Hedgehog, and TGF-β/BMP signaling cascades to form a signaling network to regulate the survival and progression of cancer cells ( 14 - 16 ). (frontiersin.org)

Thus, β-catenin became one of the first examples of moonlighting: a protein performing more than one radically different cellular function. (wikipedia.org)
The team found that CD9 and CD82 boosted the release of exosomes containing beta-catenin, thereby reducing cellular levels of the protein and inhibiting the Wnt pathway. (eurekalert.org)
β-Catenin is a fascinating protein with many important cellular and developmental functions. (chemdiv.com)
β -catenin has many binding partners that mediate a diverse set of cellular functions, and the protein probably acts as a 'hub' on which many cellular signaling networks impinge. (chemdiv.com)

β-catenin is a subunit of the cadherin protein complex and acts as an intracellular signal transducer in the Wnt signaling pathway. (wikipedia.org)

As a result, beta-catenin is not broken down and, instead, accumulates in cells. (medlineplus.gov)

beta-Catenin levels and signaling were determined using Western blot and luciferase reporter assays in cells transfected with a combination of GSK3B and MAPT complementary DNA. (ox.ac.uk)

2008. Protective versus promotional effects of white tea and caffeine on PhIP-induced tumorigenesis and beta-catenin expression in the rat. . (oregonstate.edu)

Although biallelic deletion of Yap1 from intestinal epithelium has little effect on intestinal development, inactivation of a single Yap1 allele reduces Yap1 polypeptide abundance to nearly wild-type levels and, despite the continued Yap hypophosphorylation and preferential nuclear localization, normalizes epithelial structure. (harvard.edu)
In conclusion, our study demonstrated that Notch3 plays a role in modulating the stemness of tumor cells via the inactivation of the Wnt/β-catenin pathway. (oncotarget.com)

Exosomal release of beta-catenin and inhibition of Wnt signaling may explain why CD82 and CD9 suppress tumor metastasis. (eurekalert.org)
Researchers reveal a new way in which cells restrain beta-catenin and potentially suppress tumor metastasis: the protein can be ejected from cells in small vesicles called exosomes. (eurekalert.org)
CD82 may act as a metastasis suppressor by targeting beta-catenin for exosomal release and thereby reducing its availability as a Wnt signaling mediator," Caplan proposes. (eurekalert.org)
An imbalance in the structural and signaling properties of β-catenin often leads to disease and unregulated growth associated with cancer and metastasis. (chemdiv.com)
In addition, Wnt/β-catenin has emerged as a critical regulator of cancer stem cells (CSCs), which is considered one of the root causes of cancer recurrence and metastasis because of their heterogeneity and plasticity ( 13 ). (frontiersin.org)
Together," they write, "our data suggest that LINC00673-v4 is a driver molecule for metastasis via constitutively activating WNT/beta-catenin signaling in [lung adenocarcinoma] and may represent a potential therapeutic target against the metastasis of [lung adenocarcinoma]. (genomeweb.com)
Yale researchers have discovered how metastasis, the spread of cancer cells throughout the body, is triggered on the molecular level, and have developed a tool with the potential to detect those triggers in patients with certain cancers. (scitechdaily.com)

The exosomal release of beta-catenin may be compromised in certain cancers, where Wnt signaling is often hyperactive. (eurekalert.org)
Deregulation of components involved in Wnt/β-catenin signaling has been implicated in a wide spectrum of diseases including a number of cancers and degenerative diseases. (chemdiv.com)
These studies identify CK1ε as a critical contributor to activated β-catenin signaling in cancer and suggest it may provide a potential therapeutic target for cancers that harbor active β-catenin. (plos.org)
With a series of follow-up experiments, together with data from the Atlas of Noncoding RNAs in Cancer, they found that LINC00673-v4 was not only found at higher-than-usual levels in lung adenocarcinoma cells, but also appeared to influence the invasiveness of lung cancer cell lines as well as the progression and metastatic potential of lung cancers in a mouse model. (genomeweb.com)

Degradation of β-catenin is thus mediated by this N-terminal segment. (wikipedia.org)
In the absence of Wnt ligands, a complex containing APC, AXIN and GSK3 phosphorylates β-catenin, marking it as a substrate for ubiquitination by β-TrCP and subsequent proteasomal degradation. (plos.org)
This motif in beta-catenin resembles a motif in IkappaB (inhibitor of NFkappaB) which is required for the phosphorylation-dependent degradation of IkappaB via the ubiquitin-proteasome pathway. (bioseek.eu)

tyrosine-phosphorylated p120 Cas, but not tyrosine-phosphorylated beta-catenin, now is detected in E-cadherin complexes. (rupress.org)

Activation of the Wnt pathway stabilizes beta-catenin, allowing it to move into the cell nucleus and control the expression of many different genes. (eurekalert.org)
The roles of b-catenin are 'classically' defined: as an adhesion protein and as a signaling protein, transducing extracellular signals to the nucleus to modify gene expression. (chemdiv.com)
CWP232228, a highly potent selective Wnt/β-catenin signaling inhibitor, antagonizes binding of β-catenin to T-cell factor (TCF) in the nucleus. (dcchemicals.com)

Wnt/β-catenin signaling is a delicate and complex signal transduction pathway mediated by multiple signaling molecules, which plays a significant role in regulating human physiology and pathology. (frontiersin.org)
Conceptually, it is an efficient way to treat cancer involved the hijacking of PTMs of the key molecules in Wnt/β-catenin. (frontiersin.org)
With a method they devised that mimics the cell environment, the researchers explored the EMT process at the molecular level and discovered two separate feedback mechanisms -- that is, two or more molecules inhabiting or activating each other. (scitechdaily.com)
Conversely, cotransfection of both of these molecules increased beta-catenin signaling. (ox.ac.uk)

In Cyclin A2-depleted normal murine mammary gland (NMuMG) cells expressing RasV12, we found that beta-catenin was liberated from the cell membrane and cell-cell junctions and underwent nuclear translocation and activation. (cnrs.fr)
Diminished phosphorylation, enhanced abundance, and nuclear localization of the transcriptional coactivator Yes-associated protein 1 (Yap1) is evident in Mst1/Mst2-deficient intestinal epithelium, as is strong activation of beta-catenin and Notch signaling. (harvard.edu)
During blast crisis of chronic myelogenous leukemia (CML), abnormal granulocyte macrophage progenitors (GMP) with nuclear beta-catenin acquire self-renewal potential and may function as leukemic stem cells (Jamieson et al. (ca.gov)

Liver Specification in the Absence of Cardiac Differentiation Revealed by Differential Sensitivity to Wnt/β Catenin Pathway Activation. (xenbase.org)
This suggests that a WNT-independent mechanism of beta-catenin activation via phospholipase C is involved in the EMT induced by Cyclin A2 depletion. (cnrs.fr)

Michael Caplan's group at Yale University uncovered a new way in which cells restrain beta-catenin's activity. (eurekalert.org)
Wnt/β-catenin signaling is a branch of a functional network that is involved in a broad range of biological systems including stem cells, embryonic development and adult organs. (chemdiv.com)
To uncover genetic dependencies in breast cancer cells that harbor active β-catenin signaling, we performed RNAi-based loss-of-function screens in breast cancer cell lines in which we had characterized β-catenin activity. (plos.org)
Furthermore, we demonstrate that breast cancer cells that harbor activated β-catenin activity exhibit enhanced sensitivity to pharmacological blockade of Wnt/β-catenin signaling. (plos.org)
We also find that expression of CK1ε is able to promote oncogenic transformation of human cells in a β-catenin-dependent manner. (plos.org)
The molecule apparently does so by regulating levels of beta-catenin in bone cells known as osteoblasts. (smithsonianmag.com)
Starting with a luciferase assay, insights gleaned from the Cancer Genome Atlas transcriptome sequencing efforts, and a rapid amplification of cDNA ends experiment, the researchers found a LINC00673 isoform that appeared to influence WNT/beta-catenin signaling in lung adenocarcinoma cells. (genomeweb.com)
These results provide further evidence that BCR-ABL-transformed GMP with abnormal beta-catenin activity can function as leukemic stem cells. (ca.gov)
The agents identified will be tested for their ability to alter DT cell proliferation, Beta catenin protein level and differential effects on stem cells. (dtrf.org)
Prolonged exposure to LPS increases iron, heme, and p22phox levels and NADPH oxidase activity in human aortic endothelial cells: inhibition by desferrioxamine. (oregonstate.edu)
Whereas in the normal cells beta-catenin is found in association with E-cadherin, p120 Cas is not. (rupress.org)
Inhibitors of tyrosine kinases decrease the level of tyrosine phosphorylation and restore a normal epithelial morphology to the ras-transformed cells. (rupress.org)
The Notch3-positive cells had higher levels of aldehyde dehydrogenase (ALDH) activity, and a tendency to differentiate into Notch3-negative cells. (oncotarget.com)
1 Wnt/b-catenin is also known to drive the emergence and maintenance of leukemia stem cells in AML. (haematologica.org)
2 Protein interactions are critical to the stability, localization and activity of b-catenin, and we recently performed the first proteomic analyses of the b-catenin interactome in myeloid cells. (haematologica.org)
We cultured primary fibroid cells on hydrogels of known stiffness to decipher the influence of biomechanical cues on β-catenin expression and revealed increased levels of β-catenin when cells were cultured on a stiffer surface. (embies.com)
We have made an effort to use this technology to reduce the expression of beta-catenin in colon cancer cells. (txst.edu)
namely siRNA in Lipofectamine 2000 to identify the difference in the levels of beta-catenin protein in HCT 116 cells. (txst.edu)

Beta-catenin is a central component of the Wnt signaling pathway that controls cell proliferation and differentiation. (eurekalert.org)
Thus, supraphysiologic Yap polypeptide levels are necessary to drive intestinal stem cell proliferation. (harvard.edu)
2003. Promotion versus suppression of rat colon carcinogenesis by chlorophyllin and chlorophyll: modulation of apoptosis, cell proliferation, and beta-catenin/Tcf signaling. . (oregonstate.edu)

β-catenin is a multipurpose and evolutionarily conserved molecule that plays a critical role by metazoans in a variety of processes in development and homeostasis. (chemdiv.com)
β-catenin belongs to the catenin molecule family. (chemdiv.com)

beta-catenin is a central component of the cadherin cell adhesion complex and plays an essential role in the Wingless/Wnt signaling pathway. (bioseek.eu)

β-Catenin was initially discovered in the early 1990s as a component of a mammalian cell adhesion complex: a protein responsible for cytoplasmatic anchoring of cadherins. (wikipedia.org)
HelixC is not necessary for β-catenin to function in cell-cell adhesion. (wikipedia.org)
The protein produced from the APC gene helps regulate levels of beta-catenin in the cell. (medlineplus.gov)
Shown are YAP (red), beta-catenin (green), and cell nuclei (blue). (scitechdaily.com)
PNU-74654 is an inhibitor of Wnt/β-catenin pathway with an IC50 of 129.8 μM in NCI-H295 cell. (dcchemicals.com)
In parallel, we found that Notch3 attenuation resulted in the upregulation of β-catenin and the downregulation of Nanog in the hepatoma cell lines QGY7701 and HepG2. (oncotarget.com)
In order to idenitfy appropriate cell lines in which to study b-catenin:WT1 interplay we first performed a screen of myeloid cell lines to examine b-catenin and WT1 protein expression. (haematologica.org)
We observed a statistically significant correlation between b-catenin and WT1 expression across 16 myeloid cell lines, with 50% (8/16) co-expressing b-catenin and WT1 to varying degrees ( Figure 1A , B). There was no particular association of this correlation with cell line morphology or genotype. (haematologica.org)
Association between b-catenin and WT1 in myeloid cell lines. (haematologica.org)
A) Immunoblot of myeloid leukemia cell lines showing the relative level of b-catenin (~92 kDa) and WT1 (~50 kDa) protein, with b-actin (42 kDa) used to assess protein loading. (haematologica.org)

ChemDiv's Inhibitors of beta-Catenin Signaling Library contains 8,000 compounds. (chemdiv.com)
ChemDiv proposes the new library of beta-catenin inhibitors/modulators. (chemdiv.com)

This is in contrast to (B), where injection of cer1 or hhex MOs in AE leads to downregulation of both cardiac and liver marker gene mRNA levels in conjugates. (xenbase.org)

β-Catenin is regulated and destroyed by the beta-catenin destruction complex, and in particular by the adenomatous polyposis coli (APC) protein, encoded by the tumour-suppressing APC gene. (wikipedia.org)

Alterations in the localization and expression levels of β-catenin have been associated with various forms of heart disease, including dilated cardiomyopathy. (wikipedia.org)
Notch3 expression positively correlated with alpha-fetoprotein (AFP) levels ( p = 0.0311) and negatively correlated with the differentiation grade ( p = 0.042). (oncotarget.com)
We discovered that Notch3 expression is inversely correlated with β-catenin content but positively associated with the protein level of Nanog. (oncotarget.com)
Liquid chromatography-mass spectrometry (LC-MS), Western blotting and immunohistochemistry were used to monitor the expression of β-catenin. (embies.com)
We showed that β-catenin expression was increased in fibroids compared to the adjacent myometrium samples. (embies.com)
However, β-catenin expression showed no correlation with MED12 mutation status. (embies.com)
Biomechanical changes upregulate β-catenin expression in fibroids, providing an attractive avenue for developing new treatments for this disease. (embies.com)
[ 4 ] Other molecular factors that have been identified in aggressive or recurrent craniopharyngiomas are low expression levels of macrophage-inhibiting factor (MIF) and galectins, retinoic-acid receptor levels, low cathepsin levels, and high vascular-endothelial growth factor (VEGF) levels. (medscape.com)

However approaches to modulate β-catenin activity for therapeutic purposes have proven elusive to date. (plos.org)
The leukemogenic GMP displayed higher levels of beta-catenin activity than either the nontransformed GMP or the transformed nonGMP, both in culture and in transplanted mouse BM. (ca.gov)
SKL2001 is an agonist of the Wnt/β-catenin pathway, with anti-cancer activity. (dcchemicals.com)

Using an emerging experimental model from the Hydrozoa, Clytia hemisphaerica1, we have identified embryonic axis determinants at the molecular level as localised maternal mRNAs, coding for a Wnt ligand and two Frizzled-family receptors with antagonistic activities2,3. (cam.ac.uk)

The core of β-catenin consists of several very characteristic repeats, each approximately 40 amino acids long. (wikipedia.org)
The primary structure of beta-catenin consists of an NH2-terminal domain (NDT), a central region represented by 12 Arm-repeats (R1-12), and a COOH-terminal end (CTD). (chemdiv.com)

Yet these intrinsically disordered regions play a crucial role in β-catenin function. (wikipedia.org)
Keeping beta-catenin at the proper levels appears crucial for the formation of new high-density bone. (smithsonianmag.com)

PF-04691502 resulted in increased mean fasting serum glucose, insulin, and c-peptide levels, and produced partial blockade of PI3K signalling in five paired tumor biopsies, as demonstrated by reductions in phosphorylated Akt, FKHR/FKHRL1, and STAT3. (researchgate.net)

E- and P-cadherin levels changed during culture, the former increasing after confluence, and the latter were markedly reduced. (ox.ac.uk)
All detectable E-cadherin was bound to beta- and gamma-catenins. (ox.ac.uk)

β-catenin-IN-2 can be used for the study of colorectal cancer. (dcchemicals.com)

These mRNAs become translated following fertilisation, initiating a sequence of interactions that restricts Wnt-beta catenin signalling to the future oral territory of the blastula. (cam.ac.uk)

Across all dose levels, average steady-state plasma PF-04691502 concentrations approximated or exceeded the target concentration of 16.2 ng/mL required for ≥75 % tumor growth inhibition in preclinical models. (researchgate.net)

When beta-catenin is no longer needed, the APC protein attaches (binds) to it, which signals for it to be broken down. (medlineplus.gov)

Anatomy10

Diseases6

Chemicals and Drugs44

Analytical, Diagnostic and Therapeutic Techniques and Equipment7

Phenomena and Processes10

Disciplines and Occupations1

Information Science2

Reduced beta-catenin protein levels1

Proteins10

Tumors7

Stabilization5

CTNNB14

Mesenchymal cells2

Inhibits3

Accumulation3

Regulation10

Armadillo2

Transcription7

Mutations1

Adherens junctions2

Protein levels3

Canonical5

Pathway plays2

Interaction8

Poor prognosis2

Crosstalk1

Cellular4

Intracellular1

Accumulates1

Determined using Wester1

Tumorigenesis1

Inactivation2

Metastasis7

Cancers4

Degradation3

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Molecules4

Nuclear3

Activation2

Cells18

Proliferation3

Molecule2

Wingless1

Cell10

Inhibitors2

Downregulation1

Destruction complex1

Expression8

Activity3

Embryonic1

Consists2

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Binds1