• stroke
  • On September 30, 2004, Merck withdrew rofecoxib from the market because of concerns about increased risk of heart attack and stroke associated with long-term, high-dosage use. (wikipedia.org)
  • Mitral stenosis poses a high risk of forming emboli which may travel to the brain and cause stroke. (wikipedia.org)
  • Myocardial infarction and stroke prophylaxis in patients with type II diabetes There have been recent studies suggesting that high-dose statin therapy plays a plaque-stabilizing role in people suffering from acute coronary syndrome and thrombotic stroke. (wikipedia.org)
  • patients
  • As the level of leptin in the body is proportional to the amount of adipose tissue present, AGL patients also have a deficiency of leptin which contributes to excessive eating and worsens the metabolic syndrome. (wikipedia.org)
  • Further research presented in 2016 showed the role of high cholesterol and possibly the role of statins improving the mortality and survival of patients with breast cancer, lung cancer, bowel cancer and prostate cancer and strengthening calls for a clinical trial of statins in cancer. (wikipedia.org)
  • Geriatric: Plasma concentrations of atorvastatin in healthy elderly subjects are higher than those in young adults, and clinical data suggests a greater degree of LDL-lowering at any dose for patients in the population as compared to young adults. (wikipedia.org)
  • Hepatic impairment: In patients with chronic alcoholic liver disease, levels of atorvastatin may be significantly increased depending upon the extent of liver disease. (wikipedia.org)
  • risk
  • What puts me at a higher risk to have a cerebrovascular accident? (drugs.com)
  • Nandrolone esters have also more recently been proposed for the treatment of androgen deficiency in men due to favorable properties including their high ratio of anabolic to androgenic effect and consequent much lower risk of prostate enlargement, prostate cancer, and scalp hair loss relative to testosterone. (wikipedia.org)
  • While there is an association between increased levels of C-reactive protein and risk of developing cancer, there is no association between genetic polymorphisms influencing circulating levels of CRP and cancer risk. (wikipedia.org)
  • In a 2004 prospective cohort study on colon cancer risk associated with CRP levels, people with colon cancer had higher average CRP concentrations than people without colon cancer. (wikipedia.org)
  • Other research focusing on young South Asians has shown that they have a higher risk of Diabetes and associated heart disease compared to other ethnic groups. (wikipedia.org)
  • Severe
  • Severe changes in the levels of protein and electrolytes in the blood have the potential to disrupt the function of the brain and may cause seizures, in rare cases. (news-medical.net)
  • Higher levels are found in late pregnant women, mild inflammation and viral infections (10-40 mg/L), active inflammation, bacterial infection (40-200 mg/L), severe bacterial infections and burns (>200 mg/L). CRP is a more sensitive and accurate reflection of the acute phase response than the ESR (Erythrocyte Sedimentation Rate). (wikipedia.org)
  • protein
  • Low levels of protein in the blood stimulate the synthesis of protein in the liver, leading to increased production of lipoproteins. (news-medical.net)
  • It occurs due to excess fluid in the body, which is linked to low levels of protein in the blood. (news-medical.net)
  • Increased levels of protein in the urine and lack of protein in the blood can have a significant impact on the function of many areas of the body. (news-medical.net)
  • It is associated with hyperlipidemia more frequently than with elevated protein. (wikipedia.org)
  • C-reactive protein (CRP) is an annular (ring-shaped), pentameric protein found in blood plasma, whose levels rise in response to inflammation. (wikipedia.org)
  • A diet high in plant sterols, soy protein, viscous fibre, almond (diet portfolio) for a month. (wikipedia.org)
  • statin
  • Since individuals with FH underlying body biochemistry is slightly different, their high cholesterol levels are less responsive to the kinds of cholesterol control methods which are usually more effective in people without FH (such as dietary modification and statin tablets). (wikipedia.org)
  • Nevertheless, treatment (including higher statin doses) is usually effective. (wikipedia.org)
  • If dietary and life style management is ineffective, medication such as statin will be used to in conjunction to reduce blood cholesterol levels. (wikipedia.org)
  • LDL level was reduced significantly in both the statin group and the diet portfolio group. (wikipedia.org)
  • liver
  • Interferon alpha inhibits CRP production from liver cells which may explain the relatively low levels of CRP found during viral infections compared to bacterial infections Measuring and charting CRP values can prove useful in determining disease progress or the effectiveness of treatments. (wikipedia.org)
  • markedly
  • Markedly elevated CPK levels or if a myopathy is suspected or diagnosed after dosing of atorvastatin has begun. (wikipedia.org)
  • sodium
  • Potential side effects include poor kidney function, electrolyte imbalances especially low blood potassium and less commonly low blood sodium, gout, high blood sugar, and feeling faint initially upon standing up. (wikipedia.org)
  • concentrations
  • Gender: Plasma concentrations are generally higher in women than in men, but there is no clinically significant difference in the extent of LDL reduction between men and women. (wikipedia.org)
  • several
  • HIIT exercise sessions generally consist of a warm up period, then several repetitions of high-intensity exercise separated by medium intensity exercise for recovery, then a cool down period. (wikipedia.org)
  • Professor Martin Gibala and his team at McMaster University in Canada have been researching high-intensity exercise for several years. (wikipedia.org)
  • Dosage
  • The 100 mg/mL formulation is used to treat women with inoperable breast cancer, which requires a higher dosage. (wikipedia.org)
  • significantly
  • Prostacyclin/thromboxane are produced by both COX-1 and COX-2, and rofecoxib suppresses just COX-2 enzyme, so there is no reason to believe that prostacyclin levels are significantly reduced by the drug. (wikipedia.org)
  • Hemodialysis: Hemodialysis will not significantly alter medication levels or change clinical effect of atorvastatin. (wikipedia.org)
  • occurs
  • Hyperlipoproteinemia type II, by far the most common form, is further classified into types IIa and IIb, depending mainly on whether elevation in the triglyceride level occurs in addition to LDL cholesterol. (wikipedia.org)
  • steady-state
  • Rofecoxib crossed the placenta and blood-brain barrier, and took 1-3 hours to reach peak plasma concentration with an effective half-life (based on steady-state levels) of approximately 17 hours. (wikipedia.org)
  • periods
  • Produced in high levels during periods of stress, infection, etc possibly leading to diabetic ketoacidosis, a very serious condition. (wikipedia.org)
  • A type of high-intensity interval training with short recovery periods was used in the 1970s by the athletics coach Peter Coe when setting sessions for his son Sebastian Coe. (wikipedia.org)